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Benzaldehyde Azine

    • Product Name Benzaldehyde Azine
    • Alias Benzalazine
    • Einecs 211-099-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    505745

    Chemicalname Benzaldehyde Azine
    Casnumber 2461-02-9
    Molecularformula C14H12N2
    Molarmass 208.26 g/mol
    Appearance Yellow to orange solid
    Meltingpoint 112-116 °C
    Solubility Slightly soluble in water, soluble in organic solvents
    Density 1.15 g/cm³ (approximate)
    Structure C6H5CH=N-N=CHC6H5
    Synonyms Benzalazine, N,N'-dibenzylidenehydrazine
    Odor Characteristic aromatic odor

    As an accredited Benzaldehyde Azine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of Benzaldehyde Azine, tightly sealed, labeled with chemical details, hazard symbols, and handling instructions.
    Shipping Benzaldehyde Azine should be shipped in tightly sealed containers, protected from light, moisture, and incompatible materials. It must be handled as a hazardous substance, in accordance with local, national, and international regulations. Suitable cushioning, labeling, and temperature controls are recommended to ensure safe and compliant transportation.
    Storage Benzaldehyde Azine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and incompatible materials such as strong oxidizers and acids. Protect it from light and moisture. Ensure proper labeling, and keep it in a designated chemical storage cabinet to prevent unauthorized access or accidental exposure.
    Application of Benzaldehyde Azine

    Applications of Benzaldehyde Azine in Industrial Manufacturing

    Benzaldehyde Azine serves as an essential intermediate in several specialty chemical and material production streams. Our manufacturing processes provide high-purity material tailored for specific downstream integration, supporting manufacturers in meeting stringent quality, safety, and efficiency requirements across differentiated industrial sectors.

    1. Polymer Additive Synthesis for Crosslinking Agents

    Polymer producers rely on Benzaldehyde Azine as a selective cross-linker in condensation polymerization, particularly in specialty nylon and polyacrylate resin manufacturing. Its bifunctional azine group forms stable bridges within polymer matrices, enhancing mechanical integrity and thermal performance for technical plastics deployed in electronic and automotive parts. Downstream plant formulation engineers carefully calibrate dosing to control polymer chain structure and processing windows, ensuring batch-to-batch consistency within tight regulatory frameworks.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for polymer compounding
    • REACH (EC) No 1907/2006—Annex XVII (chemicals used in polymers)
    • RoHS Directive 2011/65/EU for electrical/electronic polymers
    • UL 94 Certification for flammability ratings

    Typical usage ratio

    • 0.3–1.0 wt% of the total monomer mass, adjusted according to desired cross-link density and application specification

    Downstream process integration

    • Addition during pre-polymerization blending stage or as part of post-polymerization modification line; incorporation typically controlled by continuous dosing pumps under N2 atmosphere

    Final product types

    • Glass fiber reinforced nylons
    • Engineering-grade polyacrylates
    • Polymer blends for electrical connectors or housings
    • High-performance automotive resin components

    2. Pharmaceutical Intermediate for API Synthesis

    In pharmaceutical production, Benzaldehyde Azine functions as a key building block for several active pharmaceutical ingredient (API) classes, particularly for the synthesis of azine-based drug scaffolds and heterocyclic compounds. GMP-certified drug synthesis lines use the compound in intermediate steps to introduce the azine moiety, under tightly controlled reaction conditions to satisfy batch-release and pharmacopoeial specifications required for later stages of medicinal chemistry scale-up.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) ICH Q7
    • United States Pharmacopeia (USP) General Chapter <467> Residual Solvents
    • European Pharmacopoeia (Ph. Eur.) Monographs for intermediates
    • EMA Guideline on Quality of Impurities

    Typical usage ratio

    • Stoichiometric levels based on the target API synthetic route, typically 1.0–1.2 equivalents relative to the next coupling partner

    Downstream process integration

    • Introduced during the heterocyclization or azine condensation phase, at the intermediate or penultimate step of multi-stage synthesis; purified by recrystallization before downstream conversion

    Final product types

    • Pyrazole and triazole family APIs
    • Antimicrobial and antifungal active compounds
    • Pharmaceutical intermediates for CNS drugs
    • Fine chemicals for contract drug development

    3. Fine Fragrance and Flavor Manufacturing

    In the aroma chemicals sector, Benzaldehyde Azine acts as a complex scent precursor for ‘balsamic’ or ‘almond’ notes in high-value perfumery and fine flavor blending. Professional flavorists and perfumers source high-purity grades due to their minimal off-odor and stable reactivity. Manufacturing labs dose it during thermal coupling for aroma concentrate compounds, integrating downstream with strict sensory panel and allergen control to comply with international IFRA and flavor food safety codes.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards
    • Flavor and Extract Manufacturers Association (FEMA) guidelines
    • ISO 9235:2013 for Aroma Chemicals
    • EU Regulation (EC) No 1334/2008—Flavorings

