Bis(Dibenzylideneacetone)Palladium
- Product Name Bis(Dibenzylideneacetone)Palladium
- Alias Pd(dba)2
- Einecs 247-328-8
- Mininmum Order 1 g
- Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
- Price Inquiry admin@sinochem-nanjing.com
- Manufacturer Sinochem Nanjing Corporation
- CONTACT NOW
- Characterized by its high catalytic activity, it functions as a homogeneous catalyst in pharmaceutical synthesis and conforms to ACS specifications.
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HS Code |
305459 |
| Cas Number | 51364-51-3 |
| Molecular Formula | C34H28O2Pd |
| Molecular Weight | 576.00 g/mol |
| Appearance | Yellow to orange crystalline powder |
| Melting Point | 150-153°C |
| Solubility | Soluble in chloroform, insoluble in water |
| Purity | Typically ≥98% |
| Storage Temperature | Store under inert atmosphere, 2-8°C |
| Density | 1.34 g/cm³ |
| Chemical Name | Bis(dibenzylideneacetone)palladium(0) |
As an accredited Bis(Dibenzylideneacetone)Palladium factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 5-gram Bis(Dibenzylideneacetone)Palladium is packaged in a sealed amber glass bottle with a secure screw cap. |
| Shipping | Bis(Dibenzylideneacetone)Palladium is shipped in tightly sealed containers, protected from light and moisture. It is classified as a non-hazardous solid under most regulations, but should be handled with care. Packaging ensures minimal exposure to air to prevent decomposition, and typically includes padded, secondary containment during transit. Store at ambient temperature upon arrival. |
| Storage | Bis(Dibenzylideneacetone)Palladium (Pd(dba)₂) should be stored in a tightly sealed container under an inert atmosphere, such as nitrogen or argon, to prevent oxidation and degradation. It should be kept in a cool, dry place, away from light, moisture, and incompatible substances such as strong oxidizers. Refrigeration (2–8°C) is recommended for prolonged storage. |
Applications of Bis(Dibenzylideneacetone)Palladium in Industrial ManufacturingBis(Dibenzylideneacetone)Palladium, known in industrial chemistry as Pd(dba)2, functions as a homogeneous catalyst precursor in a range of commercial synthesis processes. Technical manufacturers rely on its high catalytic performance and reproducibility for cost-effective operations. Below we outline verified downstream industry applications, each with process-specific compliance, loading ratios, integration stages, and end product outputs. 1. Pharmaceutical Active Pharmaceutical Ingredient (API) SynthesisAPI manufacturers select Pd(dba)2 as a key catalyst source for various C–C and C–N cross-coupling reactions, such as Suzuki, Buchwald-Hartwig, and Heck reactions. Its solubility in common organic solvents prioritizes it for scale-up in multi-step synthesis lines. Operators need strict control over residual metal per ICH Q3D and final batch homogeneity, as reactions often occur at kilogram or ton scale under cGMP conditions. Industry leaders validate both traceability and final batch purging methods. Industry compliance standards
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2. Fine Chemical Synthesis for Electronic MaterialsAdvanced display and electronics chemical producers employ Pd(dba)2 as a catalyst for key steps in the manufacture of OLED intermediates, photoresist compounds, and specialty aryl amines. The molecule’s high activity and low impurity profile meet the trace metal and particulate limits required in semicon and microelectronic fabrication. Quality assurance focuses on ensuring sub-ppm Pd residue and conformity to material purity norms for reliable device performance. Industry compliance standards
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3. Agrochemical Intermediate ProductionProducers of new-generation herbicides and pesticide actives leverage Pd(dba)2 for introducing aryl or alkyl linkages under mild conditions. This technology allows for the development of environmentally benign molecules while maximizing yield per kilogram of palladium input. Full regulatory documentation and reproducible SOPs support customer audits, especially for export to regulated markets. Industry compliance standards
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4. Specialty Polymer Monomer SynthesisChemical manufacturers use Pd(dba)2 in the controlled synthesis of functionalized aromatic monomers. Applications include specialty polymers for filtration, membrane, and engineering plastics—where precise substitution patterns enhance material properties. Each lot undergoes internal purity tests and is validated through end-use hydrolytic and mechanical property analysis. Industry compliance standards
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5. Active Ingredient Production for Fragrance and Flavor ChemicalsFlavors and fragrance raw material companies deploy Pd(dba)2-mediated reactions for constructing substituted aromatic and heterocyclic compounds. Its ability to promote high-purity transformations supports the industry’s strict standards for organoleptic properties and residual metal content. Reaction routes align with process hygiene and batch reproducibility targets required by global flavor houses. Industry compliance standards
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- Bis(Dibenzylideneacetone)Palladium is manufactured under an ISO 9001 quality system and complies with relevant regulatory requirements.
