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Carbamoyl-DL-Aspartic Acid

    • Product Name Carbamoyl-DL-Aspartic Acid
    • Alias DL-Aspartylurea
    • Einecs 699-312-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    220020

    Chemical Name Carbamoyl-DL-Aspartic Acid
    Molecular Formula C5H8N2O5
    Molar Mass 176.13 g/mol
    Cas Number 986-10-7
    Appearance White to off-white powder
    Solubility In Water Soluble
    Melting Point >300°C (decomposes)
    Purity Typically ≥98%
    Storage Temperature 2-8°C
    Synonyms DL-N-Carbamoylaspartic acid
    Application Biochemical research, enzyme substrate
    Stability Stable under recommended storage conditions
    Logp -3.13 (estimated)
    Iupac Name 2-[(Carbamoylamino)succinic acid]

    As an accredited Carbamoyl-DL-Aspartic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Carbamoyl-DL-Aspartic Acid is supplied in a sealed 25g amber glass bottle with tamper-evident cap and chemical labeling.
    Shipping Carbamoyl-DL-Aspartic Acid is shipped in a secure, tightly sealed container to prevent contamination and degradation. The packaging complies with chemical safety regulations, typically including labeling and cushioning materials. It is transported at ambient temperature unless otherwise specified, and documentation such as Safety Data Sheets (SDS) accompanies the shipment for safe handling.
    Storage Carbamoyl-DL-Aspartic Acid should be stored in a tightly sealed container, protected from moisture and light, at 2–8°C (refrigerated). Ensure the storage area is dry and well-ventilated, away from incompatible substances, such as strong oxidizers. Proper labeling and secure placement are important to minimize risks and maintain chemical stability. Always follow safety guidelines outlined in the material safety data sheet.
    Application of Carbamoyl-DL-Aspartic Acid

    Applications of Carbamoyl-DL-Aspartic Acid in Industrial Manufacturing

    Carbamoyl-DL-aspartic acid supports several advanced chemical and life science manufacturing segments. As the producer, we target high-value sectors that require precise synthesis and validated process controls. The following sections outline key downstream industries utilizing this raw material, with specific compliance, formulation ratios, process stages, and end products described for each application.

    1. Active Pharmaceutical Ingredient (API) Synthesis for Antiviral Drugs

    Pharmaceutical companies employ Carbamoyl-DL-aspartic acid as a protected intermediate in nucleobase or carbamoylated amino acid assembly for antiviral and cytostatic APIs. Production teams use this material during the construction of uracil and thymine derivatives, achieving site-specific incorporation essential for nucleic acid analogs. Reliable sourcing ensures batch-to-batch quality and traceability throughout GMP-regulated processes.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for APIs
    • US FDA 21 CFR Parts 210/211
    • EU GMP EudraLex Vol. 4
    • USP/NF Monographs (where the derivative is listed)

    Typical usage ratio

    • 5–15% weight basis in reaction mixtures, adjusted based on target nucleotide synthesis yield and side reaction minimization

    Downstream process integration

    • Incorporation during the amidation or carbamoylation reaction step before hydrolysis and further purification in multi-step API synthesis

    Final product types

    • Nucleotide analogs (prodrug precursors)
    • Modified pyrimidine APIs
    • Intermediate substances for cytostatic active agents

    2. Diagnostic Reagent Raw Material for Enzyme Substrate Kits

    Diagnostics manufacturers formulate Carbamoyl-DL-aspartic acid as a core substrate or calibration compound in enzymatic assays targeting aspartate transcarbamoylase and related enzymes. It enables accurate control in high-throughput screening platforms and research reagents, requiring stringent batch homogeneity and analytical traceability for regulatory submission and lot release.

