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Choline Citrate

    • Product Name Choline Citrate
    • Alias choline-citrate
    • Einecs 242-222-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    926817

    Chemical Name Choline Citrate
    Molecular Formula C8H18NO8
    Molecular Weight 271.23 g/mol
    Appearance White crystalline powder
    Solubility Highly soluble in water
    Cas Number 77-91-8
    Taste Slightly salty and sour
    Ph Approximately 3.5–4.5 (1% solution in water)
    Odor Odorless
    Storage Conditions Store in a cool, dry place, tightly closed
    Stability Stable under recommended storage conditions
    Uses Nutritional supplement, source of choline
    Melting Point Decomposes before melting
    Synonyms 2-Hydroxyethyl(trimethyl)ammonium citrate
    Source Synthetic or plant-based

    As an accredited Choline Citrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle, 500 grams. Labeled “Choline Citrate,” with hazard symbols, batch number, expiry date, and manufacturer details. Sealed cap.
    Shipping Choline Citrate is shipped in tightly-sealed, clearly labeled containers to prevent moisture absorption and contamination. Packaging complies with relevant regulations, ensuring safe transit. The product is typically transported in fiber drums, plastic containers, or bags. It should be kept dry, cool, and away from incompatible substances during shipping and storage.
    Storage Choline Citrate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight and sources of heat or ignition. It should be kept away from incompatible substances such as strong oxidizing agents. Proper labeling and handling procedures must be followed to prevent contamination and ensure safety during storage.
    Application of Choline Citrate

    Applications of Choline Citrate in Industrial Manufacturing

    We directly supply choline citrate to manufacturers across key downstream sectors where this raw material delivers tangible formulation and process advantages. This section outlines the principal industrial scenarios where choline citrate demonstrates consistent and compliant performance, based on established end-use standards and real-world production methods.

    1. Infant Formula Production

    Infant formula manufacturers incorporate choline citrate as a critical nutrient source to support cognitive and physiological development in newborns and infants. Its high bioavailability, compared with inorganic forms, allows precise control over fortification levels without introducing chloride load. Quality departments monitor its integration to ensure batch uniformity and trace nutrient stability through shelf life evaluations, as required by infant formula regulators worldwide.

    Industry compliance standards

    • Codex Alimentarius Standard for Infant Formula (CODEX STAN 72-1981)
    • EU Regulation (EU) 2016/127 on infant formulae composition
    • China GB 10765 National Food Safety Standard - Infant Formula
    • Good Manufacturing Practices (GMP)

    Typical usage ratio

    • 0.05%–0.3% of total formula powder weight; adjusted based on target choline content, alongside dietary reference intake guidelines and matrix composition

    Downstream process integration

    • Added to the blend tank after primary protein and carbohydrate mixing, prior to homogenization and spray drying; monitored for dispersion to prevent hot spotting and ensure declared nutrient levels

    Final product types

    • Powdered infant formula
    • Ready-to-feed liquid infant formula
    • Follow-on and growing-up formula for children aged 6–36 months

    2. Functional Food and Beverage Fortification

    Functional beverage and meal-replacement manufacturers use choline citrate to deliver scientifically substantiated cognitive and metabolic health claims targeting adults and seniors. Its taste-neutral profile and high solubility allow seamless incorporation into ready-to-drink products, powdered drink mixes, nutrition bars, and meal shakes, while maintaining a clean label and declared ingredient transparency. Production teams track its addition to ensure bioactive integrity during pasteurization and shelf-life processing.

    Industry compliance standards

    • US FDA 21 CFR Part 184.1436 (GRAS status as choline salts for use in food)
    • EU Regulation (EC) No 1925/2006 on Addition of Vitamins & Minerals and Certain Other Substances to Foods
    • FSSC 22000 Food Safety System Certification for processing plants
    • EFSA scientific opinions on nutritional reference values for choline

    Typical usage ratio

    • 0.01%–0.2% w/w in beverages and powders; final dosage determined by target choline levels, local nutrition guidelines, and product positioning (general wellness, senior, sports, etc.)

