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Atropic Acid

    • Product Name Atropic Acid
    • Alias Vitamin B8
    • Einecs 204-669-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    438559

    Chemical Name Atropic Acid
    Iupac Name 2-Phenylacrylic acid
    Molecular Formula C9H8O2
    Molecular Weight 148.16 g/mol
    Appearance White crystalline solid
    Melting Point 105-106°C
    Boiling Point 280°C (decomposes)
    Solubility Slightly soluble in water, soluble in alcohol and ether
    Cas Number 104-47-2
    Density 1.2 g/cm3
    Smiles C1=CC=C(C=C1)C=CC(=O)O
    Pubchem Cid 7687

    As an accredited Atropic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Atropic Acid, 100g, is packaged in a sealed amber glass bottle with a secure screw cap and clearly labeled for laboratory use.
    Shipping Atropic acid should be shipped in tightly closed containers, away from strong oxidizers and moisture. Store and transport at ambient temperature, ensuring proper labeling according to local regulations. Utilize secondary containment to prevent leaks, and handle with appropriate personal protective equipment to avoid exposure during transit. Follow all relevant chemical transport guidelines.
    Storage Atropic acid should be stored in a tightly sealed container, placed in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Protect it from moisture, direct sunlight, and excessive heat. Proper labeling and safety precautions must be followed to prevent accidental exposure, contamination, or degradation of the chemical.
    Application of Atropic Acid

    Applications of Atropic Acid in Industrial Manufacturing

    Atropic Acid serves as a critical intermediate across diverse sectors in the chemical industry. Its unique aryl-acrylic structure enables downstream synthesis, process control, and compliance for high-value end products. As a primary manufacturer, we supply Atropic Acid conforming to regulated specifications for precise integration in established industrial processes.

    1. Pharmaceutical Intermediates: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Synthesis

    Leading pharmaceutical producers employ Atropic Acid as a key building block in multi-step syntheses of certain NSAIDs, including tolmetin and related arylacetic acid derivatives. The controlled purity and reactivity of Atropic Acid enable secure amide formation and Friedel-Crafts reactions under monitored conditions. Stringent validation and batch tracking ensure compliance from intermediate handling to the final API preparation stage.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for intermediates
    • US FDA 21 CFR Part 210/211 for drug substance manufacturing
    • cGMP documentation and traceability requirements

    Typical usage ratio

    • Reaction charges: 1.0–1.2 molar equivalents per equivalent of amine or aromatic partner
    • Exact ratio depends on downstream product target and reaction pathway

    Downstream process integration

    • Enters synthesis during initial condensation or amidation steps
    • Used as a starting reagent in multi-step flow or batch organic synthesis
    • Subject to purification prior to subsequent coupling reactions

    Final product types

    • API-grade NSAIDs (e.g., tolmetin sodium)
    • Pharmaceutical intermediates for further transformation
    • Diagnostic reagents derived from similar arylacrylic backbones

    2. Agrochemical Synthesis: Herbicide Intermediate Production

    Agrochemical formulators apply Atropic Acid in the synthesis of selected phenylacetic acid-based herbicide actives. The material’s defined aromatic structure participates in alkylation and chlorination reactions, serving as a precursor in large-scale, continuous-flow processes. Ongoing documentation and in-process controls align with international pesticide registration obligations for safe environmental handling.

    Industry compliance standards

    • OECD Principles of GLP for chemical testing
    • FAO/WHO Guidelines for pesticide manufacturing
    • REACH Annex II Safety Data Sheet requirements
    • ISO 9001:2015 for agrochemical quality management

    Typical usage ratio

    • Batch synthesis: 1.05–1.15 molar equivalents relative to downstream haloalkyl reagent
    • Ratio fine-tuned based on efficiency/yield optimization and side product minimization

    Downstream process integration

    • Charged during intermediate-step alkylation of the aromatic ring
    • Subject to aqueous work-up, solvent extraction, and distillation before onward formulation
    • Incorporated into technical concentrate production for pre-emergent herbicides

    Final product types

    • Aromatic herbicide actives (e.g., arylacetic acid derivatives)
    • Intermediates for broadleaf weed control solutions
    • Bulk concentrates for downstream blending into finished agrochemical products

    3. Polymer Additive Synthesis: UV Stabilizer Manufacturing

    Chemical manufacturers introduce Atropic Acid as a precursor for synthesizing specific benzylidene-based UV stabilizers for high-performance polymers. Reaction control and reagent purity directly impact the yield of light absorber molecules critical in automotive, construction, and packaging plastics. Constant monitoring ensures conformity with established standards for additive purity and migration limits in food-contact and outdoor-grade polymers.

