Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Alpha-Cyclopentylmandelic Acid

    • Product Name Alpha-Cyclopentylmandelic Acid
    • Alias ACPM
    • Einecs 256-442-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    601014

    Productname Alpha-Cyclopentylmandelic Acid
    Casnumber 36020-44-7
    Molecularformula C12H16O3
    Molecularweight 208.26 g/mol
    Appearance White to off-white solid
    Meltingpoint 96-100°C
    Boilingpoint 423.9°C at 760 mmHg
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically >98%
    Storageconditions Store at room temperature, keep container tightly closed
    Density 1.17 g/cm³
    Smiles C1CCC(C1)C(C2=CC=CC=C2)C(=O)O

    As an accredited Alpha-Cyclopentylmandelic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Alpha-Cyclopentylmandelic Acid, 25g, supplied in a sealed amber glass bottle with tamper-evident cap and clear labeling.
    Shipping Alpha-Cyclopentylmandelic Acid is typically shipped in tightly sealed containers to prevent moisture and contamination. It is transported under ambient conditions unless otherwise specified, following relevant chemical shipping regulations. The package is clearly labeled with hazard information, and a Safety Data Sheet (SDS) is included for safe handling and emergency reference.
    Storage Alpha-Cyclopentylmandelic Acid should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible substances. Protect it from direct sunlight, excessive heat, and moisture. Store at room temperature and avoid conditions that may induce hydrolysis or degradation. Ensure proper chemical labeling and handle with appropriate safety precautions, including protective gloves and eyewear.
    Application of Alpha-Cyclopentylmandelic Acid

    Applications of Alpha-Cyclopentylmandelic Acid in Industrial Manufacturing

    Alpha-Cyclopentylmandelic Acid serves as a critical intermediate in several advanced chemical manufacturing sectors. Our plant’s direct supply supports global partners focused on high-value, regulated downstream applications. Below we identify and detail the principal industrial scenarios where this specialty acid is implemented, including compliance standards, functional integration within production workflows, precise formulation usage, and the types of finished products achieved.

    1. Synthesis of Advanced β-Blocker Pharmaceutical Intermediates

    Pharmaceutical manufacturers utilize this compound as a chiral building block in selective β-adrenergic receptor antagonists. It plays a central role during enantioselective synthesis for developing APIs where molecular precision, traceability, and regulatory compliance drive the full batch process, starting from raw material qualification to final purification prior to API formation. The compound is typically introduced post-initial condensation, right before key stereoselective catalytic steps that establish the desired configuration, ensuring bioactive integrity and yield consistency in finished pharmaceutical intermediates.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) standards for chiral intermediates
    • US FDA cGMP (21 CFR Parts 210/211) regulations
    • China Pharmacopoeia (ChP) guidelines for key pharmaceutical substances

    Typical usage ratio

    • 1.5%–4% w/w relative to initial condensation substrate; varied by target enantiomer and API pathway. Adjusted to optimize crystallization and chiral purity.

    Downstream process integration

    • Fed into the chiral step following base-catalyzed condensation, immediately prior to stereoselective hydrogenation or amination. Integrated under inert gas atmospheres to maintain compound stability and is tracked in process analytical technology (PAT) for precise monitoring of enantiomeric excess.

    Final product types

    • Chiral intermediates for propanolol, metoprolol, and other β-blocker drugs
    • Bulk APIs for cardiovascular therapeutics
    • High-purity pharmaceutical intermediates exported under DMF registration
    • R&D reference standards for clinical trial synthesis

    2. Fine Chemicals for Chiral Agrochemical Synthesis

    Producers in agrochemical markets employ this acid to prepare key intermediates in the synthesis of advanced selective herbicides and fungicides, specifically where chirality affects biological selectivity. The compound enters after the initial Grignard or Suzuki coupling, supporting the downstream formation of enantio-enriched final actives. This role requires upstream traceability and documentation throughout the batch record, and the process is designed for recovery and reprocessing of unused starting material for economic and environmental reasons.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • Food and Agriculture Organization (FAO) and World Health Organization (WHO) pesticide specification and evaluation scheme
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (EU)
    • China ICAMA (Institute for the Control of Agrochemicals, Ministry of Agriculture) registration requirements for chiral pesticide actives

    Typical usage ratio

    • 0.8%–2.2% of reaction mass, depending on desired enantiomeric yield. Dose rates adjusted by target crop selectivity and regulatory pre-registration.

