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Benzyl 2-Chloroacetate

    • Product Name Benzyl 2-Chloroacetate
    • Alias Benzyl chloroacetate
    • Einecs EINECS 209-529-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    637372

    Cas Number 1765-34-0
    Molecular Formula C9H9ClO2
    Molecular Weight 184.62 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 282-284°C
    Melting Point -5°C
    Density 1.199 g/cm³ at 25°C
    Refractive Index 1.544
    Purity Typically ≥98%
    Solubility Insoluble in water; soluble in organic solvents
    Odor Faint aromatic odor
    Flash Point 129°C
    Smiles ClCC(=O)OCC1=CC=CC=C1
    Storage Temperature Store at room temperature, tightly sealed

    As an accredited Benzyl 2-Chloroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Benzyl 2-Chloroacetate is packaged in a 500 mL amber glass bottle with a screw cap, labeled with hazard warnings.
    Shipping Benzyl 2-Chloroacetate should be shipped in tightly sealed chemical-resistant containers, protected from moisture and incompatible substances. Transport according to local, national, and international regulations for hazardous chemicals. Clearly label the package, ensure upright positioning, and include appropriate hazard warnings. Handle with care to prevent leakage or accidental exposure during transit.
    Storage Benzyl 2-Chloroacetate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and sources of ignition. Keep it away from incompatible materials such as strong bases, strong oxidizers, and acids. Store at room temperature, and handle using proper protective equipment to prevent inhalation, skin, or eye contact.
    Application of Benzyl 2-Chloroacetate

    Applications of Benzyl 2-Chloroacetate in Industrial Manufacturing

    Benzyl 2-Chloroacetate, produced in our dedicated synthesis lines, serves as a critical intermediate for multiple high-value industrial sectors. The following application sections provide detailed process insights, compliance frameworks, and technical data reflecting current downstream deployment across specialty chemicals, advanced materials, and pharmaceutical manufacturing.

    1. Pharmaceutical Intermediate Synthesis

    Our material finds extensive application as a core-building block within pharmaceutical synthesis pathways, particularly where selective esterification reactions are required in the preparation of cephalosporin side chains and other beta-lactam derivatives. Its purity profile and controlled reactivity support consistent yields in industrial pharmaceutical production, supporting both pilot and commercial batch operations.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF General Chapters relevant to starting materials
    • European Pharmacopoeia Substance Monographs (applicable to APIs starting materials)

    Typical usage ratio

    • Introduced at 0.5–2.0 molar equivalents relative to the core amine substrate, with adjustments based on target molecule and reaction scale

    Downstream process integration

    • Charged during the controlled acylation step under anhydrous conditions post-amine activation, followed by purification through crystallization or liquid–liquid extraction prior to subsequent synthetic transformation

    Final product types

    • Semi-synthetic cephalosporin antibiotics (e.g., cefotaxime, cefuroxime intermediates)
    • Advanced pharmaceutical synthetic intermediates
    • Amidated side-chains for peptide and beta-lactam APIs

    2. Agrochemical Active Ingredient Synthesis

    Downstream agrochemical manufacturers utilize our material as a selective alkylating agent during the assembly of complex ester functionalities found in several crop protection molecules. The defined chloroacetate group enables precise molecular architecture for families of selective herbicides and insecticides, supporting consistent field efficacy and regulatory registration compliance.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 certified production environments
    • REACH registration for agricultural intermediates (EC No. 202-309-0 where applicable)

    Typical usage ratio

    • Applied at 1.1–1.5 molar equivalents relative to base phenol or alcohol nucleus during downstream synthesis, with fine-tuning for target purity and minimization of byproducts

    Downstream process integration

    • Integrated at the esterification stage following initial ring functionalization, typically under phase-transfer conditions or in the presence of mild base

    Final product types

    • Selective herbicide intermediates (e.g., chloroacetanilide derivatives)
    • Industrial-grade insecticide precursors
    • Fungicide raw material ester groups

    3. Fragrance and Aroma Ester Manufacturing

    Producers of specialty fragrance esters incorporate our product in the controlled synthesis of benzyl-based aroma compounds, where its performance allows for the introduction of unique olfactory notes through carefully managed transesterification and esterification reactions. Our technical grade ensures a high yield of pure aroma esters with consistent sensory profiles, supporting large-batch production in regulated perfumery environments.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and guidelines
    • Cosmetic Ingredient Review (CIR) Safety Assessments for fragrance raw materials
    • ISO 9001:2015 for Fragrance Ingredients

