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Amino-Cyclohexyl-Acetic Acid

    • Product Name Amino-Cyclohexyl-Acetic Acid
    • Alias Gabapentin
    • Einecs 245-315-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    460274

    Cas Number 10497-10-4
    Molecular Formula C8H15NO2
    Molecular Weight 157.21
    Appearance White to off-white solid
    Melting Point 149-153°C
    Purity Typically ≥98%
    Solubility In Water Slightly soluble
    Storage Conditions Store at room temperature, dry place
    Synonyms 2-Amino-2-cyclohexylacetic acid
    Smiles C1CCC(CC1)C(C(=O)O)N
    Inchi InChI=1S/C8H15NO2/c9-8(7(10)11)6-4-2-1-3-5-6/h6,8H,1-5,9H2,(H,10,11)
    Usage Intermediate for pharmaceutical synthesis

    As an accredited Amino-Cyclohexyl-Acetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle labeled "Amino-Cyclohexyl-Acetic Acid, 100g." Features hazard symbols, batch number, and tightly sealed screw cap.
    Shipping Amino-Cyclohexyl-Acetic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture exposure. Packaging complies with regulatory standards for chemical safety. During transit, the material is protected from extreme temperatures and rough handling to maintain its integrity. Proper labeling ensures safe and compliant transportation.
    Storage Amino-Cyclohexyl-Acetic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Protect it from moisture and direct sunlight. Store at room temperature, and ensure containers are properly labeled. Always follow all relevant safety and regulatory guidelines when handling and storing this compound.
    Application of Amino-Cyclohexyl-Acetic Acid

    Applications of Amino-Cyclohexyl-Acetic Acid in Industrial Manufacturing

    Our production-grade Amino-Cyclohexyl-Acetic Acid (ACA) supports a select range of industrial manufacturing sectors. The following segments illustrate current, real-world incorporation in downstream industries, summarizing market-driven practices and regulatory frameworks. Explore how ACA integrates into specific applications, with technical insights into standards compliance, formulation roles, typical process steps, and finished goods output.

    1. Pharmaceutical API Intermediate in CNS Drug Synthesis

    Pharmaceutical producers incorporate ACA as a building block for synthesizing central nervous system (CNS) drug intermediates, particularly in the development of cyclic amino acid derivatives for specialty active pharmaceutical ingredients. ACA is valued for its cycloalkyl structure, offering unique steric arrangements during salt and ester formation steps in multi-stage batch synthesis. In these processes, close monitoring of raw material purity and trace metal content remains necessary for active substance consistency and regulatory adherence.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR 211: US FDA cGMP for Finished Pharmaceuticals
    • European Pharmacopoeia Monograph 2034 (where applied)
    • EDQM CEP (when part of EU API application dossier)

    Typical usage ratio

    • Batch reactions use ACA in 0.5–1.5 molar equivalents, with the precise input based on the desired API yield and stoichiometry of amide or esterification steps.

    Downstream process integration

    • Introduced at intermediate coupling or cyclization stages following the initial backbone construction, ahead of final deprotection and purification steps.

    Final product types

    • Branded CNS active pharmaceutical ingredients (APIs)
    • Bespoke psychoactive intermediates
    • Small-molecule CNS precursors supplied to contract manufacturing organizations (CMOs)

    2. Fine Chemical Synthesis for Agrochemical Intermediates

    Manufacturers of specialty agrochemicals harness the aminocyclohexyl moiety of ACA as a precursor for producing compounds with selective herbicidal and fungicidal activity. ACA provides a platform for building more complex molecular scaffolds, with process emphasis on controlling isomer ratios and minimizing side-product formation during functionalization. Careful compliance with chemical manufacturing and environmental standards underpins these syntheses, particularly for export-focused facilities.

    Industry compliance standards

    • FAO/WHO Technical Guidelines for the Manufacture of Pesticides
    • ISO 9001 Quality Management System
    • Regulation (EC) No 1907/2006 (REACH) for chemical registration
    • China GB 2763 for agrochemical residues (where produced in China)

    Typical usage ratio

    • Commonly 1–10% weight by weight in multi-component syntheses or coupled reactions—the loading tailored to molecular target and scale.

    Downstream process integration

    • Activated prior to halogenation, acylation, or amidation steps; fed into the reactor during early-to-mid synthesis to enable ring modification or side-chain extension.