    Downstream process integration

    • Dissolved in blending tanks post-sugar and acidulant addition, prior to final pasteurization or aseptic packing; subject to in-process QC testing for ingredient homogeneity and declaration compliance

    Final product types

    • Fortified functional beverages
    • Nutritional meal replacement shakes
    • Protein and energy drink powders
    • Nutrition and snack bars

    3. Animal Feed Premix Manufacturing

    In the animal nutrition sector, choline citrate supplies a highly bioavailable form of choline to premix manufacturers, offering enhanced stability and lower risk of dusting compared to choline chloride. Formulators choose citrate salt versions in sensitive compounded feeds or where chloride content must be minimized, such as poultry starter diets and aquafeed for larval stages. Quality managers verify input conformity to ensure nutrient guarantee levels align with label claims and regulatory requirements.

    Industry compliance standards

    • AAFCO Official Publication (American Association of Feed Control Officials), Feed Ingredient Definitions
    • European Feed Additives Regulation (EC) No 1831/2003
    • China GB/T 17819-2017 National Feed Hygiene Standards
    • ISO 22000 Certified Feed Manufacturing Processes

    Typical usage ratio

    • 0.05%–0.3% of total premix (depending on species, diet phase, and regulatory choline requirements); formulators adjust according to nutrient matrix and chloride contribution constraints

    Downstream process integration

    • Dosed during dry blend or liquid addition stage in micro-component mixing; critical for uniform dispersion and formation of stable, dust-free premix granules prior to downstream pelletizing or extrusion

    Final product types

    • Poultry starter and breeder feed premixes
    • Swine weaning compound feeds
    • Aquaculture starter and grower feed mixtures
    • Specialty livestock vitamin-mineral premixes

    4. Parenteral Nutrition (IV Solutions) Compounding

    Choline citrate acts as a controlled choline donor in the compounding of parenteral nutrition (PN) solutions, particularly in neonatal and critical care formulations where rapid and reliable systemic absorption is required and strict chloride load limits apply. Hospital and contract compounding pharmacies rely on pharmaceutical-grade material, conforming to injection safety standards, with each lot traceable back through full GMP production.

    Industry compliance standards

    • US Pharmacopeia (USP) standards for Parenteral Nutrition Components
    • European Pharmacopoeia (Ph. Eur.) monographs on Parenteral Ingredients
    • Good Manufacturing Practice (GMP) for sterile medicinal product production
    • ISO 13485 Quality Management System for Medical Devices where applicable

    Typical usage ratio

    • 0.001%–0.02% w/v in compounding solutions; healthcare providers calculate exact amounts per patient based on age, clinical diagnosis, and total PN protocol requirements

    Downstream process integration

    • Introduced as a sterile filtered solution during final admixture preparation in aseptic cleanroom environments; subject to post-batch sterility, pyrogen, and constituent concentration assays prior to dispensing

    Final product types

    • Total Parenteral Nutrition (TPN) IV bags for neonates, pediatrics, and adults
    • Custom parenteral micronutrient component vials
    • Hospital-prepared IV admixtures

    5. Pharmaceutical Tablet and Capsule Formulations

    Pharmaceutical and nutraceutical factories use choline citrate as an active ingredient in cognitive health, liver support, and prenatal supplement products. Its low hygroscopicity compared to other choline sources allows stable direct compression and encapsulation even in high-speed production environments. Analytical QC tracks both content and stability in tablets and capsule fill for batch release and regulatory registration.

