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Cinnamamide

    • Product Name Cinnamamide
    • Alias cinnamic acid amide
    • Einecs 208-965-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    438671

    Cas Number 621-82-9
    Molecular Formula C9H9NO
    Molar Mass 147.18 g/mol
    Iupac Name E-3-phenylprop-2-enamide
    Appearance White to beige solid
    Melting Point 115-117°C
    Boiling Point 340°C (estimated)
    Solubility In Water Slightly soluble
    Density 1.181 g/cm³
    Smiles C1=CC=C(C=C1)C=CC(=O)N
    Pubchem Cid 83466

    As an accredited Cinnamamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed plastic bottle labeled "Cinnamamide, 100g," featuring hazard symbols, product code, manufacturer details, and handling instructions.
    Shipping Cinnamamide should be shipped in tightly sealed containers, protected from light, moisture, and sources of ignition. It must be packed in compliance with local and international regulations for chemical transport, including appropriate hazard labeling. Avoid rough handling to prevent container breakage and ensure compatibility with shipping materials to prevent leaks or contamination.
    Storage Cinnamamide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Keep it protected from direct sunlight and moisture. Store at room temperature, and avoid exposure to excessive heat. Proper labeling and handling procedures should be followed to prevent accidental spills or contamination.
    Application of Cinnamamide

    Applications of Cinnamamide in Industrial Manufacturing

    Cinnamamide, an aromatic amide, plays a precise role in specific industrial verticals due to its distinct molecular properties, regulatory acceptance, and unique compatibility with advanced processing. As the direct producer, we support manufacturers by supplying cinnamamide that meets stringent process and regulatory benchmarks across every approved downstream scenario. The following sections detail its main established fields of application.

    1. Food and Beverage Flavoring Compounds

    Major global flavor houses use cinnamamide as a character-impact compound to develop warm, spicy notes in complex flavor bases for baked goods, confectionery, and beverage enhancers. Manufacturers dose cinnamamide alongside vanillin and allied molecules, with its integration controlled and monitored to meet national and international additive regulations for safe consumer contact. Strict batch traceability is maintained from the initial flavor compounding through to the final shelf-ready product.

    Industry compliance standards

    • FAO/WHO JECFA Food Additive Evaluations
    • European Regulation (EC) No 1334/2008 on Flavorings and Certain Food Ingredients
    • United States FDA 21 CFR 172.515 (Synthetic Flavoring Substances & Adjuvants)
    • GB 2760-2024 National Food Safety Standard for Food Additives in China

    Typical usage ratio

    • 0.01%–0.10% of total product weight, adjusted by organoleptic calibration and the target food matrix

    Downstream process integration

    • Dosed during the primary blending step of compound flavor creation; can be introduced at the emulsification or cold blending stage depending on product form (liquid or powder)

    Final product types

    • Ready-to-use bakery flavors
    • Chocolate and confectionary inclusions
    • Soft beverage syrups
    • Processed spice mixtures

    2. Pharmaceutical Intermediate for Anticonvulsant APIs

    In the pharmaceutical supply chain, cinnamamide sees targeted use as a synthetic intermediate in active pharmaceutical ingredient (API) routes, particularly those relating to phenyl derivatives for novel anticonvulsant medications. Contract and generic API manufacturers demand controlled purity and batch documentation to satisfy issued country-specific pharmacopoeias and GMP standards. Cinnamamide enters the staged synthesis processes at clearly defined nodes where control over amide bond formation and subsequent conversion is crucial to yield and regulatory registration.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF general chapter <795> and <797> (when used in compounding context)
    • EU Guidelines for GMP Part II (APIs)
    • China Pharmacopoeia ChP 2020 and associated DMF requirements

    Typical usage ratio

    • Variable; typically 0.1–0.5 molar equivalents as dictated by the specific reaction pathway and scale of API batch synthesis

    Downstream process integration

    • Charged during the amidation or condensation steps of phenyl alkene upgrade, followed by purification and further derivatization en route to final API crystallization

