Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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Choline

    • Product Name Choline
    • Alias vitamin-b4
    • Einecs 200-043-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    358535

    Name Choline
    Chemical Formula C5H14NO
    Molar Mass 104.17 g/mol
    Appearance White, hygroscopic crystalline solid
    Solubility In Water Very soluble
    Melting Point 302 °C (decomposes)
    Cas Number 62-49-7
    Iupac Name 2-hydroxy-N,N,N-trimethylethan-1-aminium
    Pka 13.9 (of conjugate acid)
    Function Essential nutrient for humans
    Synonyms Vitamin B4, Trimethylethanolamine
    Odor Mild, fishy
    Storage Conditions Keep in a cool, dry place

    As an accredited Choline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g Choline comes in a sealed, white HDPE bottle with a tamper-evident cap, labeled with safety and handling information.
    Shipping Choline is shipped as a stable, non-flammable compound, typically in sealed containers, under standard temperature and pressure. Containers must be clearly labeled and protected from moisture and physical damage. Handling should comply with relevant safety guidelines, and transport follows regulations set by agencies like DOT, IATA, or IMDG, depending on destination.
    Storage Choline should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. It should be kept away from incompatible substances such as strong oxidizing agents. Proper labeling is essential, and access should be limited to trained personnel. Follow standard laboratory practices and local regulations for chemical storage and handling.
    Application of Choline

    Applications of Choline in Industrial Manufacturing

    As an established manufacturer of choline series chemicals, we focus exclusively on supplying high-purity choline raw material to sectors with proven, large-scale industrial integration. Our product supports measurable process improvement and compliance for manufacturers across nutraceutical, food, animal nutrition, pharmaceutical, and chemical synthesis industries. Below is an in-depth overview of the principal downstream application scenarios, with specific details on standards, formulary roles, site of process usage, and finished product types.

    1. Nutritional Additives for Animal Feed (Feed-Grade Formulations)

    Choline’s inclusion in animal feed formulations—particularly as choline chloride—addresses metabolic demand for methyl-group donors, promotes lipid transport, and supports animal growth performance. Industrial producers rely on accurate dosing in accordance with regulatory mandates for livestock, poultry, and aquaculture diets. Our high-concentration material ensures reliable batch-to-batch performance during intensive premix and pelletizing operations.

    Industry compliance standards

    • FAMI-QS (European Feed Additives and Premixtures Quality System)
    • European Union Feed Additives Regulation (EC) No 1831/2003
    • AAFCO (Association of American Feed Control Officials) Guidelines
    • GB/T 20808 (China National Standard for Feed Additive Choline Chloride)

    Typical usage ratio

    • Range: 300–2,000 mg/kg of complete feed, depending on species, life stage, and diet formulation objectives

    Downstream process integration

    • Added during the vitamin & trace mineral premix blending step; homogeneously mixed with macronutrient/energy carriers before pelletizing or extrusion

    Final product types

    • Poultry feed (broilers, layers)
    • Swine feed (sow, piglet, finishing pig diets)
    • Aquaculture rations
    • Ruminant fodder premixtures

    2. Infant and Adult Nutritional Formulas

    Choline is an essential nutrient for neurodevelopment and liver function, underpinning its mandatory fortification in regulated infant formula and specialty nutritional beverages. Formula producers depend on its consistent assay and solubility for production of stable, compliant pre-mix slurries and liquid or powder dosing, in line with global safety and labeling requirements.

