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HS Code |
948137 |
| Cas Number | 472-90-6 |
| Molecular Formula | C32H50O4 |
| Molecular Weight | 498.73 g/mol |
| Synonyms | Lup-20(29)-ene-3,28-diol diacetate |
| Appearance | White to off-white powder |
| Melting Point | 255-260°C |
| Solubility | Insoluble in water, soluble in organic solvents (ethanol, DMSO, chloroform) |
| Purity | Typically ≥98% (HPLC) |
| Storage Conditions | Store at 2-8°C, protected from light |
| Iupac Name | Lup-20(29)-ene-3β,28-diol diacetate |
| Chemical Structure | Pentacyclic triterpenoid diacetate derivative |
| Inchi Key | HQTKPFUDGFMRRE-UOAJLRJESA-N |
As an accredited Betulin Diacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Betulin Diacetate is packaged in a 25g amber glass bottle with a secure screw cap, labeled with chemical details and hazard warnings. |
| Shipping | Betulin Diacetate is shipped in secure, sealed containers to prevent moisture and contamination. It is typically packaged in amber glass bottles or HDPE containers. The material should be stored and transported in a cool, dry place, protected from light, and handled according to chemical safety regulations to ensure integrity and safety. |
| Storage | Betulin Diacetate should be stored in a tightly sealed container, protected from light, moisture, and air. Keep it in a cool, dry, and well-ventilated area, preferably at room temperature or lower. Avoid heat sources, strong acids, and oxidizing agents. Ensure proper labeling and restricted access to authorized personnel, following all applicable chemical safety guidelines. |
Applications of Betulin Diacetate in Industrial ManufacturingAs the direct manufacturer of betulin diacetate, we supply this natural triterpene ester to sectors requiring high-purity intermediates for specialized industrial transformations. Our material integrates into multiple downstream production lines where traceability, compliance, and formulation stability remain core priorities. 1. Pharmaceutical Active Ingredient SynthesisPharmaceutical manufacturers incorporate betulin diacetate during the semi-synthetic production of triterpenoid-based APIs. Its unique chemical structure facilitates controlled acetyl group removal and modification steps, enabling the reaction pathways needed for key pharmaceutical actives, including anti-inflammatory, anti-viral, and oncology candidates. Technicians ensure each batch meets designated pharmacopoeia standards and regulatory limits while maintaining accurate documentation across cGMP environments. Industry compliance standards
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2. Cosmetic Ingredient FormulationsLeading cosmetic labs formulate with betulin diacetate for its natural origin and high stability in creams, serums, and skin barrier enhancers. Its presence improves active compound longevity, supports controlled release, and delivers specific emollient and calming characteristics. Formulators must verify compliance with cosmetic ingredient regulations in key export markets and align product documentation with global labeling requirements. Industry compliance standards
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3. Nutraceutical Intermediate ProcessingNutraceutical producers integrate betulin diacetate as a conversion intermediate to access bioactive triterpene acids or fermentable derivatives. Material purity and traceability are essential to meet food-grade and dietary supplement production protocols. Standard operating practices mandate testing for residual solvents, heavy metals, and compliance with additive codes, ensuring material safety from input through encapsulation or tablet pressing. Industry compliance standards
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4. Speciality Polymer Additives ManufacturingSpeciality polymer producers use betulin diacetate as a biodegradable additive or structural modifier in advanced bioplastics and coatings. Chemists value its influence on mechanical flexibility, thermal stability, and surface energy characteristics. Full material disclosure and toxicological assessment are required to satisfy polymer safety certifications and product stewardship programs in regulated markets. Industry compliance standards
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Producing Betulin Diacetate starts with a concrete understanding of birch bark extraction and a tradition in handling complex triterpenes. For decades, our facility has refined this process, so the Betulin Diacetate you see here reflects continuous on-the-floor technical improvements. We settle for nothing less than a product with excellent chemical purity, sustainable sourcing, and consistency from batch to batch because we stand behind every kilogram coming off the line. Every step, from extraction to acetylation, runs under our technicians’ eyes—people who have worked with natural triterpenes, not outsiders distributing compounds they haven’t witnessed being manufactured.
Betulin Diacetate is a specialty derivative of birch bark betulin, a molecule often overshadowed by betulin itself in commercial use. Acetylation changes betulin’s basic handling, physical stability, and suitability in certain formulations. As a result, Betulin Diacetate solves real formulation challenges companies face with unmodified betulin. For researchers and formulators who work every day to stabilize actives or make more advanced topical products, these changes mean fewer hurdles in developing prototypes and scaling production. We produce Betulin Diacetate for partners wanting a naturally derived, structurally enhanced triterpene ester, not just a commodity extract.
