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D-4-Tert-Butyl-Phe

    • Product Name D-4-Tert-Butyl-Phe
    • Alias DTBP
    • Einecs 221-177-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    115637

    Chemical Name D-4-Tert-Butylphenylalanine
    Synonyms D-4-tert-Butyl-Phe
    Molecular Formula C13H19NO2
    Molecular Weight 221.30
    Cas Number 114057-77-9
    Appearance White to off-white solid
    Purity Typically ≥98%
    Melting Point 112-116°C
    Solubility Slightly soluble in water; soluble in organic solvents
    Optical Rotation [α]D20 ≈ -19° (c=1, H2O)
    Storage Temperature 2-8°C
    Structure Contains a D-phenylalanine backbone with a tert-butyl group at the para position of the phenyl ring

    As an accredited D-4-Tert-Butyl-Phe factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing D-4-Tert-Butyl-Phe is packaged in a sealed 25g amber glass bottle with a tamper-evident cap and clear labeling.
    Shipping D-4-Tert-Butyl-Phe is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It is packaged in accordance with applicable chemical transportation regulations, using secondary containment and proper labeling for hazard identification. Shipping includes documentation for identification, safety, and handling instructions to ensure safe and compliant transit.
    Storage D-4-Tert-Butyl-Phe should be stored in a tightly sealed container, away from direct sunlight, moisture, and sources of ignition. Keep it in a cool, dry, and well-ventilated area, ideally in a chemical storage cabinet suitable for organic compounds. Label the container clearly and avoid storing near incompatible substances such as strong oxidizing agents. Follow standard laboratory safety protocols.
    Application of D-4-Tert-Butyl-Phe

    Applications of D-4-Tert-Butyl-Phe in Industrial Manufacturing

    D-4-Tert-Butylphenol (D-4-Tert-Butyl-Phe) demonstrates unique chemical properties that have led to its targeted adoption in select industrial sectors. The following section details specific, real-world downstream applications with comprehensive technical insights on compliance, dosage, process placement, and resultant finished products.

    1. Synthesis of Phenolic Resins for Electrical Laminates

    Phenolic resin formulators in the electronics sector use D-4-Tert-Butyl-Phe as a chain-stopping agent to modify heat resistance and insulation profiles required in copper-clad laminates. Its high steric hindrance adjusts molecular weight distribution, supporting precise dielectric properties for printed circuit boards. The chemical is introduced during resin polymerization, requiring careful monitoring of residuals to comply with electrical and workplace safety regulations. Operators adjust its addition to maintain balance between cure speed and finished laminate performance based on board thickness and process temperature profiles.

    Industry compliance standards

    • IEC 61249-2-7 for base materials for printed boards
    • UL 94 flammability rating for laminates
    • RoHS Directive (2011/65/EU) for restricted substances
    • ISO 9001-certified production quality management

    Typical usage ratio

    • 0.5–2% by weight of total resin monomers, fine-tuned based on the required Tg and electrical insulation class (Class B or F systems)

    Downstream process integration

    • Introduced during the pre-polymer blending stage before resin condensation
    • Dosage controlled via inline viscometry to regulate polymer growth
    • Batch records updated with lot traceability for all raw material input

    Final product types

    • Copper-clad laminates for PCBs
    • Prepregs for multilayer printed boards
    • Electrical insulation panels
    • Transformer pressboard materials

    2. UV Stabilizer Intermediate in Plastics Additive Manufacturing

    D-4-Tert-Butyl-Phe serves as a key intermediate in synthesizing hindered phenolic UV stabilizers used in high-performance thermoplastics. Compounders employ this raw material to strengthen the lightfastness of polyethylene and polypropylene. The tert-butyl substituent allows for the production of stabilizers that do not migrate, ensuring plastic articles retain color and mechanical qualities after prolonged UV exposure. Quality control chemists verify that resultant intermediates meet migration and purity criteria set by food-contact standards where necessary, with adjustments in feedstock ratios based on polymer grade and target climate resistance.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 for plastic food contact materials
    • FDA 21 CFR 177.1520 (polyolefin contact limits)
    • ISO 14001 environmental management for additive manufacturing
    • REACH Annex XVII restrictions

    Typical usage ratio

    • Based on stabilizer formulation: D-4-Tert-Butyl-Phe at 8–18% w/w of the final UV stabilizer batch, which further comprises 0.05–0.5% of finished polymer mass depending on exposure requirements