    Typical usage ratio

    • 0.02–0.10% in fragrance concentrate formulations, based on headspace compatibility and regulatory limits for end-use markets

    Downstream process integration

    • Dosed at the aroma precursor formulation stage; undergoes controlled condensation reactions with aldehydes or ketones before addition to fragrance oil blends

    Final product types

    • Fine perfume compositions
    • Flavor formulations for confectionery and beverages
    • Aroma compounds in home care applications
    • Industrial scent additives for consumer goods

    4. Corrosion Inhibitor Formulation for Industrial Fluids

    Benzaldehyde Azine is adopted by specialty fluid blenders as a key organic component in corrosion inhibitor packages for closed water circulation systems and engine coolants. Its azine structure establishes chelating interactions with multivalent metal ions, helping to maintain passivation films on system pipework. QC teams establish dosage by pilot testing under simulated operational pH, hardness, and temperature to align inhibitor effectiveness with local and industry performance standards.

    Industry compliance standards

    • ASTM D1384 Corrosion Test for Engine Coolants
    • ISO 22241 for chemical fluid purity (where relevant)
    • DIN 51360-2 Corrosion Protection Testing
    • OECD Guidelines for Testing of Chemicals—Biodegradability

    Typical usage ratio

    • 0.05–0.15% (500–1500 ppm) in finished fluid, based on specific water chemistry and required corrosion protection timeframe

    Downstream process integration

    • Added during bulk blending of water-based fluid concentrates; homogenized under stirring before dilution and packaging

    Final product types

    • Engine coolant inhibitors
    • Water-based metalworking fluids
    • Industrial hydraulic fluids
    • Process water corrosion protection additives

    5. Analytical Reagent and Laboratory Use

    Certified analytical laboratories employ Benzaldehyde Azine as a derivatization agent in trace metal analysis and organic contamination profiling, given its selective reactivity with aldehyde/ketone functional groups. QC chemists utilize it to increase detection specificity in both HPLC and GC-MS workflows, ensuring accurate quantification for process release and regulatory documentation. Purity traceability and solvent compatibility require manufacturing to pharmacopoeial and laboratory reagent standards.

    Industry compliance standards

    • ISO/IEC 17025:2017—Testing and Calibration Laboratories
    • American Chemical Society (ACS) Reagent Grades
    • USP General Reagent Monographs
    • OECD GLP (Good Laboratory Practice) guidelines

    Typical usage ratio

    • Stoichiometric molar equivalents, typically 1:1 relative to analyte, with adjustments based on matrix characteristics

    Downstream process integration

    • Added to sample pre-treatment vials in controlled dosing; reaction conducted prior to chromatography separation or spectrometric analysis

    Final product types

    • Analytical standard solutions
    • Chromatographic derivatization kits
    • Certified analytical reagents
    • Laboratory reference materials for QA/QC
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    Certification & Compliance
    More Introduction

    Benzaldehyde Azine: A Manufacturer’s View on Quality, Application, and Differentiation

    Understanding What We Make

    Benzaldehyde Azine stands out as more than just a compound on a catalog sheet. At our facility, we approach each batch with attention to consistency, purity, and the practical demands of those using our material. Our team monitors every step, from raw benzaldehyde sourcing through to the complex condensation reaction that produces the azine. We are not traders buying bulk and reselling blind—the focus is always on the details and conditions that shape final quality. We have learned through years of production that Benzaldehyde Azine’s properties can shift with even small changes in reaction time, solvent, or purification process. Our manufacturing tracks each factor closely, because users expect predictability—down to the last decimal of purity.

    Specifications We Deliver

    Our Benzaldehyde Azine comes in the crystalline yellow form, with chemical formula C14H12N2. Typical batch purity exceeds 98%. The melting point regularly lands between 90 and 93°C, and water content, by Karl Fischer titration, sits well below 0.5%. We include GC-MS and NMR data in our batch records for partners who need full traceability, because questions about potential trace byproducts come up frequently. Every order gets packed in HDPE or glass lined drums, with optional nitrogen blanket to slow oxidation. Although this sounds routine, each step draws on lessons learned from years of feedback and cooperation with labs who put this product to use every month.

