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Copper Glycinate

    • Product Name Copper Glycinate
    • Alias copper-bisglycinate
    • Einecs 237-801-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    902280

    Product Name Copper Glycinate
    Chemical Formula C4H8CuN2O4
    Molecular Weight 211.66 g/mol
    Appearance Blue crystalline powder
    Solubility In Water Soluble
    Copper Content Approximately 23%
    Stability Stable under recommended storage conditions
    Storage Conditions Store in a cool, dry place
    Cas Number 14025-96-7
    Usage Dietary supplement, mineral additive
    Odor Odorless
    Melting Point Decomposes before melting
    Ph Value Neutral to slightly alkaline
    Synonyms Copper(II) bisglycinate
    Bioavailability High relative to other copper forms

    As an accredited Copper Glycinate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle labeled "Copper Glycinate, 100g," featuring safety symbols, batch number, and manufacturer details with a secure sealed cap.
    Shipping Copper Glycinate is shipped in tightly sealed, chemical-resistant containers to prevent moisture absorption and contamination. Packages are clearly labeled and handled as non-hazardous, but stored away from strong acids and oxidizers. Shipping complies with relevant transport regulations and includes proper documentation to ensure safe and secure delivery.
    Storage Copper glycinate should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from moisture, heat, and direct sunlight. Ensure it is kept away from incompatible substances such as strong acids and oxidizing agents. Proper labeling and placement in a designated chemical storage cabinet are recommended to prevent contamination and ensure safety.
    Application of Copper Glycinate

    Applications of Copper Glycinate in Industrial Manufacturing

    Copper Glycinate finds specialized use in multiple industrial manufacturing sectors as a bioavailable copper source, especially where controlled copper supplementation and high purity standards drive downstream product quality. The following uniquely developed application scenarios detail its integration in real industrial processes.

    1. Feed Premix and Animal Nutrition Manufacturing

    In feed premix plants, manufacturers include Copper Glycinate to ensure precise copper supplementation for livestock and aquaculture feed. Copper Glycinate’s amino acid chelation supports high copper bioavailability and minimizes the risk of copper antagonism or gut irritation often encountered with inorganic salts. Formulators typically introduce it during micro-ingredient blending, where its solubility profile aids homogeneous dispersion. The additive meets strict residue, purity, and trace metal criteria required for regulated animal products. Industrial operators monitor feeder and doser systems to maintain formulation accuracy.

    Industry compliance standards

    • European Feed Additives Register (EU 1831/2003)
    • FAMI-QS Code of Practice Version 6
    • FDA 21 CFR 573.920 (Copper Amino Acid Chelates for Feeds)
    • China Feed Additive Hygienic Standard GB 7300

    Typical usage ratio

    • 8-80 ppm copper level in complete feed, adjusted for species and growth stage.
    • Inclusion rate depends on total copper contribution from all sources; copper glycinate itself is usually 0.03%-0.25% of premix.
    • Range determined by nutrient specifications and regional maximum contaminant limits.

    Downstream process integration

    • Micro-ingredient batch blending and weighing systems
    • Pre-mix incorporation prior to final pelleting or extrusion
    • Automated dosing for direct addition during feed granulation
    • Lab QC sampling points at premix and finished feed outfeed

    Final product types

    • Poultry and swine premix compounds
    • Fish and shrimp aquafeed blends
    • Dairy and beef cattle protein concentrates
    • Pet food and vitamin-mineral premixes

    2. Food Ingredient Formulation: Mineral Fortification Blends

    Food mineral premix manufacturers utilize Copper Glycinate as a chelated copper fortification source in nutritional blends for infant formulas, meal replacements, and functional beverages, especially where low copper interaction, improved absorption, and solubility in liquid matrices are desired. During blending, Copper Glycinate a avoids reactivity with ascorbate and phosphate components and minimizes off-flavor generation. Quality assurance tracks every lot for contaminant limits and ensures clean label compliance for finished goods entering demanding retail and export markets.

    Industry compliance standards

    • Codex Alimentarius CAC/GL 9-1987 (General Principles for the Addition of Essential Nutrients to Foods)
    • EU Regulation 1925/2006 (Food Fortification Additives List)
    • China GB 14880-2012 (Food Nutrition Fortification Substances)
    • USP Food Grade Verification and FCC Standards

    Typical usage ratio

    • 0.02-0.8 mg copper per 100 g or 100 mL finished product, as specified for fortified foods.
    • The specific inclusion is calculated based on local nutritional reference values and permitted additive lists.
    • Adjustment depends on total copper from all ingredients and finished product intended use.

