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Cyclopropanecarboxylic Acid Hydrazide

    • Product Name Cyclopropanecarboxylic Acid Hydrazide
    • Alias CYCLOPROPANOYLHYDRAZINE
    • Einecs 253-855-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
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    VTB
    Specifications

    HS Code

    502723

    Product Name Cyclopropanecarboxylic Acid Hydrazide
    Cas Number 4441-22-3
    Molecular Formula C4H8N2O
    Molecular Weight 100.12 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 83-87°C
    Solubility Soluble in water
    Purity Typically ≥98%
    Storage Store in a cool, dry place
    Synonyms Cyclopropanecarbohydrazide
    Smiles C1CC1C(=O)NN
    Inchikey WXXFZZPOPFLSRX-UHFFFAOYSA-N
    Hazard Statements May cause irritation to skin, eyes, and respiratory tract

    As an accredited Cyclopropanecarboxylic Acid Hydrazide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cyclopropanecarboxylic Acid Hydrazide, 25 grams, is packaged in a sealed amber glass bottle with a secure screw cap.
    Shipping Cyclopropanecarboxylic Acid Hydrazide should be shipped in tightly sealed containers, protected from light and moisture. Transport as a stable solid at ambient temperature unless otherwise specified. Ensure compliance with local, national, and international regulations for chemical shipping, and label as a laboratory chemical with appropriate hazard warnings if required.
    Storage Cyclopropanecarboxylic Acid Hydrazide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area. Protect from direct sunlight, moisture, and sources of ignition. Store away from incompatible substances such as oxidizing agents and acids. Ensure proper labeling and secure storage to prevent unauthorized access. Recommended storage temperature is typically room temperature (20-25°C), unless otherwise specified by the manufacturer.
    Application of Cyclopropanecarboxylic Acid Hydrazide

    Applications of Cyclopropanecarboxylic Acid Hydrazide in Industrial Manufacturing

    Cyclopropanecarboxylic Acid Hydrazide serves as a specialized intermediate in multiple advanced chemical sectors. Our facility supplies this raw material for integration into precise downstream formulations requiring high purity and batch consistency. Below, we detail proven application scenarios according to market feedback and regulatory standards.

    1. Agrochemical Synthesis: Herbicide Active Ingredient Production

    Agrochemical companies deploy cyclopropanecarboxylic acid hydrazide for the synthesis of heterocyclic intermediates used in selective herbicide actives. Its unique cyclopropyl backbone enhances the performance of hydrazide-based block-building reactions during the generation of triazole and pyrazole frameworks found in modern formulations. Commercial production requires strict management of residual hydrazide via validated analytical protocols. Our technical support covers compatibility and real-time monitoring in continuous or batchwise systems deployed by major crop science manufacturers.

    Industry compliance standards

    • EU Regulation (EC) No 1107/2009 on Plant Protection Products
    • US EPA FIFRA Timelines and Analytical Requirements
    • ISO 9001 Quality Management Systems for Agro Raw Inputs
    • REACH Registration Compliance for Industrial Chemical Supply

    Typical usage ratio

    • 0.5% to 3% m/m as a key intermediate, adjustable based on targeted actives synthesis yield and desired impurity profiles

    Downstream process integration

    • Initial introduction at condensation step with diketone or triazole-generating reagents in herbicide synthesis route
    • Feeds into designated reactor loops for hydrazinolysis followed by cyclization
    • Purification post-condensation and residue analysis prior to downstream formulation coating/blending
    • Batch QC for trace residues per MRL (maximum residue limit) requirements

    Final product types

    • Granular selective herbicide actives containing triazole or pyrazole scaffolds
    • Suspension concentrates for post-emergent application
    • Micro-encapsulated agro ingredients
    • Pre-mix herbicide blend bases for international markets

    2. Pharmaceutical Intermediates: API Building Blocks for CNS Drug Synthesis

    Regulated pharmaceutical manufacturers use cyclopropanecarboxylic acid hydrazide as a core intermediate in the assembly of API skeletons targeting central nervous system disorders. Its incorporation occurs at hydrazine exchange steps for the introduction of constrained ring substituents, which modulate pharmacokinetic and physiochemical properties. Process development involves validated impurity control protocols and robust traceability from raw material intake to final API crystallization batch. Our supply chain supports GMP-grade material and custom specification adjustment to comply with multi-market registration demands.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 US cGMP Requirements
    • European Pharmacopoeia Monograph 2.2.2 Purity Guidelines
    • Chinese Pharmacopoeia (if applicable to regional registrations)

