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Aminoguanidine Hydrochloride

    • Product Name Aminoguanidine Hydrochloride
    • Alias Piminodine
    • Einecs 215-699-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    733625

    Chemicalname Aminoguanidine Hydrochloride
    Casnumber 1937-19-5
    Molecularformula CH6N4·HCl
    Molecularweight 110.55 g/mol
    Appearance White crystalline powder
    Solubility Soluble in water
    Meltingpoint 212–216 °C (decomposes)
    Purity Typically ≥98%
    Storagetemperature Store at 2-8 °C
    Ph Approximately 5.5 (1% solution in water)
    Odor Odorless

    As an accredited Aminoguanidine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A white, sealed HDPE bottle labeled “Aminoguanidine Hydrochloride, 100g,” featuring hazard symbols and handling instructions, securely shrink-wrapped.
    Shipping Aminoguanidine Hydrochloride is shipped in tightly sealed containers, protected from moisture and light. It is classified as non-hazardous but should be handled with proper personal protective equipment. Packages are clearly labeled, and temperature during transit is maintained at ambient conditions to ensure chemical stability and safety for transport.
    Storage Aminoguanidine Hydrochloride should be stored in a tightly sealed container in a cool, dry, well-ventilated area, away from moisture, heat, and incompatible substances such as strong oxidizers and acids. Protect the chemical from direct sunlight and sources of ignition. Properly label storage containers, and ensure access is restricted to trained personnel following standard laboratory safety protocols.
    Application of Aminoguanidine Hydrochloride

    Applications of Aminoguanidine Hydrochloride in Industrial Manufacturing

    Aminoguanidine hydrochloride serves as a specialized reagent and intermediate in various chemical manufacturing sectors. Our production facility supplies consistent, high-purity grades meeting rigorous quality demands for diverse synthesis and finishing applications. Below, we outline key industrial uses based on actual customer demand and regulatory realities.

    1. Pharmaceutical Intermediates for Cardiovascular Agents

    Pharmaceutical producers use aminoguanidine hydrochloride as a crucial chemical intermediate in the synthesis of specific antihypertensive and antidiabetic agents. It participates directly in controlled condensation and cyclization steps, forming the backbone of hydrazone-based drug molecules. Consistent quality and batch traceability are critical to ensure final APIs comply with finished drug approval requirements in regulated markets.

    Industry compliance standards

    • United States Pharmacopeia (USP) Chapter 1078 (Good Manufacturing Practices for Bulk Pharmaceutical Excipients)
    • European Pharmacopoeia (Ph. Eur.) monographs for APIs (where applicable)
    • 21 CFR Part 210/211 (Current Good Manufacturing Practice in Manufacturing, Processing, Packing, or Holding of Drugs)
    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)

    Typical usage ratio

    • 0.8–1.1 molar equivalents relative to carboxylic acid precursor, depending on drug synthesis pathway
    • Adjustment according to impurity profile monitoring and process validation requirements

    Downstream process integration

    • Added during controlled cyclization/condensation in reaction vessels between 15–60°C under nitrogen blanket
    • In-process HPLC/GC used to track reaction endpoint and residual raw material

    Final product types

    • Hydralazine hydrochloride API
    • Pimagedine (aminoguanidine) formulations
    • Research-grade anti-glycation agents

    2. Synthesis of Polymer Stabilizers and Antioxidants

    Manufacturers of polymer additives employ aminoguanidine hydrochloride to produce stabilizers that extend the service life of plastics during thermal processing. It acts as a precursor for hydrazone and triazole derivatives embedded within polyolefin masterbatches or specialty polymers for electrical and automotive applications. The finished stabilizers require strict purity to meet regulatory and customer performance specifications.