    Industry compliance standards

    • Codex Alimentarius Standard for Infant Formula (CODEX STAN 72-1981)
    • US FDA 21 CFR 107.100 (Infant Formula Nutrient Specifications)
    • EU Regulation (EU) 2016/127 on Infant Formula and Follow-on Formula
    • GB 10765–2021 (China National Food Safety Standard for Infant Formula)

    Typical usage ratio

    • Ranges from 7–50 mg/100 kcal in infant formula, adjusted to comply with target regulatory minimums and upper intake limits

    Downstream process integration

    • Dosed as part of micronutrient vitamin/mineral premix, dissolved in liquid phase and blended prior to spray drying or aseptic UHT processing

    Final product types

    • Powdered infant formulas
    • Ready-to-feed infant and follow-on milk drinks
    • Paediatric clinical nutrition beverages
    • Adult medical nutrition supplements

    3. Pharmaceutical Excipient and API Manufacturing

    Industrial-scale pharmaceutical manufacturers use choline and its derivatives (e.g., choline bitartrate, choline alfoscerate) for precise excipient roles or as active ingredients in cognitive health products. Regulatory compliance requires validated purity, traceability, and process control throughout batch synthesis and final pharmaceutical processing, under stringent GMP environments.

    Industry compliance standards

    • USP-NF Monographs (e.g., for Choline Chloride, Choline Bitartrate)
    • European Pharmacopoeia (Ph. Eur.) specifications
    • China Pharmacopoeia (ChP)
    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients

    Typical usage ratio

    • Varies by formulation—typically 250–1,000 mg per dose unit for APIs, 1–5% as pharmaceutical excipient by mass

    Downstream process integration

    • Processed as part of granulation or solution compounding; subjected to blending, tableting, or encapsulation downstream of API intermediate synthesis

    Final product types

    • Tablets, capsules, sachets for cognitive health and liver support
    • Parenteral nutrition additives
    • Prescription-grade oral and injectable medications

    4. Industrial Synthesis of Specialty Chemicals and Intermediates

    Large-volume chemical processors employ choline salts as phase-transfer catalysts, methyl donors, or functional group precursors in the synthesis of quaternary ammonium compounds, ionic liquids, and water-soluble intermediates. Process conditions demand stable supply of industrial-grade choline to meet productivity and reproducibility standards in continuous and batch chemical manufacturing.

    Industry compliance standards

    • ISO 9001:2015 for manufacturing quality systems
    • Chemical Control Law compliance (US TSCA, EU REACH registration for chemical intermediates)
    • Responsible Care® Program (global chemical industry initiative)

    Typical usage ratio

    • 5–25% by weight in catalyst systems; variable loading as per specific reaction stoichiometry and scale-up protocol

    Downstream process integration

    • Fed continuously or batchwise to reactor vessels during quaternization, methylation, or ionic liquid synthesis reactions

    Final product types

    • Quaternary ammonium phase-transfer catalysts
    • Hydrotropes for textile and surfactant industries
    • Ionic liquids and deep eutectic solvents
    • Intermediates for advanced chemical synthesis and agrochemicals

    5. Food and Beverage Fortification Additive

    Food processors utilize choline salts to boost choline levels in fortified foods and beverages, meeting regulated labeling claims for “good” or “excellent” source of choline. Dosing adapts to matrix pH, solubility, and process heat stability, with careful validation to preserve nutritional content through thermal or mechanical processing.

    Industry compliance standards

    • Codex General Standard for Food Additives (CODEX STAN 192-1995)
    • US FDA GRAS Notice Inventory for Choline Salts
    • EU Regulation (EC) No 1925/2006 on Adding Vitamins and Minerals to Foods
    • China GB 14880–2012 Standard for Use of Nutritional Fortifiers in Foods

    Typical usage ratio

    • 20–125 mg/serving, based on product type, serving size, and desired label claim

    Downstream process integration

    • Added to beverage base during pre-mix blending or to dry food blends; validated for retention post-pasteurization or during baking/confectionery operations

    Final product types

    • Fortified juices and dairy drinks
    • Meal replacement shakes
    • Breakfast cereals and energy bars
    • Infant and toddler complementary foods
    Free Quote

    Competitive Choline prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

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    Certification & Compliance
    More Introduction

    Choline: A Foundation for Growth and Vitality

    Every Batch, Every Time — Manufacturing Choline with Purpose

    Years spent at the reactor, watching raw materials transform and checking process temperatures, have taught me that not all choline is the same. From our earliest days on the line, we understood that integrity matters in each step — from selection of base alkaloids to the reaction controls that tune moisture and color, even down to the last granule of finished product. Any choline manufacturer can talk of formulas and reaction yields, but in our experience, it’s the details that separate a robust, clean choline chloride from a powder that clumps in storage or loses potency on the shelf. Every batch we make reflects thousands of hours spent tuning these details.

