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Angelic Acid

    • Product Name Angelic Acid
    • Alias angelic-acid
    • Einecs 204-241-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    779461

    Chemical Name Angelic Acid
    Alternative Names cis-2-Methyl-2-butenoic acid
    Chemical Formula C5H8O2
    Molar Mass 100.12 g/mol
    Cas Number 463-42-1
    Appearance Colorless to pale yellow liquid
    Odor Pungent, unpleasant odor
    Solubility In Water Slightly soluble
    Melting Point -45 °C
    Boiling Point 185 °C
    Density 0.961 g/cm3
    Acid Strength Pka 4.86
    Origin Occurs naturally in plants such as Angelica
    Hazards Irritant to skin and eyes
    Uses Intermediate in organic synthesis

    As an accredited Angelic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of Angelic Acid, sealed with a screw cap, clearly labeled with hazard information and purity.
    Shipping Angelic Acid should be shipped in tightly sealed containers, away from direct sunlight, heat, and sources of ignition. Handle with care to prevent leaks or spills. Transport in accordance with local, national, and international regulations for hazardous chemicals. Proper labeling and documentation are required to ensure safe and compliant shipping.
    Storage Angelic acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and incompatible substances such as strong oxidizing agents. Protect it from moisture and direct sunlight. Proper labeling and secure storage are essential to avoid accidental exposure or contamination. Follow local regulations for the storage of chemicals.
    Application of Angelic Acid

    Applications of Angelic Acid in Industrial Manufacturing

    As a direct manufacturer with extensive process experience, we supply high-purity Angelic Acid to multiple industrial verticals where it serves critical functions in synthesis, formulation, and performance enhancement. All listed use cases focus on downstream markets with established, practical uses verified by commercial scale-up data.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers employ Angelic Acid as a crucial building block for semisynthetic APIs, including anti-infective and antispasmodic pharmaceuticals. It reacts efficiently in esterification and amidation reactions to produce customized drug side chains, supporting regulatory filings that require clear traceability and process validation.

    Industry compliance standards

    • EU EudraLex Volume 4 GMP for active substances
    • U.S. FDA 21 CFR Parts 210/211 (cGMP)
    • ICH Q7 Good Manufacturing Practice Guidance
    • JP, USP, Ph. Eur. relevant monographs for pharmaceutical intermediates

    Typical usage ratio

    • 0.8–2.5 molar equivalents relative to amine or alcohol reactant; adjusted for side chain yield and desired purity

    Downstream process integration

    • Charged during initial reaction steps for intermediate synthesis or modification steps in multi-stage API manufacturing

    Final product types

    • Antibiotic precursors (e.g., macrolide derivatives)
    • Antispasmodic intermediates
    • Specialty ester-based drug compounds

    2. Synthesis of Fragrance Ingredients

    In aroma chemical manufacturing, Angelic Acid serves as a feedstock for producing high-impact esters and lactones essential to fine fragrance blending. Direct esterification with natural alcohols yields signature notes for perfumery groups, and its controlled reactivity ensures batch-to-batch profile consistency in commercial compounding plants.

    Industry compliance standards

    • IFRA Code of Practice for raw material safety and usage limits
    • REACH Regulation (EC) No 1907/2006 for registration and safe handling
    • ISO 9001:2015 (applied to fragrance manufacturing quality systems)
    • Good Manufacturing Practices for Cosmetic Ingredients (ISO 22716)

    Typical usage ratio

    • 1–4% by weight in esterification blends; modulated for intensity and stability of the desired fragrance note

    Downstream process integration

    • Directly introduced to batch reactors for acid-alcohol esterification under controlled temperature and catalyst conditions

    Final product types

    • Angelica lactone ester bases
    • Herbaceous and musky tonalities for fine fragrance oils
    • Cyclic aroma intermediates (for flavor and fragrance compounding)

    3. Agrochemical Synthesis

    Producers of selective herbicides and pheromone formulations use Angelic Acid for synthesis of functionalized molecules with well-defined reactivity and degradation profiles. Its introduction as a carboxylic fragment facilitates targeted molecule design, contributing to ecological sustainability and registration dossier compliance.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals (relevant for ecotoxicology and degradation)
    • U.S. EPA FIFRA regulatory requirements for technical-grade raw materials
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • ISO 17025 Laboratory Accreditation for downstream QC

    Typical usage ratio

    • 0.5–3.0 molar equivalents within active ingredient precursor synthesis, adjusted for stoichiometry and environmental fate

    Downstream process integration

    • Sourced in the initial backbone construction or modification stage during active ingredient synthesis in controlled reactors

    Final product types

    • Selective herbicide active ingredient bases
    • Pheromone analog precursors for integrated pest management
    • Growth regulator intermediates

    4. Modifier for Biobased Polymer Synthesis

    Industrial polymer suppliers integrate Angelic Acid as a comonomer or chain transfer agent to introduce controlled branching or carboxy functionality into bio-derived polyester and polyamide formulations. This functionalization enables fine-tuning of degradation rates and hydrophilicity in materials targeting advanced packaging and specialty fiber applications.

