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Acetoacetanilide

    • Product Name Acetoacetanilide
    • Alias AAA
    • Einecs 204-510-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    893098

    Cas Number 102-01-2
    Molecular Formula C10H11NO2
    Molar Mass 177.20 g/mol
    Appearance White to light yellow crystalline powder
    Melting Point 85-89°C
    Solubility In Water Slightly soluble
    Density 1.19 g/cm³
    Iupac Name N-phenyl-3-oxobutanamide
    Synonyms N-Phenylacetoacetamide
    Odor Odorless
    Storage Temperature Room temperature
    Flash Point 253.1°C
    Stability Stable under recommended storage conditions

    As an accredited Acetoacetanilide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Acetoacetanilide is packaged in a sealed, labeled 500g amber glass bottle, featuring hazard warnings and storage instructions for safety.
    Shipping Acetoacetanilide should be shipped in tightly sealed containers to prevent contamination and moisture absorption. It must be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances. Comply with local and international regulations; typically classified as non-hazardous for transport. Ensure appropriate labeling for safe handling.
    Storage Acetoacetanilide should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from sources of heat and ignition. Protect it from moisture, strong oxidizers, and direct sunlight. Proper labeling and segregation from incompatible substances are essential. Always follow appropriate chemical storage regulations and ensure that safety data sheets are accessible for reference.
    Application of Acetoacetanilide

    Applications of Acetoacetanilide in Industrial Manufacturing

    We support leading industrial producers by supplying high-purity acetoacetanilide for regulated, large-scale manufacturing. The applications below reflect the major downstream sectors integrating this raw material in compliance with regional and global industrial protocols.

    1. Organic Pigments for Coatings and Inks

    Leading pigment manufacturers use acetoacetanilide as a key coupling component in synthesizing high-performance azo pigments, particularly for coatings and printing inks. By participating in diazo coupling reactions with diazonium salts, the material produces vivid, stable colorants such as Pigment Yellow 74 and Pigment Yellow 65. Downstream plants monitor residual content and batch purity strictly, adhering to occupational safety and product purity regulations for pigment intermediates in both industrial and decorative surface coatings.

    Industry compliance standards

    • EN 71-3 (Europe): Migration of certain elements in pigments used for toys
    • ISO 9001: Quality management for pigment manufacturing
    • REACH (EC 1907/2006): Registration and hazard communication of chemical substances
    • ASTM D5538: Standard for pigment powder characteristics

    Typical usage ratio

    • 15%–35% by weight in pigment intermediate synthesis, depending on ion exchange activity and target tinting strength

    Downstream process integration

    • Added to reactor as base component in the coupling stage after diazotization of aromatic amines
    • Reaction conditions such as pH and temperature precisely controlled for pigment formation

    Final product types

    • Azo organic pigments (yellow, orange)
    • Industrial automotive coatings
    • Flexographic and gravure printing inks
    • Architectural paints

    2. Agrochemical Active Ingredient Synthesis

    Major agrochemical companies integrate this intermediate in the synthesis of selective herbicides and fungicides. It acts as an essential building block for pyrazole and triazole based actives by reacting under controlled temperature and pH with functionalized reagents. Technical production teams document raw material lot numbers and trace impurity levels for regulatory submissions. The process often forms part of a multi-step batch protocol to achieve target purity and stability.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 17025: Laboratory quality systems for active ingredient analysis
    • US EPA 40 CFR Part 180: Tolerances for pesticide residues
    • Good Manufacturing Practice (GMP) for crop protection chemicals

    Typical usage ratio

    • 5%–12% by mass in target molecule precursor formulations, ratio adjusted by product yield analysis

    Downstream process integration

    • Introduced at cyclization or chain extension step post-alkylation or nitration
    • Acts as carbon skeleton contributor in one-pot or staged syntheses

    Final product types

    • Triazole fungicide actives
    • Pyrazole herbicide actives
    • Intermediate mother liquors for further chemical refining
    • Custom formulation bases for branded agrochemicals

    3. Pharmaceutical Intermediate Production

    Acetoacetanilide is essential for specialty API and intermediate houses during multi-step synthesis of antipyretic and analgesic intermediates. It participates in condensation and cyclization reactions that form core pharmaceutical building blocks. Regulatory inspections require real-time monitoring of synthesis purity, batch records, and adherence to pharmacopoeial standards. GMP documentation and validated procedures govern handling and storage within the active manufacturing area.

