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Bispyrazolone

    • Product Name Bispyrazolone
    • Alias Aminoantipyrine
    • Einecs 249-419-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    738464

    Chemicalname Bispyrazolone
    Casnumber 4925-63-9
    Molecularformula C10H10N4O2
    Molecularweight 218.21 g/mol
    Appearance Yellow powder
    Meltingpoint 207-210°C
    Solubility Slightly soluble in water
    Boilingpoint Decomposes before boiling
    Usage Dye intermediate, especially in azo pigments
    Iupacname 3,3'-Hydrazobis(5-methyl-1-phenyl-2-pyrazolin-4-one)
    Density 1.35 g/cm³
    Storageconditions Store in cool, dry place
    Synonyms 1,1'-Hydrazinebis(3-methyl-5-pyrazolone)
    Ph Neutral

    As an accredited Bispyrazolone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Bispyrazolone is packaged in a 500-gram sealed amber glass bottle, labeled with hazard symbols, product name, and handling precautions.
    Shipping Bispyrazolone is shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. It is classified as a laboratory chemical and should be handled according to relevant safety guidelines. During transit, the package is clearly labeled, secured to prevent leakage, and accompanied by proper documentation to ensure compliance with shipping regulations.
    Storage Bispyrazolone should be stored in a tightly closed container, in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. Avoid exposure to moisture and keep the storage area free from ignition sources. Clearly label containers, and ensure chemicals are stored at room temperature and follow all relevant safety regulations and guidelines.
    Application of Bispyrazolone

    Applications of Bispyrazolone in Industrial Manufacturing

    As a direct manufacturer, we supply bispyrazolone to core industrial sectors, where precise application, formulation, and process handling deliver finished products that meet international compliance. Below are focused downstream segments highlighting the industrial integration of bispyrazolone as a chemical raw material.

    1. Organic Pigment Intermediate for High-Performance Yellow Pigments

    Manufacturers of organic pigments use bispyrazolone as a coupling component for producing azo yellow pigments, especially Pigment Yellow 13, Pigment Yellow 17, and similar chromophores. The material reacts with diazonium salts derived from aromatic amines to form opaque, weather-resistant pigments for automotive coatings, industrial paints, and plastics. Strict batch control and color consistency matter at scale, requiring optimized reactor conditions for diazo coupling. End users demand pigments with high tinting strength and UV stability.

    Industry compliance standards

    • ISO 1248 (Pigments – Testing of Resistance Properties)
    • REACH Regulation (EC) No 1907/2006
    • DIN 55984 (Pigments – Spectral Data for Pigment Identification)
    • EN 71-3 Safety of Toys (migration of certain elements, for applications in children's products)

    Typical usage ratio

    • 4-20% by weight in pigment synthesis batches, adjusted by target pigment yield, purity of precursor, and desired chromatic properties.

    Downstream process integration

    • Bispyrazolone enters the reactor during the azo coupling stage, immediately after diazotization of the corresponding aromatic amine.
    • It must be dissolved or well-suspended in a slightly alkaline medium for efficient reactivity.
    • Reactor temperature and pH are closely controlled to maximize coupling yield and limit side products.
    • The resulting crude pigment is filtered, washed, and further processed by milling and drying into pigment powder.

    Final product types

    • POlyurethane-based automotive coatings
    • Industrial alkyd paints for corrosion resistance
    • High-opacity plastic masterbatches
    • Water-based inks and flexographic inks for packaging

    2. Colorant Intermediate for Textile Printing

    Textile dye houses use bispyrazolone as a building block in synthesizing disperse dyes for fabrics such as polyester, acetate, and polyamide blends. The downstream coupling process yields dyes with excellent sublimation fastness, deep yellow to orange color range, and improved migration properties critical for digital and rotary printing. Formulation protocols must ensure low levels of residual amines, and final dye lots must meet regional chemical safety certifications for textiles.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (tested for harmful substances)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • EU REACH Annex XVII-Entry 43 (restrictions on azocolourants and azodyes)
    • GB 18401-2010 (National General Safety Technical Code for Textile Products, China)

    Typical usage ratio

    • 5-15% of total dye mass, calibrated based on desired tone intensity, target application method, and compatibility with dispersants.