- COA, SDS/MSDS, and related certificates are available upon request. For certificate requests or inquiries, contact: admin@sinochem-nanjing.com.
Bis(Dibenzylideneacetone)Palladium: Quality and Experience from a Chemical Manufacturer
Our Commitment to Bis(Dibenzylideneacetone)Palladium
From inside the synthesis workshop to our QA lab, we know that every gram of Bis(Dibenzylideneacetone)Palladium, or Pd(dba)2, traces back directly to the consistency of our methods and the reliability behind our process. Producing this deep red palladium complex for the demanding fields of organometallic chemistry and homogeneous catalysis demands both technical excellence and hands-on experience. Unlike products passed from distributor to distributor, here there’s a direct line from our raw material selection to your application bench.
Product Overview and Manufacturing Approach
Bis(Dibenzylideneacetone)Palladium, with CAS number 32005-36-0 and the formula Pd(C17H14O)2, features a molecular weight of about 576.1 g/mol. Our team synthesizes this bright red-orange crystalline complex in strictly controlled conditions, using techniques we’ve honed and adjusted over years of production. We pay keen attention to the purity levels, typically delivering a content above 98% by HPLC, and always keep a close watch for trace metals or moisture that can impact sensitive coupling or bonding reactions.
The way we choose our starting materials, such as the dibenzylideneacetone ligand and palladium(II) sources, directly impacts final product stability and color. Pd(dba)2 can show slight lot-to-lot color shifts if the process deviates, so our operators maintain hands-on oversight throughout. Each batch is air-dried, handled inside glove boxes, and packed under inert argon to keep the compound fresh and avoid trace oxidation. By keeping control in-house, we can track issues back to the raw metals or solvents and correct them early — saving both wasted time and unnecessary troubleshooting for scientists downstream.
Competitors offering repackaged material risk degradation or contamination. Sticking with a manufacturer, you gain not only authenticity but quick feedback if something goes wrong. We routinely work with academic and industrial research groups who reach out to us about their specific needs — from scale adjustments to targeted impurity analysis. The conversations aren’t faceless: customers get to interact with our chemists and batch engineers, making troubleshooting or special requests straightforward and practical.
Pd(dba)2 in Real-World Reactions
Years in the field teach us how precisely Pd(dba)2 slots into real reaction setups. In our own lab and in customer feedback, one of the most valued features is its function as a pre-catalyst in cross-coupling reactions, especially Suzuki-Miyaura, Heck, Stille, and Buchwald–Hartwig amination. Compared to chloride-based palladium precursors, the dba ligands are labile enough to release palladium(0) in situ under typical catalytic conditions. This unique attribute cuts the induction time, allowing chemistry to start promptly — especially important for sensitive or multistep transformations where time and throughput impact productivity.
When a process only tolerates minimal water or certain solvent systems, we see Pd(dba)2 consistently outperform Pd(PPh3)4 or Pd(OAc)2. With the dba ligands, catalyst activation demands less hassle, and even at low loadings researchers report outstanding turnovers, especially for challenging coupling partners. By monitoring feedback from both pilot plants and bench chemists, we steadily refine particle size, ligand-to-metal ratio, and packing so that our Pd(dba)2 dissolves quickly and leaves little residue in solvent. That’s a detail lost on traders who simply repackage without understanding real-world bottlenecks.
Research into expanding the repertoire of ligands for cross-coupling catalysis has made Pd(dba)2 particularly attractive as a “ligandless” entry point. The dba can be displaced readily by custom phosphines, NHCs, or bulky biaryl phosphines developed in major pharmaceutical chemistry programs. That flexibility puts Pd(dba)2 in an ideal position for users chasing new increases in catalyst lifetime, selectivity, or functional group tolerance. From what we’ve seen, other palladium pre-catalysts often lock researchers into inflexible ligand environments or struggle with limited substrate compatibility, which quickly stalls innovation.
Quality as Experienced by Chemists
Delivering consistent quality batch after batch depends on much more than a published certificate of analysis. Our lab and process chemists are plugged directly into customer feedback, whether it’s a routine gram-scale reaction or an escalated kilogram batch under pharmaceutical cGMP. If a researcher experiences unexplained loss of catalytic activity, our team investigates at both the analytical and process level. We track trace moisture, residual solvents, and detect even small amounts of decomposition products by NMR and mass spectrometry — a level of transparency only possible when batch history and personnel overlap from start to finish.
Our own pilot campaigns reinforce that freshly prepared and properly stored Pd(dba)2 consistently beats older, oxidized, or overheated material. An off-color or poorly soluble batch often traces to shortcutting the inert handing or packaging, a risk that grows when stock changes hands multiple times. Insisting on full inert atmosphere processing, from crystalization to final bottle capping, costs more up front but pays off when reaction yields stay high all the way from milligrams to multi-kilogram scale.