    Final product types

    • Generic and branded anticonvulsant APIs (e.g., derivatives for CNS indications)
    • Research-grade pharmaceutical intermediates for pipeline drug development
    • Finished solid oral or injectable dosage forms (upon completion of downstream synthesis)

    3. Specialty Fragrance Ingredients in Fine Chemicals

    Producers of fine fragrance and personal care chemicals adopt cinnamamide as a modifier in scent panels designed for soaps, perfumes, and cosmetic emulsions. This material imparts a distinct cinnamon nuance that cannot be replicated with natural oils alone, especially under global allergen and ingredient labeling regimes. R&D and production teams align with IFRA and national safety documentation to confirm allowable concentrations in consumer products, maintaining analytical checkpoints throughout each batch integration.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards, especially latest Amends concerning amide allergens
    • European Cosmetic Regulation (Regulation (EC) No 1223/2009)
    • US FDA Voluntary Cosmetic Registration Program (VCRP)
    • REACH (EC) No 1907/2006 substance registrations, where applicable

    Typical usage ratio

    • 0.05%–0.20% in finished fragrance oils or cosmetic concentrates, fine-tuned according to IFRA category and production end-use

    Downstream process integration

    • Added during the blending or maturation stage of fragrance oil compounding before incorporation into bulk surfactant or emulsion matrices

    Final product types

    • Liquid and solid soaps
    • Perfume bases and colognes
    • Scented lotions and body creams
    • Personal care balms and leave-on formulations

    4. Polymer Processing Modifier for High-Performance Materials

    Within the advanced materials sector, polymer compounders integrate cinnamamide as a processing modifier in select engineering plastics and specialty copolymer blends where aromatic amides act as chain transfer or nucleation agents. Adopted for effects such as improved crystallization kinetics or targeted intermolecular interactions, application teams rely on full material disclosure and technical data packages to meet regulatory and OEM-specific protocols, especially for electronics and consumer contact scenarios.

    Industry compliance standards

    • RoHS (Restriction of Hazardous Substances Directive) 2011/65/EU
    • REACH Regulation (EC) No 1907/2006
    • UL 94 Flammability Standard for Plastics Materials
    • OEM specific QMS/PPAP documentation (automotive & electronics)

    Typical usage ratio

    • 0.05%–0.30% by weight in base resin feed, calibrated based on desired mechanical modification and compatibility with other chain extenders

    Downstream process integration

    • Metered directly into twin-screw extruders during masterbatch or final compound processing prior to pelletization

    Final product types

    • High-performance engineering polymers
    • Electronics-grade polyimide and polyamide compounds
    • Custom performance masterbatches
    • Technical parts for automotive interiors and device housings

    5. Agricultural Fungicide Intermediate

    Select crop protection chemical manufacturers utilize cinnamamide as a precursor in the synthesis of certain aromatic amide-based fungicides and plant health promoters. Integration follows tight stewardship protocols for agricultural actives, including multi-stage purity clearance and full regulatory submission for each regional market. Precise dosing during the condensation chemistry is monitored by process analytics to ensure consistent fungicide performance and trace environmental safety.

    Industry compliance standards

    • FAO Specification for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals
    • China Ministry of Agriculture Pesticide Registration Standards
    • EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA Title 7)

    Typical usage ratio

    • 0.15–0.30 molar equivalents per target synthesis batch (fungicide API synthesis), set depending on underlying actives and required conversion rates

    Downstream process integration

    • Participates in the condensation stage during active ingredient synthesis, followed by isolation and formulation into bulk technical concentrate

    Final product types

    • Aromatic amide-based fungicide technicals
    • Commercial fungicide EC (Emulsifiable Concentrate) and SC (Suspension Concentrate) formulations
    • Pre-plant seed coating solutions for agriculture
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    Certification & Compliance
    More Introduction

    Cinnamamide: A Closer Look from the Factory Floor

    What We See Every Day

    At our facility, Cinnamamide occupies a unique place in production. Anyone walking through our chemical plant will catch the scent of warm spice drifting by the reactors, signaling a new batch in process. We do not just watch the metrics on screens; we handle the materials, see the crystals develop, and test the results firsthand. For years, our work with Cinnamamide has taught us more than technical instructions or data sheets ever could.