    Industry compliance standards

    • ICH Q7: Good manufacturing practice for active pharmaceutical ingredients
    • USP/NF and EP reference monographs for synthetic intermediates
    • EU GMP Annex 8: Sampling of starting materials and intermediates
    • ISO 14644: Cleanroom standard for pharmaceutical production

    Typical usage ratio

    • 1.5–4% by mass in multi-component reaction feeds, actual dose based on route and yield optimization

    Downstream process integration

    • Added at key condensation stage for formation of anilide-containing structures
    • Purified in intermediate step before conversion to biologically active APIs

    Final product types

    • Antipyretic intermediates (e.g., for paracetamol derivatives)
    • Custom building blocks for non-steroidal anti-inflammatory drug APIs
    • Chemical reference standards
    • Biologically active specialty intermediates

    4. Dye and Colorant Manufacturing for Textiles

    Textiles dye manufacturers use acetoacetanilide as a coupling agent for synthesizing monoazo dyes applied to cellulose and synthetic fiber substrates. The material contributes to dye chromophore structure under controlled aqueous coupling reactions, improving color fastness and brightness. Downstream QCs track formation of by-products and maintain finished dye compliance with textile-specific chemical limits.

    Industry compliance standards

    • OEKO-TEX Standard 100: Restricted substances in dyes
    • ZDHC MRSL v3.0: Input chemical guidance for textile dyes
    • ISO 105-X12: Color fastness to rubbing in finished textiles
    • REACH Annex XVII: Restrictions on azo colorants for textile applications

    Typical usage ratio

    • 12%–28% by mass in dye synthesis, adjusted according to saturation and substrate compatibility

    Downstream process integration

    • Charged into batch reactor for main azo coupling after generation of precursor diazonium compound
    • Subjected to purification and spray drying prior to textile application

    Final product types

    • Monoazo disperse dyes for polyester
    • Direct dyes for cellulose fibers
    • Pigment dispersions for synthetic blends
    • Ready-to-use textile dye formulations

    5. Polymer Additive and Modifier Synthesis

    Polymer and plastics additive manufacturers employ acetoacetanilide as a raw input to synthesize specialty stabilizers and cross-linking agents. The compound participates in Michael addition and condensation processes to develop functional additives for improving thermal and UV resistance in polyolefins and polyurethanes. Process engineers record exact stoichiometry and monitor in-line quality to meet stricter specifications for materials destined for food contact or medical device plastics.

    Industry compliance standards

    • FDA 21 CFR 177: Indirect food additives for polymers
    • ISO 10993-5: Biological evaluation of medical device plastics
    • RoHS Directive 2011/65/EU for electronics polymer use
    • ASTM D256: Impact resistance for finished plastics

    Typical usage ratio

    • 0.5%–3.5% by mass in additive or cross-linker formulations, depending on required performance property

    Downstream process integration

    • Fed into block copolymer synthesis during cross-linking step
    • Introduced in compounding stage prior to extrusion or injection molding

    Final product types

    • Thermo- and photo-stabilizers for polyolefins
    • Cross-linking agents for polyurethane foams
    • Specialty modifiers for food-grade packaging
    • Engineering plastics for electronics housing

    6. Photographic Chemical Formulation

    Specialized manufacturers in the photographic sector add acetoacetanilide as a photographic color coupler in silver halide systems. It enters the color development phase to produce stable yellow and red dye images with minimal fading. Production utilizes calibrated dosing systems and tracks chemical consumption per batch for consistency with image resolution specifications required by advanced color print processing.

    Industry compliance standards

    • ISO 12232: Standardization for color photographic materials
    • ANSI IT9.2: Storage of processed photographic films
    • EN 71-9: Organic chemicals for photographic products (toys and children applications)
    • Kodak Q Lab QA for chemical batch consistency

    Typical usage ratio

    • 0.2%–1.1% by mass in color coupler concentrate, optimized for intended dye yield and color density

    Downstream process integration

    • Charged during emulsion or color developer blending phase
    • Stabilized prior to coating on photographic paper or films

    Final product types

    • Color photographic films
    • Professional color printing papers
    • Instant imaging materials
    • Specialty industrial photo chemicals
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    Certification & Compliance
    More Introduction

    Acetoacetanilide: Consistency Backed by Experience in Chemical Manufacturing

    We have dedicated years of hands-on work in chemical manufacturing, closely monitoring batches to ensure that each product not only meets the required technical specifications but also fits right into fast-moving industrial lines. Acetoacetanilide stands as a dependable intermediate for us, sourced, processed, and dispatched from our own facilities under conditions that protect its purity and reactivity. Many manufacturers know this compound in the form of off-white to pale yellow flakes or powder, carrying a distinctive faint odor. Our teams produce the most common grade with an assay consistently above 99%, as verified by repeated internal and external tests, using gas and liquid chromatography as a matter of routine.