    Downstream process integration

    • Charging as a post-coupling intermediate prior to chiral isomer separation phase; enables the resolution of enantiomers critical to final bioactivity and off-target impact studies.

    Final product types

    • Chiral herbicide intermediates (e.g., for Aryloxyphenoxypropionate group)
    • Pure enantiomer fungicide actives
    • Technical-grade actives for crop protection formulations
    • Supervised field trial lots for efficacy and residue studies

    3. Manufacturing of Specialty Chemical Catalysts

    Manufacturers focused on asymmetric catalysis employ this raw acid in the tailored synthesis of ligand scaffolds for metal complex catalysts. The cyclopentyl moiety imparts steric influence, making it suitable for processes requiring high chiral selectivity, such as enantioselective hydrogenations. This involves the acid's incorporation into ligand frameworks during the advanced organic synthesis phase prior to metal chelation, impacting both yield and catalyst lifetime.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management for chemical plants
    • OECD principles of Good Laboratory Practice (GLP)
    • Responsible Care Global Charter for chemical processing
    • Internal client validation protocols for catalyst performance and extractables

    Typical usage ratio

    • 0.3%–1.1% in ligand precursor step, determined by desired steric bulk and chelating motif. Optimization based on batch scale and metal source used.

    Downstream process integration

    • Introduced into advanced organic synthesis module for ligand construction, fed as a key chiral moiety during nucleophilic addition to aryl halides, followed by immediate in situ stabilization for subsequent metal binding.

    Final product types

    • Chiral phosphine and NHC ligand precursors
    • Commercial asymmetric hydrogenation catalysts
    • Metal-organic catalyst complexes for pharma and fine chemical markets
    • Specialty catalysts for contract R&D

    4. Stereospecific Building Block for Advanced Material Monomers

    Producers targeting advanced polymers and specialty materials select this compound to construct high-performance monomers, conferring unique chirality and rigidity in resultant specialty plastics. The acid is incorporated in the oligomerization stage, prior to condensation polymerization, where its steric core leads to improved material glass transition temperatures and impact moduli. Continuous-flow QC tracks monomer purity to support regulatory submissions for materials in regulated and engineering applications.

    Industry compliance standards

    • ISO 9001:2015 for specialty polymer production
    • RoHS (Restriction of Hazardous Substances, EU) for electronics-grade materials
    • REACH Annex XVII as applicable to plastic additives in the EU
    • ASTM International Standards (e.g., D256 - Impact resistance testing of plastics)

    Typical usage ratio

    • 0.4%–1.5% by weight in monomer feed; tuning based on targeted polymer chain length and final material property requirements.

    Downstream process integration

    • Added post-initial oligomerization, preceding the final condensation polymerization; allows introduction of defined chiral centers leading to thermal and mechanical property modifications in specialty plastics.

    Final product types

    • High-performance engineering thermoplastics
    • Chiral specialty polyesters
    • Impact-resistant polymer blends for electronics and medical device housings
    • Test lots for pilot plant material property validation
    Free Quote

    Competitive Alpha-Cyclopentylmandelic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Reliable Sourcing and Practical Uses of Alpha-Cyclopentylmandelic Acid

    An Honest Look at Alpha-Cyclopentylmandelic Acid

    Alpha-Cyclopentylmandelic Acid stands out as a specialty intermediate with real value across multiple markets, from pharmaceutical research to fine chemicals. At our facility, consistency and practicality shape how we approach each batch. Our team faces the daily realities of building a robust product—purity doesn’t happen by accident. It takes experience with chiral separation, years of investment in reaction control, and a careful eye on thermal conditions and crystallization. This background matters to those who want to avoid troubleshooting downstream. We don’t guess; we measure, test, and adapt until our acid meets the right optical rotation, solid appearance, and assay targets. Suppliers and traders rarely see this side of the process.