    Industry compliance standards

    • EN 13432:2000–12 (compostable plastics)
    • U.S. FDA 21 CFR 177.1630 (polyethylene phthalate polymers in food contact)
    • ISO 14855 (aerobic biodegradability testing of plastics)
    • ISO 9001:2015 for specialty polymer manufacturing

    Typical usage ratio

    • 0.3–1.2% by weight in feed formulations, optimized for polymer chain length, targeted functional group density, and compatibility with main diacid/diol components

    Downstream process integration

    • Added in the polymerization step—specifically during esterification or amidation for functional copolymer synthesis in stirred-tank or continuous reactors

    Final product types

    • Compostable packaging films
    • Biodegradable molded containers
    • Modified polyester or nylon engineering fibers

    5. Corrosion Inhibitor Formulation for Metalworking Fluids

    Specialty lubricant and fluid blenders rely on Angelic Acid to synthesize tailored corrosion inhibitor additives that form protective complexes on ferrous and non-ferrous metal surfaces. Integration into additive packages improves long-term rust resistance and stability in demanding machinability environments, meeting the needs of automotive and precision metalworking industries.

    Industry compliance standards

    • ASTM D4627 (Corrosion Inhibitors in Metalworking Fluids)
    • DIN 51360-2 (Testing of water-miscible cooling lubricants)
    • REACH Regulation (EC) No 1907/2006 (registration and safe use)
    • ISO 6743/7 (Category M metalworking fluids classification)

    Typical usage ratio

    • 0.05–0.25% by weight within additive concentrate, fine-tuned based on base oil composition and target corrosion protection timeframes

    Downstream process integration

    • Synthesized in additive manufacturing, then introduced to metalworking fluid blending lines prior to final QC and drum filling

    Final product types

    • Water-miscible cutting fluids
    • Neat oils for high-speed machining applications
    • Temporary corrosion protection fluids for transport and storage
    Free Quote

    Competitive Angelic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

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    Certification & Compliance
    More Introduction

    Introducing Angelic Acid: Pure Manufacturing Experience, Consistent Performance

    Real Production, Real Chemistry

    In the specialty chemicals sector, our perspective comes directly from the shop floor. Angelic acid isn’t just another carboxylic acid to us—every metric ton ties back to decades of hands-on synthesis, filtration, and purification. As one of the longest-standing manufacturers dedicated to this unique C5 unsaturated acid, we know the strengths, quirks, and the daily challenges that come with each batch.

    Product Overview & Model Options

    We synthesize Angelic acid in batch reactors under strict temperature and atmospheric controls. This acid takes its name from Angelica archangelica—a plant where it occurs naturally—but in industry, we rely on chemical synthesis for volume and reproducibility. Our main commercial model, coded ANG-581, delivers a minimum purity of 98% by GC. Regular lots run clear to faint yellow, with acid values and refractive indices measured every shift.

    Strict quality control means we run each lot through full-spectrum analysis, covering melting point, specific optical rotation, and moisture. Our team maintains analytical records stretching back decades, giving us a deep archive of historical data for trend analysis. Exact parameters for each lot are available on request, but our longest-standing partners trust that every drum will meet or exceed the standards set years ago.

    Why Angelic Acid Matters in Chemical Processing

    Some chemical feedstocks have faded from view as industries evolve. Not so with Angelic acid. In our experience, its unique geometry, with a cis double bond next to the carboxylic group, grants chemistry options that saturated or straight-chain acids simply can’t achieve. Polymer scientists, pharmaceutical teams, and fragrance formulators ask for it again and again because its reactivity profile opens doors to molecules other acids struggle to build.

    From manufacturing standpoints, one attribute stands out: Angelic acid maintains high reactivity in esterification, giving reliable yields with alcohols where steric hindrance affects other acids. The pungent odor isn’t just a sign of purity; for synthetic fragrance houses, it serves as a starting material for crafting nuanced, persistent esters. In pharmaceutical synthesis, our customers cite high selectivity for conjugate addition reactions—something that lowers byproduct formation, reduces purification costs, and shortens project timelines.

