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9-Aminoacridine Hydrochloride Hydrate

    • Product Name 9-Aminoacridine Hydrochloride Hydrate
    • Alias 9-AA
    • Einecs 223-672-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    653539

    Product Name 9-Aminoacridine Hydrochloride Hydrate
    Cas Number 676-45-9
    Molecular Formula C13H11ClN2 · xH2O
    Molecular Weight 246.70 g/mol (anhydrous)
    Appearance Yellow to orange powder
    Solubility Soluble in water
    Melting Point Variable (hydrated form), typically around 234-236°C (decomposes)
    Purity Typically ≥98%
    Synonyms Aminacrine hydrochloride hydrate; 9-Aminoacridine·HCl·H2O
    Storage Temperature 2-8°C (refrigerated)
    Ph 1 Solution Approximately 5.0-6.0
    Inchikey WFLLHRRTOCGOMP-UHFFFAOYSA-N

    As an accredited 9-Aminoacridine Hydrochloride Hydrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 9-Aminoacridine Hydrochloride Hydrate, 5g, packaged in a sealed amber glass bottle with tamper-evident cap, labeled with hazard precautions.
    Shipping 9-Aminoacridine Hydrochloride Hydrate is shipped in tightly sealed, chemically resistant containers to prevent moisture absorption and contamination. It is packaged in accordance with regulatory standards for hazardous chemicals, typically shipped at ambient temperature. Appropriate labeling for safe handling and hazard identification is provided to ensure compliance with safety and transportation regulations.
    Storage 9-Aminoacridine Hydrochloride Hydrate should be stored in a tightly sealed container, away from moisture, heat, and light. Keep the chemical in a cool, dry, and well-ventilated area, ideally at room temperature (15–25°C). Ensure it is clearly labeled and segregated from incompatible substances. Follow standard laboratory safety guidelines and keep it out of reach of unauthorized personnel.
    Application of 9-Aminoacridine Hydrochloride Hydrate

    Applications of 9-Aminoacridine Hydrochloride Hydrate in Industrial Manufacturing

    As a direct manufacturer of 9-Aminoacridine Hydrochloride Hydrate, we enable its use in several established downstream sectors with well-defined compliance requirements and standardized processing methods. The following sections detail real-world industrial application scenarios, each underpinned by industry regulations, customary formulation guidance, process integration practices, and final product profiles from actual downstream users.

    1. Pharmaceutical Intermediate for Antiseptic and Antibacterial Formulations

    Pharmaceutical manufacturers rely on 9-Aminoacridine derivatives as building blocks in the synthesis of antiseptic agents and antibacterial intermediates. Regulatory frameworks control its use at every stage, from raw material qualification to batch production. Downstream chemists employ precise formulation ratios to maintain purity and minimize byproduct formation. Integration occurs predominantly in the early phases of multi-step synthesis, leading to final actives in solution, ointment, and tablet forms.

    Industry compliance standards

    • Ph. Eur. (European Pharmacopoeia) monographs for intermediates (current edition)
    • 21 CFR Part 210/211 (US FDA cGMP guidelines for finished pharmaceuticals)
    • ICH Q7 (GMP for Active Pharmaceutical Ingredients)
    • ChP (Chinese Pharmacopoeia, where locally registered)

    Typical usage ratio

    • 0.5–1.5% w/w as an intermediate; adjustments depend on targeted derivative yield and impurity control requirements.

    Downstream process integration

    • Charges into the initial synthetic step or amidation reaction as a limiting reagent.
    • Participates in condensation protocols for acridine-based antimicrobial actives.
    • Subject to strict in-process QC sampling and residual solvent monitoring.

    Final product types

    • Bacterial ointments (containing acridine derivatives)
    • Topical antiseptic solutions
    • Tablet and lozenge forms with acridine molecular cores
    • Bulk API intermediates for contract synthesis

    2. Analytical Reagent Manufacturing for Fluorescent Dye Production

    Research reagent specialists and fluorescent dye manufacturers exploit the unique aromatic structure of 9-Aminoacridine for the preparation of nucleic acid stains and molecular probes. Downstream QC and analytical method validations reference international standards. Formulation precision is essential to maintain emission specificity and photostability in finalized products. The compound is charged during coupling or substitution reactions for label synthesis, ultimately yielding dyes supplied to genomics and life science labs.