    The model we focus on boasts an enantiomeric excess fitting for advanced synthesis. A clean, white crystalline powder gives a key indication—impurity nearly always introduces a color shift, smell, or texture change. We sample every lot using HPLC, NMR, and melting point analysis. If a customer wants 98% assay, we show the data behind that label. Minute traces of byproducts and solvents can alter final pharmaceutical activity or catalyst efficiency, so our team never skips the details. Our chemists have learned where shortcuts lead: batch failures, lost time, and failed regulatory audits.

    What Matters During Production

    Producing Alpha-Cyclopentylmandelic Acid involves several tightly controlled steps. Cyclopentanone and benzaldehyde derivatives must react in the right proportions under carefully monitored pH and cooling stages. Each operator understands the smell of product at different steps, notes subtle grains in the filter cake, and recognizes the reaction’s “sweet spot” before the exotherm gets out of hand. Few resellers recognize that moisture at even 1% level can ruin a batch, or that a slight temperature swing throws off the isomer ratio.

    We hold product in our own environmental chambers, logging temperature and humidity over time, because we’ve seen real-world complaints when storage gets sloppy. We cap every drum with tamper-resistant seals. Whether a company wants single or multi-ton orders, the same vigilance follows the product. We've tracked lots months after shipment—if a customer calls back about clumping or discoloration, we pull retained samples for comparison. We stake our reputation on details most end-users never see.

    In the Field: Where Alpha-Cyclopentylmandelic Acid Proves Its Worth

    Customers use Alpha-Cyclopentylmandelic Acid mostly for its role as a chiral synthon or intermediate. We see interest from contract and scale-up pharmaceutical plants—both generics and innovators. Chemists appreciate that the cyclopentyl group gives both conformational rigidity and a point of differentiation in target molecules. Antihypertensive drug R&D teams often require its unique architecture. Some development labs push for ultraviolet absorption measurements and employ the acid as a resolving agent, relying on our certificates of analysis to comply with both internal and external protocols.

    Outside pharma, we notice more attention from material scientists. They lean on specialty acids to tweak optical performance in custom polymers. Engineers from the electronics sector have annotated how trace impurities can poison reaction vessels or sink yields. That experience cuts through marketing spin—we’ve been asked about the source of every additive and never shy from showing the paperwork.

    In real projects, speed and certainty matter more than slogans. A drug development timeline depends on reliable delivery. Missed spec means weeks lost and repeated analytical tests. Alpha-Cyclopentylmandelic Acid isn’t just a line item on a supply list; it drives progress in work that’s often under pressure.

    What Sets Our Alpha-Cyclopentylmandelic Acid Apart

    Competitors sometimes focus on offering the lowest price per kilo, but that doesn’t reflect the total cost in practice. Many of our clients come to us after other sources led to surprises: lower isomeric purity, failed couplings, or regulatory headaches. We base our value on repeatable synthesis, tight lot-to-lot purity, and transparent documentation.

    We keep a process log on every batch produced. Solvent recovery, precise pH gradients, correct enantiomer handing, and avoidance of cross-contamination are not afterthoughts. Our team tailors workup conditions after reviewing each campaign’s actual yield and impurity trends. If something drifts—a batch shows unexpected chiral impurity—we dig in and redesign the crystallization or switch the base used during the synthesis. It’s a chemist-to-chemist conversation, not just a business transaction.

    Some other offerings on the market use secondary recovery steps or blend several batches to achieve target assay. We sort out failures before anything leaves the plant. Each order matches what's on our certificate—every pound can be traced back to original reagents. We welcome supplier audits. Experienced buyers find value not only in high-purity acid but in never having to call for replacements or argue over inconsistent paperwork.

    Specs mean more than a number on a sheet. Analytical checks reach into polymorph detection, water content, elemental analysis, and solvent residue. People who have faced regulatory inspections or customer qualification protocols know why it matters. Lower-cost options often cut corners in drying, leading to storage stability problems. We've kept drum samples for over a year and can attest to the actual shelf life, not just a guess meant for sales brochures.

    The Chemistry Behind Reliable Quality

    Alpha-Cyclopentylmandelic Acid presents unique production challenges: the chiral center is both an asset and a risk factor. Our experience handling this molecule began over a decade ago, dealing with non-selective formation and separable byproducts. We hit setbacks early—a few failed campaigns, an analysis that told ugly truths, and a fair amount of bench-scale “fixes” that didn’t scale up. Hard-won lessons pushed us to refine temperature programs, improve solvent selection, and install newer analytical tools. Stability under storage, behavior under stress conditions, compatibility with various solvents—for our team these aren’t hypotheticals, they’re part of the day-to-day.