    Final product types

    • Herbicide intermediates
    • Fungicide precursor compounds
    • Chemical intermediates for custom agrochemical R&D

    3. Chiral Starting Material for Specialty Polymer Modifiers

    Industrial polymer manufacturers use ACA to derive monomers and chain extenders with cyclic amino acid groups, directly affecting the steric and thermal properties of specialty resins and elastomers. This application responds to increased demand for tailor-made polymer additives designed for medical devices and precision industrial components, where consistent molecular geometry and impurity profiles are crucial. Product validation adheres to both polymer-specific and end-use compliance protocols.

    Industry compliance standards

    • ISO 10993 for biocompatibility (if for medical-use polymers)
    • ASTM D638 for polymer tensile testing
    • REACH registration for polymer precursors in the EU
    • RoHS Directive (2011/65/EU) for electronics-related materials

    Typical usage ratio

    • Incorporated at 0.5–3% by weight, adjusted to achieve target cross-linking density and mechanical property modification in the final resin formulation.

    Downstream process integration

    • Introduced during prepolymerization as a functional group modulator or as a chain extender after primary polymer backbone synthesis.

    Final product types

    • Custom co-polymer resins for medical device housings
    • Specialty elastomers with controlled stiffness or permeability
    • Polymer modifiers for electronics encapsulation

    4. Analytical Reagent Manufacturing

    Producers of laboratory-grade analytical reagents utilize ACA as a precursor in the preparation of calibration mixes and derivatization standards for chromatographic analysis. Its defined stereochemistry enables development of reference standards crucial for accurate quantitation in HPLC and GC assays. Manufacturers focus on batch reproducibility and certification under recognized reagent quality systems to guarantee downstream traceability and laboratory compliance.

    Industry compliance standards

    • ISO 17034: General requirements for the competence of reference material producers
    • ISO/IEC 17025 for laboratory reagent supply
    • USP Reagent Standards Section
    • Good Laboratory Practice (GLP) principles

    Typical usage ratio

    • Prepared at 0.1–1.0% (w/v or w/w) concentrations, with specific dosages set based on sensitivity requirements of downstream analytical protocols.

    Downstream process integration

    • Used in initial reference substance synthesis, followed by purification, blending, and packaging as declared analytical reagents.

    Final product types

    • Certified reference standards for HPLC
    • GC-derivatization agents
    • Ready-to-use laboratory calibration solutions
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    Certification & Compliance
    More Introduction

    Amino-Cyclohexyl-Acetic Acid: An Insider’s Look from the Factory Floor

    Introduction to Amino-Cyclohexyl-Acetic Acid

    Each batch of Amino-Cyclohexyl-Acetic Acid that rolls off our line reflects years of cumulative experience in chemical synthesis. The journey turning raw materials into this valuable intermediate involves precise handling at every step. Our operators recognize the importance of minor details—temperature control during reactions, specific solvents, and evaporation points that help yield a product with consistent quality. Such care doesn’t just show respect for chemistry; it shows respect for the people downstream putting trust in what we make. One might overlook the impact of a single intermediate, but by working with Amino-Cyclohexyl-Acetic Acid every day, its place in synthesis becomes obvious.

    Bringing Reliable Value to Synthesis

    We see demand for Amino-Cyclohexyl-Acetic Acid from researchers, development teams, and manufacturers with a clear goal in mind. They want a consistent building block that can anchor synthetic routes toward pharmaceuticals, advanced materials, or specialty chemicals. The molecular structure—a cyclohexane ring bearing both amino and acetic acid functions—carries versatility. Our R&D chemists identified early that small changes in route or environment can shift the purity of the end product or generate unwanted isomers. By refining the process over repeated campaigns, we’ve learned control. That reliability opens options for those designing new molecules, not just replicating what’s on paper.

    Our Model: Focused on Purity and Batch Consistency

    We manufacture Amino-Cyclohexyl-Acetic Acid in both technical and high-purity models. Feedback from our key partners—pharmaceutical innovators in Asia and materials firms in Europe—drove us to tighten specifications beyond industry baseline standards. We routinely measure by HPLC and GC, with clearly defined limits for related substances, moisture, and residual solvents. Production engineers on our line calibrate every analytical run against retained reference samples, and we never shy away from pulling up data from a two-year-old batch if a customer has a question. Most outsiders only see the number on the COA, not the routine cross-checking that stands behind it. That vigilance protects projects downstream from delays and missteps.