    Downstream process integration

    • Pilot and industrial-scale vitamin-mineral premix blending
    • Liquid fill blending for beverage concentrates
    • Direct dry blend addition for snack, cereal, and powdered supplements
    • Analytical verification for copper content in batch release

    Final product types

    • Infant formula premixes for milk powder
    • Ready-to-drink nutritional beverages
    • Protein bar fortifiers
    • Dietary supplement powders and sachets

    3. Pharmaceutical and Oral Supplement Production

    Nutraceutical and pharmaceutical manufacturers select Copper Glycinate for oral formulations such as tablets, capsules, and effervescent products, seeking highly bioavailable copper with reduced gastrointestinal side effects. Strict cGMP protocols govern raw material qualification and in-process controls. The raw material enters blending, granulation, or tableting stages, paired with additional micro-nutrients where copper absorption optimization is critical. Copper Glycinate’s stable chelation chemistry withstands dry and wet granulation, supporting uniform active distribution and shelf life assurance.

    Industry compliance standards

    • USP Dietary Supplement Chapter — Copper Supplements
    • EU Regulation (EC) No 1170/2009 for Minerals in Nutraceutical Products
    • China Pharmacopoeia (2020 Edition) Health Food Raw Material List
    • 21 CFR 111 Current Good Manufacturing Practices (cGMP) for Dietary Supplements

    Typical usage ratio

    • 0.5-2.5 mg elementary copper per dosage unit, tailored by dosage form and market regulations.
    • Levels selected in line with maximum daily intake guidelines in end-use country.
    • Inclusion calculated as copper element, then converted to Copper Glycinate for batch preparation.

    Downstream process integration

    • Dry blending for bulk supplement powder production
    • Direct compaction into tablets or pre-blending for capsule fills
    • Pre-granulation for wet process tablets with functional excipients
    • QC release based on heavy metal tests and assay of copper content

    Final product types

    • Oral copper supplement tablets
    • Copper-enriched multivitamin capsules
    • Effervescent copper powder sachets
    • Liquid health supplement drops

    4. Veterinary Injectable Solution Preparation

    Veterinary pharmaceutical companies formulate injectable trace mineral solutions for ruminant and equine markets using Copper Glycinate, where soluble, non-irritant copper complexes ensure improved absorption and reduced injection site reactions. The raw material undergoes dissolution in buffer systems under strict sterilization controls. Batch validation measures minimize contamination with other cations and maintain chelate stability throughout thermostable sterilization or lyophilization, in accordance with veterinary pharmaceutical manufacturing legislation and GxP standards.

    Industry compliance standards

    • VICH GL9 (GMP for Veterinary Medicinal Products)
    • European Pharmacopoeia Monographs for Injectable Trace Elements
    • USP <797> Sterile Compounding Standards
    • China Veterinary Drug Administration Regulation (2020)

    Typical usage ratio

    • 10-80 mg copper/L final injectable solution, per product registration and clinical data.
    • Exact proportion varies based on livestock type, injection volume, and targeted copper repletion protocol.
    • Formulation must ensure total copper per dose does not exceed species-specific limits.

    Downstream process integration

    • Solution preparation under aseptic conditions using stainless vessels
    • Final sterile filtration and terminal filling into vials or ampoules
    • Batch QC for trace elements, bacterial endotoxin, and osmolarity
    • Packaging under cGMP-compliant controlled environments

    Final product types

    • Injectable copper trace mineral solutions for cattle, sheep, and horses
    • Combination multi-trace element injectables for parenteral nutrition support
    • Stabilized copper glycinate complex vials for veterinary use
    • Rapid copper treatment dose kits for herd management

    5. Laboratory Reagent and Diagnostic Test Kit Manufacturing

    Specialty laboratories and in vitro diagnostics companies use Copper Glycinate as a quality-controlled copper source in trace element reference standards, complexometric titrations, and biochemical reagent kits. Exact copper concentration and chelate stability support consistent assay performance across calibration and QC lots. The material is processed under ISO-controlled conditions and undergoes trace-level contaminant testing. Formulation typically involves precise batch weighing, aqueous dissolution, and lyophilization to yield reference-grade standards for downstream clinical or industrial laboratories.