    Industry compliance standards

    • ISO 13485 Quality Management for Medical Devices
    • IVD Directive 98/79/EC / In Vitro Diagnostic Regulation (IVDR) 2017/746
    • Chinese NMPA YY/T 0466 requirements

    Typical usage ratio

    • 0.1–1.0 mM in buffer solutions for microplate diagnostic kits, optimized per enzyme specificity and detection sensitivity

    Downstream process integration

    • Blending into lyophilized or liquid reagent formulations during kit assembly, followed by QC verification and filling into ELISA or rapid test components

    Final product types

    • Enzyme activity detection kits
    • Amino acid cycling test kits
    • Clinical chemistry analyzer reagents

    3. Fine Chemical Synthesis for Pyrimidine Derivative Production

    Producers of specialty pyrimidine compounds use Carbamoyl-DL-aspartic acid as a building block for complex heterocycle construction, benefiting from its bifunctional reactivity. Chemical manufacturers demand high purity and mono-isomer specification to support downstream condensation reactions, notably in libraries of intermediates for agrochemicals and research applications.

    Industry compliance standards

    • ISO 9001 Quality Management Systems
    • Internal analytical SOPs for purity (HPLC/GC/MS)
    • REACH registration for handling and transport within the EU

    Typical usage ratio

    • 10–30 mol% for target mole ratio, based on pyrimidine ring formation sequence and desired throughput size

    Downstream process integration

    • Charged into the ring-closing reaction with complementary amines or acids, followed by heat treatment and chromatographic purification steps

    Final product types

    • Pyrimidine-based intermediates
    • Research-scale nucleoside analogs
    • Custom biochemical probes

    4. Feedstock in Biotechnological Fermentation Pathways

    Bioprocessing companies incorporate Carbamoyl-DL-aspartic acid as a limiting substrate for optimizing metabolic flux studies and engineering microbial strains. It serves as a tracer or auxiliary for uracil biosynthesis manipulation in controlled fermenters, requiring validated input quality and documentation in regulated bioindustrial production facilities.

    Industry compliance standards

    • ISO 9001 for traceability and quality
    • ISO 22000 for feedstock safety when used in food-grade biotech processes
    • GMP+ B2 (where relevant to production inputs)

    Typical usage ratio

    • Variable between 0.05–0.5 g/L in fermentation broth, determined by strain type and pathway engineering goals

    Downstream process integration

    • Dosed at the inoculation or induction phase in bioreactors, with monitoring of residue and metabolite output for batch record analysis

    Final product types

    • Engineered nucleotides
    • Microbial biomarker reference standards
    • Synthetic pathway optimization reagents

    5. Analytical Chemistry Reference Standard Manufacturing

    Reference laboratories and quality assurance suppliers utilize Carbamoyl-DL-aspartic acid as a traceable calibration standard in amino acid and nucleoside analytical panels. The material’s well-defined structure ensures reliable quantification across HPLC and capillary electrophoresis applications, supporting verification protocols in both academic and industrial laboratories.

    Industry compliance standards

    • ISO/IEC 17025 Laboratory Competence
    • USP Reference Standard eligibility (where specified)
    • AOAC International Method guidelines for validation

    Typical usage ratio

    • 1–10 ppm as calibration spike in standard curves for quantitative instrument settings

    Downstream process integration

    • Dissolved into solvent standards during analytical method setup or batch QC, followed by certificate of analysis verification

    Final product types

    • Certified reference standards
    • Analytical quality control reagents
    • Comparative amino acid quantification benchmarks
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    Competitive Carbamoyl-DL-Aspartic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Carbamoyl-DL-Aspartic Acid: Practical Insights from the Manufacturer’s Floor

    Deep Experience, Real Values

    Every batch of Carbamoyl-DL-Aspartic Acid rolling off our filling lines represents both technical knowledge and daily discipline. Over years of hands-on production, patterns emerge—the steady hum of reactors, the continuous testing in the lab, and close dialogue with chemists and formulators in fields ranging from pharmaceuticals to biochemical research. In this environment, product quality isn’t an abstract concept. It reveals itself clearly in the stability and consistency that chemists rely on to scale up experiments or to meet demanding regulatory frameworks.

