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Benzylaminoacetic Acid Hydrochloride

    • Product Name Benzylaminoacetic Acid Hydrochloride
    • Alias BAAA HCl
    • Einecs 238-223-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    516294

    Product Name Benzylaminoacetic Acid Hydrochloride
    Cas Number 127-93-5
    Molecular Formula C9H12ClNO2
    Molecular Weight 201.65 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 178-183°C
    Solubility In Water Freely soluble
    Storage Conditions Store in a cool, dry place, tightly closed
    Purity Typically ≥98%
    Ph Value 2-3 (1% solution in water)
    Chemical Structure C6H5CH2NHCH2COOH·HCl
    Synonyms N-Benzylglycine hydrochloride
    Odor Odorless
    Hs Code 29224999

    As an accredited Benzylaminoacetic Acid Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, tamper-evident HDPE bottle containing 100 grams of Benzylaminoacetic Acid Hydrochloride, clearly labeled with chemical details and hazard information.
    Shipping Benzylaminoacetic Acid Hydrochloride is shipped in tightly sealed containers to protect it from moisture and contamination. The shipment is labeled according to chemical safety regulations, and packaged with cushioning material. Typically, it is transported under ambient conditions, following all applicable local and international regulations for non-hazardous chemicals.
    Storage Benzylaminoacetic acid hydrochloride should be stored in a tightly sealed container, away from moisture and incompatible substances, such as strong oxidizers. Store it in a cool, dry, and well-ventilated area, ideally at room temperature (15–25°C). Protect from direct sunlight and sources of ignition. Follow applicable safety regulations and ensure proper labeling for identification and hazard communication.
    Application of Benzylaminoacetic Acid Hydrochloride

    Applications of Benzylaminoacetic Acid Hydrochloride in Industrial Manufacturing

    Benzylaminoacetic Acid Hydrochloride serves as a specialized intermediate in fine chemical production, supporting industries where precise formulation and stringent process controls are essential for high-value end products. Below, we detail key sectors and address core requirements related to compliance, formulation, production workflow, and downstream output.

    1. Pharmaceutical Intermediates for Active Pharmaceutical Ingredient (API) Synthesis

    This raw material functions as a protected amino acid derivative during multi-step syntheses for active pharmaceutical ingredients. Chemists reference it when optimizing side-chain protection or coupling reactions for specific betalactam, antineoplastic, or CNS drug molecules. Its unique contribution lies in maintaining reaction specificity and enhancing yield during intermediate-stage transformations for new molecular entities.

    Industry compliance standards

    • International Council for Harmonisation (ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • European Pharmacopoeia (Ph. Eur.) monographs for starting materials
    • United States Pharmacopeia (USP) General Notices for API intermediates
    • Chinese Pharmacopoeia (ChP) pre-API control guidelines

    Typical usage ratio

    • 0.5–3.0 molar equivalents based on the target substrate, with adjustment after laboratory kinetic and selectivity tests

    Downstream process integration

    • Charged as a reactant during stepwise peptide synthesis or amide bond formation (pre-final API) within jacketed hydrogenation or condensation reactors
    • Deprotection and purification follow, integrated with high-performance liquid chromatography (HPLC) for endpoint confirmation

    Final product types

    • Pharmaceutical active substances (e.g., anti-cancer drug intermediates, CNS modulators, protected amino compounds)
    • API key intermediates registered in CTD dossiers

    2. Peptide Synthesis Reagents in Biotech Manufacturing

    In industrial peptide assembly, this chemical acts as a customizable amino acid precursor, enabling the selective construction of side-chain protected sequences. Research-scale and large-scale GMP peptide manufacturers use it during chain elongation when seeking to minimize racemization and to control side reactions. Its tailored utility supports production of both synthetic therapeutic peptides and diagnostic probes.

    Industry compliance standards

    • US Food and Drug Administration (FDA) 21 CFR 210/211 (cGMP for finished pharmaceuticals)
    • European Medicines Agency (EMA) guidelines for synthetic peptide APIs
    • ISO 13485:2016 (for IVD peptides)
    • ICH Q11 (Development and Manufacture of Drug Substances)

    Typical usage ratio

    • 0.8–1.2 molar equivalents per protected coupling step, titrated according to peptide chain susceptibility to side reaction

    Downstream process integration

    • Introduced immediately prior to solution or solid-phase coupling on resin beds, used with HATU or EDC linking agents
    • Followed by iterative deprotection, washing, and cleavage into target sequence

    Final product types

    • Synthetic peptide therapeutics (e.g., GLP-1 receptor agonists, cancer targeting ligands)
    • Peptide reference materials and labeled control samples for IVD assay manufacturers