    Getting Down to the Chemistry

    Cinnamamide carries the formula C9H9NO. It forms white to off-white fine crystals or powder, depending on purification and drying stages. Our process yields consistent, high-purity material with very low moisture and trace impurity content, making it well-suited for downstream applications.

    In our manufacturing model CA-99, the typical assay exceeds 99.5%, and residual solvents do not show up above detection thresholds in routine batches. Melting points settle close to 133°C to 135°C, which reflects both purity and correct molecular structure. We bracket particle size within well-defined ranges, depending on end-users’ demands, focusing on sieving and milling steps to avoid over-processing or degradation. Achieving reliable batch-to-batch reproducibility demands strict temperature and vacuum controls throughout synthesis and purification.

    Main Uses as We Understand Them

    Most Cinnamamide leaves our plant for use as an intermediate in pharmaceutical and fragrance manufacturing. Our team understands how sensitive some reactions can be, especially where Cinnamamide acts as a scaffold for further modifications or coupling. We routinely see orders from API manufacturers, flavor labs, and even food research groups pursuing exotic taste-modifying agents.

    Much of the world’s cinnamon flavor does not come straight from bark or oil anymore. Instead, Cinnamamide plays a key role in synthetic blends, offering a stable, easy-to-handle core ingredient. Unlike cinnamon aldehyde, which evaporates quickly and brings an irritating sharpness to workers’ lungs, Cinnamamide resists volatility. It carries a similar olfactory signature without the acute reactivity, which makes things safer for our team and for our clients’ production lines.

    For pharmaceutical intermediates, our Cinnamamide product allows for sulfonation, nitration, or reductive coupling steps with reliable conversion due to the material’s consistent reactivity. The strict control we maintain over carbonyl content and minimal by-products makes subtle side reactions less likely down the chain, as complex molecules are built up. In academic settings, researchers use it as a model amide in studies of organic mechanism, protein modification, and enzyme mimicry. We hear from university labs that the purity and crystalline habits achieved by our manufacturing route make analytical work more straightforward, cutting down on ambiguous peaks in NMR or chromatography runs.

    Why We Sweat the Details

    Each year, analytical technology grows more precise. Small inconsistencies that once disappeared in the noise now show up clearly in spectral analysis or chromatography logs. Early on, we learned to invest in upgraded in-line UV spectrophotometry, HPLC, and mass spectrometry to identify any trace by-products or contaminants before packaging.

    Our people monitor each reactor charge by more than just the clock—they step through the area several times per shift, checking color, consistency, and even scent. A faint amine smell instead of the usual cinnamon note signals issues in condensation or incomplete washing. Over time, these observations shape the tweaks we make in process settings: solvent choices, washing steps, crystallization temperature ramps, and drying cycles.

    We keep close track of customer feedback and end-user reports. If a downstream application stalls due to an impurity, we trace the problem back, scrutinizing batch records from raw material receipts through to the last drying hour. One of our biggest challenges remains keeping oxidation products and hydrolysis-related by-products out, especially in humid weather. Years of refining our steps and doubling up on nitrogen blanketing for storage reduced such surprises drastically. If our finished Cinnamamide does not melt sharply or if an off-note appears in an aroma sample, the batch does not ship.

    Cinnamamide in Comparison to Related Materials

    It helps to understand why end users reach for Cinnamamide rather than other cinnamon derivatives or amide compounds. Cinnamaldehyde, perhaps the more headline-friendly molecule found naturally in cinnamon oil, dominates traditional spice flavor manufacturing. But in daily production, Cinnamamide proves less volatile, easier to store, and infinitely more stable under ambient conditions.

    Shippers like the fact that Cinnamamide is classed as a low-hazard solid for transit—compared to cinnamaldehyde, which can require ventilation and special handling due to its volatility and reactivity with air and skin. Process engineers report fewer headaches and far less hazard paperwork by swapping to Cinnamamide when they can reformulate.

