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Bis(Phenylsulfonyl)Methane

    • Product Name Bis(Phenylsulfonyl)Methane
    • Alias BPSM
    • Einecs 221-284-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    374447

    Chemical Name Bis(Phenylsulfonyl)Methane
    Cas Number 1293-11-6
    Molecular Formula C13H12O4S2
    Molecular Weight 312.37 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 157-160°C
    Boiling Point Decomposes before boiling
    Solubility In Water Insoluble
    Density 1.44 g/cm3
    Synonyms Bis(benzenesulfonyl)methane
    Smiles C1=CC=C(C=C1)S(=O)(=O)C(S(=O)(=O)C2=CC=CC=C2)
    Inchikey XJPGKZCZXAEZMA-UHFFFAOYSA-N

    As an accredited Bis(Phenylsulfonyl)Methane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Bis(Phenylsulfonyl)Methane, 100g, supplied in a sealed amber glass bottle with a tamper-evident cap and hazard labeling.
    Shipping Bis(Phenylsulfonyl)Methane is typically shipped in tightly sealed containers to prevent moisture and contamination. It should be stored and transported in a cool, dry place, following relevant chemical safety guidelines. Proper labeling and documentation are required, and handling should conform to local regulations for non-hazardous specialty chemicals.
    Storage Bis(Phenylsulfonyl)methane should be stored in a tightly sealed container in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Protect the chemical from moisture and direct sunlight. Ensure that it is stored at room temperature and properly labeled. Personal protective equipment should be used when handling the compound to prevent exposure.
    Application of Bis(Phenylsulfonyl)Methane

    Applications of Bis(Phenylsulfonyl)Methane in Industrial Manufacturing

    As a specialized manufacturer, we provide high-purity Bis(Phenylsulfonyl)Methane serving the needs of multiple advanced industrial sectors. The following application areas represent major, real-world downstream domains that account for the majority of global consumption, with precise guidance for safe formulation, integration, and product standardization.

    1. Pharmaceutical Industry: Synthesis Intermediate for APIs

    Pharmaceutical manufacturers widely apply Bis(Phenylsulfonyl)Methane as a key building block in the synthesis of advanced intermediates and active pharmaceutical ingredients (APIs), including antibiotics and selective enzyme inhibitors. Strict traceability and reproducibility during production batches depend on the consistency of this raw material at the coupling and protection step within complex multistage organic syntheses, especially in non-aqueous media under controlled temperature and pH. Both generic and novel molecule routes leverage its unique sulfonyl functionalization for selective modification of aromatic systems.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • US Pharmacopeia (USP) monographs for relevant APIs
    • European Pharmacopeia (Ph. Eur.) requirements for pharmaceutical intermediates
    • FDA 21 CFR Part 211 for finished pharmaceuticals

    Typical usage ratio

    • 0.5–1.5 equivalents per coupling step, adjusted according to desired substitution pattern and reaction scale; optimization based on molar conversion rates

    Downstream process integration

    • Charged as a coupling or protection reagent in batch or semi-continuous reactors during intermediate stage synthesis, ahead of hydrolysis, crystallization, or further functionalization

    Final product types

    • Active Pharmaceutical Ingredients for anti-infectives, enzyme inhibitors, and oncology therapies
    • Regulatory-submitted intermediates shipped for secondary synthesis

    2. Polymer Additives: Heat Stabilizer in Engineering Plastics

    Major producers of high-performance engineering plastics and specialty polymers employ Bis(Phenylsulfonyl)Methane as a thermal stabilizer to inhibit degradation during high-temperature extrusion and molding. Its aromatic sulfonyl groups effectively trap radical species, protecting polymer chains in demanding compounding cycles. Applications are especially important in polyamide and polyester formulations used in automotive, electrical, and consumer goods, where mechanical strength and color retention must meet tight quality benchmarks after long-term thermal exposure and repeated processing.