    Common Grades and Purity Matters

    Inside the factory, every drum we prepare comes from batches filtered and crystallized with our proprietary methods that reduce contaminants well below acceptable thresholds for most dyes and pigment customers. We focus on minimal moisture levels during packaging because water readily causes hydrolysis, which reduces performance and clogs machinery. Our standard grade maintains a dry state, moisture below 0.3%, and is completely free from foreign particulates. Every lot ships with the supporting documentation you count on, including spectroscopic data and trace element analysis where requested.

    Applications Built on Real Production Experience

    From what we see on the shop floor, most acetoacetanilide leaves our gates bound for the colorant industry, especially for use as a coupling component in synthesizing azo and phthalocyanine pigments. Formulators working with various arylamines require a stable precursor; acetoacetanilide consistently fills this role, helping deliver hues with strong fastness against light and washing. Over the years, large-scale printing ink makers, plastic pigment suppliers, and textile dye formulators have all relied on us for regular supply, knowing how even a small shift in purity brings visible changes in shade and brightness. We've also seen growth in requests from agrochemical formulators and pharmaceutical labs, searching for intermediates capable of delivering a clear, reproducible reaction yield.

    Advantage of Direct Manufacturing for Reliability

    We place a high value on offering acetoacetanilide direct from our own reactors. It becomes easier to pinpoint and adjust production parameters that matter most to end-users. Temperature, catalyst selection, filtration steps—all these influence crystallinity, color quality, and downstream handling. When solvent traces pop up in our in-house GC runs, we reprocess or reject those batches. The same goes for the trace heavy metals that can disrupt sensitive syntheses or cause downstream discoloration; our QC teams sample each drum during filling, running atomic absorption and ICP tests before shipments leave.

    Working with Industry Standards and Expectations

    Over years of serving established pigment producers and new entrants, we've tuned our workflows to reflect real-world customer needs. Repeat buyers notice steady melting points, minimal residue after heating, and sharp performance in coupling reactions. Different pigment houses push us on color-forming consistency, especially when switching between shades—reds, oranges, and even deeper violets or blues. They need assurance the starting material behaves reliably, whether running kilo-lab syntheses or ramping up to metric tons in an automated plant. We don't just test the product by itself; many times, application tests occur in parallel, using sample couplers and amines under typical conditions found in industry labs.

    Differences from Other Intermediates

    Chemically, acetoacetanilide separates itself from other intermediates—like acetoacetates or acetoacetamides—by having a high degree of aromatic compatibility and predictable reactivity in the hands of pigment formulators. Some pigment grade couplers show subtle but significant performance losses unless acetoacetanilide checks certain criteria: clean melting (range above 85°C, narrower spread), precise solubility, absence of colored byproducts after synthesis, smooth processing in automatic dosing systems. In-house comparison trials make these differences apparent; plenty of acetoacetanilide on the open market exhibits micro-crystallinity issues or residual odors that affect nuanced color outcomes. Through controlled manufacturing, our samples retain batch-to-batch uniformity, so formulating chemists avoid time spent recalibrating. Our process design avoids byproduct contamination that often shows up in acetamidophenyl derivatives or cheap imported batches.

    Lesser-Known Uses and Research Directions

    While most production heads toward pigment plants, our technical contacts sometimes seek acetoacetanilide for exploratory work in catalysis, polymer modification, or specialty resins. A few research labs blend it into epoxy hardeners or experimental adhesives, taking advantage of its carbonyl and amide functionality. Batch records show that careful solvent washing improves compatibility with certain specialty polymers, mitigating issues with surface roughness or tack. We work with universities that request high-purity samples for examining new reaction pathways, seeking improved yields or more selective transformations. Feedback flows directly from bench scientists, helping us tailor purity and particle size by adjusting crystallization and grinding steps.

    Packaging and Handling from a Production Perspective

    We fill and seal each package under dry nitrogen when requested by overseas clients, minimizing degradation on long-haul voyages. Inventory storage benefits from low humidity, climate-controlled conditions—habits we picked up after watching a few batches clump or yellow after several months in sub-tropical depots. Bulk buyers sometimes specify custom packaging to speed up plant transfers or integrate with automated feed systems. Our operations crews keep up with these technical requests, regularly switching between drums, fiber-lined bags, and IBCs based on customer logistics. In any case, direct traceability follows every unit from reactor to loading dock, easing any rare returns or technical complaints.

    Managing Risks in Shipping and Compliance

    As the legal and regulatory lines shift, our plant managers stay involved in compliance training, ensuring every outgoing consignment meets the international rules governing transport and documentation. Safety Data Sheets reflect up-to-date hazard communication standards. Importers count on full transparency about residual solvent, trace metals, and other analytical data. We comply with the chemical inventories and registration requirements of most major markets, submitting samples for third-party audits when needed. Unlike trading agents, our position as a manufacturing source allows quick response to new regulatory developments, whether they stem from the chemical registration law in Europe, the TSCA requirements in the USA, or environmental mandates coming down from Asia’s strategic markets.