    Model, Purity, and Reliable Specifications

    We manufacture Carbamoyl-DL-Aspartic Acid chiefly as a white to off-white powder, using a defined synthesis route that ensures purity remains above 98%. Every run gets scrutinized with HPLC and NMR analysis, with each batch certificate referencing the exact results from the day’s production. Particle size distribution usually ranges within tens of microns. We watch for moisture content because it directly impacts shelf life and storage conditions. Excessive moisture has plagued the field for years, so we keep levels under 0.5%. Bulk density and flow properties meet the expectations of R&D and commercial scale users alike, especially those working with automated feed or dispensing systems. Each specification grew out of conversations in plant rooms and feedback from technical partners.

    Building Trust with Application Experience

    We meet honest questions in every supply: “Will the acid interfere with our peptide synthesis?” or “Can your product handle buffer creation for our diagnostic assay?” Years of real-world data let us answer directly. In peptide synthesis, Carbamoyl-DL-Aspartic Acid functions reliably as a building block because the carbamoyl group presents little risk of unexpected reactivity. In biochemical assays, users turn to this compound to support enzyme tests since its impurity profile stays well below common interference thresholds. We still keep an open line to end users; when an unfamiliar by-product emerges, we dig in, adjust parameters, and get the profile clean again. The work is iterative, not just transactional.

    Not All Carbamoyl Aspartic Acids Are Equal

    Chemical manufacturing rewards strict attention to stereochemistry and by-product management. The DL form of Carbamoyl-Aspartic Acid contains both D and L isomers, bringing distinctive value to synthetic and screening workflows. This contrasts with the L-only version, which fits better into enantioselective biological applications. We see customers who benefit from the racemic blend—especially in academic labs screening a wide spectrum of enzymatic activity, or in preclinical studies where chiral purity is less critical. From time to time, researchers request custom batches, searching for an exact D/L ratio or wishing to reduce a specific trace impurity.

    We’ve encountered supply issues in the market from bulk traders whose material introduces inconsistency or leaves difficult-to-detect residues. Our process control reduces that risk. The most important difference comes out over repeated synthesis runs or experiments—where consistency saves time, money, and countless headaches.

    Understanding the Chemistry and Use Cases

    Carbamoyl-DL-Aspartic Acid appears in pathways mimicking those inside living cells. Academic teams often integrate it into studies of the urea cycle and nucleotide biosynthesis. Pharmaceutical firms develop enzyme assays where Carbamoyl-DL-Aspartic Acid is a necessary reactant or substrate, measuring catalytic activity across temperature and pH ranges. Some agricultural biotech companies have utilized it within metabolic pathway studies, looking to express proteins efficiently or discover points of metabolic flux. Having seen our batches go into these workflows, it’s clear that minor changes in purity, trace elements, or stereochemistry make a measurable difference in results.

    Quality Every Step of the Way

    We see the full story of each lot, from raw input materials to final packaging. Incoming aspartic acid and urea pass rigorous ID tests—IR spectra, melting point verification, and each new vendor faces extended qualification before their shipments make it near the reactor. Operators running synthesis lines spot trends in color, reaction time, and byproduct evolution, stopping and recalibrating with every unexpected peak during chromatography. We design drying and milling protocols so that each drum contains powder with low clumping tendency and high dispersibility—critical for end users running automated weigh-and-dispense systems.

    Final QC relies on methods developed in-house and honed by experience. HPLC measurements confirm purity. Elemental analysis checks that all C/N/O ratios fit expected values. TLC spot checks, even though less common these days, still catch outliers before packing. Teams fill UV-blocked containers under nitrogen to keep out moisture and prevent slow hydrolysis or decomposition during shipping and storage. This isn’t just box-ticking; our focus on quality comes from seeing too many projects derailed over long-forgotten storage errors or reactions lost to batch inconsistencies.