    Function in Real-World Applications

    Benzaldehyde Azine serves niche but essential roles. We’ve worked with customers producing specialty polymers, organic intermediates, and selective analytical reagents. The compound’s reactive nitrogen linkage makes it valuable for trapping specific metal ions or acting as a ligand in research. Some teams use it as a starting point for synthesizing more complex heterocycles, while others value its distinct reactivity toward certain oxidizing agents. We have learned, through post-delivery technical calls and lab visits, that no two users approach it the same way. Some prioritize chromatographic purity, others want unambiguous melting behavior, or absolute freedom from residual benzaldehyde.

    In our view, Benzaldehyde Azine’s most prominent use remains in academia, where research chemists keep looking for new organic synthons that don’t rely on halogen chemistry. The compound’s structure gives an entry point for biochemistry developments—particularly when a project tries out new ligands for metals or explores enzymatic degradation pathways. Students and postdocs working on novel synthetic routes value the simplicity of purification and the presence of sharp IR and NMR signals. Our quality control team receives occasional requests for ultra-high-purity batch runs where even trace colored byproducts are unacceptable, as these labs run sensitive UV-Vis assays. Meeting these requirements does not happen by accident—every week we adapt protocols, paying special attention to filtration and vacuum drying.

    How Benzaldehyde Azine Differs from Similar Materials

    From a manufacturer’s perspective, comparing Benzaldehyde Azine to the more familiar benzaldehyde or its hydrazones brings out some clear distinctions. Benzaldehyde itself, a simple aromatic aldehyde, brings challenges when used as an intermediate because it is volatile, prone to oxidation, and emits a strong, lingering odor. Benzaldehyde Azine, on the other hand, is solid, easy to weigh with precision, and does not evaporate away during careful heating. For labs where atmospheric emissions are subject to strict monitoring, this makes handling far less problematic.

    Benzaldehyde hydrazone may seem a close relative, but users soon realize that the azine provides greater thermal stability. Hydrazones often decompose under mild heating or during prolonged storage. Our clients in pharmaceutical R&D report that azines stand up to repeated recrystallization cycles. We recognize a tradeoff: azines are harder to get clean if the reaction temperature drifts or if the parent benzaldehyde is not fresh. To counter these issues, our lab monitors the peroxide content of starting reagents and schedules quick processing of freshly distilled materials.

    Some synthetic chemists consider oximes or Schiff bases as alternatives. In these cases, Benzaldehyde Azine shows better performance in reactions requiring sequential transformations, especially those needing a stable aromatic core with nitrogen donors. The azine’s reactivity profile complements transition metal coordination studies, so users testing new chelating agents or catalysts come back to it repeatedly. Other derivatives can be more reactive but also more hazardous—an issue we confront head-on in both our plant safety assessments and guidance to customers.

    Solving Issues from the Production Line Up

    Manufacturing brings everyday challenges not always visible outside the plant. Occasionally, we get uneven color development, a sign that a trace contaminant snuck in during workup. To tackle this, our operators switch up glassware cleaning protocols and tweak the nitrogen flushing stages. Some users require additional pre-drying on finished azine to prevent caking after long sea shipments in humid seasons, so we invested in better vacuum ovens and refined our in-process checks. If a batch yields crystals larger than typical, we provide technical support to ensure that dissolution in solvents used for end-use goes smoothly, offering small-scale pre-dissolution testing and adjustment at our own lab bench.

    Every few months, feedback from a research group triggers a new round of impurity tracking or solvent switch efforts. Benzaldehyde Azine, like many aromatic azines, can show batch-to-batch fluorescence changes if a reagent stock degrades. Our QA team routinely verifies baseline fluorescence to flag subtle changes. These steps mean extra work but save customers time and questions about reproducibility. Our goal remains quick troubleshooting—everything from switching suppliers for raw solvents to altering the ambient light exposure in our packaging area—all based on outcomes we see, not just on-paper compliance.

    Safety and Regulatory Matters from Manufacturing Practice

    Working at scale with Benzaldehyde Azine pushes us to keep practical safety at the forefront. While the MSDS covers acute hazards, our staff recognizes that chronic exposure to even trace aromatic azines needs careful monitoring. All workers have direct venting at weighing, and our plant odor threshold testing relies on people who know what to expect from an off-spec batch. Where regulations require reporting and tracking, our hoppers and packing lines feed digital records straight into compliance systems, cutting out manual transfer mistakes.

    End-users often ask about residual solvents and regulatory certifications, especially research groups in the EU, US, and Japan. While Benzaldehyde Azine falls outside many controlled substance regulations, demand for documentation rises every year. We keep third-party analyses on file for banned solvent residues and run random batch analyses for unknowns flagged by our own R&D. Supply chain traceability gets tougher as more customers require proof of ethical sourcing and validated waste disposal. We built relationships with our upstream partners and even visited several benzaldehyde producers. These direct visits helped us screen out producers using lower-grade feedstock, ensuring our raw material never picks up contaminants that cause usability or environmental headaches downstream.