    Industry compliance standards

    • EU Regulation (EC) No. 1907/2006 (REACH) for polymer additives
    • US EPA TSCA Inventory inclusion for chemical intermediates
    • ISO 9001:2015 Quality Management Systems certification at additive manufacturing site
    • EN 71-3 (Toy Safety) for polymer applications in children’s products

    Typical usage ratio

    • Typically 0.3–1.8% w/w of total additive batch, detailed by polymer grade and antioxidant performance target
    • Adjusted to meet aging, color stability, and thermal stability metrics in QUV exposure testing

    Downstream process integration

    • Charged to additive synthesis vessel post-polycondensation, followed by purification via recrystallization
    • Finished stabilizer dosed into polymer extrusion equipment via calibrated feeder systems

    Final product types

    • Hindered amine light stabilizers (HALS)
    • Phenolic antioxidant intermediates
    • Thermoplastic masterbatch concentrates

    3. Stem Cell and Tissue Culture Reagent Manufacture

    Specialized labs producing in vitro cell culture reagents use aminoguanidine hydrochloride as a selective inhibitor to suppress advanced glycation endproducts (AGEs) formation. It is critical in media formulations for culturing mammalian cells over extended passages, especially for diabetes research and regenerative medicine. Purity, endotoxin levels, and trace metals are closely monitored to avoid cross-interference in biological assays and preserve cell line consistency.

    Industry compliance standards

    • ISO 13485:2016 for medical device and diagnostic reagent manufacturing
    • US FDA 21 CFR Part 820 for quality system regulation
    • USP General Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products
    • ANSI/AAMI/ISO 11137 for sterilization in reagent production environments

    Typical usage ratio

    • 50–200 μM as active concentration in final media formulation, titrated for cell line sensitivity and passage number
    • High-throughput production batches rely on validated supplier lots with low bioburden

    Downstream process integration

    • Weighing and dissolution occur in sterile compounding suites equipped with laminar flow to prevent contamination
    • Solution filtered before aliquoting to minimize particulate and endotoxin introduction

    Final product types

    • Serum-free tissue culture media
    • Mammalian cell cryopreservation solutions
    • AGE-inhibiting research kits

    4. Precursor for Azine-Based Colorants and Textile Dyes

    Colorant and dye manufacturers utilize aminoguanidine hydrochloride in the synthesis of azine-structured dyes, prized for vivid color stability and lightfastness in textile finishing. The compound undergoes controlled diazotization and coupling with aromatic substrate streams. Process safety and batch tracking are enforced to comply with downstream export and toxicology standards in textiles.

    Industry compliance standards

    • OEKO-TEX Standard 100 for prohibited amines in finished textiles
    • ZDHC (Zero Discharge of Hazardous Chemicals) guideline compliance
    • REACH Annex XVII for azo colorant restrictions in EU market textiles
    • ISO 9001:2015 certified production for full batch traceability

    Typical usage ratio

    • 0.5–2.5 molar equivalents per aromatic base, set by dye intensity, substrate compatibility and fixation yield
    • Process development teams fine-tune to color strength and target fastness tests

    Downstream process integration

    • Feeds directly into diazotization reactor under chilled brine conditions (0–5°C)
    • Resultant dye paste filtered, then standardized for strength before downstream textile pad-dye application

    Final product types

    • Azine-based direct dyes (e.g., Crocein Scarlet variants)
    • Specialty textile pigment dispersions
    • Color-fast printing inks for fabrics and industrial materials

    5. Explosives and Propellant Intermediate

    Industrial explosives and specialty propellant manufacturers utilize aminoguanidine hydrochloride as a precursor for synthesizing aminoguanidine nitrate, which in turn produces high-energy materials such as tetrazene and other primary explosives used in detonators, ignition compounds, and non-percussive propellant initiators. Handling and documentation strictly follow hazardous material protocols throughout the supply chain and production process.

