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Benzophenone Oxime

    • Product Name Benzophenone Oxime
    • Alias Diphenylketoxime
    • Einecs 249-056-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    561236

    Cas Number 574-66-3
    Iupac Name N-hydroxybenzophenone imine
    Molecular Formula C13H11NO
    Molecular Weight 197.24 g/mol
    Appearance White to pale yellow crystalline powder
    Melting Point 137-140°C
    Solubility Slightly soluble in water; soluble in ethanol, ether, and chloroform
    Boiling Point 376.6°C at 760 mmHg
    Density 1.18 g/cm³
    Synonyms Diphenylketoxime, Benzophenone monoxime
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry, well-ventilated area away from incompatible substances

    As an accredited Benzophenone Oxime factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Benzophenone Oxime is securely packaged in a 500g amber glass bottle with a tightly sealed cap, labeled with hazard information.
    Shipping Benzophenone Oxime should be shipped in tightly sealed containers, protected from moisture, light, and incompatible substances. Store and transport in a cool, dry place, following local regulations. Use appropriate labeling and cushioning to prevent leaks and breakage. Handle with care, and ensure documentation complies with hazardous chemical shipping standards.
    Storage Benzophenone Oxime should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing agents. Keep the container tightly closed and protected from moisture and direct sunlight. Store in a chemical storage cabinet, following standard laboratory practices and safety guidelines to prevent contamination and accidental exposure.
    Application of Benzophenone Oxime

    Applications of Benzophenone Oxime in Industrial Manufacturing

    Benzophenone Oxime serves as a critical process aid and intermediate across specialized fields of industrial manufacturing. Our factory produces high-purity Benzophenone Oxime, enabling precise formulation and structural modification in demanding downstream environments. The following sections describe principal application areas, practical integration points, relevant compliance standards, and typical formulation ratios based on direct industrial practice and our customer portfolio.

    1. Caprolactam Synthesis for Nylon 6 Production

    Major polyamide manufacturers employ Benzophenone Oxime as a selective oximation reagent in the Beckmann rearrangement route to caprolactam, the essential monomer for Nylon 6. Consistency in reagent specification and lot traceability ensure product safety, meeting regulatory and customer requirements for both bulk and specialty polyamide grades. This application requires high batch-to-batch purity and low water content to maintain downstream process efficiency in continuous and batch cyclohexanone oxime lines.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH (EC) No 1907/2006 Substance Registration and Evaluation
    • GB/T 31210.1-2014 (Chinese Nylon 6 Technical Standard)
    • FDA CFR 21 Part 177.1500 (Polyamide Polymers, for food contact applications)

    Typical usage ratio

    • Oxime to cyclohexanone molar ratio: 1.02–1.05:1, adjusted to ensure full conversion and purity for subsequent rearrangement
    • Ratio may vary ±3% based on moisture level and targeted purity in caprolactam

    Downstream process integration

    • Benzophenone Oxime enters after pre-oxidation of cyclohexanone, forming cyclohexanone oxime by acid catalysis or using hydroxylamine intermediates
    • Fully dissolved in reaction medium before heating and acid rearrangement to caprolactam
    • QC sampling for residual oxime pre-hydrolysis and impurity monitoring before polymerization

    Final product types

    • Caprolactam monomer (liquid or crystalline)
    • Polyamide 6 (Nylon 6) resin pellets
    • Textile grade and engineering grade Nylon 6 fiber or film
    • High-purity caprolactam for electronics and automotive polymer chain extension

    2. UV Curing Resin Photoinitiator Intermediate

    Specialty chemical processors utilize Benzophenone Oxime to synthesize benzophenone-based photoinitiators for UV curing inks, adhesives, and coatings. Its precise reactivity supports functional group modification in high-purity monomer and oligomer intermediates used in photopolymerization systems. Full compliance with downstream resin and ink global food packaging and toy safety directives is critical for this application to control residuals and migration.