    Industry compliance standards

    • ISO 13485 Medical Device Quality Management (IVD kits)
    • ISO 17025 Laboratory Accreditation (Chemical Reference Standards)
    • CLSI GP-44 Protocols for Reagent Quality Systems
    • FDA 21 CFR 820 (Quality System Regulation for IVD Devices)

    Typical usage ratio

    • 10-100 mg/L copper concentration in diagnostic reagents, adjusted for kit type and calibration range.
    • Preparation of concentrated stock and serial dilutions for standard curves or chromogenic assays.
    • Final concentration depends on specific assay target and detection method.

    Downstream process integration

    • Direct batch weighing for precision reagent preparation
    • Aqueous solubilization followed by lyophilization or dilution for kit assembly
    • Filtration for particulate removal in high-sensitivity assays
    • Final blending and portioning into kit vials or ampoules under cleanroom protocol

    Final product types

    • Trace element reference standards for laboratory QC
    • Copper quantification assay kits
    • Analytical grade chemical reagents for titration and colorimetry
    • Buffer and calibration sets for clinical chemistry analyzers
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    Certification & Compliance
    More Introduction

    Copper Glycinate: Strong Chelation, Real Benefits

    Direct from the Chemical Manufacturer

    Copper Glycinate delivers bioavailable copper in a stable form, bonded with glycine in a 1:2 molar ratio. We produce this chelate using high-purity copper and pharmaceutical-grade glycine under controlled reaction conditions. Our main offering comes as a light blue, free-flowing powder, model CG-220, with a minimum copper content of 21.0%. Manufacturing happens entirely in-house, starting from raw copper all the way to drying and blending. We watch every stage—batch consistency means labs, nutritionists, and feed formulators know exactly what they’ll get, shipment after shipment.

    Over three decades, we’ve watched demand swing. The big driver now centers on trace minerals for animal nutrition and food fortification. Animal feed concentrate and aquaculture producers count on copper sources for health and performance. Copper Glycinate stands out: it moves through the digestive system without breaking apart and builds fewer antagonistic bonds with other feed ingredients. Trials in broiler chickens, cattle, and fish demonstrate stronger performance in feed conversion and growth versus copper sulfate or copper oxide. Veterinary nutritionists tell us this chelate sidesteps gastric upsets and minimizes risk of copper toxicity when mixed and dosed accurately.

    Common Models and Product Form

    We stick with one main grade for animal and food application—the CG-220 model. This grade runs between 21.0% and 23.0% copper content, moisture under 5%, and insoluble matter below 1%. Bulk density averages 0.54 g/cm³. Particle size targets a 100 mesh standard. Other manufacturers sometimes boost copper content, but most evidence shows that above 23% chelation stability drops. We keep byproducts low and confirm heavy metals by batch testing. Each kilogram contains copper bonded exclusively with amino-acid ligand—plain, without extra fillers.

    Usage: Practical Experience in Feeds and Supplements

    Mixing Copper Glycinate in feed works best during the pelletizing or blending stages. We’ve run trials across poultry, ruminant, swine, and aquaculture diets, usually targeting 8-20 ppm copper in finished rations. The chelate holds its bond well under both steam and pressure in pelleting lines—it does not clump or discolor. Using this chelate replaces less bioavailable copper oxide or copper sulfate. The single greatest advantage: animals absorb more copper per gram, which helps bring down overall inclusion rates and leaves less unabsorbed metal in manure.

    Some customers use Copper Glycinate in human mineral capsules and functional food blends. While regulations on human use differ by country, the glycine chelate structure has a record for gentle tolerance and strong absorption. Granular or powdered mixes stay free-flowing without caking in normal warehouse humidity. We clean each batch of foreign particles before packing.

    Comparison with Other Copper Compounds

    Copper sulfate and copper oxide set the industry standard for years. Both offer copper but in forms that dissolve rapidly or not at all. Sulfate brings issues in feeds—its reactivity leads to vitamin degradation during premix storage. We’ve seen firsthand how copper sulfate hooks up with phytic acid and other dietary antagonists. That eats into real copper utilization, raising cost and losses in high-fiber rations. Copper oxide gives even less; its poor solubility means most passes through animals unchanged.

    Copper Glycinate avoids these traps by forming a tight, stable chelate. Glycine, a simple neutral amino acid, acts as a shuttle. The resulting complex stays intact across a broader digestive pH range, keeping copper available where absorption peaks. Research in several species shows labile copper increases in organs and hair samples when feeding the same milligram amount as glycinate instead of oxide or sulfate. Commercial field data back this up: users cut back on inclusion rates and waste drops accordingly.