    Industry compliance standards

    • UN Recommendations on the Transport of Dangerous Goods (Orange Book)
    • US ATF Federal Explosives Law and Regulations (27 CFR Part 555)
    • REACH Annex XVII (explosives precursors) for European market
    • ISO 17025 compliant analytical test labs for trace impurity checks

    Typical usage ratio

    • Exact ratios prescribed by military or industrial proprietary process; generally 1.0–1.2 molar equivalents to acid in nitrate formation
    • Adjusted to balance stability, brisance, and safety in final energetic formulation

    Downstream process integration

    • Dosed into aqueous acid nitration reactors under controlled temperature and agitation
    • Subsequent workup and recrystallization performed in explosion-proof environments with blast containment features

    Final product types

    • Tetrazene initiators
    • Aminoguanidine nitrate propellant modifiers
    • Non-primary detonating fuse elements
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    Certification & Compliance
    More Introduction

    Aminoguanidine Hydrochloride: Quality at the Source

    What Aminoguanidine Hydrochloride Means for our Industry

    Across decades of production, a few chemicals earn a reputation for reliability and clean results. Aminoguanidine hydrochloride stands out in this group. Our experience in manufacturing this compound comes from years on the floor, focused on purity, consistency, and direct feedback from manufacturers, research chemists, and technical users. The model of aminoguanidine hydrochloride we supply emerges from carefully selected raw materials, monitored step by step through the entire synthesis and purification.

    We do not take shortcuts. Every kilo of aminoguanidine hydrochloride traces back to a controlled process with verified starting stocks, monitored pH, and crystalline product formation under operator supervision. The final compound sets up as a white, crystalline, free-flowing powder, meeting specifications for both appearance and chemical content each time. You can check through every lot: high purity, low moisture, tight control over insoluble and colored impurities, and stability even in long-term storage. The demand for reproducibility drives every batch we ship.

    Upstream Manufacturing Informs Downstream Use

    From day one, we understood that aminoguanidine hydrochloride lands in the hands of users with specific needs. It often serves as a core building block in pharmaceuticals, explosives, corrosion inhibitors, and other specialty applications. Our chemists' jobs do not end when the powder leaves the reactors. Over time, we have seen how small changes in impurity profile, crystal form, or particle size shape performance downstream. Knowing this, we do not only monitor the obvious—assay and appearance— but go further, adjusting operating details to suppress by-products or adjust texture.

    This approach means research or scale-up teams face fewer surprises. In pharmaceutical preparations, unwanted impurities disrupt synthesis or add time-consuming purification steps. Our consistent product properties ease method development and lower failure rates in pilot runs. Technical grade users in energetics or specialty chemicals request the same reliability, since off-specification material can interrupt expensive downstream transformations or even compromise safety. By listening to direct users and integrating their feedback, we developed aminoguanidine hydrochloride that supports critical work in multiple disciplines.

    Specifications We Achieve – Not Just Publish

    We manufacture aminoguanidine hydrochloride to meet specifications usually written as purity above 99%, moisture content below 0.5%, and almost invisible levels of chloride and sulfate. Users regularly require a material free from dark spots or visible contamination, with a flow that supports dosing systems and automated filling. Heavy metal limits—lead, iron, copper—stay much tighter in our batch records than official methods require. We keep spectrophotometric and wet chemistry logs on ions and total organic impurities available for inspection.

    Our team has refined drying steps and filtration methods to deal with moisture variability in different seasons. In humid climates, caking can challenge storage and transfer, but we have minimized these problems. In some runs, we periodocally use an extra sieve step or nitrogen blanketing to make sure the powder resists agglomeration until it is introduced into the customer’s process. Tanks and transfer lines see dedicated cleaning routines. No solvents or auxiliary chemicals that could carry over appear in final product. These physical and chemical features arise from continuous small adjustments—each documented, many driven by real-world user feedback.

    Real Differences from Other Suppliers’ Products

    Not all aminoguanidine hydrochloride is alike. Some manufacturers focus on throughput at the cost of observed purity. We have run comparison analyses. Material from less vigilant sources often holds more inorganic ions, more detectable colored by-products, or more variable moisture. In one year, several customers brought us off-spec lots from competitors for troubleshooting. We found unremoved starting reactants or inappropriate anti-caking agents in those samples. Their use of bulk synthesis often produces mixed crystal habits, finer dust, or tacky agglomerates that clog tablets and mixing heads.