    Typical usage ratio

    • 0.8% to 2.6% w/w as an intermediate input, adjusted according to targeted molecular backbone and stepwise conversion efficiency

    Downstream process integration

    • Transformation in stepwise hydrazinolysis during early-stage synthesis of CNS actives
    • Enters batch or semi-continuous reactors as hydrazide-reactive agent
    • Purity monitoring via HPLC or LC-MS before downstream nucleophilic substitution
    • Elimination of unreacted hydrazide during API isolation and crystallization

    Final product types

    • Bulk APIs for anti-epileptic drugs
    • Key intermediates for anxiolytic agent manufacturing
    • Finished CNS API crystallization batches
    • Export-grade pharmaceutical intermediates for European and North American markets

    3. Veterinary Drug Intermediate Manufacturing

    Animal health sector manufacturers utilize cyclopropanecarboxylic acid hydrazide in the controlled synthesis of hydrazide-containing active substances for veterinary medications. The molecule’s constrained ring assists in the development of reduced toxicity and improved delivery characteristics in parasite control agents. Our technical documentation supports full traceability and customized impurity reporting for export-oriented veterinary plants. Material is delivered with COA covering impurity fingerprint, solubility, and IR spectrum on batch-by-batch basis.

    Industry compliance standards

    • VICH GL Guidelines for Veterinary Drug Synthesis
    • US FDA Guidance for Industry #79: Veterinary Medicinal Products
    • EU GMP Volume 4 for Veterinary Product Ingredient Suppliers
    • OECD Good Laboratory Practice (GLP) for Raw Material Testing

    Typical usage ratio

    • 1.0% to 4.2% m/m based on formulation requirements and step yields in active compound synthesis

    Downstream process integration

    • Hydrazide coupling with specific acylating agents in the animal injectable and oral drug synthesis process
    • Flows via automated ingredient dosing systems into core reactor during downstream step
    • QC involves LC purity monitoring and limit test of hydrazine derivatives
    • Removal of excess hydrazide during purification and granulation phases

    Final product types

    • Veterinary injectable active compound pre-mixes
    • Granulated antiparasitic drug intermediates
    • Oral veterinary active pharmaceutical blends
    • Export-ready API loads for livestock medication

    4. Chemical Research & Analytical Reference Standards

    Analytical laboratories, specialty chemical institutes, and quality control centers procure cyclopropanecarboxylic acid hydrazide for developing calibration curves and as a reaction marker in structure–activity relationship (SAR) research. It is utilized in method development for chromatography assays checking for hydrazide group reactivity, stability, and detection limits. Our product comes with batch-specific full spectrum and C of A supporting traceable chain for certified reference material registration or custom blending projects under documented quality practices.

    Industry compliance standards

    • ISO/IEC 17025 Laboratory Accreditation Requirements
    • OECD GLP for Chemical Reference Material Production
    • USP <1040> Analytical Reference Standards Guidelines
    • Good Documentation Practice (GDP) for QC Laboratories

    Typical usage ratio

    • Used as a pure analytical standard, typically diluted to 0.1 mg/mL–5 mg/mL for calibration solutions, adjusted according to required detection sensitivity of analytical method

    Downstream process integration

    • Preparation of working and stock solutions in analytical method validation
    • Injected into LC/GC-MS or HPLC systems for calibration and quantitation checks
    • Applied in synthetic route development for SAR studies
    • Consistency and traceability documentation for accredited laboratory workflows

    Final product types

    • Certified calibration standards for chromatography
    • Reference marker spiking solutions for controlled experiments
    • Reaction monitoring samples for synthetic process validation
    • SAR research libraries for chemical discovery programs
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    Certification & Compliance
    More Introduction

    Cyclopropanecarboxylic Acid Hydrazide: Unlocking Precision in Synthesis

    Genuine Manufacturer Perspective

    Our experience as a longstanding producer of specialty fine chemicals gives us a clear view of what our clients look for in chemicals like Cyclopropanecarboxylic Acid Hydrazide. This compound, offered under model designation CPAH-025, continues to draw attention from pharmaceutical research labs and specialty chemical formulators for its unique cyclopropyl backbone. When chemists talk about building more selective, potent, or safer compounds, the cyclopropyl motif offers rigidity that can subtly change how molecules behave. Hydrazides provide concise access to hydrazones and open additional doors for derivatization. That combination gives Cyclopropanecarboxylic Acid Hydrazide a distinct edge over standard hydrazides or open-chain analogs.