    3. Organic Synthesis of Fine Chemical Building Blocks

    Manufacturers of specialty fine chemicals employ this material as a core building block for designing functionalized benzylic derivatives and complex aromatic compounds. Its controlled reactivity profile allows for strategic placement in diverse reaction types, particularly in benzylic substitution and alkylation sequences for agricultural, optoelectronic, or advanced polymer intermediates.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management System for fine chemical production)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals—EU)
    • Specific downstream applications subject to TSCA (Toxic Substances Control Act—US) inventory listing

    Typical usage ratio

    • 5–20% weight/weight of total reactants, fine-tuned for reaction yield and selectivity in bench and pilot processes

    Downstream process integration

    • Reacted in batch or flow systems for stepwise syntheses, often following activation or derivatization, with process analytical technology (PAT) employed for endpoints

    Final product types

    • Custom benzylic intermediates for agrochemical, dye, or performance polymer sectors
    • Aromatic functional group precursors in specialty electronics materials

    4. Custom Research Chemicals and Analytical Standards

    Analytical R&D labs and contract manufacturers purchase this compound as a matrix for high-purity reference standards and as a component in combinatorial chemistry for structure activity studies. Its stable hydrochloride salt ensures consistency across batches for method validation, impurity profiling, and calibration blend preparation in accordance with regulatory or ISO laboratory requirements.

    Industry compliance standards

    • ISO/IEC 17025:2017 (General requirements for testing and calibration laboratories)
    • USP Reference Standard procedures for analytical validation
    • GLP (Good Laboratory Practice, OECD)

    Typical usage ratio

    • 10–100 mg per analytical batch, with concentration chosen depending on calibration curve slope and detector sensitivity

    Downstream process integration

    • Weighing and dissolution during gravimetric preparation for calibration vials or spiked sample matrices
    • Integrated as an analytical control for purity or by-product quantitation

    Final product types

    • Certified reference standards for assay calibration
    • Analytical blends for system suitability and regulatory method development
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    Certification & Compliance
    More Introduction

    Benzylaminoacetic Acid Hydrochloride: Practical Insights From the Manufacturer’s Floor

    Clarity From the Reactor—Why Benzylaminoacetic Acid Hydrochloride Matters

    Benzylaminoacetic Acid Hydrochloride does not show up in conversation outside chemical circles, but on the production line, its profile cannot be ignored. Every day, we see the expectations that come from research teams and process engineers. The pressure to deliver authentic, pure, and timely material has changed the way we operate over the years. On the manufacturing side, just-in-time batch control and decades worth of practical tweaks allow us to offer a product with real-world reliability.

    In our facility, Benzylaminoacetic Acid Hydrochloride goes through purification stages that we have adjusted to meet shifting expectations in the life sciences and fine chemicals industries. What sets this compound apart is its clean profile, strong shelf stability, and manageable physical handling. Technicians appreciate the fact that the granules pour smoothly, with little dust, and do not require sophisticated containment. This alone saves hours in clean-up and reduces the risk for teams working next to the reactors or in packaging areas.

    The Substance and Its Shape—Getting the Model and Specs Right

    From our vantage point, we usually handle Benzylaminoacetic Acid Hydrochloride in quantities that range from laboratory-scale bottles to larger multi-kilogram fiber drums. The model we ship most often, Model BZG-193, is the result of consistent small tweaks to synthesis and refinement, not arbitrary branding. Every model iteration in our book means someone has found a way to improve filtration or reduce trace byproducts below inspection thresholds.

    We provide materials with clear assay values and minimal moisture content, typically below 0.3% by weight. Free-flowing, white crystalline powder is the physical form most requested. Teams trust our lot-level documentation because each step in production is tied to batch-level sample checks—not just spot testing for marketing reports. IR and NMR analyses are standard parts of our outgoing QA. We do not cut corners, since the success of downstream syntheses often depends on absence of unknown impurities.

    Real-World Applications From the Factory Floor

    Customers turn to Benzylaminoacetic Acid Hydrochloride for its dependable performance as a building block in pharmaceuticals and as a versatile intermediate in research pilot plants. Academic chemists value straightforward reactivity in nucleophilic substitution and amide coupling; our laboratory partners report less residue and fewer cleanup headaches compared to some alternative compounds. Peptide chemists mention the clear advantages during coupling stages, where purity levels can spare them costly chromatographic separations. Several major projects in our history have highlighted this: production runs that started with us set smooth, reliable syntheses downstream.