    Industry compliance standards

    • EU Regulation (EC) No 2023/2006 (Good Manufacturing Practice for Materials Intended to Come into Contact with Food)
    • EN 71-3 (Safety of Toys: Migration of Certain Elements)
    • ISO 14001:2015 (Environmental Management Certification for chemical synthesis)
    • Swiss Ordinance on Materials and Articles in Contact with Food (SR 817.023.21 Annex 10)

    Typical usage ratio

    • 0.8–2.0 wt% as an intermediate versus acrylate or methacrylate monomer weight (adjusted to targeted photoinitiator synthesized)
    • Final benzophenone photoinitiator inclusion: typically 1–5 wt% in resin application formulas

    Downstream process integration

    • Benzophenone Oxime reacts with halogenated or alkylated benzenes in closed reactor trains to form functionalized photoinitiators through condensation and reduction sequences
    • Full removal of unreacted raw material by solvent extraction or distillation pre-final purification
    • Final photoinitiator purification performed under nitrogen or inert gas to control oxidation

    Final product types

    • Photoinitiator resins for UV-curable inks and clearcoats
    • Energy-cured adhesives for packaging and laminate industries
    • UV curing varnishes for food and graphic substrates
    • Acrylate reactive oligomers and additives for 3D printing systems

    3. Analytical Grade Reference Standard in Pharmaceutical Synthesis

    Leading pharmaceutical companies employ Benzophenone Oxime as a traceable analytical standard and specialty reactant for structural identification, process monitoring, and impurity profiling. Laboratories require ultra-pure oxime as a calibration reference and derivatizing agent to detect related substances in synthetic active pharmaceutical ingredient (API) routes, ensuring compliance with pharmacopoeial monographs and GMP guidelines.

    Industry compliance standards

    • Ph. Eur. (European Pharmacopoeia 11.0)
    • USP-NF (United States Pharmacopeia and National Formulary)
    • Chinese Pharmacopoeia 2020 Edition
    • ICH Q7 (Good Manufacturing Practice for APIs)

    Typical usage ratio

    • 0.01–0.5 wt% in analytical HPLC or GC sample preparation, according to validated method protocols
    • Reactant quantities for API impurity synthesis: 1–2 molar equivalents versus targeted pharmaceutical intermediate

    Downstream process integration

    • Acts as a derivatization agent during sample preparation for chromatographic trace analysis
    • Integrated in small-molecule synthesis steps for reference impurity or metabolite generation
    • Stored, weighed, and handled in ISO 17025-compliant laboratory workflows under controlled humidity

    Final product types

    • Pharmaceutical research reference standards
    • Matched impurity markers for API impurity profiling
    • Synthesized metabolites and related substances for oral and injectable APIs
    • High-precision chromatographic calibration kits

    4. Polymer Additive Synthesis for High-Performance Engineering Plastics

    Global plastics compounders use Benzophenone Oxime as a raw material for the design and scale-up of UV-absorbing and anti-yellowing stabilizers. This application demands stringent process control and documentation for regulatory compliance, especially in the automotive, electronics, and packaging segments. Blending Benzophenone Oxime-derived additives into targeted polymer matrices enables downstream processors to formulate custom compounds for lightfastness and weathering resistance.

    Industry compliance standards

    • UL 94 (Standard for Safety of Flammability of Plastic Materials)
    • RoHS (Restriction of Hazardous Substances Directive 2011/65/EU)
    • ISO 4892-2 (Plastics – Methods of Exposure to Laboratory Light Sources)
    • Automotive OEM OEM-Specific Material Standards (e.g., Volkswagen TL 527, GM GMW 16352)

    Typical usage ratio

    • Precursor to additive loading: 0.5–3.5 wt% versus resin weight depending on targeted UV stability and application thickness
    • Final masterbatch: 1–10 wt% additive concentrate, diluted during plastic compounding stages

    Downstream process integration

    • Benzophenone Oxime enters as an upstream reactant in the synthesis of UV absorber intermediates, then masterbatchers blend these additives into polymer melts through twin-screw or single-screw extrusion
    • Control of additive distribution and homogeneity by in-line QC sampling
    • Regulatory batch traceability maintained from precursor to compound

    Final product types

    • Automotive exterior and interior trim parts
    • Weather-resistant films and sheets for construction and agriculture
    • Electronics housings and device enclosures
    • Transparent and tinted packaging with extended color stability

    5. Metal Extraction and Separation in Hydrometallurgy

    Nonferrous metallurgy operations implement Benzophenone Oxime as a selective chelating agent for the extraction and separation of copper and other transition metals from complex ores and process effluents. Plant operators rely on this reagent for circuit optimization based on ore composition and regulatory wastewater discharge standards. Application consistency and minimized degradation of the extractant are critical for both economic and environmental performance in solvent extraction (SX) plants.