    Our Choline Models: From Farm to Table

    We have concentrated on two principal models of choline: choline chloride 60% corn cob and choline chloride 75% liquid. Each format serves its own place in animal nutrition and feed formulation. Field results show animals don’t just rely passively on choline; their growth, liver function, and health change measurably when the right form and purity hit the feed. This isn’t anecdotal, either. Progressive poultry and swine producers document stronger feed conversion ratios and improved resilience during stress. Experience in the warehouse has convinced us that purity of choline chloride, especially tight limits on trimethylamine and moisture, matter as much as label guarantees when talking about shelf life and freedom from caking.

    Grinding and blending have long been seen as simple tasks, but it is not until you try to mix a low-quality choline product into vitamin-mineral premixes that you realize how much particle size distribution and anti-caking go toward smooth production. Our customers rarely see sticking in their mixers or dust clouds from oversize fines. This comes down to careful process control and, frankly, a refusal to cut corners on binders or diluents. No amount of advertising can hide when a kilogram of product leaves residue in the bag or lumps during transport.

    The Chemistry No One Sees — Why Purity and Formulation Affect Results

    Years ago, one of our team leaders demonstrated what happens when choline raw materials aren’t handled right — a batch with just a slight excess of residual dimethylamine turned an entire ton of feed into a sour-smelling, rejected shipment. Markets overseas rejected it, and the farmer lost weeks chasing down problems. Stories like these stick with us. Our QA checks trimethylamine, pH, and color against strict standards. Moisture content stays below 3% in dry product. Liquid choline chloride is filtered and tested for compatibility in water blends before it ever gets out the door. Anyone can say they offer “high purity,” but unless you run the titrations and odorous compound checks yourself, you quickly realize how easy it is to miss important signs.

    We test our choline for more than label claims. Some manufacturers leave out detailed micro tests, thinking that visible quality will do. We have learned that even small changes in residual amines or off-color can spell trouble in tonnage feed. It is not abstract: a 0.2% difference in choline content means whole silos drift off specification over the months. Similarly, uncontrolled moisture creeps up, pulling in more caking and ruining mixer flow. Our feedback comes straight from those who fill their augers and see results at the farm gate. Their animals either start well or they don’t; there’s no argument with results that show in daily gain and meat yield.

    Beyond Nutrition — Choline’s Role in the Science of Animal Health

    Choline is not just for growth; it forms a cornerstone of cell structure and methyl group metabolism. Over the years, we’ve worked with veterinarians and animal scientists who track neural tube development and fatty liver prevention in breeding stock. They tell us time and again that consistent choline input makes all the difference between strong viability and higher morbidity in the farrowing house. Extended fieldwork in hot climates, where feed intake suffers due to heat stress, has proven to us that choline supplementation is more than a bonus—it keeps flocks and herds functioning at levels the formulation trials once promised, even under tough conditions. We have seen declining incidence of fatty liver in layers and improved carcass grade in broilers that receive the correct dosage without surprises from batch to batch.

    It is tempting to pass over the specifics and market choline just as a standard commodity. We took a different route, focusing on education and direct discussions with nutritionists who want more than just crude numbers — they want dependable batch-to-batch delivery and documented effectiveness. Not long ago, our team worked through an issue with a large integrator who had been seeing late-phase production dips. The root problem came down to incompatible mixing caused by a competitor’s variable choline flowability. By changing to our product, uniformity in mixing came naturally, and within a few weeks, the integrator noticed better post-peak laying rates.