    Industry compliance standards

    • ISO 9001:2015 (Quality management systems for laboratory reagent producers)
    • ISO 17034 (Reference material producers)
    • REACH Annex VII (EU chemical safety for laboratory reagents, as applicable)
    • RoHS compliance (where dye products enter electronics or imaging sectors)

    Typical usage ratio

    • 1.0–5.0% w/w in precursor formulations; adjusted for desired fluorescence intensity and matrix compatibility.

    Downstream process integration

    • Loaded into batch reactors for diazotization or nucleophilic aromatic substitution reactions.
    • In-line monitoring with HPLC confirms dye purity and extinction coefficient.
    • Followed by purification steps such as recrystallization and preparative chromatography.

    Final product types

    • DNA/RNA fluorescent stains (for agarose gel electrophoresis)
    • Microscopy dyes for cellular imaging
    • Synthetic molecular probes for life sciences
    • Stock solutions for analytical kit manufacturers

    3. R&D and GMP-Grade Bulk Material for Chemical Synthesis

    Chemical contract research organizations and pilot-scale GMP manufacturers use the compound as a reference material or synthetic building block, supplying both development and regulated production pipelines. Strict adherence to GMP and analytical validation ensures traceability and batch-to-batch consistency. Formulators specify usage quantities for reaction efficiency, while high-purity grades reduce downstream purification needs. Integration is typically at the multi-kilogram scale for custom synthesis contracts.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice Guidance for APIs)
    • USP-NF (United States Pharmacopeia, for R&D standards qualification)
    • ISO 13485 (for raw material supply into medical device R&D pipelines)
    • GMP certificate (as required by client and regulatory region)

    Typical usage ratio

    • 0.2–2.0% w/w in custom synthetic routes; determined by project-specific stoichiometry, scalability studies, and desired reaction throughput.

    Downstream process integration

    • Direct addition to pilot reaction vessels for multi-step syntheses.
    • Sampled at defined stages for full analytics (LC-MS, GC-MS, NMR) documentation.
    • Further processing into regulatory submission standards or reference grade materials.

    Final product types

    • Research-grade reference materials
    • Small molecule lead compounds for pharmaceutical candidates
    • Specialty chemistry intermediates
    • Bulk analytical standards for method development

    4. Histology and Pathology Dye Conjugate Manufacturing

    Producers of diagnostic stains apply 9-Aminoacridine to generate nucleus-selective dyes for fixed tissue preparation in histological and cytological examinations. Compliance with histological product standards and user safety regulations determines batch release. Usage ratios optimize contrast clarity and dye uptake, with adjustments based on tissue permeability profiles. Integration involves mixing during the conjugation phase of dye synthesis, followed by formulation into ready-to-use staining solutions or powder kits for hospital and laboratory markets.

    Industry compliance standards

    • ISO 13485 (Medical devices — Quality management for diagnostic reagent manufacturers)
    • 21 CFR 864.7010-9 (US FDA for in vitro diagnostic products)
    • EN ISO 15189 (Medical laboratories — Requirements for quality and competence)
    • CE marking (where applicable in the European diagnostics market)

    Typical usage ratio

    • 0.05–0.4% w/w in staining agent preparation; adjusted to sample type and target tissue penetration efficiency.

    Downstream process integration

    • Added at the dye-substrate coupling step in semi-continuous batch synthesis.
    • Subjected to process filtration and purification steps for removal of unreacted monomer.
    • Final blending and packaging into single-use vials or bulk containers for laboratory use.

    Final product types

    • Nuclear DNA stains for histopathology
    • Pre-formulated tissue staining kits
    • Reference dyes for cytological diagnostics
    • Microscopy slide preparation reagents
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    Certification & Compliance
    More Introduction

    Introducing 9-Aminoacridine Hydrochloride Hydrate: Direct from Our Production Line

    Genuine Manufacturing Roots in Every Batch

    Every day in our chemical factory, we handle compounds meant for labs and research centers around the globe, and 9-Aminoacridine Hydrochloride Hydrate stands out as a compound we’ve come to know in depth, both through production and ongoing feedback from our partners. This isn’t a product we buy from others and pass along — we craft it ourselves, monitor every drum, and understand the nuances behind its purity and consistency. Our pride comes from seeing our material enabling real-world breakthroughs in biochemistry, molecular biology, and pharmaceutical development.