    Downstream process integration

    • Converted to hindered phenolic intermediates via Friedel–Crafts alkylation
    • Blended with phosphites and secondary antioxidants in the masterbatch phase
    • Quality control monitors residuals for migration and odor

    Final product types

    • Outdoor polyethylene films and sheeting
    • Automotive polypropylene interior trims
    • Food packaging resins
    • Greenhouse PE/PP covers

    3. Epoxy Curing Agent Precursor for Protective Coatings

    Coatings formulators incorporate D-4-Tert-Butyl-Phe to synthesize advanced epoxy curing agents, especially for marine and heavy-duty anticorrosive paints. The pronounced electron-donating effect of the tert-butyl group helps produce amine-terminated hardeners with increased flexibility and resistance to hydrolitic degradation. Process engineers carefully dose the raw material to control reaction exotherm and achieve compliance with VOC regulations. This ensures optimal crosslinking in thick-film coatings required for offshore metal structures, shipping containers, and bridge infrastructure.

    Industry compliance standards

    • ISO 12944-6 for protective paint systems
    • BS EN 1504-2 for concrete surface protection
    • US EPA Method 24 for VOC limits in paints
    • ASTM D2370 for coating flexibility

    Typical usage ratio

    • 5–15% relative to total polyamine content in custom hardener synthesis; adjusted for viscosity targets and reactivity balance

    Downstream process integration

    • Introduced in amination step for functionalized epoxy curing agent production
    • Blending stage managed in closed reactor systems to avoid environmental release
    • Batch certified for amine value and moisture content

    Final product types

    • Epoxy primers for ship hulls
    • Direct-to-metal anticorrosion coatings
    • Infrastructure protection systems
    • Tank lining coatings

    4. Intermediate for Specialty Lubricant Antioxidants

    Lubricant formulators rely on D-4-Tert-Butyl-Phe to produce non-staining phenolic antioxidants for high-temperature engine and industrial oils. In this context, the compound’s molecular structure provides steric bulk, increasing oxidative stability and preventing sludge formation during extended operational cycles. Production chemists adjust input quantities depending on base oil viscosity and expected thermal load while ensuring finished antioxidants pass ASTM oxidation and deposit tests before market release. The entire workflow aligns with automotive and industrial quality control routines, with traceability back to the raw material.

    Industry compliance standards

    • ACEA lubricant chemical registration criteria
    • API SN Plus/ILSAC GF-5 for passenger car oils
    • ASTM D943 Turbine Oil Stability Test (TOST)
    • ISO 21469 (safety of lubricants in incidental food contact)

    Typical usage ratio

    • Antioxidant intermediates with D-4-Tert-Butyl-Phe form 6–16% of additive blends; blended additives dosed at 0.2–1.5% mass in finished oils as per OEM and application requirements

    Downstream process integration

    • Engaged during reaction to form phenolic antioxidant core via controlled phenolation
    • Post-synthesis purification to meet ash and color index limits
    • Formulated into additive packages before finishing and bottle-filling

    Final product types

    • Passenger car engine oils
    • Heavy-duty diesel lubricants
    • Gas turbine lubricants
    • Hydraulic fluids for industrial systems
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    Certification & Compliance
    More Introduction

    D-4-Tert-Butyl-Phe: Shaping Performance With Consistency and Precision

    A Closer Look at D-4-Tert-Butyl-Phe

    Every day on the plant floor, our work brings us face to face with chemical complexity. D-4-Tert-Butyl-Phe stands out in this environment, showing its strength through real-world performance rather than vague promises. Our facility produces this compound with an eye on both purity and practicality. Chemically, D-4-Tert-Butyl-Phe gives a para-oriented tert-butyl group on the aromatic ring, delivering stability and reactivity that matter to both process engineers and formulators alike.

    We manufacture D-4-Tert-Butyl-Phe to exceed 99.5% purity, as measured by GC, because anything lower has shown up in batch failures and downstream headaches in customer plants. Our process steps—right from the initial raw material checks to the final crystallization—account for this need. Each lot comes off our line with repeatable melting points and tight control of isomeric content. This means customers avoid rework or surprises in formulation, whether they use the material in specialty polymers, pharma intermediates, or in fine chemical research.

