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HS Code |
867918 |
| Product Name | Acetone 2,4-Dinitrophenylhydrazone |
| Cas Number | 1007-76-7 |
| Molecular Formula | C9H10N4O4 |
| Molecular Weight | 238.20 g/mol |
| Appearance | Yellow to orange solid |
| Melting Point | 188-191°C |
| Solubility | Slightly soluble in water, soluble in ethanol and acetone |
| Purity | Typically >98% |
| Storage Conditions | Store in a cool, dry place, tightly closed |
| Synonyms | Acetone DNPH derivative |
| Boiling Point | Decomposes before boiling |
| Safety Hazards | Irritant; handle with care |
As an accredited Acetone 2,4-Dinitrophenylhydrazone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 50g amber glass bottle with screw cap; labeled "Acetone 2,4-Dinitrophenylhydrazone," CAS, hazard pictograms, and storage instructions. |
| Shipping | Shipping of Acetone 2,4-Dinitrophenylhydrazone requires compliance with chemical safety regulations. The compound must be packed in leak-proof, properly labeled containers and cushioned against physical damage. It should be accompanied by a safety data sheet (SDS) and shipped using a certified carrier, adhering to all hazardous materials transport guidelines and documentation requirements. |
| Storage | Acetone 2,4-Dinitrophenylhydrazone should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Protect from light and moisture. Store at room temperature, following appropriate chemical hygiene and safety procedures. Ensure proper labeling and restrict access to authorized personnel only. |
Applications of Acetone 2,4-Dinitrophenylhydrazone in Industrial ManufacturingAcetone 2,4-Dinitrophenylhydrazone is primarily adopted in scientific and industrial settings as an analytical reagent and as an intermediate in specialty organic syntheses. Below we detail its key application domains, focusing on high-purity production chains and compliance-driven end uses that require both quality tracking and batch formulation integrity. 1. Analytical Reagent Compounding for Carbonyl Compound DetectionIn quality control laboratories and pharmaceutical production lines, Acetone 2,4-Dinitrophenylhydrazone serves as a targeted derivatization reagent for the quantitative detection and identification of aliphatic and aromatic carbonyl groups, particularly ketones and aldehydes. Formulation chemists value its capacity to generate stable hydrazone derivatives, supporting both routine monitoring and regulatory batch validation processes required for drug substance development and active pharmaceutical ingredient (API) release testing. Industry compliance standards
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2. Intermediate in Synthesis of Custom Hydrazone Ligands for CatalysisSpecialty chemical producers use Acetone 2,4-Dinitrophenylhydrazone as a tailored intermediate during the synthesis of ligand systems intended for homogeneous catalysis, especially in fine chemistry applications such as precision hydrogenation and C–C bond formation reactions. The molecule’s specific substitution pattern enables downstream ligand architects to modulate steric and electronic properties essential for catalyst selectivity and stability in complex organometallic frameworks. Industry compliance standards
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3. Reference Derivatization for Environmental Monitoring & Residue TestingEnvironmental testing laboratories utilize Acetone 2,4-Dinitrophenylhydrazone in method-validated derivatization protocols to detect airborne or waterborne aldehydes and volatile organic compounds (VOCs) at trace levels. Compliance-driven test protocols rely on its selective derivatization, which provides stable, easily identified markers necessary for reporting regulated pollutants such as formaldehyde, acetaldehyde, and acetone in workplace, industrial, and public health monitoring environments. Industry compliance standards
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4. Synthetic Chemistry Research and Method DevelopmentAcademic and industrial research laboratories depend on Acetone 2,4-Dinitrophenylhydrazone as a reagent for structural elucidation and as a building block in the exploration of new organic synthesis pathways, especially in exploratory studies involving condensation reactions and the generation of new hydrazone scaffolds for bioactive molecule development. Laboratory supervisors deploy it in reaction optimization campaigns and for benchmarking newly developed synthetic methodologies. Industry compliance standards
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Acetone 2,4-dinitrophenylhydrazone stands out in the world of laboratory reagents as a robust, crystalline compound with a long track record in qualitative organic analysis. In our factory, where every batch starts from base raw materials and strict controls govern each step, our team views the product as more than a specialty chemical: it’s a cornerstone for accurate identification and reliable quantification of carbonyl compounds in research and industry settings.
We produce this compound in a range of purities, though the most standard offering remains the form with a minimum purity level of 98%. Consistency in both melting point and appearance reflects careful selection of sources, purification techniques, and packaging materials. Each step, starting with the precise reaction between acetone and 2,4-dinitrophenylhydrazine under controlled temperature, has seen countless refinements as a direct response to feedback from analytical chemists and lab technicians who count on us to remove possibility for contamination or inconsistency.
Usage has always dictated our standards: most customers want reliable melting points and sharp, well-formed crystals in a rich orange color—simple signals of purity. These details matter far more than abstract measurements; we learned early on that poorly defined crystals tend to indicate premature precipitation or uncontrolled pH during synthesis. Each issue, once identified on our floor, required hands-on changes, such as updated reaction vessels or better batch agitation, to bring every lot in line with the expectations of those running qualitative tests.