    A Closer Look at What Sets Apart 9-Aminoacridine Hydrochloride Hydrate

    Our 9-Aminoacridine Hydrochloride Hydrate, with the chemical formula C13H10N2•HCl•H2O, arrives as a light yellow to orange crystalline powder. Over years of precise manufacturing, we’ve kept a watchful eye on critical parameters, especially purity, since even trace impurities in this product can throw off the very studies and reactions it supports. Most users we talk with prioritize the product’s ability to intercalate DNA, and having shipped to labs and university research teams for decades, we know an unreliable batch can jeopardize weeks of experiments. That’s where our rigorous solid-phase purification comes in — we keep spectral and chromatographic records, not because people ask, but because we've witnessed firsthand how just a whisper of contamination can skew results.

    Our process starts with high-grade acridine, carefully controlled reaction atmospheres, and tightly measured hydration. Unlike some sources who dry and rehydrate the compound at shipment to save on logistics, we maintain hydration states consistent from synthesis through packaging. This ensures solubility remains exactly as researchers expect, removing the guesswork from dissolving or weighing the compound for each use. The product enters the world as we made it — no shortcuts, no unexplainable variation from bottle to bottle. In side-by-side NMR or HPLC comparisons with third-party samples, you see fewer extraneous peaks and tighter purity yields, something that matters when chasing clean, reproducible data.

    Where Our Material Goes and What It Enables

    Over the years, we've supplied 9-Aminoacridine Hydrochloride Hydrate into applications ranging from DNA dyeing in gel electrophoresis to fluorescence studies, DNA footprinting, and as an intercalator in cancer research. The capabilities of the acridine backbone blend with the amine group’s DNA affinity, making it valuable in fundamental and applied research settings. Some researchers choose phenanthridine-type analogs or unsubstituted acridines for particular applications, yet our 9-Aminoacridine Hydrochloride Hydrate keeps finding its way to labs focused on nucleic acid work, including those pursuing gene regulation, DNA repair mechanisms, and small molecule-DNA interaction profiling. In fact, several collaborating teams have told us our batch-to-batch consistency helped them meet strict reproducibility requirements in peer-reviewed projects and patent filings.

    Solubility remains a practical concern. Our careful control of hydrochloride salt hydration produces a material easily dissolved in aqueous buffers and many organic solvents at room temperature, avoiding precipitation or gel-formation headaches. We've seen researchers put countless solvents through their paces trying to coax low-quality material into solution, losing time and valuable samples along the way. Our in-house testing program includes not just basic solubility checks, but extensive pH range, temperature, and buffer compatibility runs. Consistently, bench chemists note how smooth our batches dissolve; this may sound like a minor benefit, but it spares countless headaches, especially in high-throughput or sensitive analytical environments.

    Our Experience with 9-Aminoacridine Hydrochloride Hydrate in the Field

    A research group once reached out, frustrated after sourcing from a distributor whose product arrived clumpy and with a brownish tinge. After switching to our freshly-produced material, they reported clear, reliable fluorescent bands right from the first gel — no wasted reagents on false starts or troubleshooting. Over time, we’ve learned that subtle problems — batch aging, micro-contamination from poor handling, improper crystallization — lead to missed research deadlines and unnecessary costs. By producing, storing, and handling everything under well-maintained, temperature-controlled conditions, we consistently avoid those pitfalls.

    Our quality control doesn’t stop at the obvious. Each release goes through UV-vis and fluorescence spectral profile testing, confirming the classic excitation and emission responses biochemists have come to expect when working with this dye. Differences between lots can arise with the smallest deviations in process parameters. The value of long-term technical staff shows here — many of our team members have handled the transition from small-batch pilot runs to scalable production, and their experience filters into every protocol refinement and final product. Whenever we hear about a tricky prep or problematic downstream assay from a partner lab, we bring their feedback into our next batch run, confirming that small improvements add up over years.

    Not every sample involves leading-edge research. Industry partners in the pharmaceutical field use 9-Aminoacridine Hydrochloride Hydrate for small-scale screening and analytical reference standards. Some have even adopted our product into GLP (Good Laboratory Practice) pipelines, citing our ability to deliver reliable Certificates of Analysis along with detailed lot histories. That ongoing collaboration ensures we keep our benchmarks high, not by chasing abstract standards, but by meeting the concrete needs communicated directly from the field.

    Comparing Our Product to Other 9-Aminoacridine Hydrochloride Batches

    In our conversations with researchers and procurement staff, several themes stand out regarding differences between our material and what’s available elsewhere. Some providers offer “off-the-shelf” batches sourced from resellers or brokers; those sources rarely can vouch for production legacy or handling conditions. Our operation tracks each batch from raw chemical right to delivery. When a lab asks for historical batch data, spectral overlays, or certification that ties directly to a given bottle they received, we provide them, no excuses. That level of transparency comes only from direct manufacturing, not after-the-fact relabeling.