    Industry compliance standards

    • US Pharmacopeia (USP) dietary supplement ingredient monographs
    • EU Directive 2002/46/EC on Food Supplements
    • China Pharmacopoeia for choline-containing supplements
    • ISO 9001 Certified Pharmaceutical Quality System

    Typical usage ratio

    • 100 mg–650 mg per daily serving (converted to formulation % based on final product size); ranges adjusted for target health claim, tablet/capsule fill constraints, and jurisdictional upper limit rules for choline intake

    Downstream process integration

    • Added during dry blend stage for tablets and as a pre-milled powder for hard-shell capsule filling; requires moisture control during blending for finished product uniformity and content validity throughout declared shelf life

    Final product types

    • Cognitive and brain health tablets
    • Liver health and prenatal supplement capsules
    • Over-the-counter choline complex nutraceuticals

    6. Oral Liquid Nutraceutical Manufacturing

    Producers of oral liquid supplements incorporate choline citrate for fast-absorption choline delivery in adult and pediatric applications. Its high aqueous solubility allows for stable inclusion at label-declared doses, with integration parameters closely monitored to prevent precipitation or flavor imbalance during bottling and thermal stabilization. Regulatory compliance teams validate constituent levels to match supplement facts and ensure compliance with food supplement declarations.

    Industry compliance standards

    • EU Regulation (EC) No 852/2004 on food hygiene
    • US FDA cGMP for dietary supplements (21 CFR Part 111)
    • FSMA-compliant hazard analysis in the US market
    • National technical standards for health food (China: GB 16740-2014)

    Typical usage ratio

    • 10 mg–200 mg per serving (typically 0.005–0.1% w/v in finished liquid); dosage based on age, product format (ampoule, syrup, shot), and national maximum nutrient guidelines

    Downstream process integration

    • Dissolved in water or syrup solution following excipient and preservative blending; subject to inline pH adjustment and flavor balancing pre-pasteurization or cold-filtration prior to final filling and capping

    Final product types

    • Pediatric choline liquid supplements
    • Adult cognitive support oral solutions
    • Health-food grade ampoule drinks
    • Ready-to-drink shot format supplements
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    Certification & Compliance
    More Introduction

    Choline Citrate: An Essential Nutrient for Modern Industry

    Why Choline Citrate Earns Its Place in Nutritional and Chemical Manufacturing

    Producing choline citrate carries more weight and responsibility than many outside the industry would guess. Our experience in the field has made one fact clear: not every choline salt suits every need, and the careful balance of choline with citric acid unlocks unique benefits that many manufacturers, feed formulators, and health supplement creators now depend on.

    We manufacture choline citrate as a crystalline, highly water-soluble powder. The appearance matters. Consistency in particle size and color signals quality at every step of the process, from blending to final packaging. Inconsistent batches can ruin automatic dosing and complicate inspection. That’s why our technical team inspects every batch before release, not just relying on analytical tools but by using production experience to spot any deviations early. With every shipment, we build on direct feedback from our partners, making adjustments that stem from years spent on the floor with hands on the product.

    Why Choline Matters: Human, Animal, and Industrial Value

    Choline itself is one of those nutrients that frequently goes unrecognized until its absence causes headaches. In animal and human nutrition, choline provides crucial methyl groups for metabolic processes, helps with lipid transport, and supports nervous system health. In practical terms, farmers and feed manufacturers see direct benefits in growth rates, egg production, and litter quality when choline reaches proper levels in livestock diets. Less often discussed is the way choline draws value in personal healthcare and infant nutrition—where purity, safety, and reliable supply chain security play just as important a role as the nutritional science behind it.

    Unlike choline chloride, commonly paired with chloride ions, choline citrate introduces a citrate group from citric acid. This composition translates into improved palatability and reduced corrosiveness, which manufacturers appreciate during equipment maintenance and process troubleshooting. Handling choline chloride can corrode feed mixers and metal bins, sometimes leading to production shutdowns or recurring costs for replacement parts. The less-aggressive citrate salt offers a practical answer where investors ask us about protecting their hardware, not just their animals or end customers.

    Our Product Model: Purity, Stability, and Functional Simplicity

    We supply choline citrate in grades targeted for specific uses: nutritional supplements, food and beverage fortification, and animal feed. Though the chemical composition remains the same——choline hydrogen citrate, often written chemically as C8H20NO8——we differentiate by purity and moisture content, since these parameters tie directly to how our customers use the material. In our plant, we monitor both parameters throughout the process, drawing on thorough records and digital traceability systems that allow us to trace any batch through every stage of production.