We avoid adding excessive stabilizers, as unnecessary binding can block activation and slow down key organometallic steps. Each batch carries a full profile, including elemental palladium content by ICP and a spectrum check for unreacted dba. If issues arise in customer labs — cloudiness, precipitation, trouble with ligand exchange — our technical support picks up the entire production record for troubleshooting. Rather than rely solely on sales, our team supports the entire journey from order to application, which has built long-term relationships with process chemists at both pharmaceutical and fine chemical producers.
Specification: What Actually Matters
Instead of flooding customers with jargon, we emphasize the specs that actually influence catalysis: weight percent of palladium, dba ligand content, and residual solvents or water. Most lots analyze to 24-25% elemental Pd by mass — matching theoretical values — with ligand content confirmed both by NMR and melting point profile. Water content stays consistently below 0.05%, which keeps the compound dry and free-flowing for glovebox handling.
Analytical verification doesn’t stop at the catalog listing. Each bulk batch undergoes full characterization, including not just HPLC and HRMS, but careful observation for minor colored impurity bands and headspace gas checks for early signs of decomposition. When issues come up, we can pull entire production records from our database and trace glassware, operator, and even specific lots of solvents back to source.
Application Insights From Our Experience
Pd(dba)2 shines as a base material in laboratories setting up combinatorial libraries or scaling up cross-coupling steps for clinical trial manufacturing. Most complex small molecules, especially where sensitive functional groups or aryl chlorides come into play, show their highest isolated yields in the hands of experienced chemists using pure, freshly opened Pd(dba)2 from a manufacturer who guarantees both purity and traceability. Customers working in OLED materials, chiral ligand synthesis, or natural product modifications draw on our material for its fast activation profile and compatibility with air- and moisture-sensitive processes.
In our own practice, we find that processes requiring minimal by-products and low residue after work-up benefit from the high solubility and minimal binding of Pd(dba)2. Downstream purification steps run faster, as the dba ligands are easy to remove under vacuum, which especially benefits teams churning through dozens of runs for medicinal chemistry or high-throughput screening.
How Our Materials Differ
Materials supplied directly from us differ from those that have sat in repackaging warehouses or changed hands multiple times. The most obvious marker sits in the color and crystal habit: freshly made Pd(dba)2 shows vivid red or clear orange crystals, not the faded brownish powder sometimes seen from older sources. Over time, dealers and brokers mix and re-bottle, leading to lots that lose subtle but critical differences in solubility and reactivity. Chemists starved for time encounter inconsistent results, lost time on solvent swaps, and tedious troubleshooting.
As the actual manufacturer, we monitor the entire pipeline — from raw metal sources, through ligand synthesis, to final bench-inert bottling. Every step aims to reduce contamination, maintain anhydrous state, and preserve the fragile zero-valent palladium core until the very last moment before reaction. The logistical simplicity of buying direct eliminates uncertainty, reduces hidden delays, and keeps support channels open for technical questions that reach real chemists, not just customer service representatives.
Unlike distributors, we control scale-up protocols. Raw materials are kept under inert gas from delivery, and workers monitor temperature and agitation continuously to prevent hot spots that cause fine-particle formation or local overreduction. Each batch’s solvent selection, filtration pore, and recrystallization final step gets matched with customer needs — so whether the application is bench research or ton-scale industrial synthesis, product characteristics stay consistent and predictable.
Real Challenges and Practical Solutions
Handling air- and moisture-sensitive materials presents daily challenges. Even small lapses in packaging or glovebox technique lead to subtle drops in catalyst activity. By investing heavily in integrated inert-handling equipment and staff routines, we keep batch-to-batch consistency reliable for users. The QA process never stops at a single analytical confirmation: operators undergo regular retraining, and incoming raw materials face strict screening for trace chlorine, sulfur, and metal contaminants.
Sometimes customers ask why we don’t lower prices to match bulk resellers. The answer lands in the details: outsourced product often comes from leftover stock, swept up by traders with little knowledge of the last air exposure or storage environment. We don’t skip cold storage or inert transfer steps, even if costs run higher, because our own team has seen yields crash when users unknowingly work with subpar precatalyst. In catalysis, those few percent differences become painful in wasted time and rework.
Another real-world issue comes from solvent and ligand compatibility. Pd(dba)2 requires careful attention to dissolution. Because it dissolves well in common organic solvents like toluene, THF, or DMF, and swaps ligands readily, it easily adapts to a wide array of transformations. Our application team regularly shares dissolution tips with synthetic chemists challenged by vigorous crystallization or unusual color formation, based on feedback and our own in-house reaction trials.
