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Cycloheptylamine

    • Product Name Cycloheptylamine
    • Alias Heptamethyleneimine
    • Einecs 209-786-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    522277

    Cas Number 2185-98-0
    Molecular Formula C7H15N
    Molecular Weight 113.20 g/mol
    Iupac Name cycloheptanamine
    Appearance Colorless to yellow liquid
    Boiling Point 162-164 °C
    Density 0.86 g/mL at 25 °C
    Refractive Index 1.4550
    Melting Point -14 °C
    Solubility In Water Miscible
    Flash Point 54 °C
    Smiles C1CCCCCC1N

    As an accredited Cycloheptylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cycloheptylamine is packaged in a 500 mL amber glass bottle with a secure screw cap and hazard labeling clearly displayed.
    Shipping Cycloheptylamine should be shipped in tightly sealed containers, protected from moisture and extreme temperatures. It is typically transported as a hazardous chemical, following local, national, and international regulations for flammable and corrosive substances. Proper labeling, documentation, and safety data sheets must accompany the shipment to ensure safe and compliant handling.
    Storage Cycloheptylamine should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition, strong oxidizing agents, and acids. Keep the container tightly closed when not in use and avoid exposure to moisture. Proper labeling and compliance with relevant regulations are necessary to ensure safe handling and storage of this chemical.
    Application of Cycloheptylamine

    Applications of Cycloheptylamine in Industrial Manufacturing

    As a specialized producer of Cycloheptylamine, we work directly with industrial formulators and manufacturers operating in tightly regulated sectors. We support the integration of this advanced chemical intermediate in real-world synthesis routes, emphasizing regulatory adherence, precise formulation control, and scalable downstream processing.

    1. Active Pharmaceutical Ingredient (API) Synthesis for Antihypertensive Drugs

    Cycloheptylamine acts as a crucial amine building block for certain proprietary and generic cardiovascular APIs, especially in the synthesis of alkylamine-based compounds. Manufacturers consistently rely on its reactivity for N-alkylation and reductive amination steps, which enables the construction of secondary and tertiary amine functional groups in API frameworks. Close attention to purity, traceability, and documentation is essential throughout these multi-step GMP manufacturing environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice
    • US FDA 21 CFR Part 210/211
    • EU GMP for Active Substances (Part II)
    • Relevant monographs: European Pharmacopoeia, USP, JP (finished dose application)

    Typical usage ratio

    • Generally 1.1 – 1.4 equivalents relative to key precursor acids or ketones
    • Ratio adjusted by batch scale to optimize yield and minimize side-product formation
    • Excess managed through downstream recovery or purification

    Downstream process integration

    • Added at intermediate condensation or amination stage
    • Neutralization with suitable acids post-reaction for salt formation
    • Followed by process filtration, crystallization, and final API purification
    • Utilized prior to chiral resolution or API salt selection, depending on drug target

    Final product types

    • Antihypertensive tablets and capsules (e.g., beta/alpha-blocker derivatives)
    • Parenteral solutions containing amine-based active substances
    • Pre-formulated fixed-dose cardiovascular medications

    2. Agricultural Herbicide Intermediate Production

    Cycloheptylamine serves as a nitrosamine-free amine source in the synthesis of certain selective post-emergence herbicide active compounds. Its alicyclic structure often improves the physiochemical characteristics of herbicidal molecules, including improved volatility control and environmental stability. Manufacturers must demonstrate that downstream intermediates do not contribute to regulated impurities under crop safety regimes.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • REACH registration (EC) No 1907/2006 for intermediate classification
    • OECD Guidelines for Testing of Chemicals
    • Local agrochemical safety regulations (e.g., US EPA 40 CFR, EU Regulation (EC) No 1107/2009)

    Typical usage ratio

    • Usually employed at 1.05 – 1.2 molar equivalents relative to acid chlorides or activated esters
    • Ratio adjusted to minimize unreacted amine and optimize yield during cyclization or coupling

    Downstream process integration

    • Used in amidation or carbamate formation steps for active ingredient manufacture
    • Integrated into continuous or batch esterification / amination lines
    • In-process controls required for residual amine detection via GC or HPLC
    • By-product minimization managed via solvent extraction and subsequent purification

    Final product types

    • Post-emergence crop herbicides for cereal, maize, and grassland
    • Ready-to-use herbicide formulations
    • Intermediates for further synthesis of multi-mode herbicidal actives

    3. Flexible Polyurethane Catalyst Manufacturing

    Cycloheptylamine is integrated as a key co-catalyst and chemical modifier in the production of tertiary amine-based polyurethane catalysts. Its use facilitates fine-tuning of both the reactivity and final fizzy-cell structure in flexible foams, critical in automotive seating, furniture, and bedding applications. Systematic control of addition level impacts rise time, cure profile, and physical foam properties, requiring strict batch-to-batch consistency.