    Day-to-Day Challenges: Scaling and Cleaning

    Transforming laboratory recipes into commercial manufacturing does not follow a straight path. Cyclohexyl-containing intermediates sometimes throw unexpected challenges; one campaign last summer taught us that minute changes in stirring speed could impact byproduct formation. Solvent recovery plays a bigger role than many realize, both for cost control and for minimizing the trace contaminants that can sneak into product. The tanks, filters, and dryers holding Amino-Cyclohexyl-Acetic Acid require thorough cleaning to avoid trace amines or acids from prior use impacting current batches. We never let our cleaning records slip—a shortcut leads to headaches later.

    Uses: Going Beyond Standard Intermediates

    In the fine chemical world, Amino-Cyclohexyl-Acetic Acid offers more than a link in a synthetic chain. Medicinal chemists value the cyclohexyl ring for its ability to introduce bulk and shape into bioactive molecules. It’s a simple tweak, but it affects how a molecule fits targets or evades metabolism. The amine and acid can anchor further modifications—amidation, esterification, coupling with diverse fragments. Our colleagues in polymer science use it to influence polymer flexibility and thermal stability. Plant biologists even test it in growth regulator work. Lab teams share stories with us about the hurdles of sourcing stable, reproducible starting materials; consistency from the factory makes the difference between a successful run or weeks of troubleshooting.

    Distinguishing Features: What Sets Ours Apart

    Others on the market offer Amino-Cyclohexyl-Acetic Acid, often by repackaging or reselling. We see the corners cut: variable melting points, cloudiness, or unpredictable pH in solution. Our product goes out only after passing spectral and chromatographic checks against authenticated standards. Granulation and particle sizing remain stable throughout storage; workers in the warehouse keep logs that track humidity and temperature to prevent hidden degradation. Shipments head out in moisture-barrier bags with internal protection against oxidation or hydrolysis. The bigger difference rests in aftersales support—when a client’s in scale-up trials and needs historical analysis or shelf-life documentation, we answer with real data accumulated over years, not textbook guesses.

    Drawing from Real-World Applications

    Pharmaceutical projects can hinge on subtle chemical characteristics. A trusted partner in India once told us that a missed melting point range on our Amino-Cyclohexyl-Acetic Acid pushed back their project by a quarter. That lesson drove us to invest in more robust in-process controls and tighter release criteria. We value critical feedback—it keeps us honest and highlights how real-world conditions test theory. Synthetic chemists pushing a molecule through clinical evaluation care about every impurity profile and odor, not just paperwork. Frequent two-way communication matters; direct conversations help everyone adapt quickly rather than working from guesswork.

    Handling and Storage: From Our Plant to Production Lines

    Incoming materials receive a full battery of identity and purity checks ahead of use. Finished product moves from stainless storage to sealed containers, minimizing air and moisture exposure. Workers log each lot with details on environmental exposure, date, and batch runner. We monitor warehouse climate using wireless sensors; extremes in summer humidity or winter dryness are flagged before product quality drifts. End users often call for advice on shelf life and storage. Our suggestions come from real experience: keep the drum sealed and cool; let it reach room temperature before opening to avoid condensation; never use scoops with residual acid or base. Stories of fouled batches or lost work trace back almost every time to ignored precautions.

    Safety, Documentation, and Compliance

    Teams in our compliance division stay current on TSCA, REACH, and regional safety standards, but front-line operators also play their part. MSDS forms get routine updates whenever literature or field data add new findings. Each batch includes documentation that reflects not just composition, but also our observations on safe handling—even for rare cases where something unexpected popped up on a scale-up trial. Local safety officers tour our lines, and their input shapes process improvements. We don’t hide difficulties or treat regulatory needs as paperwork. Fewer surprises for us means fewer surprises for our partners.

    Continuous Improvement: Learning from Every Campaign

    Improvement comes not from big leaps, but from constant assessment. After each production campaign, our process and QA teams review performance, yield, and quality variation—not just from the current run, but by comparing against trends from previous years. Some differences link to shifts in raw material supplier; others stem from minor tweaks in SOPs. Every change is logged and referenced in future troubleshooting. Suggestions from customer labs—like tweaks to filtering or drying steps—feed back into our protocols. This culture of continuous improvement pushes us to challenge our complacency.