    Industry compliance standards

    • ISO 14001:2015 (Environmental Management in Mining and Metallurgy)
    • IFC Environmental, Health, and Safety Guidelines for Mining
    • ASTM D1688-17 (Standard Test Methods for Copper in Water)
    • PRC “Integrated Wastewater Discharge Standard” GB8978-1996

    Typical usage ratio

    • Organic phase concentration: 1–10% wt/vol in kerosene or aliphatic solvent, adjusted to ore type and plant flow rate
    • Ratio altered seasonally and by plant-specific recovery rate targets

    Downstream process integration

    • Added to organic extraction circuit in counter-current SX plants for copper transfer from aqueous PLS (pregnant leach solution) streams
    • Cycled through loaded and stripped organic phases, with make-up dosing for reagent loss compensation
    • Continuous performance monitoring for extractant degradation and recovery yield

    Final product types

    • Electrolytic copper cathodes
    • Purified copper sulfate and copper oxide products
    • Other separated base metals dependent on ore matrix (e.g., nickel, cobalt concentrates)
    • Environmentally compliant process effluents and refined wastewater
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    Certification & Compliance
    More Introduction

    Benzophenone Oxime: Direct from the Source

    Benzophenone Oxime stands as a time-tested intermediate in our daily production lines. Over the decades, we’ve learned that the real value of this compound isn’t found in its catalog entry — it’s found on the shop floor, in how we make it, and how our clients use it. Our model carries the experience of thousands of tons produced, every batch tracked and sampled, purity confirmed by direct measurement before we ship. Our lot registers typically trace a GC content above 99%, minimizing worries over residual benzophenone or side-reaction artifacts. That detail matters in any facility expecting consistency, whether the end use lands this oxime in an agrochemical process or dyes and pigments synthesis.

    We’ve committed real resources to make sure every drum and bulk tank of Benzophenone Oxime we fill carries not just a product but a piece of predictable reliability. We use only pharmaceutical-grade raw benzophenone and reagent-grade hydroxylamine hydrochloride. Our technicians mind every step during the oximation reaction, managing temperature, pH, and mixing rates with a practiced touch — not just by relying on automated process controls. Any shift operator here will tell you how easy it is for a hot spot or an off-balance addition to introduce unwanted isomers, so our training runs deeper than just SOPs. The granular, powder, or flake form we offer comes from a drying and screening system that limits caking and keeps pourability high, which keeps silo blockages and dosing inconsistencies off our customers’ worries lists.

    Buyers often ask how our Benzophenone Oxime compares with other available intermediates like acetophenone oxime or cyclohexanone oxime. Our experience has shown that Benzophenone Oxime’s aromatic backbone makes it indispensable in the synthesis of certain specialty chemicals, especially where downstream hydrolysis or rearrangement requires high oxidative stability. While cyclohexanone oxime dominates the caprolactam market, the ketone group in benzophenone oxime opens doors to unique polymer applications and advanced pharmaceutical syntheses, notably in pathways that tolerate a more rigid, planar structure. Our R&D teams have worked hand in hand with customers tuning these molecules for high-performance coatings and photographic chemicals, precisely because alternatives don’t meet the needed thermal or chemical resistance.

    Handling Benzophenone Oxime in bulk takes equipment and care. Because this oxime picks up atmospheric moisture without much fuss, our operations rely on real-world process adjustments, not just theoretical water activity charts. Our operators use modified stainless and glass-lined tanks lined with moisture-control indicators. Workers in our plant suit up with the right gloves and goggles without shortcuts, because the powder can irritate on contact. On the shipping end, we pack to minimize clumping and loss, sealing with heat-welded liners, each pallet batch-stamped and logged for in-house and customer traceability. Every step comes from field lessons: we stopped using standard 50 kg fiber drums years ago after learning how easily seals can break down in humid weather — customer feedback drove us to shift packaging and logistics entirely.