    Industry compliance standards

    • ISO 9001 Quality Management Systems
    • REACH chemical safety assessment
    • CertiPUR standard for foam production
    • Automotive OEM restricted substances lists (e.g., GADSL)

    Typical usage ratio

    • Generally 0.1% – 0.3% by weight of total polyol premix
    • Level set by formulation depending on desired foam density and resilience
    • Overdose leads to foam collapse, so dosing accuracy is monitored in line production

    Downstream process integration

    • Charged to polyol blend during main catalyst mixing phase
    • Homogenized with other tertiary amines and metal catalysts
    • Full mixing achieved before isocyanate addition
    • Compatible with both continuous and batch foam slabstock systems

    Final product types

    • Flexible furniture-grade PU foams
    • Automotive seating and headrests
    • Carpet underlay sheets
    • Specialty bedding and mattress products

    4. Corrosion Inhibitor Additive for Closed-Loop Cooling Systems

    The cyclic structure of cycloheptylamine allows for efficient vapor-phase protection in steam and closed-loop water systems. As a neutralizing amine, it is formulated into corrosion inhibitor blends that target carbon steel and copper alloy surfaces. Its efficient pH stabilization and volatility profile make it suitable for high-pressure heating networks in power generation and district heating.

    Industry compliance standards

    • ASTM D6200 Standard Guide for Corrosion Inhibitors
    • AMPP/NACE Standard Practice SP0108
    • US EPA regulations for boiler water additives (40 CFR 417.42, where applicable)
    • EU Biocidal Products Regulation (BPR) (EU) No 528/2012 (for additive mixtures)

    Typical usage ratio

    • Introduced at 3 – 9 ppm of total system water volume
    • Dosing calculated by real-time conductivity and pH monitoring
    • Low overdosing risk; blend concentrations typically adapted to system metallurgy and flow rate

    Downstream process integration

    • Dosed via automated inhibitor injection pumps to recirculating network
    • Blended with other neutralizing and filming amines
    • Real-time dosing system links inhibitor concentration to system demand
    • Compatible with high-pressure boiler and chiller operations

    Final product types

    • Amine-based corrosion inhibitor concentrates
    • Complete water treatment formulations for district energy plants
    • Specialized inhibitor blends for industrial boiler houses
    • Multi-component steam system additives

    5. Chemical Synthesis Intermediate for Pharmaceutical Discovery

    Cycloheptylamine plays a central role as a chain-elongating and ring-modifying agent in medicinal chemistry labs and scale-up plants. Research and pilot teams use it in the modular construction of alkaloid derivatives, CNS drug scaffolds, and other nitrogen-containing probe molecules. Storage and handling procedures comply with strict traceability and contamination control requirements for early-stage drug synthesis.

    Industry compliance standards

    • GLP (Good Laboratory Practice) for R&D
    • ISO 13485 for excipient and raw material control in pharmaceutical prototypes
    • Local chemical safety regulations (Hazard Communication, GHS labeling)
    • Controlled substance compliance if used in fine chemical routes

    Typical usage ratio

    • Standard protocols use 1 – 2 molar equivalents depending on reaction type
    • Precise ratio determined per target molecule by medicinal chemistry team
    • Most syntheses run on 1g – 500g pilot lots with flexible stoichiometric adjustment

    Downstream process integration

    • Charged at nucleophilic substitution, reductive amination, or protection group introduction steps
    • Integrated with automated reaction platforms in kilo-lab and pilot plant environments
    • Supply in sealed, inerted containers for moisture- and air-sensitive SOPs
    • Batch-wise traceability maintained from delivery to waste documentation

    Final product types

    • Small-molecule drug candidates for pre-clinical / Phase I use
    • Advanced pharmaceutical intermediates (APIs-in-development)
    • Reference standard compounds for analytical validation
    • Custom probe molecules for screening libraries

    6. Flotation Agent Component in Mineral Processing

    Cycloheptylamine forms part of certain mineral flotation reagent formulations where its adsorption behavior enhances the selective separation of non-ferrous metal ores, including copper and nickel. Its cyclic amine structure promotes adsorption on mineral surfaces and improves selectivity in systems sensitive to linear alkyl amines. Usage requires compliance with environmental, workplace safety, and tailings management regulations.