    Choline Chloride 60% vs. Liquid Choline Chloride 75%: Real-World Use

    Farm operations vary widely in their infrastructure. Dry choline chloride 60% has become the industry mainstay for premix manufacturers and compounders using conventional mixing lines. This product stays stable through humid seasons, remains easy to handle, and integrates without hassle into most blends. Anyone who has cut open a premix bag only to find clumps will agree that dryness and anti-caking count in a practical sense just as much as test results. On the other side, our choline chloride 75% liquid comes into play for larger feed operations equipped with automated dosing lines. Liquid formulation enables more accurate dosing and reduces dust, which is crucial for worker safety in plants running 24-hour shifts. Our plant maintenance teams have told us many times how much easier it is to run pumps and lines when you’re not fighting residue and clogs from poor-quality liquids.

    When considering alternatives to choline chloride, we often get questions about straight choline salts like choline bitartrate or choline dihydrogen citrate. These forms have their own roles in human nutrition, but for animal feed, choline chloride brings unmatched stability, cost-effectiveness, and compatibility with large-scale mixing equipment. Industry trials repeatedly show no other salt matches the utility per cost, especially when ensuring minimum losses during transport and storage. Our partners in feed milling have confirmed time and again that dependable bulk choline chloride prevents formulation drift across entire feed cycles.

    Lessons From Decades in Production — No Shortcuts in Manufacturing

    Watching new staff run their first batch, mistakes practically announce themselves: maybe a seal isn’t tight, a steam valve is slow, or quality slips through a rush in production. We don’t hide from these mistakes; we trace them back and learn. Unlike script-based resellers or traders, we have boots on the production floor and take responsibility for equipment calibration and process controls. The business of choline demands relentless detail: quality teams probe finished product for micro-quality levels, not just gross label content. Our lab staff tracks every batch by time, material, shift, and even environmental conditions during production — a habit built from hard lessons learned when standards weren’t so clear.

    Years ago, during a market shortage, we watched as several substandard batches entered regional commerce from unregulated sources. A few months later, case reports showed increased animal health incidents. We met with local nutritionists, spotted the patterns with them, and established batch-level tracking for every shipment, linking product ID to customer. With this system, farms quickly verified origin, and trust built on more than just claims. Out of those challenges, we made it a policy to provide comprehensive batch analyses and open, transparent communication with all partners.

    Environmental and Supply-Chain Considerations

    No operator can ignore sustainability and environmental impact. We use corn cobs and other agricultural byproducts in our solid choline production, putting lower-value feedstock into high-value use. Efficient conversion processes have cut our energy and water use over the years. Waste handling and emissions matter: regulatory compliance isn’t just paperwork — it’s about running a plant that keeps the confidence of nearby communities and export destination countries. Our environmental monitoring teams regularly assess all plant streams for compliance, not just at government-required intervals but as part of day-to-day operation. This has helped us avoid fines and — more importantly — maintain steady delivery even during changing regulatory climates or trade disruptions.

    Trading partners frequently ask about our raw material sourcing and container tracking. We operate on the basis of traceability, keeping detailed records from raw input through delivery. Whenever we hear about imported choline being held in customs due to documentation lapses, we know firsthand that proper tracking improves turnaround and saves customers from unexpected delays. These behind-the-scenes disciplines reduce the headaches downstream, letting nutritionists and purchasing managers rely on scheduled integration without diversion.

    Solving Real-World Problems With Choline

    Animal producers often just need reliable solutions for persistent problems: risk of fatty liver, low hatchability, susceptibility to stress, and difficulties in feed mixing. Each issue brings its own technical and economic challenges. Over the years, we have collaborated with universities and independent researchers for feed trials, tracking outcomes across multiple cycles with direct producer feedback. Several years ago, a breeder operation documented consistent improvements in hatching weights and uniformity after shifting from generic, often impure product to our controlled choline chloride blend. The lessons were clear — details in sourcing, process, and finished product all turn up in the final outcome.

    Acute shortages in supply and fluctuating input costs pose tough challenges. By keeping close relationships with regional grain suppliers and backup raw feedstock options, we stabilized our inventory even during high price volatility in global methylamine markets. There have been periods where alternative choline sources were considered, but the steep cost and variable supply never matched the consistency and value of our established lines. Maintaining this consistency has given customers confidence to commit to longer-term contracts, minimizing price and inventory risk in an unpredictable world market.