    Industry compliance standards

    • EU Regulation (EC) No 1907/2006 REACH Annex XVII (chemical safety)
    • ISO 9001 management system for additive production
    • FDA 21 CFR 177.1520 for polyolefins with additives (food contact)
    • EN 71-3 for toy safety chemical content (if applicable)

    Typical usage ratio

    • Synthesis charges: 0.9–1.1 mole per mole of co-reactant in light stabilizer precursor synthesis
    • Adjusted by formulation requirements and process scale

    Downstream process integration

    • Charged as aromatic feedstock in condensation or Michael addition reactions
    • Subject to purification before blending into masterbatch or polymer compound
    • Used in both solvent and melt-phase synthesis lines

    Final product types

    • UV-absorbing oligomers and monomers (benzylidene-type stabilizers)
    • Polymer masterbatches with integrated stabilizers
    • Finished polymer goods with improved weathering/UV resistance

    4. Flavor and Fragrance Intermediates: Synthesis of Cinnamic Derivatives

    Producers of flavor and fragrance intermediates utilize Atropic Acid for downstream synthesis of selected aromatic aldehydes and esters. The aromatic-acrylic acid backbone enables efficient transformations using controlled esterification and hydrogenation techniques. Precise monitoring of residual contaminants and consistent profile testing ensure suitability for food-grade and fine fragrance applications in regulated international markets.

    Industry compliance standards

    • ISO 22000:2018 for food safety management systems
    • IFRA (International Fragrance Association) standards
    • FEMA GRAS (Generally Recognized as Safe) listing review for relevant derivatives
    • US FDA 21 CFR Part 172 for food additives

    Typical usage ratio

    • Feed ratios: 1.0–1.05 molar equivalents, adjusted for the target ester/aldehyde synthesis
    • Calculated based on conversion monitoring and by-product minimization

    Downstream process integration

    • Charged for acid-catalyzed esterification or hydrogenation in batch reactors
    • Subjected to distillation and quality control before transfer to flavor/fragrance compounding
    • Measured and tracked per customer ingredient batch records

    Final product types

    • Cinnamic acid esters and derivatives for flavor formulations
    • Aromatic aldehydes for fragrance enhancement
    • Fine chemicals for perfumery comps and food flavor systems
    Free Quote

    Competitive Atropic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

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    Certification & Compliance
    More Introduction

    Atropic Acid: Reliable Performance for Critical Applications

    Understanding Our Approach

    In the business of producing bulk chemicals, you get to know each substance like a coworker. Atropic Acid, or 2-phenylacrylic acid, is one of those products that demand attention, from the earliest planning stages to the final drum sealed on the dock. We see this acid power a range of industrial processes, but its reliability doesn’t come from chance. Our production pulls from years of process optimization, choice of raw inputs, and a team that respects precision chemistry.

    People working with Atropic Acid expect consistency and clarity. We make it in batches that are detailed down to purity, stability, and trace impurity content. Model variations exist, but the principles remain: a clear white crystalline solid, with melting points in the upper 100-degree Celsius range, soluble in polar organic solvents, and packaged to prevent degradation. The markets for this acid aren’t glamourous, but they’re unforgiving—not a place to cut corners.

    Uses in Manufacturing and Synthesis

    Real-world use for Atropic Acid is mostly technical. In pharmaceutical syntheses, it sits on the raw material list for antihistamines and muscle relaxants, bridging complexity between aromatic precursors and specialized building blocks. Our clients look for our product because they don’t want variability in downstream activity or reaction rates. Each lot runs through HPLC analysis and contaminant profiling. We track benzaldehyde and cinnamic derivatives from receipt to finished product. If a batch drifts off target, it never leaves the plant.

    Beyond pharma, Atropic Acid sees steady demand in fine chemicals and fragrance intermediates. Some facilities rely on it to prep stabilizers or produce modified monomer units for copolymerization. It can act as a Michael acceptor in organic synthesis, delivering a clean handle for nucleophilic addition. This isn’t theory from textbooks—it’s based on day-in, day-out feedback from users who keep batch yields posted right on the wall by the reactor. If the input has issues, the process engineer hears about it before the lunch whistle.

    What Sets Atropic Acid Apart

    Old-timers in the craft talk about margins: not profit margins, but quality margins. Atropic Acid shows how small differences in process control change final use. We maintain batch-to-batch purity over 99%, with minimal benzoic and cinnamic acid co-products. Even trace yellowing gets flagged. Many traders and resellers don’t have this peer-level visibility; they pass along paper specs. Our facility logs test data for every outgoing lot. When you run a multi-step synthesis, it’s not the typical acid number that matters—it’s whether the lot holds up under thermal and oxidative stress.