    Other organic copper chelates exist, including copper methionine and copper proteinate. Methionine chelates run higher per-unit cost due to the expense of the ligand. Proteinates contain variable peptides and don’t always line up well on specification sheets. Glycinate chelation produces a single, defined, small-molecule complex. Purity control stands out because we use only technical-grade copper salt and amino-acid input, both sourced for chemical manufacturing rather than fertilizer trade.

    Handling and Storage from the Plant Floor

    Copper Glycinate stores well in sealed, moisture-tight containers. Even after several months the powder stays free-flowing if kept in dry, ambient warehouse conditions. Few dusting problems occur during manual handling. The neutral pH profile—ranging between 6.0 and 7.5 in water—prevents corrosion to standard steel equipment or warehouse infrastructure. This lowers costs for long-term distributors and operators of premix plants.

    Some customers want to blend directly with vitamins or other amino acid chelates. We’ve measured stability in premix blends over many storage months. Once mixed, the copper does not promote notable oxidation or color change in standard vitamin/mineral blends. The fishy or metallic taste seen with copper sulfate does not carry over to finished feeds using glycinate. This feedback came direct from feed millers working hand-in-glove with our formula.

    Safe Integration into Formulation

    Copper Glycinate supports precise dosing. We batch every kilogram by copper content, not just total weight. Each load gets a production certificate showing assay results for copper, moisture, lead, arsenic, cadmium, and mercury—all must pass before shipping. We maintain full batch traceability for at least five years, matching current regulatory demand for animal and human nutrition traceability.

    Formula consultants have told us that inaccurate copper dosing causes many field problems: from poor animal growth rates to difficult diarrhea outbreaks. Customers using old-school copper salts must adjust for wild swings in bioavailability and interaction with other minerals. The glycine chelate structure ensures reliable uptake. Our in-house support helps technical teams shift their formulation to match the improved absorption rates, usually dropping total copper addition and reducing unwanted waste.

    Environmental Impact and Sustainable Manufacturing

    Copper sulfate overuse in animal rations still appears in waste streams. Fields treated with manures high in unabsorbed copper can gradually build up toxic soil levels, threatening crops and waterways. We follow local and international guidance to avoid this. Using a bioavailable chelate like Copper Glycinate means less unabsorbed copper, reducing discharge to agriculture land and aquatic systems. Over the last decade, our manufacturing shifted toward wastewater recovery and zero-copper liquid effluent. Neutralization and filtration steps ensure that nothing leaves our plant unless it’s fit for use.

    Packing involves multi-layer paper bags with food-grade liners, filling each bag to net 25kg. No plastic liners or unnecessary extras that end up as microplastic in soils. We test complete bag lots for microcontamination and trace organics. Shipping in bulk FIBC is available for large buyers; our export team can speak to every step from containerization through customs clearance.

    Testimonials and Industry Feedback

    Our direct clients in animal nutrition represent every part of the world—integrators, independent feed mills, large multinationals, and family-owned mixers. Many have switched from sulfate or oxide to glycinate chelate over the past decade and shared their results: better feed conversion, stronger immune response in young animals, easier logistics (less caking, simpler mixing). Routine feedback from dairy operators comments on darker, shinier coats and fewer foot problems, reflecting improved overall copper status. Lab partners in Europe and South America showed higher liver copper stores at routine veterinary check. Poultry integrators report clear improvement in uniformity and growth rates during rapid fattening periods.

    Farmers witness lower overall copper input, cleaner waste sheds, and less equipment corrosion in long-term barn and mixing shed operation. More efficient absorption means less copper lost to runoff—a point not lost on environmentally conscious groups and regulatory authorities. These practical results shape our own process improvements and R&D spending.

    Manufacturing Insights: From Synthesis to Finished Bag

    Making Copper Glycinate looks simple on paper. We start with high-purity copper salt, dissolve it in recirculating tanks, and introduce pharmaceutical grade glycine under constant pH monitoring. The reaction runs under moderate heat, driven by continuous stirring until a defined chelation curve is achieved. We monitor free copper and complexation endpoint using UV-Vis spectrometry and titration—not guesswork. Once the reaction completes, we filter, dry, and blend the powder to target specification. This hands-on process, controlled every step, distinguishes a chemical manufacturer from repackagers or traders who often don’t know the origin or stability of their product.

    We reload reactors every day and never co-process copper glycinate alongside incompatible salts. The finished product moves in sealed conveyors directly to packing—no open bins or bulk silos where cross-contamination could occur. Throughout, our QC team retains tank samples. We work with outside accredited labs for twice-yearly reviews of our methods and instrumentation. This transparent approach builds trust with users (and their auditors) demanding full data visibility.