    One distinction with our choline citrate lies in its physical properties. The powder dissolves rapidly in water, forming a clear, neutral-tasting solution. Human supplement companies appreciate this, as it allows for easy blending into syrups, beverages, and tablet pre-mixes without leaving residue or clumping that would mar finished goods. In the animal nutrition sector, this easy dispersal means farmers can add choline citrate to water systems for flock or herd delivery, reducing mixing times and minimizing labor costs.

    Our choline citrate meets established standards for heavy metals and microbial contamination. Every few months, we dedicate team meetings to reviewing these procedures, not out of regulatory obligation but because shortcomings here would directly affect our own brand’s reputation in key export markets. Over the years, we’ve seen the way a single contaminated batch can close off trade to entire regions, costing jobs and threatening long-standing partnerships. These experiences push us to maintain conservative limits, invest in qualified personnel, and double-check even when there isn’t an immediate crisis.

    Production Insights: What Sets Our Approach Apart

    Chemical manufacturing doesn’t leave room for shortcuts. With choline citrate, the key stages run from the precise reaction of choline base with citric acid, through careful crystallization and gentle drying, to minimal exposure to environmental moisture. If humidity rises too high at any point, product can clump or degrade, leading to batch rejection. Our facility runs dehumidification across sensitive zones. The cost for environmental controls may seem high up front but we saw major reductions in customer complaints about caking once we committed to this approach.

    Packing presents its own challenges. Unlike some “bulk” commodities, choline citrate packs for both food and feed applications. Some companies try for a one-size-fits-all packaging method, but our experience has shown that feedgrade and foodgrade customers want clear differentiation. Our food and nutraceutical clients expect packaging in double-lined, food-contact grade bags, while animal feed partners value strong, puncture-resistant sacks that stand up to rough handling. Listening directly to their needs has helped us avoid spoilage, off-odors, or breakage during shipping and storage.

    Comparing Choline Citrate with Other Choline Salts

    Most customers entering the market for the first time find themselves comparing choline citrate with the more prevalent choline chloride or choline bitartrate. Here’s how these materials diverge in the realities of manufacturing and usage:

    User Experiences: From Feed Mills to Nutraceutical Brands

    Over the past decade, choline citrate has found its way into an increasingly wide variety of applications. In industrial animal agriculture, it quickly became favored for applications in hatcheries and grow-out farms. Field trials in broiler chickens have shown less dust in feed bins and easier cleaning of water lines. With our steady supply chain, producers rely on regular deliveries, knowing batch-to-batch variation won’t surprise them.

    In the personal health realm, our material enters direct compression tablets and liquid supplements. Supplement formulators highlight several advantages: our choline citrate does not cake during storage, meaning longer shelf life and easier large-scale mixing. Manufacturing teams, often under pressure to release new product lines on tight deadlines, have shared that the powder’s consistent moisture levels help them hit production targets for pressing tablets or bottling.

    Mothers and pediatricians searching for safe forms of choline for infant formula prioritized purity and traceability, particularly in regions where food scandals have eroded trust. Our production records and open door auditing policy allow third-party verification for any client or regulator. We arrange yearly walkthroughs for representatives from partner companies as well as food safety officials, not just because we are required but because we have seen alliances form based on demonstrated transparency.

    Quality Control: Stories from the Production Floor

    Anyone in manufacturing long enough develops a sense for pinpointing quality failures before they escalate. With choline citrate, our most critical time runs from drying to packing. Workers have found that even minor fluctuations in room humidity or slightly off-target particle size can result in material that cakes or fails to flow, complicating everything from automated filling to customer mixing downstream. For this reason, the team runs regular manual checks as a supplement to our real-time process controls, and we empower our operators to flag suspect batches with no penalty. Pride in product quality grows when team members see their vigilance rewarded with zero returns or complaints from loyal clients.