Our Betulin Diacetate meets lab-verified purity benchmarks for triterpene derivatives—each lot emerges as a white solid crystalline compound, melting sharply above 210°C, and contains negligible residual solvents. Documents can only tell part of the story. Every sample sent out matches what we use for in-house performance testing. The acetylation procedure, tuned over years, leaves behind no sticky residues or off-odors, a result that has taken thousands of hours of process optimization. Real-time HPLC and GC analysis track impurities specific to birch bark sources. Contaminants sometimes pop up in commercial-grade betulin; our acetylated product undergoes a much stricter clean-up cycle, and the certificates you receive always tie to validated internal data sets—not just typical COA boilerplates.
Selecting triterpenes is about more than just content percentage or color. Many clients ask how our Betulin Diacetate differs from others they see online or in technical catalogs. First off, our process keeps molecular integrity by using mild solvents, avoiding harsh oxidizers, and maintaining moderate reaction temperatures. No forced vacuum conditions or extreme pH swings. This matters: aggressive processing tends to create side products that complicate downstream applications—particularly for skin care, food-contact polymers, and pharmaceutical intermediates. Every metric—particle size, ir-spectra, absorption—gets tied into process records so that reordering means receiving the same molecule, not a roulette of polymorphs or unknown impurity spikes. The “model” signals which batch route and quality benchmarks apply—ask our technical team, and they can share field-level detail from actual runs.
Modifying betulin with two acetate groups gives Betulin Diacetate greater solubility in moderately polar and aprotic solvents. If you’ve tried working with unmodified betulin, especially in emulsions or advanced film-forming systems, you know poor dispersibility can complicate manufacturing. Our acetate-derivative pours smoothly, disperses into esters and glycols without excessive agitation, and resists lump formation during storage. Customers in cosmetics have shared practical feedback—less gumming, more consistency, and faster throughput on pilot lines. Chemists with years of manufacturing experience know that ingredient volatility, stickiness, and particle clumping make downstream processing a pain. Addressing these headaches starts in the reactor, not downstream in a mixing vat, which is why all of our technical staff contribute to continuous improvements in every batch we make.
Betulin Diacetate’s usage traces back to researchers looking to exploit both the bioactivity of lupane triterpenes and the practical benefits of chemical modification. Through regular collaboration with application chemists, we’ve seen interest span from antioxidant-loaded gels to nanoformulations in drug delivery. The real strength comes in topical products and wound care matrices; the acetate groups help maintain stability over time. Unlike betulin, which can turn chalky or react with certain excipients, Betulin Diacetate sits well alongside common solvents, emollients, and structuring agents. Over the years, we’ve seen partners successfully use it in high-end emulsions, sprays, and even biodegradable packaging, benefiting from reduced crystallization and easier melt-processing.
Working at a chemical manufacturer gives a unique perspective. Other products out there might check a main chemical box, but they rarely deliver consistency or supply assurance when clients actually run scaled syntheses or try to commercialize new products. Our manufacturing site has built a ton of knowledge dealing directly with variation in raw birch sourcing and in the acetylation itself. For us, differentiation comes through tight specification control, transparent supply documentation, and direct support to R&D labs. That’s why we invest in large-scale pilot lots long before a product reaches bulk status. With every lot, we document input traceability back to origin and share that detail with customers looking for true transparency.
We get questions all the time from researchers and product managers comparing our product to “generic” or “industry standard” sources. Truth is, so-called standards often shift with each harvest or supplying country. We use a single-source approach for birch bark inputs to prevent seasonal or botanical variation in the triterpene backbone—in real-world production, these botanical shifts can lead to headaches in consistency, downstream viscosity, or regulatory documentation. All our documentation backs up the source and method, with full access to chromatograms and spectra, so you see exactly what the batch delivers.
Researchers need more than a bottle from a catalog. Scientific workflows depend on reproducibility and transparency. Our technical support team—all with backgrounds working hands-on in synthesis or application chemistries—answers direct questions about handling, storage, and reactivity. We noticed many users in academic or pharma applications ran into trouble with previous lots of other materials because paperwork didn’t line up with reality. Every batch we ship arrives with closely matched support data, including actual impurity profiles and thermal analysis, so customers can make informed decisions about bioactivity or downstream derivatization. Over the years, this approach has prevented more repeat lab work and scrapped projects than marketing promises ever could.
Every chemical company speaks about sustainability these days. In practice, a production chemist knows real change means changing suppliers, logistics, and waste-handling. Our Betulin Diacetate uses birch harvested through certified sustainable methods, because we’ve spent years developing supplier agreements with foresters who understand what branch harvesting does to future growth. Traceability covers not just input origin, but solvent recovery, water usage, and post-processing filtration. Our plant operators track energy consumption per kilogram of Betulin Diacetate made. This kind of hands-on commitment pushes us to lower environmental impact with every run—details we share when clients conduct environmental audits or footprint analysis.