    Applications & Practical Use Cases

    We see the acid ship in bulk to three main areas: pharmaceuticals, flavors and fragrances, and specialty chemicals. Year after year, researchers come back because their downstream processes tie in tightly with the peculiarities of its double bond. Alkylation reactions, for instance, use our acid to build key intermediates due to lower energy requirements—critical for projects under tight efficiency or sustainability targets.

    In pharmaceutical plants, teams leverage our acid in the synthesis of antipyretics, analgesics, and intermediates bound for more complex heterocycles. We're frequently consulted to fine-tune specifications for reactions that demand stricter chiral control or narrower impurity thresholds; often our historical production data guides those adjustments. Fragrance engineers appreciate the acid for what it contributes to nuanced basenotes—no small feat, since off-odors from trace impurities can ruin months of formulation work.

    Customers working on specialty coatings and advanced polymers routinely cite our acid’s cis-configured structure as a game-changer. They achieve backbone rigidity in ways that straight-chain or fully saturated acids simply can’t create. These applications rarely draw headlines, but the difference shows in the performance and reliability of the final products—endurance under thermal cycles, UV resistance, and flexibility where needed.

    Material Handling and Safety: Perspective from the Production Floor

    Daily operations run smoothly because our facility design takes the volatility and pungency of Angelic acid seriously. Our teams train extensively on closed handling systems, inert gas atmospheres, and proper PPE for each step. Spilliage during loading or transfer not only causes workplace discomfort; it risks batch loss and equipment corrosion. We schedule regular plant walkthroughs and preventive maintenance on all glass- and PTFE-lined equipment to prevent exposure of metal surfaces.

    Shipping partners receive our guidance paper on handling details—ranging from temperature controls during transit to best practices for warehouse storage. As manufacturers, we know that material mishaps don’t just happen in the factory; cold weather can cause solidification, and misguided heat can quickly degrade product quality. Local teams in each region get periodic training, and we incorporate their feedback to minimize risk and lost product.

    Transparency in Sourcing and Traceability

    In a world increasingly focused on supply chain transparency, we treat traceability as a central pillar, not a regulatory checkbox. Each lot of Angelic acid can be traced from raw material procurement through final QC analysis. Full documentation is available for audit—purchase orders, synthesis logs, purification data, and loading certificates. Our customers, many of whom face their own regulatory audits, often use our documentation as a model for their own traceability efforts.

    Sometimes raw material shortages tighten capacity in the market. We maintain steady relationships with upstream suppliers, diversifying sourcing to weather market shocks. That consistency lets downstream processors trust both our product’s pedigree and its regular delivery—avoiding the scramble and costly halts that come from quality excursions.

    Comparisons: Angelic Acid Versus Other Carboxylic Acids

    Plenty of alternatives exist in the carboxylic acid landscape—crotonic, sorbic, hexanoic, and caproic acids all see regular use. But none balances double bond location, chain length, and isomeric purity the way Angelic acid does on our lines. Crotonic and sorbic acids offer similar unsaturation, but in practice, crotonic’s chain branching and sorbic’s extended length unpredictably affect polymer formation and reactivity. Our acid allows for more precise control in chemical modifications, especially in addition and condensation reactions aiming for high yields with fewer side products.

    Customers often approach us looking to switch from maleic or fumaric acid, hoping to retain unsaturation but swap cis/trans configurations. The difference proves critical in certain applications. For instance, esterification reactions with alcohols deliver different odor profiles thanks to Angelic acid’s distinct backbone geometry. If you formulate for fine perfumes, that nuance translates into a competitive advantage.

    We’ve run dozens of joint trials with partners evaluating cost, reaction kinetics, and end-use performance between Angelic acid and easily sourced alternatives. The results nearly always favor Angelic acid in applications demanding stereochemical precision or very selective conjugate addition. Exceptions exist—some large-scale industrial polymerizations benefit from cheaper, less nuanced acids. We routinely recommend using the right tool for the job, and Angelic acid’s high purity and specific structure lend unique value where these differentiators matter most.

    Challenges, Pitfalls, and Solutions from Real-World Production

    No specialty chemical process comes free of headaches. Angelic acid’s most persistent issue remains isomerization during storage and transport. Warm weather, improper drum closure, or mixing with traces of amines risks conversion to its geometric isomer, tiglic acid. Downstream, this causes headaches in both analytical reproducibility and chemical reactivity. Years on the plant floor taught us that meticulous sealing, temperature control, and rapid use after drum opening stop quality drift in its tracks.

    Another challenge centers on odors, especially in multipurpose manufacturing sites. Angelic acid’s potent aromatic character migrates quickly and can invade adjacent workspaces, affecting both worker comfort and contaminating unrelated process steps. Our facility isolates the entire production line via dedicated HVAC and high-efficiency vapor collection, keeping cross-contamination to an absolute minimum. Downstream processors adopting open handling systems learn quickly from the value of effective air movement and containment—our technical service team visits regularly to help set up best-in-class mitigation.