    Performance in Downstream Synthesis

    Experienced pigment manufacturers quickly spot the difference in performance between authentic, high-grade acetoacetanilide and cheaper, less consistent off-grade powders. Our product passes strict melt point and HPLC tests, demonstrating the lack of split peaks indicating impurities. In coupling reactions, chromophore formation occurs faster and more predictably. Color drifts, which can cause significant waste on multiton ink or fiber runs, almost never originate from high-quality acetoacetanilide. This consistency matters most to plants operating on tight batch cycles and high-throughput timelines, where a small discrepancy throws off production schedules and leads to expensive rework.

    Environmental and Worker Safety Focus

    Direct handling of acetoacetanilide, especially on production scales, calls for a thorough approach to worker safety and environmental stewardship. Staff across all shifts receive ongoing training on ventilation, dust management, and the personal protective equipment suitable for handling powdered aromatic compounds. Wastewater from washing and reactor cleaning passes through multi-stage treatment, including activated carbon filtration and pH balancing. We designed our system after years of audits, knowing that environmental authorities increasingly inspect trace effluent quality. Used drums and transport packaging are recycled or disposed of following the latest chemical waste standards, preventing the product from reentering the waste stream in uncontrolled ways.

    Collaboration and Customization in a Real-World Context

    Over decades, end-users have contacted us about adjusting the product for newer pigment chemistries or advanced composite resins. Some require ultra-low iron or copper for electronic applications; others specify finer or coarser particle size for rapid dissolution or pass-through screeners. Our technical support isn’t separated from our manufacturing reality—R&D, engineering, and production adjust process streams together, giving customers more than just a standard off-the-shelf item. In responding to feedback, close coordination across shifts delivers consistent improvements, whether that involves swapping out drying beds, tweaking filtration mesh sizes, or switching reactor charging protocols.

    Growing with Industry Demands

    As demand for high-performance pigments grows worldwide, especially across plastics, coatings, and inks, what matters most is a reliable supply chain that bends rather than breaks under stress. Our own experience with raw material shortages, freight disruptions, and changing labor patterns means we favor resilience. By investing in redundant production lines, local feedstock sourcing, and stable logistics partnerships, we anchor availability for both long-term and spot purchases. Some customers value regular supply schedules; others ramp up suddenly following major contract wins. Running our own plant allows us to respond to real lead times, shipping partial or full truckloads on tight notice.

    Addressing Quality Issues Through Direct Intervention

    At every stage, from incoming raw materials to final packaging, our engineers and QC teams remain directly responsible for product fitness. Unlike handlers or brokers, we control root causes of off-specification—adjusting temperature, vacuum, or agitator speeds as production demands shift. Any true quality issue, like color changes in finished pigments or residue left behind after processing, prompts a review of the detailed plant logs and retention samples kept in our storage rooms. Over time, these habits create a foundation of trust between us and experienced pigment or dye producers, helping solve real production issues rather than pushing blame down the chain.

    Moving Forward with New Technologies

    As pigment and dye technologies evolve, so do our manufacturing and analytical capabilities. We've invested in more precise instrumentation for impurity profiling, thermal analysis, and particle imaging, ensuring our acetoacetanilide meets newer, tougher customer requirements. Pilot-scale reactors give us the flexibility to develop custom batches, supporting R&D from our industry partners as they bring new colors and applications to market. A few years ago, plant upgrades allowed us to further reduce solvent losses and minimize even minor byproduct residuals. Continuous improvement in process yield and environmental footprint stays high on our agenda, not only for cost savings but because customers increasingly demand bottom-line sustainability and clarity over production methods.

    Building on Decades of Manufacturing Heritage

    Our commitment to supplying reliable acetoacetanilide grows from decades spent side-by-side with pigment makers, textile processors, and specialty chemical formulators. Their feedback shapes adjustments in our own plant, from rethinking grinding operations to retooling filling lines or redesigning batch reactors. Relationships built over years matter as much as the molecules themselves. Direct involvement in manufacturing creates a lineage of trust, something not possible through third-party trading channels. Customers see the same attention to reporting, the same clear technical support, and the same practical solutions—batch after batch.

    Looking Ahead

    Changing color technologies demand stable, high-purity intermediates, tailored by manufacturers who understand the nuances of scale, sustainability, and end-use applications. Doing this work at the source lets us pass those advantages forward. The confidence that comes from long-term, hands-on manufacturing means sharpened responses to new pigment chemistries, environmental challenges, and global supply shifts. Every kilo of acetoacetanilide that leaves our plant draws on this commitment—offering industry not just a chemical, but a direct connection to real production experience, honest feedback, and forward-looking support for what comes next.