    Typical usage ratio

    • Standard addition at 0.8–1.5 molar ratio relative to alcohol substrates, adjusted to optimize sensory yield and process economy

    Downstream process integration

    • Introduced during batch or continuous esterification reactions, typically in the presence of acid or enzymatic catalysts, followed by direct distillation of the volatile ester

    Final product types

    • Benzyl ester aroma compounds
    • Fine fragrance ingredients for perfumery and cosmetics
    • Flavoring agent precursors used in specialty food industry (subject to food-grade batch validation)

    4. Specialty Polymer Modification and Additive Manufacture

    Polymer and plastics producers employ our product in the functionalization of specialty resins and plasticizers, leveraging its chloroacetate moiety to introduce polar groups and improve compatibility between polymer phases. Controlled grafting reactions use its reactivity to modify backbone properties for customizable tensile and chemical resistance, meeting advanced electronics, membrane, or adhesive formulation specifications.

    Industry compliance standards

    • ISO 9001:2015 for Additive and Polymer Raw Materials
    • FDA 21 CFR 177 (where limited food contact is involved in downstream polymer)
    • RoHS Compliant (when required for electronics-grade plastics)

    Typical usage ratio

    • Generally incorporated at 0.1–0.5% w/w in the polymer matrix, with formulation scientists optimizing based on desired mechanical and chemical properties

    Downstream process integration

    • Metered into extrusion or suspension polymerization or used in solution grafting as a functional co-monomer, with subsequent cure or cross-linking as required

    Final product types

    • Modified acrylic resins for specialty coatings
    • Functionalized film and membrane materials
    • Adhesive intermediate resins with enhanced substrate bonding

    5. Fine Chemical Synthesis for Photographic Chemicals

    Within the production of fine chemicals for the photographic and imaging sector, our material serves as a key intermediate for the preparation of specialty esters and reagents. These substances must meet stringent purity and stability requirements to function as coupling agents and light-sensitive material precursors in silver halide imaging and related chemistries.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management (for silver halide chemical manufacturing)
    • ISO 9001:2015 for Specialty Fine Chemicals
    • Specific imaging chemical purity protocols (as per downstream OEM requirements)

    Typical usage ratio

    • Applied at 0.6–1.3 equivalents in ester–etherification steps, modulated for trace impurity control and downstream photo-reactivity

    Downstream process integration

    • Blended during the synthesis of coupling agents at the key esterification stage, followed by purification and formulation into dry or liquid photo-chemical packs

    Final product types

    • Color coupler intermediates for photographic emulsions
    • Light-sensitive additive components for films and plates
    • Photographic reagent packs for lab and industrial imaging applications
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    Certification & Compliance
    More Introduction

    Benzyl 2-Chloroacetate: Quality, Practical Application, and Value for Chemicals Manufacturing

    The Real Story Behind Benzyl 2-Chloroacetate

    Drawing from years of hands-on chemical manufacturing, Benzyl 2-Chloroacetate—a molecule carrying a benzyl group bonded to a chloroacetate—has positioned itself as a reliable workhorse in modern synthesis lines. Our team produces this compound using tightly controlled chlorination routes, guided by consistent quality controls at every stage. Each batch reflects not just world benchmark expectations, but the kind of chemical consistency that underpins years of smooth, reliable operation in real production plants.

    Producers, especially pharmaceutical and agrochemical companies, attach great importance to both the purity and predictability of intermediates. In our experience, even minor variations in raw material quality can create costly bottlenecks. Subtle deviations affect downstream yields or create extra waste removal headaches. We have narrowed impurities and optimized our process to reduce undesirable side-products to trace or non-detectable levels. Typical runs offer high assay—routinely above 99.0%—giving your lab or plant the confidence to scale without fearing unexpected rework or failed batches.

    Molecular Details and Batch Specifications

    This product, Benzyl 2-Chloroacetate, has the molecular formula C9H9ClO2 and a molecular weight of 184.62. It appears as a pale yellowish to clear liquid. Our technicians pay close attention at every crystallization or distillation sequence. Small adjustments on process temperature, pressure, and raw material input often spell the difference between a high-yield batch and a troublesome one. Many operators struggle with batch-to-batch variability, but extended process monitoring and real-time sampling in our facility keep composition within tight bounds. We routinely see minimal moisture content, residual solvents far below regulatory triggers, and long-term shelf stability under recommended storage.