    Byproduct management presents hidden costs too. Impurities introduced during synthesis—chiefly through raw material variability or suboptimal reaction control—can trigger off-odors, lower product performance, or fail regulatory testing. Continuous process monitoring remains our best solution. Real-time sampling and in-process GC analysis let us spot and halt off-spec trends before they affect the final drum. Margins may tighten when we reject non-compliant lots, but long-term partnerships grow stronger when batches meet expectations every time.

    Supporting Innovation and Collaboration

    Many new applications for Angelic acid begin with an inquiry to our technical team. Startups and established labs both look to us for sample runs, pilot-scale support, and down-to-earth recommendations grounded in factory experience. Some of our favorite projects push traditional boundaries—using our acid as a key intermediate in antiviral agent synthesis, or for new classes of UV-resistant polymers.

    Our historical data proves invaluable in scaling up customer projects. We keep detailed records not only on standard specifications, but also on unusual lots developed for one-off projects: custom acid value ranges, unique color or odor thresholds, tailored water content, and similar tweaks. In a market where time means everything, our experienced crew brings project ideas off the drawing board and into steady, repeatable production.

    We’ve hosted dozens of customer audits, each one bringing a fresh set of requirements, questions, and improvement opportunities. Factory tours foster collaboration because they reveal how practical chemical manufacturing underpins long-term reliability—a truth our customers see in every drum shipped. Product documentation runs deep for those first-time orders and grows deeper with every repeat shipment. Our R&D personnel stay close to the lines, working hand-in-hand with production and QC to ensure new grades or process improvements land safely, without risk to ongoing business.

    Compliance, Safety Standards, and Market Trust

    Markets and regulations move quickly, especially for feedstocks serving pharmaceutical and food applications. We keep up by participating directly in standard-setting bodies, offering feedback based on our manufacturing realities rather than just regulatory text. Our safety documentation and hazard communication support every shipment, backed up by in-person training when needed. Supply chain partners, particularly those new to working with Angelic acid, benefit from a real-world understanding of chemical safety—not just paperwork.

    Auditors regularly inspect our lines for cGMP adherence, and our QA teams run mock recalls, document reviews, and root-cause analyses as part of daily business. The end goal remains unchanged: keep Angelic acid as a trusted, reliable component in critical downstream processes. Whether a drum feeds a research project or a long-term pharmaceutical production campaign, its origins and quality controls stand up to scrutiny.

    Future Directions, Industry Outlook

    Looking across the last twenty years of Angelic acid manufacturing, demand has shifted alongside global priorities. As biobased chemistry grows, we continue research into fermentation-based production routes, aiming to lower carbon footprints and decouple from fossil feedstocks. Early results look promising for pilot facilities, but scaling fermentation yields to match synthetic production’s cost and consistency takes careful groundwork and honest assessment of design limits.

    We partner with academic groups investigating new applications—in antimicrobial finishing agents, as building blocks for advanced surfactants, and even as control points in flavor release systems. These partnerships keep the product relevant, drive manufacturing improvements, and open pathways to new markets.

    Some customers look to international standards for reassurance. We work with independent labs for external validation and certification, sharing real batch data to confirm specifications. Over the years, we’ve learned that transparency—both about raw material origin and practical limitations—earns deeper trust than any marketing claim. When fluctuations in purity, color, or odor crop up, we address them head-on, updating partners and collaborating on workarounds as needed.

    Working Direct with the Manufacturer

    Buying direct from a manufacturer means tapping into real experience and a full record of lot production, not just a brochure. We answer technical questions straight from the people who handled the last shift—no delayed email chains, no uncertain answers. Our support crew fields everything from handling advice to troubleshooting complex reactions, drawing on the day-to-day realities of running bulk and specialty campaigns.

    We view every order not as a transaction, but as the next entry in a decades-long partnership. Product reliability isn’t a commodity outcome—it’s a craft built up through serious production know-how, steady investment in equipment, and a team who makes these results their life’s work.

    Closing Thoughts: Angelic Acid's Quiet but Crucial Role

    Many valuable chemicals don’t make headlines, yet their role is irreplaceable. Angelic acid has kept its relevance through flexibility, structural peculiarities, and a reputation for consistent quality. We owe that reliability to time-tested production methods, a loyal team, and a close connection to every customer’s success. Chemical manufacturing rewards patience, transparency, and real knowledge—the most important assets we bring to every new and returning partner.