    Industry compliance standards

    • ISO 14001 Environmental Management Systems
    • ICMM Mining Principles (for sustainability management)
    • Occupational Exposure Limits (e.g., OSHA, ACGIH)
    • REACH compliance for downstream environmental impact

    Typical usage ratio

    • Added at 20 – 60 grams per tonne of processed ore
    • Optimization trials required per ore body to maximize target recovery and minimize loss
    • Dosage adjusted per ore mineralogy and slurry parameters

    Downstream process integration

    • Blended on-site into collector and modifier reagent batches
    • Fed directly to flotation cell circuits at ore handling sections
    • Regular process audits for residual amine in plant effluent
    • Tank farm supply managed under chemical containment procedures

    Final product types

    • Upgraded base metal concentrates (Cu, Ni)
    • Refined metal intermediate slurries
    • High-purity ore fractions for subsequent hydrometallurgical or smelting operations
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    Certification & Compliance
    More Introduction

    Cycloheptylamine: Reliable Sourcing Direct from the Manufacturer

    Trust Built on Real Production Experience

    Our team has spent years in the chemical plant halls and on the logistics floor, coordinating every batch of cycloheptylamine from raw material intake to sealed drum. With hundreds of tons behind us, we've come to understand the practical side of manufacturing a pure, stable, and consistent amine compound. Unlike trading houses or brokers, we keep a hands-on approach, watching the reactors, tracking batch consistency, and checking every shipment ourselves. Direct production means tighter quality control, fewer unknowns, and a short supply chain you can track right back to us. Our customers—especially those in pharma and specialty synthesis—count on that difference.

    What Sets Cycloheptylamine Apart

    Cycloheptylamine comes as a clear, colorless to pale yellow liquid, best known for its role in building complex organic molecules. Not every amine fits every purpose; the cycloheptyl group brings unique chemical properties, particularly in the way it resists ring strain and influences solubility compared to open-chain amines. Over years of operation, we've seen how our consistent production leads to more predictable reaction outcomes for our customers.

    This product makes a difference when customers need a starting material for pharmaceutical ingredients, crop protection agents, or rubber accelerators. Other amines—like cyclohexylamine or ethylamine—may get more attention, but cycloheptylamine stands out because of the seven-membered ring. This ring size offers different steric effects in synthetic pathways, making it valuable for chemists devising selective syntheses. When researchers switch from a six- to a seven-membered ring, they look for a reliable cycloheptylamine supply, not a blended or contaminated version that might throw off entire reaction schemes.

    Specifications: What Matters in Real Production

    Every batch we ship meets industry standards, with typical purity above 99% by gas chromatography. Moisture content, color index, and residue on evaporation fall well within the values set by leading pharmaceutical inspection authorities because we control every step of our manufacturing. From handling the starting cycloheptanone under inert atmosphere to the final purification and packaging, the process emphasizes chemical safety and purity.

    Our technical teams monitor nitrogen, amine value, and trace impurity profiles. This vigilance shields downstream applications from surprises. With years of dialed-in reactor conditions, we turn out product that meets the needs of both development and full-scale industrial chemists. If researchers want low water content for sensitive synthesis, we listen. If a rubber producer requires drums filled and sealed under nitrogen, our plant has the set-up and discipline to deliver that exacting requirement.

    Comparing Cycloheptylamine with Other Amines

    Deciding between cycloheptylamine and more common cycloalkylamines boils down to structure and reactivity. Our field visits with formulators and reaction chemists confirm that cycloheptylamine, due to the seven-membered ring, offers a larger cavity size and more flexibility than cyclohexylamine. This seemingly small jump in ring size drives substantial changes in binding properties and basicity. Cycloheptylamine resists acid degradation well and imparts different solvation behavior, especially when dissolved in alcohols or mixed with polar aprotic solvents. This comes up repeatedly in requests from pharma groups developing API intermediates that need both stability and reactivity tuning.