    Our direct process knowledge lets us avoid those pitfalls. With our product, customers can use standard filtration units and blending setups. They rarely see residues in transfer lines, and tablets or extrusions do not suffer from variable lumping or streaking. We know that in explosives manufacture, the variability in impurity content not only changes sensitivity but can force expensive re-formulations. In pharmaceutical syntheses, high and consistent purity means fewer side reactions and easier purification of target products. By producing aminoguanidine hydrochloride ourselves, we set each control point based on these field realities rather than compromising for quick output or easier shipment.

    Applications that Drive our Quality Focus

    Our aminoguanidine hydrochloride flows into multiple sectors, each with its own demands. In organic synthesis, it functions as a reagent for the generation of heterocycles and related pharmacophores—key intermediates for some antibiotics and anti-diabetic drugs. Process chemists have told us that our product’s stability and narrow impurity window help drive high yields in these complex syntheses, reducing waste and rework. In energetic materials, purity and characteristic particle size hold a direct link to both safety in handling and performance metrics of the final composition.

    Small changes in the raw material can drive week-long batch failures or even halt development. One energetic materials group reported that inconsistent particle size from other producers forced costly filter changes and led to unplanned downtimes. Our ongoing dialogue with them led us to install an in-line sieving and monitoring stage that ensures batch-to-batch uniformity. Over the years, our product often finds use in rust inhibitors and specialty corrosion control chemistries, where subtle co-contaminants either catalyze unwanted side reactions or shift pH, both of which undermine long-term field performance.

    Differentiation Rooted in Operating Discipline

    While competitors boast about volume, our edge comes from tight control of all operating conditions. Every shift runs documented in-process tests. Operators compare real-time readings against validated batch protocols, not just post-hoc sampling. Quality assurance reviews link production data to outgoing shipments, so lot tracking is immediate can track down to the raw material batch and timestamped process step. We invest in operator training, and many of our line staff have years of history working with aminoguanidine salts. That frontline experience speeds up troubleshooting and gives early warning of drift from established norms.

    Those who depend on aminoguanidine hydrochloride in critical tasks—process analytics, large-scale reactions, regulated applications—tell us that this depth matters. When lots match specs every shipping cycle, they can count on predictable results without wasting time on requalification. Customers scaling up new programs get validation faster because representatives from our technical team can provide detailed records or, when needed, rapid support for specific investigations. We have stood beside our buyers through technology transfers, new equipment installations, and regulatory audits.

    Safety and Compliance: Direct Accountability

    We do not treat safety and compliance as a paperwork burden but as a daily responsibility embedded in our operation. Occupational, environmental, and regulatory teams work side by side with operators on the floor. Each batch of aminoguanidine hydrochloride undergoes hazard assessments, both in terms of product stability and potential release scenarios. We invest in containment, dust control, and redundant engineering safeguards.

    Compared to less formal markets, direct manufacturing control means every customer knows exactly what standards our product meets. We document shelf-life, storage requirements, and traceability for each batch. Our plant audits routinely involve regulatory authorities and internal third parties for review, so certification and declarations for GMP, REACH, or country-specific dossiers stand up to independent review. Documentation goes beyond a simple certificate of analysis; it includes operator sign-off, maintenance histories, and any test anomalies.

    This level of transparency makes a difference when customers go through regulatory review or forensic examination of process batches. They can pull root-cause data without delay or finger-pointing across the supply chain. From direct user feedback, this accountability shrinks downtime and builds a level of trust that surpasses the usual vendor–buyer relationship. With aminoguanidine hydrochloride, safety and compliance reflect a real-world assurance rooted in live, documented plant practice.

    Consistency and Future Development

    Markets and requirements will always change. We have invested accordingly—in pilot-scale process rigs, environmental upgrades, expanded crystallization lines, and real-time analytical capabilities. These investments feed back into mainline production, not only supporting new product models or tighter future specs, but also reinforcing current quality. Machine upgrades allow us sharper control of grind size and more complete removal of mother liquors, while updated lab methods speed up impurity tracking. Research partners have shared with us their emerging needs in pharmaceutically active intermediates, advanced energetic materials, and corrosion scientists seeking new technical tradeoffs.