    From Raw Materials to Consistency

    Our manufacturing starts with carefully sourced cyclopropanecarboxylic acid, steadily reacting it with hydrazine hydrate under controlled conditions. Tight temperature and pH oversight minimizes side-product formation—something less-disciplined processes often miss, which can cause headaches for those running multi-step synthesis. Time and again, customers switching to our lot report fewer purification issues downstream. Every batch leaves our facility with a certificate showing purity ≥99%, checked by NMR and HPLC. That level of quality lets medicinal chemists step straight into the next stage of their project rather than spending extra hours cleaning up avoidable impurities.

    Physical Form and Handling

    In our hands, Cyclopropanecarboxylic Acid Hydrazide comes as a fine crystalline solid, pale white, and stays stable for years under dry, ambient storage. Its melting point falls near 123–125°C, consistent with what has been published in the literature. We use sturdy, moisture-tight packaging to prevent clumping or hydrolysis during long transit—even across continents. Our QA records show less than 0.2% deviation in melting point or appearance for hundreds of production lots shipped globally.

    Comparing to the Usual Hydrazides

    Standard hydrazides like acetic or propionic acid hydrazide show up on lab benches, but Cyclopropanecarboxylic Acid Hydrazide carries distinct advantages. In medicinal chemistry, the cyclopropyl group often blocks metabolic oxidation, increasing a candidate compound’s half-life. It can lock side chains in spatial arrangements that boost activity or selectivity at biological targets. We have seen clients in preclinical drug discovery use our product to move past puzzles with metabolic instability or undesired isomerization.

    Other hydrazides with aromatic rings or longer open chains tend to add unnecessary bulk or leave molecules exposed to oxidation. Cyclopropanecarboxylic Acid Hydrazide, with a compact ring and minimal branching, fits nicely into scaffold modification where spatial economy counts. Some agrochemical labs told us this hydrazide helped them design candidates that resisted breakdown by soil microbes better than others they tested.

    Applications in Modern Research

    Medicinal chemists prize Cyclopropanecarboxylic Acid Hydrazide because it forms reliable hydrazones—key intermediates in synthesis of heterocycles, active pharmaceutical ingredients, and imaging probes. The hydrazide function readily condenses with aldehydes or ketones, but thanks to the cyclopropyl core, the resulting products often show notable rigidity and metabolic resistance. Over the past decade, most patent applications using this intermediate trace back to lead optimization in oncology, CNS disorder therapies, and selective pesticides.

    Our direct users rarely stick to textbook steps. We engage with synthetic teams using reductive amination, click-chemistry, and even electrochemical functionalization with Cyclopropanecarboxylic Acid Hydrazide as a starting block. Because our manufacturing allows scaling from gram to multi-kilogram quantities, we often support programs going from concept through to initial clinical supply without a hitch in quality or traceability.

    Technical Reliability in Complex Synthesis

    Some compounds look fine on paper but create bottlenecks when you take them plant-scale. Poor solubility, sticky residues, batch-to-batch drift—small annoyances at gram scale can become disasters at 10 or 100 kilograms. Our R&D chemists figured out how to crystallize Cyclopropanecarboxylic Acid Hydrazide in a tightly controlled manner. We avoid discoloration, run comprehensive moisture analysis, and test for hydrazine left over in every batch. As the manufacturer, we attribute our process success to repeated, hands-on troubleshooting and careful equipment maintenance. You don’t need to worry about residues or trace metals—ICP-MS data from our QC lab shows well below ppb levels.

    Safety and Environmental Responsibility

    Producing hydrazides, particularly those involving hydrazine intermediates, requires stringent safety systems. We invested heavily in closed handling, careful pressure control, scrubbers, and employee PPE. Our records show zero incidents related to hydrazide exposure in the last five years, which few operators in this sector can claim. Once the product leaves our plant, its stability in shipment and absence of dusting reduces risk for users handling larger volumes.

    For waste management, we neutralize residual hydrazine under controlled oxidation, then recycle effluents into less-hazardous forms where possible. Our plant holds ISO certifications for both safety and environmental stewardship. That gives clients extra assurance that their own ESG (environmental, social, and governance) policies will not be at odds with their starting materials. We work with local regulators and participate in regional clean-synthesis initiatives.