    We get repeat calls from customers working in agrochemical synthesis, who tell us that switching to cycloheptylamine lets them build ring-expanded products otherwise hard to reach. This specificity is why we keep a dedicated line, unshared with short-chain amines that could cross-contaminate a batch. Our technical staff spends as much time discussing application results as running reactors—because knowing the chemistry helps us troubleshoot and adapt production if a partner’s needs shift.

    Applications: What Our Customers Achieve

    Most of our cycloheptylamine moves to companies focused on complex organic synthesis. In pharmaceuticals, it acts as a key intermediate for beta-blockers, CNS drugs, and antiviral research. The rigid seven-membered ring plays a part in receptor selectivity, so routine purity and trace analysis matter. In agricultural chemistry, formulating fungicides and innovative herbicides often calls for amine intermediates that avoid common cross-reactivity. Our production teams have developed experience shipping not just bulk containers but custom-packed lots for pilot projects. We respond to load-out requests quickly since customers' R&D timelines are tight, and real research can’t wait for an uncertain delivery window.

    We also supply sectors such as pigment synthesis and specialty coatings, where the amine group’s nucleophilicity supports direct and indirect coupling reactions. Since these markets want complete transparency with batch origins and contaminant profiles, our in-house analytic teams document every shipment. We encourage site visits—a practice that’s opened more than one partnership, because seeing real reactors and staff inspires confidence.

    Manufacturing: From Raw Materials to Finished Cycloheptylamine

    We operate our own reactor systems with control over all synthetic inputs, temperature, and pH cycling. Most of our process starts from high-quality cycloheptanone, which passes strict incoming inspection. Amination occurs with tight monitoring, and we use proprietary phase separation to drive purification. Our technical staff has developed safety protocols for handling pressurized gases and hazardous byproducts—so the people making cycloheptylamine have the training and protective systems they need.

    Solvent recovery and waste minimization have led to lower operating costs and a smaller environmental footprint. Instead of truckloads of mixed waste, we recover usable byproducts, firming up the process economics. We routinely invest in new control hardware to cut energy use, from variable-speed pumps to in-line analyzers. What comes from these investments shows up both in price competitiveness and in customer trust. The leaner the process, the clearer the chain of custody and the fewer potential quality drift issues crop up.

    Quality Control and Traceability

    As a true manufacturer, we manage certifications and third-party audits ourselves. Every drum of cycloheptylamine comes with full documentation: batch number, year, purity curve, and storage record. On-site labs run gas chromatography, Karl Fischer water analysis, and full impurity profiling before product leaves the loading bay. Over the years, our team has found that customers are more likely to request trace analysis and out-of-spec explanations than in the past. So our internal tracing system tracks every raw material lot through to the final packing stage. Customers report fewer issues with off-spec product and consistently praise our willingness to answer compositional questions, even post-shipment.

    If a new application calls for alternate packaging or a tighter water spec, our process team can re-calibrate within a short run. We’ve set aside lab and pilot reactor capacity so customers running validation batches don’t need to wait for months. Immediate feedback from the shop floor lets us catch and resolve process issues, a benefit you only see when the producer controls every stage of the operation.

    Storage, Handling, and Long-Term Stability

    Cycloheptylamine stores best in closed, inertized containers, at room temperature and out of direct sunlight. From long experience, we know oxygen and water exposure matter, even at small levels. Prolonged exposure can darken the liquid and slowly affect purity—an inconvenience during precision synthesis. By controlling bulk storage tanks with nitrogen blanketing, we secure quality for weeks or even months. We ship in steel drums or IBCs, never in soft HDPE, due to solvent vapor permeability concerns. Over time, our warehouse staff has learned to inspect each drum during loading and check for seal integrity, lesson learned from earlier customer complaints about condensation and air leaks in generic packaging.

    For most downstream applications, cycloheptylamine offers strong shelf stability, provided bulk material stays sealed. We often run stability tests by storing reference samples under real-world conditions, later re-analyzing to provide customers with data on minor degradation, color shifts, or moisture pickup. By making this information available, we help customers design better downstream QC protocols, saving headaches on large campaigns.

    Supply Security and Scalability

    We have invested in redundant production lines to support growing global demand. Our core reactor hall runs two parallel lines with crossovers, while finished product storage has weatherproof secondary containment. Routine preventive maintenance keeps downtime rare, and by holding extra raw materials on-site, we guard against upstream supply hiccups. Customers facing just-in-time requirements for synthesis campaigns or seasonal spikes in agchem production benefit from this setup.