    Innovation: Pushing Past Industry Routine

    Markets demand more than a repeat of last year’s chemistry. Several research partners have reached out to explore novel derivatives based on the Amino-Cyclohexyl-Acetic Acid backbone. We retain both flexibility and technical rigor—small-scale glass reactors for pilot batches and kilo-scale vessels for semi-commercial production. Our chemists thrive on the chance to discuss possible analogues and new coupling routes. A recent partnership with a formulation lab resulted in a salt form with improved solubility for aqueous delivery. No single product line drives innovation, but having stable, trusted intermediates lets the entire lab focus attention on real breakthroughs.

    Vertical Integration: Advantages of Direct Manufacturing

    We control sourcing of the core cyclohexylamines and monitor their purity well before they enter our reactors. Owning the manufacturing steps lets us respond quickly to new standards set by regulatory agencies or supply chain shifts. During broader solvent shortages, we built up internal recycling capacity, separating and purifying solvents for reuse. This structure not only decreases operational cost—it avoids sudden stoppages or batch variations that happen too often with spot-purchased raw materials. The team at our site knows the full sequence, from raw material gates to finished goods; any question along the way gets a hands-on answer.

    Collaboration: Direct Connections Enhance Results

    Conversation strengthens understanding. Direct manufacturing brings us closer to researchers and production chemists. Every time we run a custom lot or accommodate a novel test specification, we learn what different industries value in an intermediate. University labs sometimes call to analyze odd analytical blips or unexplained color changes. These exchanges sharpen our process controls and provide early notice of emerging needs. We find pride in delivering batches that pass their high standards so that their research can move forward without error or delay.

    Challenges and Future Outlook

    Chemical production rarely moves smoothly. Interruptions in raw material supply happen. Energy costs shift, and environmental standards tighten. Tracking these variables comes from more than theoretical models; it needs hands-on experience with every piece of equipment. During last year’s power disruptions, our plant installed backup generators and reorganized maintenance so no batch risked degradation. Investment in filtration and analytical tools paid off every time a compound’s profile changed unexpectedly. Regulatory agencies add new hurdles, and our compliance leads keep daily watch so that documentation and safety measures always match current requirements.

    Training and Team Building

    The right outcome depends on people. We dedicate time to training new operators not just in theory but in real-world troubleshooting. Senior technicians walk fresh hires through equipment, explain the smells and observations that predict issues before they reach paperwork. Our site holds regular meetings where every team member—from maintenance to lab to shipping—shares the unexpected hiccups and victories of the week. No amount of automation replaces that shared experience. Building a team with long-term commitment drives down errors, prevents accidents, and upholds reputation far more than any single investment in machines or systems.

    Supporting New Developments: Responding to Unusual Demands

    Emerging projects in pharmaceuticals or specialty materials demand quick adaptation. Recently, a customer asked for Amino-Cyclohexyl-Acetic Acid with an impurity profile narrower than any we had supplied. Our R&D crew rallied, reviewing chromatographic data and identifying process tweaks to eliminate troublesome side products. The finished lots matched the most demanding specs. Our ability to adapt on the fly draws directly from maintaining full oversight at every production stage. A field chemist or scale-up lab may not see the upstream effort, but their trust grows each time the product works exactly as intended.

    Environmental Stewardship and Responsible Practice

    As regulations evolve and awareness grows, we’ve shifted to more sustainable solvents, implemented energy-saving reactor controls, and taken steps to lower emissions from our plant. Our wastewater treatment system now captures and degrades trace organics released during purification steps. Worker suggestions led us to recapture heat and minimize losses. Each of these measures resulted in cleaner operation and less resource wastage. Clients sometimes ask for sustainability documentation; what they receive reflects the real investments from our site, not just abstract commitments. We believe improvements in process chemistry bring real value to the wider world.

    Product Knowledge Derived from Experience

    Many can list the theoretical applications of Amino-Cyclohexyl-Acetic Acid. Having made it on a large scale, we know the surprises that don’t show up on a product sheet. Water control at the final crystallization makes or breaks phase purity. Handling practices on the warehouse floor influence shelf life more than most realize. Reliable supply supports confidence in even the most complicated syntheses. Our approach always draws on lessons learned batch after batch, season after season, rather than relying solely on textbook theory.

    Conclusion: Why Direct Manufacturing Matters

    Direct engagement in manufacturing means standing behind each lot of Amino-Cyclohexyl-Acetic Acid with both technical expertise and practical experience. Every success and setback shapes future runs and builds stronger understanding. Partners relying on stable, clean intermediates to power innovation find assurance in the details we oversee from the inside. By owning the process and listening to the end user, we help better science happen every day.