    Industry compliance standards

    • UL 94 Flammability Standards for plastics
    • ISO 1043 for polymer additives
    • RoHS 2 (2011/65/EU) for restricted substances in electronic plastics
    • REACH (EC No 1907/2006) registration for chemical safety in polymers

    Typical usage ratio

    • 0.2–1.0% by weight of total polymer blend; dosage determined by polymer type, desired heat resistance, and end-use exposure cycle

    Downstream process integration

    • Direct addition to resin feed during melt compounding or masterbatch preparation, prior to injection molding or extrusion processes

    Final product types

    • Glass fiber reinforced polyamide automotive housings
    • High-durability polyester connectors for electronics
    • Consumer appliance casings requiring high thermal stability

    3. Electronic Chemicals: ETCH-Resistant Additive for Photoresists

    Semiconductor and PCB manufacturers incorporate Bis(Phenylsulfonyl)Methane as an advanced additive in photoresist formulations to enhance etch resistance and dimensional stability during micro-patterning. The aromatic sulfonyl groups interact with matrix polymers, improving resistance to plasma and wet chemical etchants in high-resolution lithography. This utility grows in deep-UV and electron-beam resist chemistries required for advanced packaging and sub-10 nm fabrication nodes, where pattern fidelity and line edge roughness critically impact device yields and lifetime performance.

    Industry compliance standards

    • IPC-6012: Qualification and performance for rigid printed boards
    • IATF 16949: Quality management for electronics
    • SEMI S2/EH&S standards for chemical materials
    • IEC 61249: Hazardous substance requirements for PCB production

    Typical usage ratio

    • 0.5–3.0% by weight in photoresist solids, adjusted for exposure wavelength, substrate type, and etch process intensity

    Downstream process integration

    • Solution blended with base resin and photoactive compound before spin coating on wafers or copper laminates, prior to soft-bake and lithography

    Final product types

    • Microelectronics IC wafers for advanced logic devices
    • High-density interconnect printed circuit boards (HDI PCBs)
    • Photomask layers for MEMS and optoelectronic components

    4. Agrochemical Synthesis: Specialty Intermediate for Sulfonamide Herbicides

    Producers of selective sulfonamide herbicides use Bis(Phenylsulfonyl)Methane as a highly functionalized intermediate in the construction of active moiety backbones. The dual phenylsulfonyl substitution offers advantages in stepwise construction of aromatic sulfonylureas and triazines, critical for field efficacy and resistance management. The intermediate stage typically involves nucleophilic aromatic substitution or condensation to create precursor scaffolds for downstream derivatization, minimizing unwanted by-products and enhancing final product purity.

    Industry compliance standards

    • ISO 9001:2015 certified agrochemical ingredient manufacturing
    • FAO/WHO specifications for technical grade active ingredients
    • EPA 40 CFR Part 158: Data requirements for agrochemicals
    • GHS (UN Globally Harmonized System) labeling for transport and workplace safety

    Typical usage ratio

    • 0.8–1.2 molar equivalents per condensation reaction; refined based on targeted active ingredient yield and waste minimization goals

    Downstream process integration

    • Reacted in controlled arylation or acylation stages within closed stirred-tank reactors, preceding quench, filtration, and purification steps in technical-grade API production

    Final product types

    • Technical sulfonylurea herbicide active ingredients (e.g., metsulfuron-methyl)
    • Precursor intermediates for triazine-based herbicide synthesis
    • Granular and suspension concentrate crop protection products

    5. High-Performance Adhesives: Crosslinking Agent in Specialty Bonding Systems

    Manufacturers of adhesives for aerospace and high-strength industrial assembly utilize Bis(Phenylsulfonyl)Methane as an advanced crosslinking agent in two-component epoxy and modified phenolic systems. Its molecular architecture enhances network density, elevating thermal endurance, chemical resistance, and mechanical integrity. The compound is introduced at precise stages during prepolymer mixing, controlling cure kinetics and minimizing exothermic spikes, which is especially crucial for large-area or multi-layer bonding applications used in critical structural and composite assemblies.