    Other amides often discussed as alternatives, like acetanilide or benzamide, do not feature the same aromatic structure, nor do they mimic the cinnamon scent profile. Synthetic chemists value the extended conjugation of the cinnamoyl group, which opens doors for additional modification in pharmaceutical lead optimization.

    Companies experimenting with controlled-release flavors or encapsulation find that Cinnamamide, with its relatively inert chemical nature, holds up well in matrix systems without expelling or breaking down too quickly under mild heat or humidity. For projects needing a steady, predictable flavor release—be it in chewing gum, baked goods, or oral-care products—these properties save development time and reduce formulation headaches.

    Challenges and Solutions We’ve Worked Through

    Producing Cinnamamide on a manufacturing scale presents different hurdles than batch-lab work. Scaling up from a beaker to a 20,000-liter reactor means small issues can instantly multiply. At our facility, we’ve reconfigured condenser systems and standardized our amination steps to avoid runaway exotherms and by-product buildup.

    Hydrolysis during washing and workup once led to significant yields of undesired cinnamic acid. We invested in more effective phase-separation equipment and trained operators to watch pH and temperature like hawks during quenching. These practical fixes came from years of observation and open conversation on the factory floor, not from procedural write-ups alone.

    We noticed one recurring issue: as soon as purification steps cut corners or staff reduced time on filtration, batch purity fell, even if upstream synthesis remained unchanged. Time after time, it proved easier to maintain high Cinnamamide quality by slowing the process and focusing on careful, cool crystallization and washing, so by-products could not sneak into the bulk.

    Downstream, we listened closely to feedback about “off” scents or inconsistent performance in customer formulations. Some partners reported batches injecting a “green” or sharp note, not the warm cinnamon they needed. Feedback like this caused us to revisit our supply chain for solvents and reagents, upgrading to higher-purity lots and overhauling our tank cleaning routines.

    What Sets Our Approach Apart

    Plenty of Cinnamamide reaches the market from traders and multi-step distributors, and it arrives in varying quality. We take no shortcuts with batch segregation or mixing—each lot stays isolated from the moment we process it until shipment. Cross-contamination between old and new lots gets eliminated through dedicated equipment and rigorous cleaning. Our line operators run cross-checks under a two-signatory system, and management reviews trendline data on yield, purity, moisture, and batch-to-batch consistency.

    Being vertically integrated means our team controls the supply chain. We procure benzaldehyde and ammonia feedstocks directly, trace their origins back to certified sources, and verify batch records through routine audits. Traceability extends not only to raw chemical lots, but even to support materials such as filter pads and washing solvents. Our clients tell us that this upstream control plays a direct role in their own regulatory audits and end-product transparency.

    Seasonal shifts in feedstock quality, temperature, and humidity challenge any industrial operation. Our on-site R&D chemists collaborate with production staff throughout the year, trialing minor process adaptations to preserve performance regardless of ambient shifts. From making real-time tweaks to heating-cooling profiles to exploring alternative washing solvents, every adjustment comes after hands-on testing and direct operator input.

    Listening to What the Market Tells Us

    Over the years, we’ve watched end-use preferences change. In the mid-2000s, nearly everything we shipped went straight to the flavors and fragrance sector. Now, a growing chunk flows to pharmaceutical and specialty chemical makers, thanks to clean manufacturing and rising regulatory standards.

    End users expect more disclosure about trace metals, residual solvents, allergens, and origin. Many buyers now request custom documentation, site inspections, and real-time video audits before placing purchase orders. Rather than treat these as burdens, we see them as validation of the trust users place in manufacturing. On calls with technical leaders at multinational labs, we explain every production step in detail, sharing both triumphs and failures, so our partners know they are dealing with direct producers, not anonymous intermediaries.

    Internal housekeeping also adapts to these demands. Before bulk orders ship, quality assurance staff run additional tests for specific markets—GC-MS for the pharmaceutical trade, or TDS and taste panel assessments for food and flavor houses. Orders headed for Japan, the EU, or the US get processed only after confirming imports comply with each region’s evolving substance requirements.