    By manufacturing aminoguanidine hydrochloride in-house, with a team that combines depth of experience and openness to customer needs, we can respond to new requests quickly. If a pharmaceutical program wants a variant with reduced trace metals or a completely changed crystal habit, our chemists and engineers come together behind closed doors and model new batch protocols. In the last few years, we have scaled up lines for custom grades that meet different pharmacopoeia requirements or technical standards—without compromise on baseline purity or safety.

    Supporting our Customers Beyond the Container

    Any bottle or drum of aminoguanidine hydrochloride we send out stands behind more than a specification. Industry veterans will tell you that the greatest headaches often come not from final testing, but from batch-to-batch variability, inconsistent support, or a faceless supply chain. We have seen firsthand the disruption that poor communication or slow response introduces, particularly in active research or high-throughput production settings. That’s why you can always reach a manufacturing chemist or technical specialist. We know the process because we built it.

    Long-term relationships with technical teams help identify not only product requirements, but also process improvement opportunities. Customers often invite us to pre-production meetings, blending trials, or troubleshooting sessions for new product introductions. Listening directly to plant operators, R&D groups, or even regulatory advisors on their goals lets us refine both product and service—sometimes resulting in custom lot preparation protocols or special shipment configurations.

    Continuous Improvement and Feedback Loops

    Our story is one of continuous feedback and evolution. Each time a customer reports a process observation—whether a lot packs more easily or residues decline when using our aminoguanidine hydrochloride—we document and analyze the details. Feedback drives changes: a user noting too-fine powder receives a batch with tailored sieving; a request for improved moisture control leads to automated packaging line upgrades.

    Feedback does not just address complaints. Insightful suggestions from end users have run our R&D pilots in directions that yield completely new strategies: more robust drying methods, continuous real-time humidity monitoring in both synthesis and packaging, or re-engineered supply chain practices that promote batch homogeneity. We invest in advanced instrumentation not only for our labs but also for tracking material through the entire plant, so we keep both product and process tightly aligned with evolving demands.

    Practical Contributions to the Marketplace

    Many companies purchase chemicals in bulk without a clear understanding of the detailed requirements facing their end users. By focusing closely on the actual process needs of aminoguanidine hydrochloride users, we pay attention to the details customers often take for granted: how the powder handles under production line realities, how small changes in humidity affect formulation success, and how elimination of trace by-products saves hours of labor during regulatory audits. In pharmaceutical manufacturing, every minor impurity profile variation shows up later on as regulatory risk or technician overtime.

    Working side by side with technical buyers reveals where most value hides: in eliminating re-tests, lowering sampling frequency, and guaranteeing that the product received matches specifications, shipment after shipment. Our in-depth commitment to source control mean that even as processes or regulatory frameworks evolve, our aminoguanidine hydrochloride does not become a risk factor. For years, customers have relied on our product as a stable foundation for pharmaceuticals, specialty chemicals, and advanced research—an outcome only possible because we control every step from synthesis through delivery.

    A Commitment to the Future of Aminoguanidine Hydrochloride

    As the landscape changes, so too will demands on every intermediate and building block. We see regulatory push for even lower trace contaminants, more rigorous sustainability requirements, and a shift toward more data-supported traceability. Our manufacturing approach gives us flexibility: with process transparency, operator depth, and a nimble scale-up system, we can meet those challenges without rerouting to third parties or relying on outside processing. We integrate feedback loops into our operating routines and invest in improvements both from within and from customer innovations.

    Aminoguanidine hydrochloride, once a staple for a limited set of applications, now plays a broader role across emerging markets and advanced research. The difference comes from how it is made. Our focus on real-world quality, technical transparency, and manufacturing discipline means it holds up wherever performance, reproducibility, and trust matter most. By supplying aminoguanidine hydrochloride direct from an integrated plant—with clear, accessible data and real technical service—we continue to provide a product that stands out from generic, commoditized offerings. Not all powders in the market deliver what their papers promise. Decades of experience and a record of zero compromise set our aminoguanidine hydrochloride apart.