    We also keep relationships across the upstream supply chain. Procurement staff check on our cycloheptanone and solvent partners every month—not just by email, but through physical site visits and batch sampling. That way, we cut risk from variable upstream suppliers and mitigate sudden quality or purity shifts often reported in the open market. This attention to supply security has earned quiet thanks from several multinational customers, especially those burned by past delays from indirect sources.

    Sustainability and Environmental Responsibility

    Our plant team cares about environmental compliance and process sustainability—not as a marketing slogan, but because it makes everyday operation smoother. We limit solvent use through recovery and recycling, run stormwater audits, and manage all amine waste by thermal oxidation under regulatory controls. Several years back, we switched over part of the utilities to heat-exchange networks based on external audit recommendations, saving both money and natural gas.

    On the packaging end, we favor bulk containers over small drums to reduce waste per unit shipped. In the past year, our team has piloted returnable steel container programs with larger buyers. That system cut both packaging waste and total transport footprint, without compromising quality. We remain open to further improvement, always reviewing best practices from both our industry associations and customers themselves.

    Regulatory Adherence and Safety Record

    We keep products compliant with relevant chemical regulations and safety submissions, maintaining up-to-date documentation for shipments into regulated markets. Regulatory staff coordinate closely with local authorities to make sure our permits, storage logs, and transport manifests stay current. Over the years, our on-site emergency response training has helped prevent accidents and reassure officials during routine inspections. As cycloheptylamine qualifies as a hazardous material in many jurisdictions, we ship with all legal documentation and provide regular hazard communication updates to our shipping partners.

    All personnel working with cycloheptylamine wear proper PPE, using closed-loop loading and unloading, and we invest in new training as regulations evolve. Annual drills and cross-team audits ensure safety culture remains strong from the laboratory to the loading dock. We’ve found this approach doesn’t just minimize risk; it reduces downtime and prevents lost material, translating into more reliable delivery commitments for our customers.

    Supporting Research and Collaboration

    We don’t just sell drums and containers; we support research and troubleshooting at the bench scale. Feedback from scientists carrying out novel amination or reductive alkylation work has shaped changes in our batch procedures. If a customer gets unexpected results on scale-up, our technical team asks about every step—solvent grade, agitation speed, downstream isolation—because we know even small process changes reroute pathways with sensitive intermediates. Our lab remains open to joint troubleshooting, and we occasionally supply analogs or related amines to support peer research goals. Collaborating directly as the manufacturer sharpens both our in-house skillset and our customers’ outcomes.

    Differences Only Real Producers Notice

    Small changes in processing—like distillation pressure, feedstock purity, or even transfer line cleaning—show up in product reliability. As the original manufacturer, we notice impurity spikes that third parties might miss. Years ago, a switch in an upstream catalyst resulted in detectable trace metals; catching it early spared customers from failed validations. This type of vigilance matters in the real world.

    Batches from non-specialist traders too often include a mix of delayed container shipments or mingled small lots. We control the whole workflow and provide a direct line to our process engineers. Questions about batch consistency, minor byproducts, or long-term storage don’t get lost in email loops—they come straight to the people who make and test every kilogram. Our operation runs on technical knowledge and accountability, and long-term buyers recognize the value in working with a production partner, not just a supplier listing a generic specification.

    Long-Term Commitments and Continuous Improvement

    We strive to be more than a one-off supplier. Our stability as a manufacturer means customers call us early in the R&D process and again during scale-up, trusting that we’ll support each stage. Feedback loops from customer experience drive routine investment in facility upgrades. We review equipment calibration schedules quarterly and pursue instrumentation upgrades before forced by incident or outage. Engineers and operators are encouraged to suggest process improvements any day, not once a year. This atmosphere builds ongoing trust with our buyers, who know future needs can be raised and addressed promptly.

    Businesses choose cycloheptylamine for its distinct properties and direct reactivity, especially where purity and structural control can’t be compromised. After years in both the laboratory and plant environment, we know which details affect both synthesis outcomes and supply reliability. In every order, our promise as the actual chemical producer: clear communication, consistent product, technical understanding, and support grounded in experience, not just a catalog listing.