    Packaging often plays a neglected role in reliability. Chemical content can break down, or trace moisture and oxygen can degrade a product unnoticed in storage. Our choice of tightly sealed, chemical-resistant drums reduces these risks. We have learned from customer feedback to tailor bottle and drum sizes not to marketing whim but to match what production teams frequently bring onto the shop floor. Improper sizing and ill-chosen packaging increase cost, so we stick to what works.

    Application in Custom Synthesis and Scale-Up

    Major application sectors like pharmaceutical actives, agricultural intermediates, and specialty polymers use Benzyl 2-Chloroacetate as a customizable building block. Its structure combines both ester and alkyl chloride groups, tuning it for a variety of transformations. Chemists regularly turn to this compound for nucleophilic substitutions, esterification, and as a precursor for more complex synthesis. A strong, reliable supply enables both pilot and plant-scale runs, facilitating swift prototype-to-scaleup transitions.

    One common use involves acting as an intermediate in making benzyl-protected compounds. The benzyl group helps stabilize molecules while allowing selective reactions at the chloro group. In hands-on work, we have seen research groups unlock otherwise tricky transformations using this compound as an entry point for downstream modifications—demonstrating the versatility built into each batch.

    Comparing with Standard Chloroacetates and Other Chlorinated Esters

    Operators sometimes ask: why not use a simpler chloroacetate or generic alkyl chloroester? Our process managers have dealt with these comparisons directly. Benzyl 2-Chloroacetate delivers a unique mix of reactivity and handling properties absent in simpler analogs such as methyl or ethyl chloroacetate. Presence of the benzyl group introduces new pathways for selective protection and deprotection, which can simplify what would otherwise involve multiple reaction steps.

    Bench chemists have told us that they notice fewer side-chain reactions and degradation products where Benzyl 2-Chloroacetate is used, compared with less hindered alkyl chloroacetates. Its slight steric bulk and electronic effects often result in cleaner conversions without excessive byproduct loads. Laboratory analysts report easier chromatographic purification, so final run times and solvent volumes come down, driving process efficiency.

    We have encountered projects where excessive volatility or poor stability creates expensive product losses with simple methyl or ethyl versions. Benzyl 2-Chloroacetate’s higher molecular weight brings better thermal stability and makes handling under standard lab and plant conditions much more manageable. Reduced vapor loss lowers occupational risk and helps our customers meet workplace exposure controls. Larger projects benefit enormously by choosing the right intermediate, as the cost of disposal or off-spec product rises with scale.

    Safety, Quality, and Repeatability in Practice

    Chemical handlers—whether in the pilot plant or loading dock—deal daily with the practical aspects of product quality. Each drum shipped undergoes systematic documentation, retention sampling, and routine retesting in our own QA laboratories. These are not marketing claims, but direct results of seeing what works across hundreds of production campaigns. In our experience, imports of poorly packaged or handled Benzyl 2-Chloroacetate sometimes arrive with dissolved impurities or separated layers, causing both delay and disposal hassles. Our shipments reflect a history of listening to customer pain points and resolving them through hands-on protocol improvement.

    Safety training remains vital at every level. We have developed routine but thorough checklists—grounded in years of incident tracking and review—covering everything from proper valve operation to secondary containment. Our plant operators and repackaging teams lean on these tools to minimize incidents and reassure downstream customers about supply chain integrity. Long-term clients testify that consistent supply and documentation have kept their own safety audits trouble-free.

    Process parameters have evolved as customers add new applications or regulatory requirements shift. Each specification revision draws upon real project data. Environmental and workplace standards, particularly for residual chlorinated organics or volatile organic compounds, raise legitimate concerns. We work directly with technical and regulatory teams to keep delivered product inside the latest compliance frameworks. This effort includes updating material certifications and sharing best-handling guides drawn from lessons learned in actual production campaigns.

    Shelf life and stability bear special mention. Benzyl 2-Chloroacetate responds to light, heat, and atmospheric oxygen, so storage protocols have been refined by trial and error. Technicians have seen first-hand how failing to control these variables leads to color changes, precipitation, or even pressure buildup inside containers. In response, we maintain strict warehouse handling rules—inventory turns, container quality, darkness, and temperature regulation all contribute to the trusted reputation batch after batch.