    Environmental Perspective from the Production Floor

    Manufacturing any aromatic azine involves solvents, glassware, and water streams. Rather than using and dumping, we set up solvent recovery for every stage where possible, with spent formaldehyde and acid scavenged for appropriate off-site treatment. We return most spent water to a closed-loop purification system, scrupulously segregating the small waste streams with any nitrogen-containing residues. Our operators learned, over time, how to balance reaction efficiency with environmental responsibility, juggling yield efficiency with easier waste treatment steps. If a process change increases solvent loss, we bring in both plant teams and outside consultants to fix the bottleneck and recalibrate.

    Over the last three years, regulatory pressure has increased—local authorities and downstream customers alike want more detail on lifecycle impacts. In response, we invested in better air abatement for off-gassing stages and switched to green-label solvents for crude cleaning. At times this means more up-front cost, but our leadership committed early to these investments in return for reliability and easier downstream acceptance. As one of the few original producers ready to open our doors to product audits, we know that real trust builds by showing every step in manufacturing practice—not by hiding behind certificates.

    Quality Control Shaped by Feedback from the Field

    No two institutions use Benzaldehyde Azine the same way. Universities and advanced labs keep us on our toes with requests for custom granular sizing, additional filtration, or even single-crystal batch separation for advanced analysis. At the same time, industrial users in pigment intermediate manufacturing demand high-throughput delivery with zero batch recalls. Each user brings a different concern to the table: some caught trace water affecting downstream crystallizations, others sought guarantees regarding the absence of halogenated byproducts. Our team takes every piece of feedback as a trigger for further improvement—whether that means better packaging, more detailed chromatograms, or even including a detailed batch narrative with each shipment.

    A decade ago, hardly anyone requested full NMR and IR packs with basic orders. These days, almost every repeat user expects them, and we built automation to ensure no data packet falls through the cracks prior to shipment. When defects or inconsistencies pop up in field use, we pull units for immediate retesting and share analytic results with the requester. Through these direct conversations, we catch trends early—such as subtle shifts in crystal color with aging, or small but detectable pH drift with ambient humidity exposure—and adapt our finishing and testing in response.

    Anticipating User Needs through Continuous Improvement

    Our product engineers and chemists treat every shipment as part of a decades-spanning learning process. We do not rely solely on analytics; we trust operator instincts forged by years of hands-on practice. If a veteran technician notices a shift in crystal habit or a faint odor, we halt packing until the reason surfaces. This process discipline earned us a reputation for stepping in even after delivery—offering replacement or advice if the material misses the mark for a specialized application.

    Research partners welcome early insight into upcoming grade shifts or planned process changes. We maintain an open line for feedforward, not just feedback, so lead times for adjustment feel measured in days, not months. Raw material variations, seasonal temperature fluctuations, and even electricity supply issues all trace into the final product in ways only careful manufacturing teams catch early enough. We share lessons learned not only in formal reports, but through technical bulletins and informal Q&A calls.

    Colleagues in the industry sometimes ask why we do not simply outsource or accept off-the-shelf intermediates for Benzaldehyde Azine. Experience taught us that real reliability in performance demands attention from source to shelf. We keep documentation not to chase metrics, but to answer questions before users need to ask them. Our entire workflow reflects trust earned batch by batch, with every data point and every story from the field shaping how we deliver the next lot.

    Looking Ahead: Meeting New Challenges in Chemistry and Beyond

    The chemical landscape never stands still. New areas in academic research and industry now probe the frontiers of nitrogen-aromatic chemistry, demanding better control over every impurity and even tighter documentation for process histories. With Benzaldehyde Azine, we stand committed to refining not just the purity but also the transparency of our production chain. Our expansion into digital tracking, better solvent recycling, and rapid response to regulatory shifts all draw upon the practical experience accumulated across hundreds of production runs.

    End markets come to us for both reliability and adaptation. Whether the next breakthrough happens in an academic lab synthesizing new ligands, or an industrial partner running scaled-up batch reactions, we listen closely to what each user reports back. The material’s properties—crystalline stability, moderate melting point, strong nitrogen donor characteristics—give users a springboard into new applications. Our job, as the manufacturer, is to ensure that every box shipped upholds the standards we set from the very first run: application-driven purity, practical safety, clear communication, and improvement rooted in fact, not just claim.

    We remain focused on technical progress backed by trust and respect for the communities relying on our work. Benzaldehyde Azine may be a specialty chemical, but in our hands it’s the product of thousands of decisions and the constant back-and-forth between manufacturer and user. As demand grows for more transparent, responsible, and innovatively managed chemical supply, we stand ready not just to keep up but to set the pace.