    Differences From Other Market Products

    Compared to materials sourced from brokers or indirect suppliers, our Carbamoyl-DL-Aspartic Acid brings repeatable performance and a traceable lineage. Many labs have lost precious weeks chasing down results only to learn that “equivalent” material from another supplier carried high levels of inorganic salts or unlisted byproducts. Our batch history records allow users to match their results, sample by sample, to a defined lot number and test regime. Purity standards stay consistent. We limit total organic impurities to below 1%, with residual solvent levels routinely below detection. Our team works with direct feedback—if a customer’s NMR finds an unfamiliar shift, we analyze reference spectra in-house before adjusting any production parameter. It’s a dynamic feedback loop shaped by hundreds of real-world cases, not speculation or generic quality claims.

    Traceability and Documentation

    Chemists demand more than just a sample; they need to trace every step. We retain full production records—reactor logs, material certificates, in-process data, and batch chromatograms—for every completed lot. When an issue arises downstream—a purification that fails or an unexpected peak in an HPLC trace—users can reach out; our archives track the story from raw starting materials to packed product. This depth of information builds confidence for critical experiments and regulatory filings. Documentation includes not just purity results but profiles of detected secondary components.

    Our team supports technical documentation requests with real, batch-based data. When clients working under GLP or GMP ask for validation runs or historic performance stats, we can provide them. This direct link between manufacturing history and application performance closes gaps that too often slow down R&D labs or regulated facilities.

    Daily Challenges, Direct Solutions

    Manufacturing high-purity Carbamoyl-DL-Aspartic Acid brings its own set of headaches. The most consistent problem? Keeping moisture low. Our staff built out twin drying systems and invested in continuous online monitoring. The cost is worth it. A handful of times, a single out-of-spec drum could have thrown off weeks of customer R&D. But consistent internal monitoring flagged it, allowing us to separate questionable lots before they left the site.

    Handling scale-up introduces a different set of problems. Lab-scale success doesn’t always transfer. In scaling from kilogram to multi-ton runs, heat control makes a big difference, so we upgraded jacketed reactors and trained operators on live temperature adjustments. Over years, we learned that small shifts in process temperature or raw material source skew impurity profiles. Keeping everything in-house and under direct control means anomalies get fixed before they reach a customer’s benchtop.

    Serving Researchers and Production Chemists

    Academic labs rely on predictability, often running through multiple rounds of experiments while targeting publication deadlines or grant milestones. Our job is to supply an acid that reacts the same way every time, whether for a single gram or large-scale synthesis. Production chemists, troubleshooting process lines, need material with no surprise variables. Experience tells us that “almost pure” is never pure enough—reaction yields and separation efficiencies depend on consistent composition.

    One common story comes from peptide chemists. Even trace amounts—often below the noise level of old QC tools—can cause significant issues during solid-phase syntheses. We work closely with users to confirm that every function group is available and that no cross-reactivity dampens the yield. Each conversation feeds process improvements. We’ve modified particle size formats and packaging options in direct response to real requests.

    Why Consistency Outpaces Price Shopping

    Short-term savings rarely compensate for long-term lost time or failed experiments. Some buyers once turned to bulk traders for “cheaper” Carbamoyl-DL-Aspartic Acid, only to find that varying impurity levels forced them to re-optimize protocols or toss out entire runs. Over time, the cost of “saving” undermined their budgets and stretched out deadlines. We keep our focus on batch-to-batch reliability, so clients don’t have to worry about unseen variances or last-minute substitutions.

    Time and again, direct collaboration between manufacturer and research team leads to higher productivity. It isn’t about handing off a product and walking away—it’s an ongoing partnership. Our technical staff helps decipher odd test results, look for trace element contamination, and recommend handling tips based upon warehouse and lab conditions reported by our partners.

    Waste Management and Environmental Commitment

    Production generates byproducts, and we manage all side streams responsibly. Acidic wash effluent, leftover solvents, and off-spec product get treated to minimize waste, following both customer standards and regulatory practice. Years back, uncontrolled side streams led to headaches during inspections. We learned to document every liter, training new operators to follow long-term protocols that go beyond box-checking. Batch reports contain full audit trails of what left and how it got recycled or treated responsibly.