    Industry compliance standards

    • EN 302: Structural adhesives for load-bearing timber applications
    • ASTM D1002: Shear strength by metal-to-metal bonding
    • AS 9100: Quality management for aerospace adhesives
    • EPA SNAP List compliance for chemical components

    Typical usage ratio

    • 0.5–2.0 parts per hundred resin (phr); variation tied to resin functionality and required final mechanical benchmark

    Downstream process integration

    • Added during hardener preparation or direct into resin mix before application; timing and order of addition influence network formation and final set properties

    Final product types

    • High-heat epoxy adhesives for aerospace structural bonding
    • Phenolic resin adhesives for mass transit and infrastructure panels
    • Composite matrix adhesives for automotive lightweighting
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    Certification & Compliance
    More Introduction

    Bis(Phenylsulfonyl)Methane: Industry Perspective from the Manufacturing Floor

    A Practical Look at Bis(Phenylsulfonyl)Methane

    From our vantage point in the manufacturing plant, Bis(Phenylsulfonyl)Methane, with the model designation DPSM-99, stands out as a critical specialty chemical with applications rooted deeply in real industry demands. Our experience handling, producing, and packing this compound gives us a front-row seat to the value and challenges this product delivers to customers in polymer, pharmaceutical, and materials development sectors. Clear, white to off-white crystalline powder, DPSM-99 leaves our lines after extensive purification, matching the highest purity grades—frequently reaching not less than 99% by HPLC, which forms the baseline for trusted, repeat performance batch after batch.

    Consistency is only possible thanks to process controls honed over years of scale-up and operational improvements. Bis(Phenylsulfonyl)Methane’s molecular structure—two phenylsulfonyl groups anchored on a central methylene—gives it a balance of stability and reactivity missing from simpler sulfone compounds. Our operators observe its fine particle profile, low moisture content, and batch homogeneity at every run, so users can expect the same outcomes every time. Satisfying those expectations calls for not just attention to detail, but a gut-level understanding of customer processes and honest feedback channels between the plant and the R&D folks working the next bench down the chain.

    Why the Industry Keeps Asking for This Sulfone

    In every ton that rolls off our lines, there's both technical skill and a real sense of responsibility packed in the drums. Bis(Phenylsulfonyl)Methane finds repeated favor as a crosslinking agent and intermediate in specialty polymerization and synthesis, especially where stability under harsh conditions cannot give way to compromise. We field questions daily about what sets this compound apart from sulfonyl butanes, simple methylene diphenyl sulfone compounds, or the cheaper bisphenylsulfone grades. Most of these start with customers struggling to balance performance targets in specialty polymers, trigger-release agents in pharmaceuticals, or intermediate reactivity in precision syntheses.

    On the plant floor, we see how this molecule bridges the gap between overactive phenylsulfones—which sometimes react too quickly, leaving inconsistencies—and more sluggish aliphatic sulfones. When heated above 200°C in composite polymers, DPSM-99 holds its structure longer, allowing for better control of polydispersity and mechanical strength in final products. We get reports from the composites industry where other crosslinking agents cause too much yellowing during compounding; our material keeps a brighter, whiter end product, a simple visual sign of the chemical stability it brings. The rigidity of the two aromatic rings on either side of the methane core deliver stiffness that passes wear resistance tests, while the electron-withdrawing sulfonyl groups also help with flame retardancy in certain polymer matrices.

    Addressing the Real-World Application Challenges

    Filling orders isn’t just about ticking boxes. Each batch gets tested beyond datasheet specs. The pharmaceutical sector asks for freedom from critical impurities—residual sulfonyl chloride or toluene, for example, which we monitor and remove using multistage crystallization and vacuum drying cycles. The same goes for the plastics industry, where every fraction of a percent in purity affects downstream processing temperatures and product yield.

    Handling requests for higher-purity grades means constant tweaking of solvent ratios, crystallizer dwell times, and drying conditions. Ultimately, all these adjustments show up in the trace impurity profile and, if left unchecked, in increased side-reactions in catalysis where DPSM-99 acts as a building block. We’ve learned through years of cooperation with process engineers that even small groups of unidentified impurities from upstream sulfonation steps or bad packing conditions can carry through and ruin entire production runs for customers.

    Experience With Sourcing, Scale-Up, and Seasonality

    Our raw materials pipeline runs tight, which often means betting on long-term procurement contracts for sulfonyl chloride and benzene derivatives. Volatility in these markets impacts our product volumes; inevitably, we manage through upswings in price or raw material rationing. DPSM-99 production is never an exercise in routine. During supply shortages, our plant engineering teams recalibrate reactor cycle times so that every raw material batch gets squeezed for maximum conversion and clean-up. We’ve walked through sudden cold snaps that slow down recrystallization kinetics, and heatwaves that cook residual moisture out too fast, risking excessive fines or sticky cake in drying. You cannot run an operation for years with automation alone; eyes on the ground, machine maintenance, and trusted process chemists make sure every order comes out as promised.