    We often receive requests for tailored specifications: increased assay, reduced metal content, or guaranteed isomeric purity over 99%. These come from organizations working in regulated environments, where the downstream cost of a failed batch dwarfs any price premium on intermediate materials. We run two or three confirmatory analyses before shipment, something that puts us head-to-head with quality standards at global pharma majors. We carry out packed column GC, LC-MS, and wet chemistry to reveal any lagging contaminants. If the spectrum looks off, nothing ships until it matches historical and theoretical profiles.

    There is a myth in the market—"a white powder is pure." People who have worked complex organic synthesis know that’s an oversimplification. True quality gets revealed only by careful isolation, repeated measurement, and a willingness to reject batches that fail subtle tests. Our positive feedback often comes from teams who have been frustrated before—struggling to explain anomalous results only to discover a bad intermediate. We help address the root, not just patch symptoms.

    Strategies for Consistency and Reliability

    Process control drives the difference between random outcome and deliverable product. Every step in our production is monitored: pressure, temperature ramps, agitator speeds, cooling profiles, and washing cycles. With Alpha-Cyclopentylmandelic Acid, this discipline means fewer surprises in both small and large-scale synthesis. Any time a technical customer calls, we can discuss actual process parameters, not just recite catalog numbers.

    Cross-contamination worries surface whenever a site handles many APIs or intermediates. We operate dedicated lines, including separate isolation and drying to avoid impurities from other campaigns. Our documentation reflects every stage of cleaning and transfer. Some partners ask to witness production in person or want chain-of-custody for every lot. We provide full process transparency, have nothing to hide, and consider these requests a mark of an engaged partner who values true traceability.

    Packaging choices affect usability at the destination. Alpha-Cyclopentylmandelic Acid leaves our facility only in liners and containers that have passed compatibility checks. We steer clear of materials that can leach or that become brittle over time. We’ve seen failures firsthand from repackaged products stored in subpar plastics—yellowing, off-odors, or unexpected caking. Our feedback loop with customers closes the gap between shipping and on-site storage challenges. Every container label gets checked for print clarity and permanence; small details can spare hours of delay during acceptance testing or internal audits.

    Shipping logistics turn minor differences into major headaches. We handle documents—certificates of analysis, import, and export records—before freight moves. Our in-house logistics staff tracks temperature exposure and transit time, and gives advance warning during delays like port congestion. We keep backup lots ready in case weather, customs, or other surprises threaten delivery. This way, clients depending on Alpha-Cyclopentylmandelic Acid for just-in-time production aren’t left scrambling.

    Comparing with Other Chiral Intermediates and Acids

    Chiral intermediates cover a broad technical landscape, but Alpha-Cyclopentylmandelic Acid brings specific features: a cyclopentyl ring that offers structural rigidity, a benzene group that can participate in further functionalization, and a clean chiral axis for pursuing enantioselectivity downstream. Classic mandelic acid derivatives sometimes lose out on stability, handling, or reactivity properties that matter in modern synthesis. We’ve supplied customers who originally tried 2-phenylglycine or simple alpha-alkylmandelic acids, but switched after yield loss or purification trouble. A more selective intermediate leads to simpler processes and purer APIs.

    From a handling perspective, not every acid offers the same blend of solubility and shelf-life. Alpha-Cyclopentylmandelic Acid holds up against atmospheric moisture better than some related intermediates. Some cheaper analogs begin clumping or turning off-white after a few months; we check each drum in quarterly stability protocols. This reliability translates into fewer customer complaints and smoother downstream workflows.

    In chemical development, cost per kilo rarely represents total cost. Handling losses, failed reactions, and reprocessing quickly erase upfront savings from cut-rate material. We price our material to reflect data-backed reliability—not trends, but experience. The difference becomes clear during scale-up or regulatory inspection, where crop failures from off-purity acids eat into budget and trust. End users who understand technical chemistry see the logic; those pressed only for price often find out the hard way through sustained headaches.