We choose glass bottle packaging by default, as the compound remains highly sensitive to both light and moisture. In several collaborative experiments, we confirmed that plastic vials, especially in humid storage rooms, often invite trace leaching or discoloration. No detail gets overlooked; after several returns from research customers, we began implementing triple-seal liners and desiccant packets—even for national shipments. These feedback loops drive improvement and make our batches more trusted by researchers relying on clear melting point data.
Acetone 2,4-dinitrophenylhydrazone has cemented its role in organic laboratories for confirming the presence and identity of acetone. Its utility stretches further: forming crystalline derivatives with other carbonyl compounds, this product simplifies and strengthens the process of distinguishing aldehydes and ketones through straightforward melting point comparison. For all the modern advancements in spectroscopy and chromatography, the 2,4-dinitrophenylhydrazone test sticks around—its reliability, low cost, and clarity make it a staple for both teaching and professional environments.
We get near-daily questions from both university and industrial analysts about possible substitutions and modifications. In our own experience, even with all the available high-tech alternatives, there is still no substitute for a fast, visually distinctive test that reveals identity at a glance, or a robust solid-state derivative that holds up under shipping and ambient handling.
The practical side speaks clearest in the stories we hear: plant chemists wrestling with batch inconsistencies in multiton acetone production, pharmaceutical researchers tracing byproducts in synthesis, or college students learning the basics of organic compound identification for the first time. In every case, the simple solid derivative and its sharp melting point give answers that machines sometimes muddle.
When discussing differences from other laboratory reagents and derivatives, real-world comparison yields insights you don’t glean from technical data sheets. In personal rounds through customer sites, we often see chemists debate between 2,4-dinitrophenylhydrazone derivatives and oxime, semicarbazone, or hydrazone alternatives. Each alternative brings some benefit—oximes crystallize more readily in aqueous conditions, semicarbazones resist acid hydrolysis better—but none matches the visibility and straightforward melting point detection of the dinitrophenylhydrazone.
Compared to the parent compound, acetone, this derivative’s solid, stable form allows shipment and storage in ways that aren’t feasible for volatile liquids. Different from other hydrazone derivatives, the prominent color and tight melting range signal whether isolation succeeded or if contamination crept in. Packs of crystalline 2,4-dinitrophenylhydrazone derivatives from our line see daily use by technicians in quality control, especially when intermediate products must be isolated and proved with confidence.
Generic, bulk offerings often show an off-color tinge, or the final powder ends up excessively fine—troublesome for filtration or for pressing into melting point capillaries. We invest in slower crystallization and careful washing, resisting external pressure for quantity over quality. This approach evolved directly from hands-on feedback. Years ago, a prominent pharmaceutical group traced a series of out-of-spec analyses back to hurried synthesis procedures upstream. Our factory spent months tweaking water/solvent ratios and recrystallization steps to bring the issue under control.
Across decades, impurity and instability remain the two quickest routes to ruined analyses. Small amounts of unreacted 2,4-dinitrophenylhydrazine, byproducts, or residual solvents might escape the eye at scale, but chemists notice instantly in the lab, especially during melting point determination. We run additional filtered washes and high-resolution purity checks before final approval. Chromatographic data—shared directly with major clients, not buried in fine print—backs each batch, resulting in deeper trust.
Handling stability always couples with user safety. Technicians depend on chemical inertness through storage and handling: unexpected decomposition, whether from mild heat or residual oxidation, interrupts analysis with streaked filtrates or inconsistent results. Controlled storage, light-proof packing, and sealed containers matter more here than in more robust or less sensitive derivatives.
Every so often, we see requests for special runs destined for high-altitude or tropical installations. Experience has taught our production chemists that even small changes in atmospheric moisture and temperature impact the crystalline character. For these specialized orders, adjusted handling and freshly dried batches leave the plant—even though this means extra labor, our team shares pride in knowing the final product handles the stresses of extreme conditions without losing luster.
On the technical service side, we receive a steady stream of questions about proper application, disposal, and troubleshooting. Our plant chemists offer guidance beyond the literature—tips such as spotting incomplete crystallization due to low acetone content, adjusting filtration pressure, or correcting color variation by retuning reaction pH. New staff join our support team only after rotating through every section of the plant, so conversations with customers always reflect direct practical knowledge rather than boilerplate advice.
We notice greater success among users who actively ask about technique rather than relying strictly on test sheet data. For example, in high-throughput quality control labs, we advise running daily melts using our product to confirm calibration, since minute drifts in temperature settings or capillary technique skew melting points and, consequently, conclusions.
Reproducibility also depends on the small choices manufacturers make, rather than labs—filter pore sizing, bottle headspace, cap liner composition—all influence long-term stability of the derivative. A drop in melting point, or a yellow tinge, sometimes traces back to storage of bottles in strong ambient light or combined shipping with volatile amines. With every product batch, we encourage feedback loops and investigation when problems arise. These investigations frequently reveal that subtle packaging tweaks or handling routine changes prevent months’ worth of recurring quality complaints.