Supporting Innovation through Manufacturing Expertise
By working closely with R&D partners, we stay tuned to next-generation catalyst libraries and new synthetic methods. The flexibility of Pd(dba)2 as a “catalyst platform” lets researchers swap out ligands or tweak conditions without re-optimizing the rest of the process. As innovation in pharmaceuticals, advanced materials, and agrochemicals pushes forward, reliable access to high-purity pre-catalysts makes or breaks new ideas in the lab.
We’ve seen how fluctuations in quality or supply chain uncertainty stunt progress. Having production, packaging, and technical support under one roof means feedback about unexpected ligand exchange rates, solubility quirks, or trace metal issues translates directly into tweaks in next week’s batch. That immediacy not only speeds up troubleshooting — it lowers the risk that a major production campaign stumbles over an avoidable raw material issue.
Because we maintain a tight loop between production and application, we’re able to support cutting-edge work in enantioselective couplings, conjugated polymer syntheses, and pharmaceutical process intensification. Our partners don’t need to submit troubleshooting requests through multiple third parties or sift through outdated documentation — they reach our technical specialists who understand not only the packing slip, but the molecular reasons that drive selectivity, reactivity, and outcome success.
Comparing Pd(dba)2 to Other Palladium Pre-Catalysts
Experienced chemists tell us that the choice between Pd(dba)2, Pd(OAc)2, PdCl2, or more complex phosphine complexes comes down to the core ligand flexibility, rate of activation, and compatibility with the intended transformation. Some substrates demand gentle conditions or need to avoid halide contaminants; others need the fastest possible catalyst initiation to minimize side products.
We find Pd(dba)2 delivers particular advantages for high-throughput screening, new ligand exploration, or reactions under non-protic conditions. Its lability ensures that the starting palladium(0) is easily accessed without cumbersome reduction steps or hazardous reagents, and its lack of chloride opens the door for transformations where even small halide contamination would harm product purity. Pd(OAc)2 and PdCl2 have their place in large-scale commercial synthesis, but for flexible discovery, where every reaction might use a new ligand or handle a sensitive substrate, Pd(dba)2 stands out.
Our own manufacturing insights show that not all Pd(dba)2 delivers the same performance. Years of process feedback reveal that batch handling, storage, and micro-level purity influence catalyst activation and subsequent selectivity — far more than certificate-of-analysis numbers alone suggest. Customers who switch from repackaged or stale pre-catalysts to our freshly prepared product often see smoother ligand exchange, better conversion, and reduced by-product formation — especially when running multiple coupling cycles without intermediate purification.
Environmental and Safety Considerations
As a responsible manufacturer, environmental stewardship ranks high among our values. All waste streams generated from Pd(dba)2 synthesis, including spent extraction solvents and ligand waste, undergo controlled treatment. We minimize palladium losses by running closed-loop filtration and offering recycling programs for unused or spent catalyst from customers. Safety protocols emphasize minimizing airborne particulates and exposure, so operators work in fully ventilated, glovebox-equipped spaces and undergo annual safety recertification. Waste compliance records are available for review, not just internally but for our partners seeking green chemistry approvals.
On the customer side, technical support covers safe storage and handling, with routine advice on minimizing palladium exposure and setup for waste-palladium recovery. That carries through in our labeling and batch tracking, making sure regulatory data and best-practice advice stay clear and accessible.
Batch Traceability and Ongoing Technical Support
Traceability stays central in our whole operation. Every batch number links directly to a full synthesis and analytical record, available by request, supporting research partners with regulatory or reproducibility needs. Analytical rechecks are encouraged; transparency with our customers deepens mutual trust and drives ongoing improvements. Inquiries receive attention from the production chemists and application scientists who actually handle the compound day-to-day — not third-party agents reading from technical sheets.
As Pd(dba)2 users broaden their portfolio, running new coupling strategies or late-stage diversification on complex molecules, we continue providing direct access to our technical team. That back-and-forth isn’t only about troubleshooting; it’s a foundation for long-term collaboration and builds expertise that benefits the whole research community. By feeding real-world use cases back to our bulk synthesis and finishing teams, we ensure that future Pd(dba)2 lots stay ahead of the requirements coming from the next wave of scientific discovery.
The Manufacturer's Perspective
Decades of synthesis, hands-on feedback, and troubleshooting in chemical manufacturing have shown that outcomes depend not just on raw analytical numbers, but on trustworthy production, documented handling, and ongoing technical support. Pd(dba)2 remains one of the most versatile and reliable zero-valent palladium complexes for today’s advanced synthesis. Supplying direct from our facility, we stand by every bottle sent out as a culmination of experience, care, and ongoing two-way engagement with the scientific community.