    Advantages Over Generic and Outsourced Production

    Clients ask us about the real difference between buying manufacturer-sourced Cyclopropanecarboxylic Acid Hydrazide versus generic material sitting with a trader. The straight answer comes down to reliability and peace of mind. As the manufacturer, we own the data, know the upstream supply chain, and issue traceable documentation. No surprise contaminants creep in from storage, transit, or repackaging steps. If a client encounters a technical hiccup, they reach our senior process chemists—not a reseller passing messages between parties.

    Supply security increases with direct manufacturing. Raw material sourcing, process scalability, flexibility in packaging, and guaranteed batch repeatability stem from our hands-on approach. During global supply chain disruptions, we ramped up production on short notice, keeping crucial research programs running. Scientists’ output shouldn’t hinge on whether a reseller happens to have a dusty drum in stock, or whether some paperwork goes missing in customs. Our system builds in process documentation, regular verification, and comprehensive shipment tracking.

    Solutions for the Chemist: Practical Notes

    Labs aiming for high yields with minimal chromatographic fuss report good outcomes using our Cyclopropanecarboxylic Acid Hydrazide. The product’s high purity and reliable crystalline form speed up workups and crystallizations. We support both small-scale screening and pilot-scale manufacture with tailored lot sizes. Requests for detailed analytical data—NMR, IR, LC-MS, residual solvent profiles—draw on our in-house records, with reports available to every client.

    Whenever synthesis gets tricky, like developing a new route for complex nitrogen heterocycles, our chemists collaborate with customers to optimize conditions. That includes sharing proven work-up procedures, solvents that suppress side reactions, or advice balancing temperature and reagent stoichiometry. Because our production never shifts to contract or external providers, the data matches the product in your hands.

    Feedback from End Users

    Clients from applied pharmaceutical research, academic labs, and specialty chemical developers frequently report on the difference that manufacturer-supplied material makes in their workflow. They mention fewer repeat experiments, easier scale jumps between batches, and reduced time arguing with regulators over quality documentation. Rarely does a week go by without a request for guidance on novel uses of cyclopropyl hydrazides—in polymers, fluorescent probes, or even new battery materials. We take those queries seriously, tracking developments so we can keep improving both manufacturing and application support.

    Why the Origin of Your Cyclopropanecarboxylic Acid Hydrazide Matters

    The market for fine chemicals flooded with intermediaries makes it hard for end users to separate genuine quality from generic bulk. When clients pick up our Cyclopropanecarboxylic Acid Hydrazide, they gain access to more than just a chemical. They receive deep technical background, transparent sourcing, rigorous purity traceability, and practical advice honed by decades of manufacturing and application. That difference shows itself not just in spreadsheets, but in real improvements in project timelines, experiment reproducibility, and confidence under regulatory review.

    For projects headed toward clinical or commercial production, every upstream mistake grows larger farther down the pipeline. Using hydrazides sourced directly from the manufacturer gives your team a head start, reduces troubleshooting, and eliminates the quiet risk that comes from sourcing off-brand chemicals. In challenging industries, where a failed experiment or contaminated reagent means lost weeks or months, certainty gets valued above minor cost savings from anonymous sources.

    A Commitment to Real-World Progress

    Innovation happens where reliable materials, deep technical knowhow, and open feedback loops intersect. Our role as a chemical manufacturer ties together decades of process knowhow, strong supplier partnerships, and close collaboration with scientists who use Cyclopropanecarboxylic Acid Hydrazide to push boundaries. We prioritize openness. Every inquiry gets answered by someone familiar with the actual product history, every batch gets archived and cross-checked, and improvement never stops. For those in the trenches of lab and pilot plant research, that trusted foundation means less energy spent second-guessing a chemical’s backstory, and more energy finding the next big breakthrough.

    Cyclopropanecarboxylic Acid Hydrazide, model CPAH-025, reflects the strengths of focused, scale-ready, and customer-driven chemical manufacturing. In our hands, this compound delivers reliability, purity, and a flexibility tailored to practical science. Each production run deepens our technical capability and builds up relationships across markets, from pharmaceuticals to specialty materials. By working directly with the manufacturer, chemists ensure every milligram shapes progress, not just protocol.