    We also compare shipment documentation and traceability. Many alternative sources lack robust batch-angle data, forwards and backwards. If an end-use product fails regulatory review, you want to know why. Our system enables batch recalls, root-cause analysis, and confidence that trace substances won’t spark audits or recalls down the line. That’s the difference between a producer with skin in the game and a distributor pushing paperwork.

    Innovation Through Partnership

    No product stays static forever. We work with development partners to tune Alpha-Cyclopentylmandelic Acid for emerging uses. New catalysis fields, sensor materials, or custom ligands sometimes require purity beyond routine offerings. We run custom purification campaigns—always open to process improvements if the application justifies changes. Technical teams send us novel requests we’ve never seen; we treat these as worthy challenges.

    For R&D organizations and contract manufacturers, sourcing doesn’t end with a delivery note. Regulatory demands outpace simple commodity trading. Our own staff undergoes continual training to handle evolving quality norms, new analytical protocols, and lessons from customer failures and successes alike. That culture adds resilience—learning from mistakes as much as from what goes well.

    We interface closely with project chemists, regulatory staff, and operations personnel. Direct conversation leads to practical solutions—whether it’s packaging sizes, custom labeling, accelerated delivery, or documentation support for filings. The market for Alpha-Cyclopentylmandelic Acid doesn’t tolerate black-box sourcing or slow communication. When a customer faces unique regulatory or technical pressure, we respond with detailed process data, technical justifications, and adaptability born of practical knowledge.

    Supporting Claims With Results

    Our internal studies support customer outcomes. Stability data comes from real storage—not just theoretical prediction. We measure residual solvents using validated GC-FID methods, confirming actual regulatory compliance. Every year, we run third-party audits and share those findings with clients. This approach opens conversation, builds trust, and closes gaps between production facility and lab bench.

    Our team understands that word-of-mouth between developers and process chemists moves faster than any marketing. A single failed reaction due to contaminated Alpha-Cyclopentylmandelic Acid carries more weight than a dozen advertisements. We back every shipment with the expectation that it will form a piece of a larger, technically demanding chain of transformations. This responsibility means we don’t view clients as anonymous order numbers, but as peers working toward mutual technical success.

    Feedback isn’t just a secondary routine. We actively seek first-hand accounts of problems and results, both good and bad. Internal post-mortems on failed deliveries or downgraded lots guide our continuous improvement. If a new impurity pops up, we flag it and redesign the clean-up or synthesis before scale-up resumes.

    The Human Factor

    Skill in chemical manufacturing never belongs only to instruments or procedures. Our crew brings deep know-how—formulating solvent mixes, diagnosing reaction hiccups, and troubleshooting problems in the heat of production. Kids new to the line learn from peers who have sweated through botched crystallizations or late-night reprocessing. Not every mishap finds its way to the data sheet, but every lesson piles up, making future success more likely.

    We’ve never pretended to be perfect. Problems still crop up: a change in starting material source, a sudden humidity spike in the drying room, a supplier that goes bankrupt. Each event forces a hands-on solution—sometimes in the lab, sometimes adjusting logistics, sometimes with an apologetic call to a customer. Real manufacturing always demands agility, trust, and honesty on both sides.

    No process or product issue is ignored for the sake of speed or optics; pressure to deliver quickly must not come at the expense of reliability. Our Alpha-Cyclopentylmandelic Acid goes to teams counting on every batch for further synthesis, analytical trial, or process development. We respect that trust through data, shared stories, and clear evidence of performance.

    Looking Forward

    We expect demand for Alpha-Cyclopentylmandelic Acid to continue growing, fueled by new molecules under evaluation and the global move toward more complex chiral synthesis. We stand ready to embrace fresh challenges posed by customers, regulators, and market trends. Regulatory scrutiny only increases, technology doesn’t slow down, and the need for responsive, evidence-based partners keeps rising.

    Direct engagement with the end-users, honest analysis of production strengths and occasional missteps, and passion for molecule-level detail drive the reliability our customers count on. Chemical manufacturing remains as much about trust and dialogue as about rigorous process. Our Alpha-Cyclopentylmandelic Acid demonstrates how close cooperation between plant, lab, and customer can overcome both daily technical headaches and long-term strategic demands.