    Understanding Myths and Marketing vs Reality

    Feed industry marketing sometimes leans on buzzwords and trends, but out in the blending plant, results count. We have heard all manner of claims about “premium” blends with “added performance” agents. Experience says nothing beats foundational raw material quality and real-world application. Low dust, reliable bulk density, and the absence of hidden residues drive repeat business. Our work has been in applying practical scale — not chasing fads, but measuring digestibility and actual animal outcomes in the field.

    Some competitors push untested “innovative” choline alternatives, touting “improved” environmental footprints but lacking field validation. We have put these alternatives through side-by-side trials. In almost all cases, our core choline chloride line not only matches but exceeds performance against the trialed newcomers. As organizations and regulatory environments demand more transparency, the discipline of rigorous batch-level control and traceability becomes even more essential. Many years of producing choline have proven to us that there are no shortcuts — only careful, steady improvements.

    How Feedback Shapes Better Choline

    Customers shape more than just product features — their feedback changes process and policy. Feed mills often want a bulk choline solution that doesn’t require expensive upgrades. Through years of site visits and technical discussions, we refined dust reduction, improved bagging techniques, and adapted delivery formats to match blending needs. As a manufacturer, listening means taking that late-night call when there’s clumping or an unexpected lab result, not pushing problems away or hiding behind third-party relationships. Sometimes, the answers are as simple as sending a fresh sample or adjusting production parameters on short notice.

    Recently a regional integrator explained a bottleneck in liquid choline dosing — too frequent filter changes slowed down their blending line. We took the problem straight back to production, adapting our filtration and particle-size controls, and delivered them an improved lot weeks later. Their next monthly report showed fewer stoppages and improved batch accuracy. This kind of ongoing feedback loop means every ton of choline laid down on farms reflects not just market demand but also real-world advice from those who rely on feed every day.

    Choline Chloride: Why We Stick To What Works

    Each feed year brings new challenges: shifting animal genetics, global economic pressures, changing regulatory targets for purity and traceability. What has not changed is our focus on core choline chemistry and reliable manufacturing practice. Industry associations and international standards have helped shape our processes; years of regular independent audits and collaborative partnerships have confirmed that sticking to workable, tested approaches pays off for everyone in the food chain. Farmers, nutritionists, processors, and end consumers all benefit when the chemistry stands up to scrutiny and the supply chain stays tight.

    We see trends come and go, but in the end, longevity depends on sound process, robust documentation, and a willingness to adapt to change. Experience running the line and working in quality control has taught us there is no substitute for transparency and hard evidence when it comes to animal feed additives. Compromises on core ingredients make themselves felt down the line — in animal health, farm economics, and the broader food system that supports us all.

    What’s Next for Choline Production and Use

    Choline’s importance only grows as feed producers push for higher yields, faster weight gain, and improved welfare, while at the same time facing tighter controls on residues and traceability. We are seeing more complex production lines, greater integration with digital tracking, and an expanding role for sustainable sourcing. Adjusting operations to support these changes means investing in better monitoring, keeping open communication with customers, and maintaining a willingness to address problems before they reach the end user.

    As discussions about food safety, animal health, and transparency mature, our team stays committed to honest manufacturing. Our technical group participates in industry working groups and standard-setting committees, bringing experience back to the plant floor. Whether working with supply chain auditors or collaborating on production improvements, real progress relies on sharing know-how and getting feedback from every link in the chain.

    Final Thoughts: Our Commitment in Every Batch of Choline

    We offer choline chloride not as a commodity, but as an ongoing partnership built on listening, learning, and improving with each lot produced. Every decision, from sourcing to QA to delivery, comes back to lessons learned over decades in the field. The strength of any animal nutrition program depends on the quality of every ingredient, and choline chloride stands out not just for its role in biology, but for the care and practical sense behind its production. We know what matters to the people who rely on us — animals that thrive, operations that run smoothly, and trust earned every day by delivering what we promise.