    Some grades come with customized sieving—crystalline or ground formulations, as requested by industrial partners who handle bulk powder and need solubility curves that match their solvents. For some customers, water content under 0.1% can mean the difference between a smooth crystallization or a failed recrystallization stage. We keep these details close because even under pressure, skipping a step leads to trouble months down the line.

    Comparing Atropic Acid with Other Aromatic Acids

    Competing acids show up on tender lists, especially cinnamic acid and phenylacetic acid. Each compound behaves differently under lab and plant-scale reaction conditions. Atropic Acid, with its conjugated double bond, provides a platform for specific condensation reactions and acts as both a substrate and an intermediate. This is not just salesmanship—process reports from end users show how switching acids shifts yield and product profile. Routine GC-MS spot-checks confirm identities and reveal side products that sometimes don’t show on the certificate.

    Handling differences are practical. Cinnamic acid forms denser clumps under humidity, an issue in facilities that store raw materials more than a month. Phenylacetic acid emits a distinct odor, often requiring separate ventilation handling compared to the relatively stable, less volatile Atropic Acid. Our team learned these differences by working plant floors, not trade shows. Less waste during weighing, fewer air quality flags in the storage area—we note these advantages in our own risk control reports.

    Sourcing, Packaging, and Traceability

    We don’t import blind stock. All feedstock sources run through quality checks at our receiving stations. Audit logs cite supplier batch identifiers, moisture content, and expected contaminant profiles. Finished acid ships in lined fiber drums or sealed bags inside carbon steel bins, depending on the route and climate. Tamper-evident banding and serialized seal numbers track each container, minimizing the odds of mix-up in shared storage yards.

    Our technical staff logs deviations immediately, whether it’s a drum with an out-of-range pH, a color shift at the warehouse filter, or an unexpected temperature spike. Errors don’t get smoothed over—they get flagged and fixed. Traceability isn’t a pitch for auditors but a practical habit. We’ve faced client audits in person, walking through warehousing and pointing out exactly where a given batch sat on the rack. Procedures stay conservative. If a spec isn’t met, the product goes back for rework or safe disposal, even when market demand runs hot.

    Worker Safety and Customer Protection

    Process operators in our plant respect Atropic Acid for its irritant properties. Routine exposure checks and physical safeguards limit contact during all stages—charging reactors, collecting crystals, and packaging for shipment. Training cycles run before every production push. Every shift logs PPE use data, and incident drills happen during daylight and graveyard shifts alike. Real people handle these materials; we answer directly to local health and environment inspectors, not outsourced compliance reviewers.

    On the customer’s shop floor, risks stay manageable if protocols hold. Our technical teams issue handling guides—dust control, solvent recommendations, and ventilation notes. Warehousing partners get update letters if best practices change. This is not overcautious bureaucracy—it’s a lesson learned from tracking lost product and near-misses over years. Shared knowledge across the industry keeps everyone’s insurance costs down.

    Supplier Relationships and Feedback Loops

    Regular customers check in with questions about process troubleshooting or changes in product appearance. Our support runs beyond just pushing product out the gate. If a customer finds an off-odor or lower-than-expected yield, tech teams review logs from receiving to shipment. Sometimes we catch an upstream issue with packaging or a shift in raw input. Joint site visits aren’t rare—mutual trust leads to better output on both sides. If there’s cross-contamination from another acid, we spot-check tanks and check mill lines before resuming production.

    Field feedback helps us refine manufacturing. An issue flagged at a pharmaceutical site about trace aldehyde content led to a wider review of one of our distillation columns. Fixing it improved yields and lowered rework cycles, which, in turn, drove better pricing for everyone. Many changes come from these ground-level reports, not consultant recommendations. Chemical manufacturing doesn’t improve in a vacuum—it needs eyes and boots close to the equipment.

    Environmental Practice and Waste Handling

    Production of Atropic Acid, like many aromatic chemicals, produces waste acids, water streams with minor organic contaminants, and spent filtration media. We operate industrial-scale neutralization and carbon scrubbing systems, maintain permits with enforcement visits, and route non-saleable side streams into proper disposal or secondary recovery. Each year, auditors review our logs for emission and water quality.

    We’ve installed condensation recovery on vent lines to trap solvent vapors lost during batch evaporation. Cooling water gets tracked in closed systems, filtering before reuse. Sludge from process settling goes for incineration at licensed facilities, not dumped on a back lot. Tight margins come from cleaner operations and the avoidance of fines and shutdowns, not by skipping corners on disposal. The plant’s environmental record factors into negotiations with next-door industrial neighbors. They’ve dealt with enough chemical leaks to know whose operations run by the book.