    Counterfeit products and supply chain substitution threaten nearly every chemical manufacturer today. We have had customers return with stories of ‘off-spec’ choline citrate supplied by traders who didn’t know the difference between animal and food grade, leading to failed product launches or costly recalls. We engraved unique batch numbers and invisible security tags into our packaging not just to set us apart, but to make sure clients receive what they ordered, made by the team they trust.

    Sustainability and Supply Security: Risks and Mitigations

    Few appreciate the full range of stressors affecting the choline supply chain in recent years. Raw choline base and citric acid, both subject to global crop cycles, face pricing and availability swings. Anytime raw material prices jump, opportunistic traders swoop in, hoping to make quick deals at the expense of reliability. Our practice leans toward longer-term sourcing contracts with vetted suppliers. In years where yields dip, this keeps prices more stable for our end users.

    Energy costs influence more of our bottom line than many anticipate. The drying steps for choline citrate eat significant electricity. We reinvested efficiency savings from improved air management and waste heat recovery back into training and quality monitoring. Unlike commodity players who seek only cost cuts, we found that a focus on durability and long-term trust pays dividends in repeat business.

    Shipping pharmaceuticals and nutrients worldwide brings risks beyond just paperwork. Mishandling in transit, unexpected customs inspections, or delays at ports can degrade quality and sow uncertainty. Our experience with direct-to-client shipment tracking, frequent temperature checks, and responsive interventions means fewer surprises. Several clients told us that the difference between a successful launch and a failed one came down to how we managed short-notice logistical challenges.

    Innovation and Technical Collaboration: Building On Experience

    Over time, our technical partnerships with leading food and feed scientists have driven steady improvements in choline citrate. In pilot projects for early-stage clinical nutrition companies, the flexibility of our manufacturing line let us supply specialized particle sizes or blends for research batches. We invited customer teams to run trials at our bench-scale mixers, sharing best practices learned from hundreds of industrial launches. Several innovations that stuck in the marketplace—such as multipurpose choline formulations—were born from hands-on sessions between our R&D chemists and customer process engineers.

    We share technical data openly when customers face a challenge. Whether it’s solubility concerns in new beverage applications or compatibility with novel excipients, our support begins at the formulation stage. Several nutraceutical brands credit our extended support network for helping navigate tricky regulatory submissions in new countries or for adapting documentation as science and standards shift. Our factory personnel know the real-world importance of old-fashioned accessibility: direct phone support or video walkthroughs can solve small issues before they turn into recalls or line shutdowns.

    Looking Forward: Expectations from Manufacturers

    Doing business as a direct manufacturer means more than just moving product. We keep our focus on reliability, safety, and transparent communication. Our direct engagement with regulatory agencies, multilayered quality systems, and real-time process monitoring provide security beyond numbers on a certificate. As scrutiny grows in the nutrition and feed additive fields, our philosophy ties back to doing things the right way, not just the most profitable way. Every batch of choline citrate leaving our facility reflects not just our skill but a working partnership with every customer who lives with the outcomes.

    At every stage of growth in the choline citrate market, our experience has shown that small details—moisture, particle size, packaging choices, raw material consistency—accumulate into big outcomes. Companies that treat those details as afterthoughts find themselves chasing after problems that could have been prevented. By focusing on the details from start to finish, we deliver a product that stands up to real-world challenges—whether in a high-throughput animal feed operation in Brazil, a nutraceutical tablet line in Europe, or a clinical nutrition facility in Southeast Asia.

    We see choline citrate continuing to grow as both industries and consumers search for nutrient forms that balance safety, ease of use, and dependability. Experience on the ground shows every improvement counts, and every problem solved earns lasting customer trust. As science uncovers more about the role of choline in health and productivity, and as equipment design evolves to accommodate new nutrient forms, our manufacturing approach will keep adapting, always rooted in lessons learned at the intersection of chemistry, practical usage, and customer feedback.