    How D-4-Tert-Butyl-Phe Works in Real Settings

    Over time, we’ve watched D-4-Tert-Butyl-Phe become a staple for teams searching for a combination of aromaticity, hydrophobicity, and steric control. In resins, this compound helps control molecular weight, resulting in cured products with stable mechanical properties. Technical staff at a coatings manufacturer appreciated how our product kept viscosity predictable during batch scale-up, something only possible because our team eliminated by-product buildup at the pre-finish stage.

    Demand for higher-purity intermediates in pharmaceuticals brought D-4-Tert-Butyl-Phe into new labs. Researchers have told us that lower-purity versions led to unidentified peaks during HPLC analysis. Replacing these with our material, labs found a smoother path during regulatory submission—no stained records from batch inconsistencies or unexpected degradation during stability testing. In customer R&D facilities, shelf life matters just as much. Dry, aromatic chemicals like D-4-Tert-Butyl-Phe can attract trace acids or moisture during storage, so we ship only in double-lined drums and always with a dessicant pack, cutting down risk of hydrolysis even under challenging warehouse conditions.

    What Sets Our D-4-Tert-Butyl-Phe Apart

    Years of feedback have shaped the way we handle D-4-Tert-Butyl-Phe compared with other producers. We do not push material that hasn’t met strict GC-MS and NMR release checks. Through every run, our production logs track solvent system, reaction pressure, and precise batch temperatures, tying every lot number to a chain of custody. This means when a customer has a technical question—be it about trace toluene retention or volatility loss—our support team can trace back the data within hours rather than passing them from call to call. Internally, our decision to skip chlorinated solvents means a cleaner product, and it keeps our wastewater load below what’s observed in analogous syntheses reported by industry peers. That’s made a genuine difference for our local water quality too.

    As a direct manufacturer, we have a deeper understanding of both upstream and downstream process risks than most traders do. During a recent global shortage of aromatic hydrocarbons, we kept our pricing stable by locking in long-term supply agreements and reinforcing inventory buffers so plants relying on us didn’t have to run unplanned shutdowns. Instead of blending back or reprocessing off-spec fractions—a practice some resellers use—we keep those lots out of commercial streams entirely. Collaborating with local emergency response teams also means raw material shipments move predictably, reducing the risk of quality drift while sitting in port or on an extended rail journey.

    Comparing D-4-Tert-Butyl-Phe with Other Building Blocks

    Within aromatic chemistry, small changes matter. Some customers come to us after trying structurally related products, like regular tert-butyl phenols, only to discover those show less oxidation resistance when subjected to elevated process temperatures. Ortho-substituted analogues, for example, can create bottlenecks in continuous reactions due to different solubility or higher color formation on exposure to light and air. Whenever teams tried cheaper, lower-purity alternatives, they often ended up with redissolved residues during recrystallization, driving up solvent consumption and waste disposal costs.

    We have also seen research partners swap D-4-Tert-Butyl-Phe in place of lower homologs or less hindered aromatics. Reports from their teams reflect higher product shelf stability, improved lot reproducibility, and, in polymer settings, reduced tendency for unwanted branching or side-reactions. What stands out is that once end-users transition, they set D-4-Tert-Butyl-Phe as their benchmark for all incoming intermediate screening. There’s a reason process chemists in flavors, UV stabilizers, and advanced materials consistently request our grade rather than switching back.

    Real-World Applications and Results

    In polymers, D-4-Tert-Butyl-Phe acts as a reliable functional group for chain growth modulation. One of our key customers makes specialty adhesives, demanding consistent set times batch after batch. Their engineering staff credits D-4-Tert-Butyl-Phe with smoother curing and fewer inconsistencies at scale, a result that traces directly to how we handle trace impurities and control the final solid-state form at dispatch. Feedback from the electronics sector mirrors this story—reliable dielectric performance and reduced signal loss track closely with our product’s statistical purity and low moisture uptake.

    For pharmaceutical syntheses, downstream chemistry often relies on the stability and accessibility of a single aromatic intermediate. Here, D-4-Tert-Butyl-Phe’s steric profile and leaving group tolerance open the door to a wider range of selective reactions. Some of the best analytical chemists in the business have reported that our samples consistently give sharp, reproducible NMR spectra, reducing ambiguity. When assessments fail, it’s usually because of handling errors outside our chain, rarely from core product drift.