    Some customers try to pivot to other sulfonyl derivatives in tough seasons. We’ve watched experiments fail in process lines—melting points shift, off-odors appear, and stability windows collapse—when DPSM-99 is swapped out for less robust substitutes. There’s a reason certain installations in the adhesives, electronics encapsulant, or medical device coatings sectors stick to our grades through price swings and disruptions. The molecule is built to serve high-end needs—long-term reliability in elevated-heat environments, compatibility with various polymer backbones, and chemical inertness in critical settings.

    Comparing to Similar Chemical Grades

    We frequently field comparison requests from formulation chemists weighing other crosslinking agents. The common stand-ins usually include simple diphenyl sulfone, bis(4-chlorophenyl) sulfone, or straight methylene bis-phenyl sulfone. In our labs, we’ve cracked, purified, and tested these against DPSM-99 under standardized conditions. When tested at processing temperatures used in typical thermoset production lines, DPSM-99 retains crystallinity longer, melts cleanly over a narrow range, and produces less evolution of unwanted byproducts. Customers handling sensitive products—electronics, high-durability paints, or specialty adhesives—report that other compounds can’t strike the same balance of crosslinking efficiency and manageable volatility.

    In specialty elastomer and thermoplastic production, it becomes clear why DPSM-99 fetches preference. When we sampled high-load plasticizers or curing agents on test lines, the mechanical tests show tighter molecular crosslink density, which translates in practice into stronger, more durable materials. None of this is theoretical—these conclusions come straight from instrument readouts, QC data logs, and customer return briefs. The repeatability helps customers reduce downtime, prevent line contamination, and move toward greener, less hazardous processes.

    Quality Control: Beyond What You See in a Data Sheet

    Since nothing leaves our site without real scrutiny, our standard checklists go past the usual melting point and assay tests. Residual solvent testing, Karl Fischer moisture analysis, and fine-particle profiling get recorded alongside each lot’s certificate. Process engineers here know how even a half-percent shift in moisture can crust up feeders or throw off blending in high-shear mixing—so we never ship product just based on “looks right.” We routinely check trace heavy metals using ICP-MS panels, as a nod to the increasingly strict standards from electronic coatings and semiconductor manufacturers.

    End customers come back to us because the test results on our material match up with pilot run behavior, not just bench-top examples. When compounders scale up from lab to plant, many find that competitive grades run into caking, sticking, or decomposing problems at moderate temperatures. Our hands-on approach—regular walkthroughs, in-line sampling, and direct operator-to-engineer communications—keeps surprises out of the system.

    Packaging and Handling: Lessons Learned in the Field

    DPSM-99 leaves our facility in high-barrier liners and PE drums for a reason. Moisture and contaminant pickup during transit or storage can sideline an entire production run. Over the years, we’ve retooled packaging to guard against clumping, static buildup, and accidental moisture ingress. We’ve weathered countless conversations with logistics coordinators about the “last mile” of delivery, since many fail-to-pass material mishaps occur not in the plant, but sitting for weeks in a humid warehouse or during cross-continental transit. The best-made batch can fail if it’s exposed to a humid typhoon en route. That’s why we work closely with supply chain partners, emphasize sealed repacking, and keep buffer stocks close to major customer clusters.

    On the receiving end, we always encourage basic protocols—dry glove handling, immediate resealing, and climate-controlled storage—because we’ve seen how even minor slip-ups can cost thousands in downtime and discard. No shield of paperwork or QR-coded batch record can replace the common sense of proper handling and open lines of communication between supplier and user.

    The Knowledge We’ve Built and Passed On

    Decades of plant operation shape our approach to making DPSM-99. From repeated refinements—rebalancing stirring rates, fine-tuning crystallizers, or re-sequencing purification steps—every improvement traces back to discussions with customer process chemists or direct plant feedback from trial partners. Our product didn’t reach its current state through isolation. Collaboration between process engineers, plant managers, and front-line operators allowed us to solve real world pain points: sporadic batch-to-batch variability, unexpected degradation on long hauls, or sudden regulatory changes.