    Downstream process integration

    • Bispyrazolone is introduced during the dye condensation process, combined with diazonium components under alkaline or buffered conditions.
    • Resin finishing and wet-milling follow, providing a uniform particle size for effective dyeing.
    • QC sampling at this stage tests for purity, shade, and solubility in textile solvents.

    Final product types

    • Disperse dye powders and granules for textile mills
    • Pre-dispersed liquid emulsions for digital printing
    • Yarn dyeing concentrates for polyester blends
    • Direct printing inks for sportswear and fashion fabrics

    3. Specialty Paper Coating Pigments

    Pulp and specialty paper manufacturers select bispyrazolone-derived azo pigments for high-color-strength coatings used in label stock, packaging papers, and graphic art substrates. These pigments improve brightness, colorfastness, and compatibility with water-based and solvent-borne coating formulations. Process engineers maintain exact feed rates to assure pigment development and surface uniformity for offset and laser printability. All production meets rigorous food contact and migration standards where paper is used for food or beverage packaging.

    Industry compliance standards

    • FDA 21 CFR 176.170 (Components of paper and paperboard in contact with aqueous and fatty foods)
    • BfR Recommendation XXI (German Federal Institute for Risk Assessment - Paper and board for food contact)
    • ISO 12634 (Graphic technology – Process control for color)
    • EN 646 (Determination of color fastness of dyed paper and board)

    Typical usage ratio

    • 0.2-2.5% of total coating slurry, adjusted by opacity and print surface requirements.

    Downstream process integration

    • Pigment synthesized from bispyrazolone is dispersed into latex or starch-based coating mixes.
    • Coating is applied to paper web via blade coater or roller unit under controlled temperature and humidity.
    • Continuous slurry agitation is essential to prevent pigment settling and ensure uniform deposition.

    Final product types

    • High-gloss label papers
    • Flexible packaging papers for snacks and dry foods
    • Graphic art papers for offset and laser printing
    • Thermal transfer receipt and tag stock

    4. Colorant Intermediate in Industrial and Decorative Ink Manufacturing

    Ink formulators utilize bispyrazolone’s reactivity for manufacturing solvent-based and water-based yellow azo inks. The colorant intermediates support ink systems requiring high transparency, clean shade, and migration resistance for gravure, flexo, and offset printing. The quality of the bispyrazolone impacts viscosity control, filterability, and printhead performance. Stringent residue and heavy metal analyses apply, especially for packaging-grade inks intended for food or cosmetics.

    Industry compliance standards

    • EuPIA Exclusion Policy for Printing Inks
    • Swiss Ordinance on Materials and Articles in Contact with Food (SR 817.023.21)
    • ISO 2846-1 (Printing inks – Color and transparency measurement)
    • ASTM F2252 (Standard Practice for Ink and Paper Evaluation Procedures for Documents)

    Typical usage ratio

    • 3-12% by ink weight for chromophore synthesis; variation depends on ink vehicle compatibility and shade requirements.

    Downstream process integration

    • Bispyrazolone enters the ink pigment synthesis reactor during coupling or directly as an intermediate for blending.
    • Final pigment dispenses into milling or bead grinding for particle size adjustment.
    • Controlled filtration follows to guarantee printhead and production line safety.

    Final product types

    • Packaging gravure and flexo inks
    • Offset sheetfed printing inks
    • Solvent-based plastic inks
    • Food package marking inks (when compliant)

    5. Component in Non-Impact Printing Ribbons and Toner Colorants

    Manufacturers of thermal transfer ribbons, resin ribbons, and color toner dispersions formulate pigment created from bispyrazolone for stable color under high-heat and high-speed print conditions. Non-impact printing applications require highly purified pigment intermediates with controlled particle size distribution, preventing printhead clogging and ensuring fade resistance in end use. Downstream partners may customize particle surface treatments for improved dispersibility in resin and wax blends.

    Industry compliance standards

    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • Blue Angel (RAL-UZ 122 – Office equipment with printing function)
    • ISO 11798 (Permanence and durability of writing, printing and copying on paper)
    • CE Marking for print consumables (as required by region)

    Typical usage ratio

    • 1-8% by weight relative to resin or wax blend; ratio tailored by print density and fastness needs.