    Some clients have asked about making the jump to greener oxime chemistry. Here too, our team has learned there’s no shortcut to optimizing reaction by-products or reducing energy load. Each batch passes through dedicated purification columns, and process water gets treated right in-house. We monitor residual organics in our waste streams with GC-MS, reporting not just to regulatory authorities but to our downstream partners who reuse our spent streams in other batches. Over the years, we have used real data from our own process upsets and downtime audits to help clients troubleshoot downstream quality issues. We’ve found more than once that an increase in residual benzophenone isn’t just a plant problem; it can signal storage temperature drift or leaks in distribution bottling, lessons that inform our shipping guidelines and customer support conversations.

    For end uses, Benzophenone Oxime’s mainstay remains as a chemical intermediate. It's valued by clients producing agricultural compounds, especially those focused on target-specific pesticides, fungicides, and herbicides. Larger multinational formulators rely on the consistency of our batch-to-batch product for reliable yields in final-step transformations. Our years of collaboration with photo-initiator manufacturers and pigment blenders have turned up countless process tweaks, from purification point additions to antistatic coating preferences for powder handling. This kind of day-to-day knowledge isn’t captured in the chemical literature — it's born from hands-on troubleshooting and honest feedback. We share tips openly with partners because a stuck valve or a foamed reactor costs more than any amount of up-front “specification” talk.

    While technical data sheets cite melting points and solubility figures, practical experience trumps numbers on paper. Our technicians note how each shipment tracks against internal logbooks of viscosity, color, and even odor, issues that can flag storage or purity shifts a week before they show on an assay. Some competitors focus on lab-tested lots without upscaling results, but we know drum-level performance proves more valuable to contract blenders and formulation houses. As a mid-sized manufacturer with decades at the same site, we’ve had to solve problems head-on: foaming in slurry reactors, dust management in filling lines, double-checking trace metal content to ward off yellowing in photo-applications, and fixing batch flow inconsistencies before loading.

    One of the most common confusions we address in our technical calls involves the interchangeability of Benzophenone Oxime with variants like benzaldehyde oxime. The chemistry isn’t remotely the same in performance or endpoints. Benzophenone Oxime’s molecular geometry creates a stability that’s key for high-temperature reactions. Users working with complex reaction cascades or photochemical syntheses soon discover alternative oximes lead to unwanted side products and yield losses, once scale-up moves beyond bench volumes. This is especially pronounced in pigment lines, where color stability can sink or swim on trace impurities, and in high-purity photo-initiators, where spectral drift affects entire production runs.

    We see frequent requests for application-specific advice — not so much about official regulatory certification, but on practical needs: shelf life in non-climate-controlled storage, sensitivity to slight thermal pulses, or reactivity with process solvents like toluene, methanol, or acetone. Our technical support group includes long-serving foremen as well as doctoral chemists, so our answers draw from production reality, not just literature or regulatory frameworks. We even share cleaning protocols for reactor changeover to avoid cross-contamination in facilities switching rapidly between oximes, a scenario that’s become much more common as flexible manufacturing gains ground in the specialty chemical industry.

    Industrially, our Benzophenone Oxime outperforms alternate sources due to strict production controls. Every key raw batch gets QC sampling, checked against previous runs for color coordinate shifts and granulation profile. If our control room spots a trend in soft caking or minor color shift, we can intervene early: reformulate drying procedures, re-adjust nitrogen flush rates, or even change agitator blade speeds. Our staff tune these parameters continually based on feedback from both our lines and end user's equipment — this makes for more stable downstream processes, fewer pump outs, and less reprocessing in customer plants.