    Regulation and Compliance

    Product registration and regulatory cross-checks keep Atropic Acid production stable. Our compliance team works through market shifts—REACH in the European Union brings one set of documentation, US FDA inquiries another. Regulatory changes often trickle down as certification audits or new paperwork requests, not always with much warning.

    We file real stability and impurity data, cross-check safety classifications, and flag anything new in hazard perception or transport rules. Some jurisdictions now demand extra classification or impose stricter labeling. We keep updated, so our stuff clears customs and doesn’t get delayed for missing paperwork. Failing a compliance review slows down our shipment schedules and makes trouble for customers downstream. Staying inside the lines isn’t optional if you hope to stay on approved supplier lists.

    Technical Troubleshooting—Stories from the Floor

    Plant experience shapes how we solve production issues. A recent example: one summer, elevated ambient humidity caused a series of packaging failures—Atropic Acid caked during warehouse storage, creating dosing problems for a pharmaceutical partner. Extra drying and revised packaging protocols fixed it, but not before we ran a root-cause study, starting with moisture readings at every step.

    Another time, a routine sampling flagged a color shift. Routine checks caught an uptick in minor benzaldehyde impurities. Full review traced it to a worn valve in a storage tank—just enough oxygen slipping in to drive oxidation. Fixing the small leak restored the clean, white appearance and kept our reputation stable. These details matter; customers choose direct manufacturers so they don’t have to gamble on product shipped blind and hope for the best.

    Some technologists seek clean chemical handles—a Michael acceptor that won’t introduce tricky side reactions. Our process chemists work hand-in-hand with these groups, testing reactivity profiles and matching solubility to help finished formulations meet their spec. Some competitors offer only an “as is” product; we support process integration, so end-users get a smoother path from starting material to final product.

    Market Shifts, Supply Security, and Resilience

    Global supply chains for aromatic precursors aren’t bulletproof. Disruptions at upstream benzene or toluene producers can ripple out, tightening supply or moving spot prices. Our plant stocks buffer inventory, watching trends so we catch swings early. Some clients hedge purchases, others buy strict just-in-time. We don’t promise what can’t be done, and we update confirmed lead times if a disruption hits. Delivering on-spec, on-time acid isn’t easy with every cycle, but most long-term clients appreciate realistic communication.

    The market wants stability more than buzz. Clients who make pharmaceuticals check for reliability and price transparency. Chemical intermediates are rarely in the spotlight—failure gets headlines, stability does not. Trust builds batch by batch, as each delivery meets process expectations and the occasional issue gets handled quickly and openly.

    Continuous Improvement—Learning from Each Run

    Each new campaign provides data for the next shift. Analytical chemists comb through results, process engineers update SOPs (Standard Operating Procedures), and warehouse managers notice unplanned holdups or stress points. We feed all of this into the next scheduling round. Sometimes, a minor tweak—such as increasing filter mesh size after a customer reports clumping—prevents bigger trouble down the line. Improving Atropic Acid production isn’t about a grand fix, but thousands of small corrections, integrated by people who care about details.

    Better doesn’t mean reinventing the process each year. Often, the most reliable improvements are simple: cleaner tanks, more deliberate raw material checks, better-trained line operators, and a culture that promotes reporting problems early. Our senior staff grew up learning from past mistakes. Each bottle that ships is the product of both experience and real-time learning.

    The Value of Direct Partnership

    Customers who call us get direct access to the production site. We discuss technical concerns, not just prices. For many, the value in Atropic Acid doesn’t reside solely in the chemical analysis but also in the certainty gained from knowing who made it, how it’s controlled, and how deviations get corrected. We ship product but supply support, technical advice, and feedback loops too.

    Over time, relationships deepen and requirements change. Sometimes a formulation adjustment drives a tweak in our grind size or purity threshold. Openness to change keeps business flexible, but our standards don’t slip. We want long-term users to gain from minor process improvements and avoid surprises.

    Commitment to End-User Results

    The Atropic Acid in our drums represents a contract of sorts—not just between our facility and a purchaser, but between every plant worker and the engineers counting on reliable, traceable, and clean feedstock. Our standards come from shared successes and the lessons learned from setbacks. Each batch gets tracked and measured, so when someone calls about process yield or appearance, we don’t guess; we open the records and run the tests.

    Making Atropic Acid is a technical responsibility, not just a business. The reputation of our people and our plant rides on product that measures up—every time. When feedback rolls in from syntheses or quality control reports, we hear it out and improve. If a downstream process unexpectedly shifts, we help troubleshoot at the source. This work is both art and science—a long-term practice of getting the small details right, lot after lot.