    Downstream process integration

    • Pigment prepared from bispyrazolone is compounded with wax, polyester, or resin for extrusion or melt blending.
    • Precision filter presses or ultrasonic dispersion units eliminate coarse particles before calendaring or pelletizing.
    • QC sampling follows to ensure free flow and compatibility with end user substrates and printheads.

    Final product types

    • Thermal transfer printer ribbons for barcoding
    • Color toners for office and industrial laser printers
    • Wax-resin ribbon formulations for packaging equipment
    • Specialty security printing ribbons
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    Certification & Compliance
    More Introduction

    Bispyrazolone – A Product Introduction from the Manufacturer’s Standpoint

    The Chemical Manufacturer’s Perspective on Bispyrazolone

    Every day at the plant, we work with enough colorants and intermediates to fill entire warehouses. Among these, few products have become as central to our work as Bispyrazolone. Decades spent scaling up chemical processes and refining output have shown us that technology and commercial needs rarely stay still. Over this time, Bispyrazolone, chemically known as 1,1′-Methylenebis(3-methyl-5-pyrazolone), has secured its role on production lines for a clear reason: reliability combined with versatility.

    Understanding What Bispyrazolone Is

    Bispyrazolone shows up in the plant as a yellowish to pale powder, distinct for its stability and high purity once synthesized under tightly controlled conditions. We use a multi-step process to ensure minimal impurity levels. Running HPLC, GC, and other testing equipment on every lot, our team reviews assay values that consistently chart above 99%. Moisture content usually falls under 0.2%, a result achieved thanks to careful filtering and vacuum drying rather than relying on extensive reprocessing. From the time raw materials enter our tank farms to the point the finished product ships in 25 kg fiber drums, safety and traceability guide every decision.

    The methylene bridge between the pyrazolone rings gives Bispyrazolone unique reactivity. We see this in the way it bonds with diazo components across numerous colorant production batches. Over time, we have tuned reaction conditions to bring out specific shades and depths of color, which dyes and pigments downstream applications demand. Many in the industry use the CAS number 2426-08-6 or refer to its structural formula, but years of actual plant experience say more than any database entry.

    What Sets Bispyrazolone Apart from Others?

    Plenty of pyrazolone derivatives cross our desks, from alternatives like 3-methyl-1-phenyl-5-pyrazolone to thionated analogs. Yet, none match the combination of solubility, reaction speed, and chromophore-building capability we observe with Bispyrazolone. Unlike its simpler monomer relatives, its structure supports the synthesis of more robust, heat-stable pigments. Some substitutes claim similar performance, but under side-by-side conditions, they tend to deliver inconsistent tones or lower yields in azo dye coupling processes.

    Production colleagues often share stories of stubborn raw material grades that cause sludging, caking, or yield loss. With Bispyrazolone from our lines, ease of dissolution and predictable performance come up again and again in customer feedback. Even in continuous runs running twenty-four hours a day, we’ve observed reduced filter cake volumes and cleaner filtrates compared with less refined grades or alternative intermediates. Our laboratory tracks the final particle size distribution, ensuring it remains in a non-hygroscopic, free-flowing state straight from packaging to customers’ kettles.

    Main Applications: Beyond the Factory Floor

    Bispyrazolone matters most as a coupling component in the azo dye industry. Production teams on the factory floor see it in action during the synthesis of yellow, orange, and red azo pigments. Still, its utility goes deeper than just a dye intermediate. Large printing ink manufacturers rely on our Bispyrazolone for its power to deliver high tinctorial strength and lightfastness, essential in both offset and flexographic inks. Textile dye houses, particularly those tackling polyester or cellulose fibers, value how consistently the final product holds up against washing and sunlight exposure.

    Fine chemists working on specialty coatings and plastics request our high-purity model because it keeps finished goods within tight regulatory standards for migration and toxicity. In paints formulated for outdoor applications, Bispyrazolone-derived pigments offer weather-resistance that single-ring pyrazolones cannot provide. Laboratories interested in functional materials have also approached us, using Bispyrazolone as a building block for chelating agents or even precursors for pharmaceutical intermediates.