    We treat compliance not just as a legal formality. Our operation walked inspectors through real storage plans and air emission charts, not just forms. Clients benefit from our embedded process checks: sealed loading bays fitted with air scrubbers, redundant dust collection in oxidizer rooms, real physical audits on PPE and emergency plans. Outbound shipments, tracked digitally, are weigh-tested and cross-checked to avoid shorting downstream mixing steps, something resellers with more transient inventory can struggle to guarantee. The transparency in our process is built to support QA teams at the next stage, so forensic audits find no gaps and no questions left hanging at the critical points.

    Supply chains have grown more unpredictable recently, so we maintain robust in-house reserves. Our product output does not hinge on single-source suppliers. We pre-order raw benzophenone from multiple audited partners and hold buffer stocks on site, a step we absorbed after several years of watching clients scramble through global supply crunches. This hedging prevents downtime not only for our own lines but for those relying on our regular shipment cadence. Lean inventories at the manufacturer level mean more risk for formulators down the chain — but we carry that buffer openly, not offloaded onto distributors with no plant of their own.

    Our experience drives home that Benzophenone Oxime is not a commodity best sourced based on price alone. Short-cuts in manufacturing, lightweight packing, or slipshod drying protocols all surface sooner or later, often after years of so-called smooth supply. We keep process logs open for partners and are up-front about yield losses from each production tweak, because long-term partnerships demand nothing less. Fielding morning calls with factory managers, we walk through shipment conditions, suggest real-time fixes, and follow up on how new lot numbers perform in application — a difference only seen by working on both sides of the production fence.

    Clients working on new applications — especially those chasing regulatory shifts or green chemistry incentives — frequently turn to Benzophenone Oxime’s resilient framework. Our R&D team has worked on catalyst-based reductions for reduced energy load, solvent recovery loops, and minimizing by-product footprint. Each of these improvements stems from the direct experience with scale, waste stream bottlenecks, or client concerns flagged during plant visits. Any claim of sustainable practice must trace back to the source: our water treatment matches local environmental rules, energy balances logged and reported, and post-reaction biomass logged and recirculated.

    Handled right, Benzophenone Oxime forms the backbone of specialty chemical chains from pigments to pharmaceuticals. In every case, value emerges through repeatable, transparent supply — qualities that come from producers with skin in the game, not just names on an invoice. We field technical questions daily, and our approaches stay rooted in shop-floor knowledge. Whether troubleshooting low yield in an agrochemical trial, tracking an odor anomaly in a pigment lot, or supporting an engineer struggling with moisture pickup, our team stands behind what goes into every bag, drum, or tank. The product succeeds not by nature of its CAS number but by what stands behind it: process, people, lessons learned, and effort put in every step of the way.

    Understanding Where Benzophenone Oxime Fits and Why It Matters

    It’s one thing to know chemical properties, quite another to witness daily how a compound shapes downstream business. Benzophenone Oxime feeds into many applications where purity and process behavior decide downstream yield and product stability. We’ve fielded questions from photo-initiator firms chasing batch reproducibility; from tank farm handlers troubleshooting clumping; and formulators wanting longer shelf stability. Each time, success circles back to controlling variables upstream — from source material certification, monitored moisture control, correct sieving, to tracking exposure and color drift.

    Our plant’s experience extends beyond specifications, into lived solutions that fix real processing bottlenecks at the user level. Take for example persistent reports of dustiness during pneumatic conveyance. Instead of blaming the receiving facility, we modified our drying curves and introduced staged nitrogen sweeps — a change that not only stabilized downstream blending but cut operator exposure risks for everyone involved. Once a photo-initiator client flagged issues with trace metals, we fast-tracked an upgrade to our filtration stages, using high-purity acid-washed media to keep by-product levels extremely low. These aren’t theoretical modifications or templates: they reflect real problem-solving evolution, day after month after year in a living plant environment.

    Our view remains that Benzophenone Oxime’s success rides on partnership. No step gets left to chance, from precursor identity validation, through reaction fingerprinting, to dry material handling and shipment records. Each customer picks up more than a product — they inherit a process refined over decades, stimulus for better runs and sharper results at their own sites. That long-haul attitude serves us and our clients, anchoring everything we make and ship. In a world of shifting quality standards, one thing remains steady inside our factory: pride in the work, openness in our records, and a commitment to real answers grounded in experience, not just paperwork or protocol.