    On the production side, there is no patience for compounds that do not dissolve properly or introduce unexpected colors and odors. Benzylaminoacetic Acid Hydrochloride brings a reassuring dull whiteness and an expected scent profile. These seem like small matters, but on large scales, deviations spark entire investigations and can shut down shifts. Years of collaboration with researchers and QC staff on both sides ensure our process filters out the causes of most in-process surprises. At no point do we lose track of what the next user needs at their bench or reactor.

    The Difference—Understanding Nuances Beyond Labels

    Requests sometimes come in for similar-sounding compounds, and mistakes here can stall weeks of research. Benzylaminoacetic Acid Hydrochloride stands apart from unmodified Benzylaminoacetic Acid by offering enhanced solubility in standard polar solvents, a property which saves time during both preparation and clean-up. Compared to the free acid version, the hydrochloride salt keeps the amine group stabilized, making it easier for process teams to weigh out precise quantities without uncontrolled clumping or airborne loss. This kind of hands-on advantage never appears in generic datasheets.

    Other compounds often sold for similar uses bring troublesome byproducts or call for more severe storage conditions. Years back, we fielded complaints from clients using non-hydrochloride intermediates that picked up environmental moisture or oxidized under storage, eventually spoiling whole reaction sequences. By contrast, the hydrochloride salt gives predictable, stable handling even in ambient warehouse conditions. It means fewer insurance headaches and less loss due to shelf-life surprises. Every kilogram we ship reflects a relationship with end users who have explained these real field requirements.

    Supporting Claims With Evidence—What Our Records Show

    Manufacturing lines generate data that lives far beyond standard paperwork. We track every batch for pH, residual solvent content, and melting point. Over the past decade, process revisions and customer feedback cycles have allowed us to keep impurity profiles tight. Regular proficiency tests against commercial benchmarks have revealed low deviation between nominal and measured assay results, something that research chemists have reported as a differentiator between smooth and failed scale-ups.

    One international partner, running a complex multi-step synthesis, reported eliminating nearly eight labor-hours per batch compared to prior runs using a generic acid. The difference: consistent grind size and moisture control. They transferred the output straight to their next step, skipping corrective drying and crushing. These are tangible gains, and they explain why end-users return for the same model even after trialing “shelf equivalents” from competitors. Quality differences often only emerge after repeated, practical use over months–something we have documented in user feedback and in our own plant audits.

    Challenges and Real Solutions: Stories From Production

    Scaling up Benzylaminoacetic Acid Hydrochloride is not a simple task. In the early years, during efforts to push capacity, we occasionally fielded complaints about batch heterogeneity and clumping—problems that might sound minor but can disrupt weighing and metering equipment across production lines. Learning from these field reports, we introduced more precise drying protocols and direct customer consultation before new packaging forms. Because practical feedback matters, we adjusted sieve mesh standards and replaced some warehouse storage containers that had been slowing down transfer times. Every step is traceable and grounded in solving actual factory and laboratory headaches.

    During transport, the hydrochloride salt resists degradation better than the free acid form. Several shipments to humid regions have arrived unchanged, sparing users extra pre-treatment steps. Years ago, we lost a batch due to a packaging failure en route to a coastal area, which could have compromised an entire phase of the customer’s project. Instead of treating this as a one-off, we revamped our lining materials and worked with suppliers who can stand behind humidity resistance claims with batch-level QA. Relationships on the purchasing end begin and end with such quiet technical victories—not generic slogans.

    Some clients request granular or milled forms for automated production, while research environments often prefer fine powders for dissolution. Instead of offering one-size-fits-all deliveries or ignoring hands-on habits, we keep communication open with users. This flexibility comes from an actual understanding of what different usage environments demand, not just chasing another line on a brochure.

    Industry Standards and Our Daily Vigilance

    Quality only comes with routine vigilance—not just following broad regulations, but with learning from operator inspection and real-world mistakes. We maintain logs for each reaction vessel, noting conditions and deviations so we can adjust the next run even when the process outline reads “identical.” No system is flawless, and every so often, a lot raises a flag. This is why we believe in releasing only after we have matched results from multiple analytic passes: HPLC, FTIR, and even visual checks from experienced technicians with decades in the field. Documentation is more than a formality; it is about accountability to downstream chemists and engineers.

    Over the years, inspection standards have become more intense, both because of increasing regulatory scrutiny and more exacting requirements from our pharmaceutical partners. Auditors do not stop at paper records—they want to see and test onsite storage, operator logs, and batch traceability systems. Meeting these demands has made us build a production and QA culture based on transparency and direct operator involvement. If something could compromise end-use reliability, we want to know before it ships.