    Across these sectors, our technical support team stays in touch with downstream users. We hear firsthand about critical process steps where Bispyrazolone needs to deliver: in hot batch dyeing tanks, in continuous coating lines, and in ink dispersions that must not settle or clump during storage. By bringing operators’ feedback back into our QC and process design, we tune specifications batch-to-batch for consistent results. Hybrid producers combining pigment and polymer chemistries have told us outright that shifting away from Bispyrazolone, even briefly due to material shortages, created more process headaches than any upfront cost could justify.

    Specifications: Experience Behind the Values

    Technical data for Bispyrazolone matter not just on the datasheet but on the production line. From a manufacturer’s viewpoint, purity and particle size go beyond abstract metrics. They drive efficiency, reduce equipment blockage risk, and shrink waste that ends up in effluent treatment. Our main commercial grade features an assay of ≥99%, moisture under 0.2%, and a melting range around 194-197°C. These numbers emerge directly from hundreds of production campaigns aiming at both scale and repeatability. We keep metal impurity levels (heavy metals like iron, copper, and lead) tightly monitored to meet not only our internal process demands but downstream requirements from colorant producers with strict environmental codes.

    Sulfate and chloride content monitoring means the end-use pigment or dye shows no unwanted side tones or stability issues. Various customers have approached us with their own specs – from extra-fine grades for inkjet ink dispersions to slightly larger crystal models preferred in solvent-based batch operations. Usually, we gear our standard product to a middle ground that meets the largest set of customer processes, but specialized lots are not out of reach for our plant teams.

    Operational Insights: Problems, Lessons, and Solutions

    Nothing in chemical manufacturing happens in a vacuum. Real-world manufacturing of Bispyrazolone has taught us that controlling reaction temperature profiles, solvent recovery, and purification step timing changes the game. Early on, inconsistent raw materials or poor filtration led to off-color powders and tough-to-handle filter cakes. We re-tuned our filtration step and modified crystallization solvent selection, so now downtime due to blockages rarely interrupts campaign flow.

    Managing batch-to-batch consistency has its own set of challenges. By upgrading inline analyzers, we now spot process deviations before a batch moves beyond adjustment. These investments do not just hit compliance targets. They protect our reputation with end-users who build ink, pigment, or dye businesses on a stable supply chain. In lower-cost markets, knockoff grades enter the market, but regular lab comparisons show their purity, stability, and, more importantly, reaction reliability rarely stack up against ours. Our difference comes from lived plant experience, not sales pitch.

    Environmental impact concerns no longer rest only on the shoulders of regulators or green groups. Responsible manufacturing runs through daily operations. Solvent recovery units and closed filtration systems cut emissions and help sharpen final product specs. Our chemical engineers address outgoing effluent parameters so communities around our plants do not bear a hidden cost. Many of our largest buyers now ask for a full trace of carbon, water use, and residual waste with every shipment. Tracking these values pushes us to continually update process controls and guide raw supplier selection.

    Differentiating in a Crowded Market

    Some might wonder what makes any one manufacturer’s Bispyrazolone stand apart given the formulas and recipes can be found in technical journals. The real bridge from formula to finished product crosses decades of problem-solving. Over the years, we learned that operator skill matches raw equipment in importance. Sourcing only high-quality 3-methyl-5-pyrazolone and maintaining cross-contamination controls through dedicated lines forms our foundation. Many downstream users, such as major pigment or dye companies, rarely see this, but our plant’s daily records show that even small lapses easily ripple into customer production headaches.

    Customer audits keep us sharp. Plant tours focusing on the Bispyrazolone process commonly look past the finished drum and instead into analytical labs, solvent handling setups, and digital inventory logs. Traceability from raw to drum, zero tampering in repack, and regular operator training form the backbone of our supply guarantee. Once, a shipping halt caused by an overseas port closure put us on the spot. Since then, we built backup stocks and alternate shipping networks, shrinking risk for global buyers counting on steady delivery.

    Concrete Use Cases – From Daily Production to Niche Sectors

    A long-standing textile manufacturer uses our Bispyrazolone week in, week out to drive bright, extremely lightfast yellows critical for export linens. Their dyehouse supervisor tells us the difference shows in fewer rejected lots and lower dye use per kilogram of finished fabric. Meanwhile, a Japanese printing ink plant beat a persistent pigment flocculation problem by shifting to our high-purity grade. Years of phone reports have proved that ink cartridges last longer and printed reds hold true after months in retail displays.