Triterpenes from natural sources bring challenges: solubility, batch consistency, shelf life, and regulatory traceability. Pure betulin can crystallize unpredictably, form gels, or react with acidic excipients; lupeol frequently arrives contaminated with sterol byproducts. Betulin Diacetate solves several headaches in one go—end-users see sharper melting, less background residue, and a clearer solubility profile across common and specialty solvents. Unlike some betulins or synthetic triterpenes, our acetylated product has passed repeat cytotoxicity tests for use in topical and material applications, and every batch has impurity content mapped and archived.
We’ve seen this firsthand in collaborative projects: a nutritional supplement producer replaced mixed triterpenes with our Betulin Diacetate in prototype coatings, fixing clumping issues and extending storage time. Polymer formulators pointed out that melt mixing runs smoother and delivers a product easier to pelletize and shape. All of these stories feed back into our process—our chemists talk directly to end users, not just QA staff. If a company encounters specific hurdles—unexpected precipitates, layer separation, incomplete dissolving—our production and technical leads get involved to resolve these issues based on direct factory-floor insight, not bureaucracy.
Betulin Diacetate’s main applications sit in skin care actives, specialty coatings, polymer modifiers, and emerging pharmaceutical technologies. In our plant, we’ve developed test formulations that push the material’s physical and chemical boundaries. These go beyond customer requests—testing at higher concentrations, extremes of temperature, multi-step blending, and long-term storage. By feeding back failures and oddities into our batch notes, we deliver a better-informed material, reducing troubleshooting for each user. Finished product factories have shared photos of smooth, high-gloss films and durable dispersions; cosmetic developers have shown ingredient blends that stay homogeneous during dynamic storage and freeze-thaw cycling.
Our relationship with formulators goes well beyond shipping product. We cycle experimental runs in-house: emulsion blends, film-forming tests, and stability chambers. Testing uncovers weaknesses—sometimes Betulin Diacetate isn’t right for legacy systems or electronic-grade resins, and we steer clients toward a better fit. This working partnership leaves very few surprises on the production floor for our customers.
All too often, ingredients seem to leave the plant and disappear into a supply chain cloud. We changed that process by building feedback loops between end users and process chemists. If a company’s pilot line hits trouble, we get the chemists and operators responsible for actual processing on the call—all based in the same facility that makes each batch.
Years of walking down the factory floor have taught us where issues crop up—not from theoretical quality control but from pumps clogging, crystallization in tanks, or drum storage quirks. Requests for nonstandard particle sizes or alternate drying profiles come directly to our process team; every change gets documented for traceability. Every claim about performance rests on repeated, controlled runs using the same equipment as customers might use, scaled down where necessary.
Supplying Betulin Diacetate doesn’t end at the loading dock. We share batch records, recommended preparation methods, and unusual use-case observations whenever requested. If a coated product or gel prototype doesn’t function as planned, our team doesn’t just supply a new sample—they dig into how formulation choices and process parameters affect outcomes. Chemists with years of plant-floor experience, not just QA or regulatory background, guide suggestions.
Some partners use the product for product launches, others for years-on-end in established SKUs. In either case, we keep dialogue open about regulatory shifts, incoming restrictions, and changes in birch bark supply—details that matter for companies operating on thin margins or under audit pressure.
Betulin Diacetate walks a regulatory line between natural and modified products. Production chemists track changes in REACH, FDA, and local chemical inventory listings to flag issues for customers. Through daily manufacturing, we see how tightening standards on impurities—especially bytopic markers or agricultural residues—necessitate stricter batch records and more advanced purification. We run impurity screens for every batch heading toward regulated markets. That attention to detail allows customers in dietary, medical, or cosmetic fields to move their own documentation processes forward, confident the data lines up with regulatory needs.
Regulatory reviewers sometimes ask for stability, trace metal, or allergen data, especially when expanding to new geographies. Our technical and QA staff prepare extra documentation, including chromatography traces and analysis reports, for every lot upon request. In production, we’ve learned that anticipating these needs, not reacting to them, leads to smoother approvals and speedier time-to-market for clients. No batch ever ships without complete regulatory support, matched directly to the production process and input testing.
No production process stands still. Field feedback and internal test results feed directly into process adjustments and raw material sourcing decisions. When we received reports of slow-melting samples years ago, we traced the issue to seasonal bark variation; today, dedicated inbound material prepping has all but eliminated those lot-to-lot changes. Similarly, requests for more detailed toxicity data drove us to invest in outsourced and in-house assessment, leading to well-supported application in sensitive uses.
Production experts benefit from the cycle of manufacture, shipment, application, feedback, and internal review. Every knowledgeable customer pushes us closer to a fully optimized, fully transparent product. This approach leads to better Betulin Diacetate for us, and for every company using it to build trusted formulations and innovative new products.