    Continuous Improvement from Inside the Plant

    Much of what helps us meet high Cinnamamide standards comes not from grand technology leaps but from daily routines and attention. For each new lot, a senior operator oversees all critical synthesis and purification steps, tracking temperature, color, and pH, and recording visible changes. Training new team members means more than passing on formulas—it’s about teaching them to notice subtle time, temperature, or appearance shifts that can mean the difference between first-grade product and rework.

    We introduced on-floor feedback sessions every week. Operators, QC analysts, maintenance, and R&D gather to review recent batches, highlight anomalies, and brainstorm new controls. The small improvements that result—like tweaking drying vacuum gradients or adjusting wash sequence order—lead to measurable declines in off-spec rates. So, every carton that ships out reflects not only chemistry, but also team learning and shared pride.

    New technologies still play a role. Adding in situ monitoring sensors, automating pH titration, and linking reactors to real-time data systems let us spot and solve developing issues sooner. Predictive maintenance programs reduce outages and stave off unwanted contamination by catching wear or failure early in filtration, mixing, or drying units.

    We prioritize green chemistry principles as demand rises for “clean label” ingredients and reduced environmental impact. Solvent recovery systems now capture nearly all high-boiling process solvents for cleaning and reuse. Process development chemists trialled biosourced and recyclable wash liquids, aiming to cut down waste effluent and resource consumption from start to finish.

    What End-Users Mention Most

    Feedback drives more changes in production than executive mandates. Flavor and fragrance blenders want stable supply and a consistent lot-to-lot flavor profile. Pharmaceutical clients highlight a need for both purity and clear documentation of residuals, especially since new drug filings require full supplier transparency and process traceability.

    Food labs and research groups sometimes request special particle sizes or fluidity properties for pilot studies. Feedback from these groups has led us to create dedicated batches with finer or coarser grains than our standard models, taking advantage of flexible plant scheduling. We adjust grind, sieve, and packaging steps for these orders, installing extra in-line checks for dust or oversize particles.

    Some buyers want tailored humidity and oxygen exclusion protocols for long-term stability in storage. For these requests, we use custom nitrogen purging and vacuum sealing after final drying, extending shelf life and reducing risk of surface discoloration or caking.

    Real-World Impact of Direct Manufacturing

    We often hear from customers burned by inconsistent quality or unclear origins from trading houses. There is no substitute for accountability at the source. We see every step, monitor every parameter, and stand by each carton packed. Mistakes or contaminants do not simply get flagged in a spreadsheet—they become a hands-on learning moment for everyone upstream. This mindset shapes not just product quality, but also the culture and reliability we deliver batch after batch.

    Consistent manufacturing means food labs avoid failed consumer panels. Pharma customers cut repeat process validations. Fragrance blenders see no drop in tonality or intensity after product switch. Most rewarding of all, new customers from markets as diverse as plant-based proteins to biodegradable polymer chemistries find they can rely on the structure and predictability of Cinnamamide straight from our reactors.

    Moving Forward in Cinnamamide Production

    Manufacturing never stands still. We work closely with formulators and researchers pursuing greener syntheses, seeking new catalyst systems or lower energy process routes. Over the past three years, we have trialed process improvements shifting away from high-batch temperature, aiming for greater yield while saving energy. New analytical tools help us chase ever-lower impurity thresholds, matching rising global standards for both purity and safety.

    As traceability and documentation standards rise worldwide, the entire team understands the importance of clear, accurate batch records and open communication. We have integrated electronic record keeping, with backups and cross-checks, so clients and auditors alike can inspect what goes into every lot we produce.

    For us, Cinnamamide remains much more than a chemical formula or a specification sheet product. Every day spent refining, analyzing, and adjusting the process reinforces our responsibility—both to the people handling our product and to the countless consumers who eventually rely on its quality and safety. Each solution we develop, each adjustment we make, comes from the perspective of people who respect craft, consistency, and the importance of doing things right the first time.