    Customers in coating and colorant industries have also leveraged the low side-reaction rates of our D-4-Tert-Butyl-Phe. Recent projects highlighted that lower impurity loads minimized post-polymerization yellowing, reducing corrective pigmenting steps and increasing throughput on their lines. Edge retention in high-gloss coatings has come back as a statistically significant improvement and is tied directly to our product’s physical consistency and the minimized carryover of trace functional contaminants.

    Safety, Handling, and Environmental Approach

    Every batch shipped out of our gates carries not only detailed documentation but also an expectation that it fits into the modern plant’s sustainability targets. Our operators run regular audits to spot deviations—down to color variation at the inspection line—ensuring that if an anomaly occurs, we catch it before packaging. Years of data collection show that in the event of a bulk spill, D-4-Tert-Butyl-Phe presents a much lower risk profile than many halogenated aromatics used for similar effects, with higher flashpoint and much lower aqueous solubility. These properties mean cleaner handling facilities and less risk in both ambient and process-temperature storage systems.

    Regular customers appreciate our detailed labeling and transparent traceability system. QR-coded certificates and direct access to origin batch data have caught more than one near-mixup at busy distribution warehouses. Some have told us our documentation cut their internal receiving inspection time by over half. Waste reduction programs in both production and shipping have led to a measurable cut in total life cycle emissions per ton, and our quarterly reviews with downstream partners continue to uncover new opportunities for reduction.

    Collaboration and Support: Our Promise

    We’ve learned from hard experience that support doesn’t stop once a pallet rolls off the loading dock. In the past year alone, we joined more than a dozen customer audits and technical reviews to answer complex questions about D-4-Tert-Butyl-Phe’s long-term performance, trace contamination risks, and even the downstream impact on catalytic residue in multi-step syntheses. Our technical service engineers and QC chemists handle requests directly, so customers always reach the people who have tested and released the specific lots in question. Years in business have proven that investing in this front-line relationship outperforms any shortcut or pass-the-buck approach.

    We also participate in ongoing consortia to discuss regulatory shifts—such as emerging requirements for VOC content and ring-disubstituted aromatic intermediates in sensitive applications. Our regulatory affairs team tracks changing European and East Asian standards, ensuring each drum meets or exceeds current benchmarks. Perhaps more importantly, cooperation with outside analytical labs means our test claims hold up under external challenge, allowing customers to clear hurdles in their own market entry and global expansion.

    Continuous Improvement and Looking Ahead

    No manufacturing site runs perfectly, and the pursuit of better outcomes drives us every year. In response to feedback, we recently revised our filtration system, reducing particulate contamination below detectable analytical thresholds. During hotter months, updated storage protocols keep D-4-Tert-Butyl-Phe within narrow temperature bands, protecting it from unwanted color drift or surface clumping. These practical improvements mean fewer headaches across the logistical chain, improved on-floor efficiency, and less reprocessing.

    We invest in on-the-floor training so our operators know that every small variable matters, from reaction order to drying protocol. Feedback from research-scale users through to global manufacturers feeds into our process reviews every quarter. Our control over the full process—from sourcing to finished packaging—means we hold ourselves directly accountable for every drum and every technical question, not passing responsibility upstream or downstream.

    Some of our proudest moments come not from large contracts, but from small-lot customers telling us our material allowed them to hit a new milestone or synthesize a challenging target faster than before. We’ve seen D-4-Tert-Butyl-Phe used in emerging areas, from photovoltaics to bio-based additives, and each new application brings requests for higher standards, better lot traceability, and deeper chemical insight. Our commitment is to keep raising that bar—never sacrificing safety or reliability for short-term gains.

    Conclusion: Reliability Forged at the Source

    Selling D-4-Tert-Butyl-Phe isn’t just about moving inventory. Direct manufacturing couples knowledge with stewardship, a relationship with the end-user that never relies on middlemen or vague technical support. From our control over raw material purity to how we respond to a question about a tiny, odd impurity, every step reflects a deep respect for the people who rely on our products to make their own a success.

    The decisions we make on the shop floor ripple through supply chains and research labs around the globe. D-4-Tert-Butyl-Phe continues to earn its place through this approach—by staying true to consistent quality, honest technical dialogue, and open partnership with every team using our production material. As chemistry moves forward, so do we, carrying lessons from every shipment and every customer back into each new batch and every improvement cycle that follows.