    Some other providers don’t stabilize the hydrate form as consistently as we do, leading to off-ratio products or fluctuations in product performance. Overdrying or mismanagement leaves end users with inconsistent mass-per-mole calculations, leading to erratic assay results. Our team’s direct attention to crystal structure and hydrate content throughout production brings predictable results in every experiment. This reliability holds particular value in quantitative DNA studies or drug-binding experiments, where minor concentration errors echo through entire research campaigns.

    Quality doesn’t end at purity. Longevity and shelf-stability matter, especially for labs that order months ahead or keep reference stocks on hand for validation. Our material remains free-flowing, untapped by clumping, for far longer than typical market alternatives. Controlled moisture levels throughout storage keep reactivity within a dependable range, avoiding unpleasant surprises after months in storage. We watched some competitors’ products turn sticky or lose solubility over time; by learning from those missteps, we've fine-tuned our process to prioritize long-term stability as much as initial specs.

    Our Day-to-Day Work Reflected in Every Bottle

    In our facility, each production line worker knows the story behind 9-Aminoacridine Hydrochloride Hydrate. On the synthesis floor, team members monitor reaction temperatures and reagent addition rates, understanding not just the numbers, but the chemistry underneath. At the filtration and crystallization stations, we use in-line measurement to avoid batch drift and keep physical form exactly as downstream users expect. In truth, it’s not automation alone that achieves this — it’s decades of hands-on experience, troubleshooting equipment, dialing in pH adjustments by eye as well as meter, and catching subtle color changes before impurity levels rise.

    Plant operators and chemical engineers cross-check product as it moves through drying and hydration, making sure sample portions reflect the batch as a whole. Any time we see deviation in color or particle form, we pull samples for further analysis. This boot-on-the-ground approach prevents the all-too-common disconnect between report and reality you sometimes find with traders or generic resellers. Questions from customers don’t get shunted to anonymous call centers; they land right with the people who handle the product themselves.

    We believe in the longevity of relationships, not just transactions. When a researcher or analytical chemist contacts us with a thorny problem or a request for data, they get straight answers grounded in hands-on production and testing, not a vague dispatch from a sales intermediary working off pre-written scripts. Every improvement in our product line stems from this direct back-and-forth — phone calls about clumping, emails about unusual NMR spectra, requests for material compatibility details — it all directly shapes how we manufacture, store, and deliver.

    Looking Ahead: Ongoing Refinement and Partnership

    What does this approach mean for labs relying on our 9-Aminoacridine Hydrochloride Hydrate? It means fewer interruptions, less troubleshooting, and more time spent on actionable science. We’ve invested in better crystalization vessels, cleaner environment controls, and live monitoring systems — not because external rules forced us, but because repeated dialogue with field users told us exactly where hangups in quality occur. Each of our upgrades, from raw material purity to final bottling improvements, connects directly to the world beyond our gates: a world of projects, grant proposals, dissertations, and applications where one bad batch could spell setbacks.

    Producer-to-user feedback loops stay alive in our operation and influence every new batch. We bring our own manufacturing lessons to bear, anticipating seasonal swings in humidity, watching delivery trends, and staying alert to global supply shifts. Our logistics team works in concert with production and QA, making sure what leaves our facility matches what’s described on our paperwork and what ends up on your bench or in your instrument.

    Why Our Role as a True Manufacturer Matters

    It’s easy to forget where the chemicals behind each experiment come from, particularly with online marketplaces and multinational distribution webs. But we see daily that origin matters. As the actual manufacturer, every decision — from sourcing raw intermediates to checking final vials — shapes the outcome for scientists relying on our work. We carry the weight of those decisions. The product isn’t anonymous. It carries our efforts and identity from synthesis to delivery.

    We keep trusted routes of communication open with every user of our 9-Aminoacridine Hydrochloride Hydrate. If a challenge arises, it doesn’t disappear into a bureaucracy. Conversations lead to fixes, not excuses. Drawing from our long-standing production experience, we improve each lot. Our focus stays fixed on tightened purity, retained color, stable hydrate form, and reproducible fluorescence qualities. Those hard-won features don’t come from generic relabeling, but from a continuous commitment to craft the best material for real science. Our journey with 9-Aminoacridine Hydrochloride Hydrate isn’t just about chemical output. It’s about the reliability that supports every lab’s next discovery, every data point, and every bit of progress made at the bench.