    We share these best practices not just in academic papers, but in technical workshops, troubleshooting sessions, and consulting calls guiding users through their next critical project. This creates a feedback loop—constant user input flows back to our teams, pushing for better traceability, more robust QA, faster response times to urgent custom specs, and incremental performance gains designed around real-world stress.

    Facing Regulatory Shifts and Customer Demands

    Recent regulatory changes—whether concerning REACH, Prop 65, or specific regional bans on trace impurities—require us to keep our lab and QA teams up-to-date. We’ve steered process development to minimize chlorinated by-products, cut residual PPM levels below global norms, and keep our documentation auditable and transparent. Every modification starts with feasibility studies in our labs, then transitions to semi-commercial pilots and, finally, to full runs at scale. We do not cut corners or look for short-term workarounds. If a specification shifts—whether for a tiny European niche polymer user or a multinational making medical devices—we adapt rapidly and keep our channels with regulators wide open for guidance.

    The Future of Bis(Phenylsulfonyl)Methane in Hi-Tech and Sustainability Applications

    Bis(Phenylsulfonyl)Methane used to serve a handful of high-spec polymer plants, but the past five years have brought its use skyrocketing in optoelectronics, advanced composites, and engineered coatings. Today, the exacting tolerances of microelectronics, LED encapsulants, and high-performance adhesives demand the kind of repeatability and reliability that our plant’s methods deliver. Our team has invested heavily in analytical verification, from high-resolution chromatography suites to advanced process simulation, so shifts in upstream feedstock purity or reaction kinetics get caught early. The rising push for sustainable production methods has seen a new wave of interest in how DPSM-99 supports recyclability and low-toxicity compositing in finished goods.

    Companies now design entire new grades of thermosets and blends based on this compound’s compatibility and performance stability. In additive manufacturing and 3D printing, its clean melt profile and chemical inertness help designers create lighter, stronger, and more intricate parts for aerospace and transport sectors. Sustainability, for us, means slashing solvent use, minimizing off-gas emission, and setting up closed-loop waste treatments within our facility. We tune washing steps to lower water footprint, use HEPA and carbon filtration on dryer vents, and recover solvents through fractional distillation in every run.

    End-users, especially those who have wrestled with new environmental standards or supply bottlenecks, return to DPSM-99 for its proven record under pressure. Polymer R&D teams roll out products with improved durability that also pass life cycle and recycling assessments, a growing market expectation. We see eco-labels and green procurement lists now prioritizing chemical intermediates that cut overall emissions by their performance and process contribution—not just their label claims. Products originating from our line equip manufacturers to meet both regulatory milestones and operational benchmarks that older crosslinkers or intermediates simply cannot achieve.

    Problems, Solutions, Opportunities: What Keeps Us Sharp

    Year after year, the most persistent challenges revolve around delivering higher purity, managing costs, and defending process stability against raw material swings. Ethical sourcing, leaner batch operations, and feedback-informed process adjustments remain central to our approach. Some problems take months to fix, like pinpointing a trace odor that stymied a cosmetics coatings applicator, traced back to upstream solvent residue. We brought in more advanced GC-MS tools and new cleaning phases, which today make our DPSM-99 run cleaner even than regulatory minimums. Others—like lowering the melting range spread—took operator retraining and better filter station controls.

    Many of our best solutions grew out of adversity. Shortages in primary raw materials led us to dual-source and, in some cases, backward integrate selected sulfonyl intermediates. We now run side pilot lines where new grades can be tested for unusual color, crystallinity, or solubility profiles in parallel to commercial production. This lets us adapt quickly when customers introduce new product lines that need tweaks—tighter particle size distributions, faster dissolution rates, or compatibility with bio-based polymer systems.

    Looking ahead, the growth of functional polymers, printable electronics, and tougher regulatory environments ensures DPSM-99 stays relevant. We prepare for shifting global standards and ongoing cost pressure by investing in people and equipment, not short-term savings. The years on the plant floor teach us: the best advances come from tight loops between production, quality, and user experience—no amount of marketing can replace that. Bis(Phenylsulfonyl)Methane remains a benchmark for specialty sulfone intermediates because it’s forged through that direct connection between the challenges on your line and the know-how built into ours.