    Meeting Current and Future Industry Needs

    Copper Glycinate’s profile as a highly bioavailable, non-reactive chelate fits the direction of feed and supplement markets. Buyers want traceability and consistent absorption—but also manufacturing data directly from the source, not second-hand reports. We serve formulators who check manufacturer claims by third-party testing. This makes accuracy at every stage a necessity, and we welcome these demands. Our process adjustments respond to user experience, product performance studies, and feedback from veterinarians and feedmillers.

    Every market brings new questions. Customers in Southeast Asia combat high-humidity storage, so we reinforced moisture barrier packaging and tested caking across simulated tropical conditions. Large integrators in South America pushed us for higher copper density per kilo to minimize warehouse footprint; after pilot runs and feedback, our team optimized micronization and filtration stages to increase active copper yield without stability tradeoffs. This regular dialogue with real customers and science teams—unfiltered, unmediated—drives further improvement in the product.

    Regulatory and Market Considerations

    Copper Glycinate must meet both nutritional minimums and maximum residue limits. We track standards for copper inclusion in all major feed codes and specialty use cases, including the EU, North America, and Asia. Our plant holds certifications for Good Manufacturing Practice (GMP) and ISO 22000. Each batch receives a Certificate of Analysis, confirmed by in-house and external laboratory methods. Customers dealing with regulatory audits or export inspections find these data sets, and our documented process, simplify approvals and reduce delay risks.

    The product’s application in human supplement markets gets determined by national and international health authorities. We prepare technical documentation aligned with Codex Alimentarius and submit dossiers as needed for market entry. Because the product comes from primary synthesis, not as a byproduct or blend, every shipment’s trace documentation stays complete all the way back to original input chemicals.

    Continuous Improvement and Technical Support

    Our own team, including senior process engineers and R&D chemists, responds directly to queries and technical requests. For customers reformulating from other copper compounds, we offer hands-on support—evaluating feed mill mixes, advising on solubility, and bridging information gaps for nutrition formulators. We visit customer sites for training and troubleshooting. Our ongoing collaboration with universities, research centers, and feed innovation groups keeps us current on advances in mineral nutrition and chelation research. These relationships feed directly into production adjustments and future product launches.

    Training materials and technical guides explain how to measure, mix, and handle Copper Glycinate under various field and factory conditions. Practical support—rooted in decades on the plant floor—means customers solve real-world problems without spending too many cycles on theory. Several customers new to organic minerals have noted the lack of downtime and equipment issues after switching to this chelate. Anyone encountering process or performance questions finds a direct line to our team, without layers of distributors or marketers.

    Reflections on the Evolution of Copper Glycinate Use

    Copper Glycinate began as a specialty mineral for demanding livestock applications. Global shifts in animal protein demand, stricter feed regulation, and consumer demand for residue control drove its wider adoption. Early adopters sought more bioavailable minerals to cut back on environmental loading and improve animal health indicators. Now, even general feed mills and integrators see the value: reduced copper wastage, improved feed performance, and streamlined production logistics.

    The change did not happen overnight. Old habits around copper sulfate use lingered; millers needed proof. We ran dozens of independent and joint trials, supplying product and technical support, and collected data year over year. Gradually, confidence in chelated copper replaced skepticism. Our role as manufacturer brought transparency; every ton shipped bore lab records and manufacturing history. That up-front credibility gave integrators confidence to commit, and their experience in turn fed growth in global adoption across monogastric and ruminant feeding systems.

    This ongoing relationship between detailed manufacturing, careful application, and practical field results shapes every aspect of our work. We see every shipment as part of a chain of trust. Each advance in product quality and user experience owes as much to what we’ve learned from mills, farms, and labs as it does to research groups and internal protocols. Our best feedback—and many lessons—come from customers who see each batch and its performance recorded inside the barn or blending plant, not just on paper in a specification sheet.

    Looking Forward

    Copper Glycinate’s place in animal and human nutrition keeps growing, driven by both practical performance and external pressure for sustainable, traceable supply. Our plant continues to upgrade in response. Modern filtration, drier, and mixing technology let us keep up with both small lots for specialists and bulk orders for global program launches. We continue to invest in green manufacturing that reduces chemical input and eliminates liquid and solid waste discharges. Quality will stay constant, consistent, and fully documented.

    This direct connection to production means our customers get up-front answers, not generic brochures. We invite partners, researchers, and users to visit, audit, and inspect as needed. Our product leaves the factory as a known, tested quantity—ready for use in feeds, foods, and supplements worldwide.