    Some research partners ask about supply chain footprint. Our team conducts regular reviews—energy efficiency, waste heat utilization, and improved yields—targeting direct reductions in both waste and emissions. There’s no shortcut; satisfying audits takes upfront investment and years of building trust with local agencies. Over time, that trust lets us keep supplying demanding multinational projects without last-minute surprises or “unexpected” non-compliance notices.

    Staying Close to the End User

    Our best process innovations emerged from user feedback. We’ve fielded requests for micronized formats, instant-dissolve grades, and packaging tailored to high-throughput environments. One pharma group challenged us to develop a form with extra-low endotoxin, aiming for use in injectable products. That led to a dedicated low-temperature purification step, filtered through several pilot runs before the new grade met their standards. As requirements shift, so do our process steps.

    In many cases, we don’t hear about a new issue until it crops up in a customer’s workflow. A PCR assay developer flagged unanticipated inhibition; in response, we analyzed upstream processes for specific enzyme inhibitors, adjusting raw input sourcing and fine-tuning recrystallization steps. The loop between frontline users and production is tight—failures become lessons for everyone and translate into better, more functional product with each cycle.

    Stacking Up Against Competing Products

    The difference between supplier and manufacturer plays out in reliability. Many third-party middlemen handle storage and shipping without oversight from makers. Our shipping teams coordinate directly with production and QA staff, verifying every container before dispatch. Ambient temperature and humidity inside logistics hubs receive real-time monitoring. We have solved shipping-related degradation by switching to insulated, moisture-sealed packaging, reflecting on years of feedback from global partners.

    Buyers who switched from generic resellers report fewer batch failures, reduced returns, and steadier downstream results. Repeat testing and process transparency win over low pricing alone. Our material never passes through unregulated storage, and our tracking system logs every handoff from final fill to customer site. In return, users can count on support, troubleshooting, and real-time feedback, not canned responses.

    The Ongoing Challenge: Upgrading Standards

    Product quality is never a finished chapter. Regulatory expectations evolve; so do best practices. We adapt by adopting new analytical technologies, from advanced chromatographic fingerprinting to updated pesticide and trace metal screening. In partnership with customers, we review and revise the full chain—from incoming raw material tests to long-term storage protocols—to anticipate new challenges before they block a project or trigger scrutiny from watchdogs. Dozens of tweaks and upgrades stem from one-off user findings or incidents, pushing the standards higher for everyone.

    We train every new hire to treat each container with seriousness. If a single bottle or drum leaves with unexplained deviation, everything from that batch gets checked and held back if necessary. It’s about pride in the craft as much as compliance—each product carries not just chemical value but the reputation built through long relationships with researchers and technical directors.

    Vision for Future Development

    Markets for Carbamoyl-DL-Aspartic Acid change as biotech, diagnostic, and pharma industries evolve. New research demands new synthesis purity, different solubility profiles, or grades customized for regulatory filings. Some applications migrate toward high-throughput robotic syntheses, others need micro- or nano-scale packaging, while a few advanced users develop direct-injection clinical workflows demanding even purer forms.

    We continue to invest in pilot-scale developments, testing out scaled-up runs with partners before rolling out full offerings. Many breakthroughs—tighter impurity control, rapid-dissolving formats, or fully traceable barcoded packaging—come directly from feedback and collaborative work with frontline scientists. This two-way exchange isn’t an extra feature; it is the ongoing reality behind every container and certificate we ship.

    Conclusion: More Than a Chemical, It’s a Commitment

    Supplying Carbamoyl-DL-Aspartic Acid is a craft requiring technical rigor and real listening. From batch records to support inquiries, the throughline is trust—built on firsthand experience, active dialogue, and the simple discipline of doing the hard work right each time. The difference comes out in clean assay lines, stable enzyme screens, and the confidence researchers express in project after project. Decades of cumulative field experience have shaped every improvement and continue to guide tomorrow’s product development. It’s an ongoing story, written together with every user who seeks not just a chemical, but a real partnership at the heart of progress.