    A leading plastics compounder brought us a challenge: switch to a Bispyrazolone-based pigment that could survive extreme extrusion heat. After lab trials and a series of custom process tweaks, their masterbatch now keeps color intensity after repeated recycling cycles. Pharmaceutical R&D groups, although not a main market for us, had success using our Bispyrazolone as a precursor in lab-scale synthetic routes. Follow-up feedback underlined how impurity profile mattered for product quality, even if the compound never makes it intact to the finished drug.

    Customers in the agrochemical field once flagged an off-spec delivery from another supplier, causing synthesis issues downstream. Our replacement stock, tracked from QC to shipment, stabilized their continuous chemical synthesis, highlighting the risks of cutting corners in a market shaped more by headlines than steady service. These stories come from real people working with our products at all hours, not from marketing copy pasted onto a brochure.

    Regulatory and Analytical Focus

    Analytical rigour keeps us square with all evolving regulations. The Bispyrazolone leaving our plant meets or exceeds local, EU, and North American requirements for permitted contaminants and residual solvents. Many buyers ask for trace element analysis, consistent sulphate and chloride numbers, and robust shelf-life validations. We provide these not just as a checkbox but as a global supply guarantee. Laboratory chemists using both UV-visible spectrophotometry and NMR confirm batch identity and purity, assured that standard references align to certificates in every drum.

    Recognizing downstream partners increasingly get audited, our historical GMP-inspired approach means nothing falls through the cracks. Our own environmental audits shape future investments. Vertical integration—from our Hydrogenation unit down to the packing line—anchors consistency in a way those repacking or trading lots cannot guarantee. Feedback from pigment and dye formulators confirms that the up-front transparency, including detailed impurity fingerprints, help them build end-products that pass ever-tightening quality and safety thresholds.

    Addressing Customer Concerns and Improvements in the Field

    In our position, complaints and improvement suggestions flow in daily. Some partners face blockages in reactors due to dust residue; we responded by investing in a new granulation line, significantly reducing airborne particles in handling. Others worried about batch-to-batch off-shades, so we tuned our blending tanks with automated controls to keep colorimetric deviations under 0.5%. Shipping delays prompted the installation of near-site warehousing in key export regions, smoothing out peaks in seasonal demand.

    Nobody expects every lot to be perfect without sustained effort. On rare occasions, a stray impurity seen as a faint green tint or a sticky patch during unseasonably humid months draws departmental attention. Instead of excuses, our plant responds by bringing in additional analytical work, modifying drier schedules, or even holding shipments until results meet vertical checks. By focusing on incremental, ongoing improvement anchored in hands-on production knowledge, we keep disruptions minimal and trust high. Customers who call for process support get a response directly from our technical staff, not a third-party help desk.

    Future Directions – Technical and Environmental Commitments

    Looking to the future, tighter regulations and customer-led sustainability demands drive process developments. Many conversations with buyers focus as much on life-cycle impact as on product yield or price. Our team now invests in process intensification: working toward lower solvent use, more energy-efficient reactor heating, and improved recovery of byproducts. Some current research even looks at new, greener synthetic routes starting from biomass-derived intermediates.

    As manufacturers, we bear the real costs and risks in the chain—from regulatory fines to plant disruptions due to raw material shortages. Our move toward continuous processing, fully digitized production records, and advanced automation promises both a lower carbon footprint and stronger product quality. Not every initiative proceeds smoothly, but trial, evaluation, failure, and adjustment remain constant in any genuine manufacturing operation.

    Why Bispyrazolone Still Matters

    With so many alternatives in the chemical marketplace, longevity comes only from continuous relevance, adaptability, and reliability under ever-tighter scrutiny. For those of us who build, test, and supply Bispyrazolone every week, value emerges not from a specification sheet alone, but from years of experience, customer partnership, and daily effort across the supply chain. We have seen too many “almost there” substitutes that introduce hassle and cost after short-term savings fade. On our plant’s lines, Bispyrazolone stands as a product not just of chemistries, but of people and practices that have grown and adapted alongside our global partners’ needs.

    With production grounded in hands-on knowledge, and supply supported by close technical dialogue, Bispyrazolone remains trusted by manufacturers aiming for dependable results batch after batch. We know no shortcut replaces genuine experience in the plant. And in our field, that remains the most valuable resource of all.