    Supporting Innovation in Pharmaceutical and Agrochemical Synthesis

    Many early-stage pharmaceutical campaigns require flexible intermediates able to pivot as research directions change. Benzyl 2-Chloroacetate, with its dual reactivity, offers a launch pad for synthetic exploration. Process development chemists regularly test new analogs or side-chain attachments. Our technical support team and application chemists work closely with customers to adjust and optimize reaction feeds, ensuring predictable outcomes. Based on in-the-field feedback, custom blends or additives help users solve specific pain points such as unwanted polymerization, trace water sensitivity, and reaction time variability.

    Within agricultural R&D, the desire for fast-moving, cost-sensitive intermediates drives demand. Several active ingredients and safeners rely on this compound for phase-selective protection or for introducing stable linkers. We have refined both small and large-batch logistics, enabling even remote or just-in-time projects to run without storehouse backlogs or delays. Project partners routinely ask for supporting spectra, batch release profiles, or side-by-side trials with other esters; we keep these detailed technical records, so teams always have the information required without unnecessary delay.

    Long-Term Partnership and Continuous Process Improvement

    Having dealt with both startups and established producers, we recognize that today’s needs rarely stand still. Scale-up programs often move surprisingly quickly—sometimes within weeks of an initial request. In serving these teams, we maintain reserve capacity for short-notice orders and carry robust raw material reserves. If a customer’s formulation changes, turnaround time matters and any disruption hits the bottom line directly. Thanks to years of process mapping and fail-safes, we can respond to spikes in demand, emergent projects, or last-minute technical changes smoothly.

    Continuous improvement defines every stage of our process. Operators, lab chemists, and managers all provide input on how to improve each production step, guided by both customer feedback and lessons drawn from unexpected issues. These improvements, whether in solvent recycling, distillation protocols, or process automation, reduce internal waste, minimize rework, and lower per-batch variability. Each new solution gets tested and rolled out only after seeing direct results across multiple pilot and manufacturing campaigns.

    Where upstream supply chains shift, we act to protect delivery timelines. Working directly with vetted suppliers of raw materials, our team conducts regular plant audits, so nothing gets lost in translation. This kind of attention prevents unpleasant surprises or costly delays at your end. We combine technical trust with old-fashioned attention to detail, ensuring the chemical you order works as expected year after year.

    Supporting Documentation, Traceability, and Customer Assurance

    In today’s regulatory climate, traceability remains essential—not just for compliance, but for operational safety and product integrity. Each barrel or drum carries a production lot code linked to comprehensive QA data, spectral records, and chain-of-custody details. Our documentation process didn’t emerge overnight; it grew out of years testing and re-testing what documentation actually helps resolve customer questions and regulatory checks.

    Competing imports, especially of variable or unstandardized material, have led customers our way after failed regulatory audits or problematic process runs. The ability to provide reliable, batch-linked supporting documentation offers real protection—especially as production volumes rise or client end-use evolves. We have helped troubleshoot numerous impurity profiles, even years after initial delivery, by digging into archived documentation covering each production run.

    Routine shipment includes not just printed certificates but digital versions for plant system uploads. Some clients have even asked for structured data feeds to streamline their internal inventory and compliance logging. These flexible options are a direct response to changing user needs and the evolving demands of the industry.

    A Practical Approach to Collaboration and Long-Term Value

    At our core, we believe chemical production goes beyond simple order fulfillment. Long-term users in the pharmaceutical and agrochemical sectors know how critical a stable, predictable supply of high-quality intermediates remains for their bottom line. Every gram of Benzyl 2-Chloroacetate passing through our lines carries both the experience of years running high-precision batch chemistry and the lessons learned in supporting partners facing urgent, high-stakes project deadlines.

    We understand the cost of plant downtime and the frustration that comes from off-spec delivery. By investing in every detail—from raw material sourcing to customer documentation and technical support—our operations create both reliable supply and ongoing process improvement. The process doesn’t stop at the warehouse loading dock. Whether responding to scheduled scale-up, supporting new regulatory filings, or troubleshooting application issues alongside client R&D teams, our entire approach reflects a partnership built on technical trust and practical, real-world solutions.

    Benzyl 2-Chloroacetate brings more than reactive sites and a molecular formula—it offers a level of certainty essential for successful modern production. Technical difference shows up not just in quality benchmarks, but in every production run that meets specification, keeps projects moving, and supports both seasoned specialists and new teams alike. As manufacturers who have stood by this compound through evolving trends and shifting challenges, we remain focused on delivering what counts: chemical integrity, customer readiness, and long-term value you can see in every drum.