Over years of supplying research institutions, contract laboratories, and industrial users, we’ve watched the standards for chemical derivatives grow stricter. The regulatory landscape shifts with new environmental and safety guidance, which directly impacts accepted thresholds for impurity, demand for closed-system packaging, and expectations around disclosure. Our investment in analytical capabilities, including full-panel spectral certification and residual solvent quantitation, not only satisfies regulatory audit but helps our clients build their own cases for best-practice compliance in their reporting.
The push toward documentation and traceability keeps intensifying, with end-users seeking deeper batch data and chain-of-custody details on every purchase. Our plant systems now include real-time tracking of synthesis steps, operator identification, and equipment maintenance—both to satisfy audits and to recognize areas for production streamlining. While these improvements began as compliance measures, they’ve turned into sources of efficiency and confidence for our direct customers. Each documented lot and timestamped workflow builds traceable assurance.
Responses from those using acetone 2,4-dinitrophenylhydrazone in clinical, educational, and quality control settings often shape our ongoing priorities more than any internal process audit. For instance, feedback from a government laboratory about unusual solvent retention led to an overhaul in our post-crystallization drying regimen. Reports from university instructors pointed to packaging that was difficult to read in low light, prompting clearer labeling and bolder color coding. In dialogue with these partners, we share lab notes, detailed chromatograms, and real-world melting point logs, reinforcing a shared sense of accountability.
Many customers, constrained by budget or time, prize a reagent that simply works without fuss. In our experience, these schools, contract labs, and multinationals alike value a manufacturer who admits fault and pursues quick, transparent problem-solving over low initial cost or exaggerated claims. The sustained relationships forged over decades reflect our belief in practical, incremental improvement—listening to hidden frustrations that don’t show up in market research surveys.
We actively seek out unusual complaints, digging into context. If a batch falls outside melting range even slightly, dedicated teams return through every notebook entry, reexamining whether a shift in water source or subtle glassware contamination occurred. We involve customers in root cause analysis, often incorporating their methods or storage practices into our experimental repeats. Shared troubleshooting yields permanent solutions, and our staff uses every case study as training for the next round of production improvements.
Some of the biggest outcomes in our production line have come from research partnerships, not just internal innovation. Collaborating scientists often look for specialized forms—for high-throughput screening, automated dispensing, or even targeted use in forensic toxicology. This feedback spurred our initial ramp-up in lot size, and triggered investment in micro-batching setups for custom orders. In many cases, our plant’s lead chemists now step into external research projects, contributing not as vendors but as collaborators who share lab space and contribute to method refinement.
We approach custom requests—whether for alternative counterions, solvents of crystallization, or impurity rejection protocols—as opportunities to invest in global team learning. Partners get transparency in process notes and failures as well as successes. Years spent at the bench taught our team that the more openly we approach development, the more likely real improvements emerge—far more than by locking proprietary details away.
Modern chemical production means taking responsibility for downstream effects—raw ingredient sourcing, waste management, solvent recovery, and supplier labor standards. Each ton of acetone 2,4-dinitrophenylhydrazone that leaves our factory reflects a series of decisions, from solvent use to packaging recyclability. We draw upon our own experience with solvent reuse protocols and water cycle controls to minimize impact. Waste material that once went to landfill now ends up in specialist recovery streams owing to on-site filtration and distillation upgrades. Bench chemists responded positively to these changes, often taking pride in contributing to less waste through improved batch yields and tighter purification cycles.
We get practical suggestions straight from the shop floor. Staff once proposed recovery of residual mother liquors from crystallization; we built a pilot system that now returns solvent for fresh batch prep, halving our total solvent waste. Reinvestment in sustainable infrastructure—sometimes sparked by frontline observations rather than external audit—translates into lower product costs and greater dependability for those buying our product.
Shipping chemical reagents, especially those prone to degradation, means risk doesn’t end at our loading dock. Our logistics team integrates practices learned from close calls—such as temperature excursions that nearly triggered decomposition during a summer heat wave. Each outbound lot now moves with data loggers to validate transport conditions, not only to ensure customer trust, but to help us refine our recommended storage conditions.
On receipt, end-users appreciate specifics on safe opening, transfer, and waste handling. We supply more than generic safety guidance, offering advice based on in-house incidents and customer stories alike—such as safe venting after long transits, or direct replacement protocols for partial-use bottles. Thorough guidance on neutralization and safe disposal, born from direct plant experience dealing with cleanup, rounds out the instructional information we provide to every customer.
Through the years, Acetone 2,4-dinitrophenylhydrazone has become more than a product code or line item for us. Every update to our synthesis protocol, every conversation with a frustrated analyst, all the steps in refining packaging and waste reduction shape the product that arrives at each laboratory. Where other suppliers push for lowest price or highest turnover, our focus sticks on real feedback and concrete performance: sharp melting points, vivid color, and confidence for chemists and students alike.
The future for this reagent, like others we manufacture, depends on engagement—listening, improving, and never shying away from fielding tough questions or tackling stubborn quality problems that emerge in daily use. We value every user who picks up the phone or writes in about a mishap or suggestion. Their perspective keeps our product strong and our standards high.