    Comparisons With Similar Products—What Users Report Back

    Our direct competitors sometimes promote lower-cost or “off-grade” material that comes from process side-streams. Over time, research labs and manufacturers bring us reports about side reactions, erratic yields, and inconsistent melting points. We believe in keeping supply consistent, because investing time to build a process around a trusted intermediate like Benzylaminoacetic Acid Hydrochloride means users expect the same chemistry every time.

    Our hydrochloride salt reveals a stability in standard polar solvents that generic benzylamino acids won’t match. We have received lab journals showing improved reaction rates and final product purification with our material as the core intermediate, based on routine user feedback. Clients are not shy about sharing failures, and we treat deviation reports as opportunities to reinforce process controls rather than excuses.

    Practical Considerations—The View From Warehouse and Lab

    Storage and handling demands shape product choice just as much as chemical performance. With this hydrochloride, inventory managers appreciate the reduced risk of caking in large batches. Mixing teams avoid “sticking” issues and get predictable behavior on every shift. Technicians in analytical departments consistently report high recovery rates and minimal sample loss, freeing up instruments and speeding up routine workflows. Experience has shown us that shaving off a minute or two per prep can add up to full hours of labor saved at scale.

    Transporting the hydrochloride version reduces risks linked to moisture absorption—a lesson learned after years of fielding logistics mishaps. Five years ago, an accidental exposure to high humidity during rail transport showed us that packaging is not just a “box and label” consideration. We invested in lined fiber drums and extra-sealed bags, and the returns showed up within months: zero clumping, zero lot rejection on arrival, and a smooth transfer into our clients’ workflow.

    Direct User Experience—In Their Own Words

    Clients report that Benzylaminoacetic Acid Hydrochloride brings less contamination to peptide synthesis, saving time on post-reaction purification. Academic researchers who order from us value reliable melting point and assay verification, because it saves guesswork on their own end. Production chemists repeatedly note that the physical handling properties allow for a faster charge-in to reactors, reducing batch setup time. The feedback reflects our internal records: repeat orders and requests for larger quantities come from users facing time and cost pressures who simply need what works.

    All of this matters upstream and down. Secondary users who source intermediates from larger pharmaceutical companies have shared their own feedback on improved batch reproducibility since switching to our hydrochloride salt. It does not take large technical reports to see the returns—simple comments about better color, less residue, and steadier yields prove the value in the field.

    Focusing on Fundamentals—What It Takes to Deliver

    Our production crew knows that every kilogram produced is a commitment. Operators stay ahead of raw material fluctuations and environmental changes through careful scheduling and line maintenance. Shifts rarely end without rounds of manual inspection and inline sampling. Customer service does not read from call-center scripts, because everyone here has direct experience with the technical and scheduling issues that manufacturing throws our way. Problems, suggestions, and even complaints reach our technical director within hours, not days.

    Every effort goes toward making sure that Benzylaminoacetic Acid Hydrochloride leaves our plant ready for real-world duty. That means reliable chemistry, consistent appearance, and properties tailored by incremental real-world improvements. Our customers do not just “order” the product—they expect continuity, reliability, and readiness to collaborate on further tweaks when their uses evolve or new requirements surface.

    Future Directions and the Role of Manufacturer Experience

    No intermediate remains static. Demand for higher standards does not let up, especially as new downstream applications emerge in both classic synthesis and fresh biotech protocols. Staying ahead means monitoring changes in raw materials, developing new analytic methods, and never shying away from feedback. Our plant does not operate on autopilot; every month brings adjustments based on users’ changing priorities—be it finer powder form, purer lots, or premeasured, batch-specific packaging.

    We keep a foot planted in the lab, always ready to consult with partners on new requirements or process changes. This offers the flexibility needed for projects moving from bench scale to full production. Every year, we adjust our protocols, rethink parts of the process, and keep data streams open, so that if a new batch falls short of the mark, changes follow before the next delivery goes out. No manufacturer can claim perfection, but a record built upon real-world usage speaks louder than product claims alone.

    Why We Stand Behind Benzylaminoacetic Acid Hydrochloride

    From raw material intake to the final QC stamp, our whole plant and staff have grown alongside user needs for this singular compound. We keep commitment at the center—learning, adapting, and delivering Benzylaminoacetic Acid Hydrochloride not as a commodity, but as a reliable partner in research and in manufacturing. Every improvement, from handling properties to packaging quality, has sprung directly from working with—and learning from—the day-to-day realities and challenges of our own production teams and our collaborators.