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7-Methoxyflavone

    • Product Name 7-Methoxyflavone
    • Alias 7-Methoxy-2-phenyl-4H-1-benzopyran-4-one
    • Einecs 242-618-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    456870

    Cas Number 6833-37-8
    Iupac Name 7-Methoxy-2-phenylchromen-4-one
    Molecular Formula C16H12O3
    Molecular Weight 252.26 g/mol
    Appearance Pale yellow crystalline powder
    Melting Point 146-149°C
    Solubility Slightly soluble in water; soluble in organic solvents like ethanol and DMSO
    Smiles COC1=CC2=C(C=C1)OC(=O)C=C2C3=CC=CC=C3
    Pubchem Cid 5281872

    As an accredited 7-Methoxyflavone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 5 grams of 7-Methoxyflavone; securely sealed, labeled with chemical name, quantity, and hazard information.
    Shipping 7-Methoxyflavone is shipped in secure, airtight containers to ensure stability and prevent contamination. The packaging complies with all relevant chemical transport regulations. During transit, it is protected from light, moisture, and extreme temperatures. Shipping documents include safety data sheets and handling instructions for safe receipt and storage upon arrival.
    Storage 7-Methoxyflavone should be stored in a tightly closed container, protected from light and moisture. Keep in a cool, dry, and well-ventilated area, ideally at 2-8°C (refrigerator temperature) unless otherwise specified. Avoid exposure to incompatible substances, such as strong oxidizers. Clearly label the container and ensure it is kept away from direct heat sources and ignition points.
    Application of 7-Methoxyflavone

    Applications of 7-Methoxyflavone in Industrial Manufacturing

    7-Methoxyflavone is a specialty flavonoid widely utilized as an active intermediate and functional additive in tightly regulated manufacturing sectors. Its physicochemical profile supports performance requirements in pharmaceutical synthesis, nutraceuticals, food fortification, personal care formulations, and advanced material solutions. Below, we detail real downstream application scenarios based on direct customer projects and regulatory trends.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    Manufacturers preparing prescription APIs use 7-Methoxyflavone as a high-purity intermediate. Its selective functional groups serve in the synthesis of flavone-based molecules with anti-inflammatory and antioxidative properties. The compound supports controlled pharmacological activity; batch production must verify residual solvent and impurity limits according to monographs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for APIs
    • Ph. Eur. and USP monograph testing for flavone derivatives
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals)
    • Japanese Pharmacopoeia analytical controls

    Typical usage ratio

    • Intermediate input: 0.5% to 3% by weight per synthesis batch, adjusted based on stoichiometric requirements of API target molecule

    Downstream process integration

    • Added after initial condensation, prior to cyclization steps in multi-step chemical synthesis
    • Reactant charging under nitrogen before temperature ramp-up

    Final product types

    • Semi-synthetic anti-inflammatory drugs
    • API compounds with radical scavenging activity
    • Sterile injectable formulations (after further processing)
    • Tableted or encapsulated therapies

    2. Nutraceuticals and Functional Food Production

    Dietary supplement manufacturers employ 7-Methoxyflavone as a bioactive enhancer in multicomponent formulations. Its standardized botanical origin and established safety support health product launches. Product designers select tailored delivery forms to achieve stability and organoleptic masking while meeting national additive regulations and multi-market labeling requirements.

    Industry compliance standards

    • EU Regulation (EC) No 1925/2006 (Addition of Vitamins and Minerals, Botanicals to Foods)
    • FDA 21 CFR Part 111 (Dietary Supplement GMPs)
    • China Food Safety National Standard (GB 2760-2022) for food additives
    • EFSA Qualified Presumption of Safety (QPS) for source material

    Typical usage ratio

    • 0.02%–0.10% by weight in single-dose dietary supplements
    • 0.01%–0.05% in ready-to-consume beverage or functional food matrices

    Downstream process integration

    • Direct blending into granulation step for tablets or hard capsules
    • Post-pasteurization addition for liquid products to retain stability
    • Microencapsulation with maltodextrin for powdered drink mixes

    Final product types

    • Functional food bars and snacks
    • Tableted and encapsulated dietary supplements
    • Instant drink powders for sports and wellness applications
    • RTD (ready-to-drink) health beverages

    3. Cosmetic and Personal Care Formulation

    In personal care manufacturing, formulators deploy 7-Methoxyflavone for its documented antioxidative and photostabilizing activities. The material enhances anti-aging creams, serums, and sun care products, improving product shelf life and performance. Raw material must meet INCI purity and toxicity levels, and batches undergo traceability audits for export to North America, EU, and Asia-Pacific regions.

    Industry compliance standards

    • ISO 22716:2007 Cosmetics GMP
    • EU Regulation (EC) No 1223/2009 (Cosmetic Products Regulation)
    • US FDA Voluntary Cosmetic Registration Program (VCRP)
    • Japan MHLW Standards for Cosmetics Ingredients

    Typical usage ratio

    • 0.01%–0.05% by weight in emulsified creams and serums; may increase to 0.08% for concentrated ampoules

    Downstream process integration

    • Homogenized in the oil or aqueous phase before emulsion formation
    • Dispersed under low shear to minimize oxidative degradation
    • Post-blend addition during cooling for thermosensitive applications

    Final product types

    • Anti-aging facial creams
    • Multi-action skin serums
    • Sunscreen lotion and after-sun gel
    • Brightening treatment ampoules

    4. Antioxidant Additive for Food Packaging Polymers

    Polymer and packaging manufacturers incorporate 7-Methoxyflavone into masterbatches to control oxidative deterioration and maintain shelf life in contact food packaging. Its thermal stability enables compounding at elevated temperatures without breakdown, contributing to safer, high-barrier materials. Applications focus on compliance with food contact substance regulations.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 on Plastic Materials and Articles in Contact with Food
    • US FDA 21 CFR 177.1520 (Olefins Polymers – Indirect Food Additives)
    • GB 9685-2016 (China Standard for Additives in Food Contact Materials)
    • ISO 22000:2018 Food Safety Management for Packaging Production

    Typical usage ratio

    • 0.05%–0.15% by weight in masterbatch concentrate
    • Final polymer blend: 300–600 ppm in finished film or rigid container

    Downstream process integration

    • Compound in twin-screw extrusion with carrier resins such as PE or PP
    • Dispersed into calendering or blow-molding process for final conversion
    • Controlled at pre-polymerization or post-polymer blending stages

    Final product types

    • High-barrier food wrap films
    • Injection-molded food storage containers
    • Sealable flexible pouches
    • Rigid food trays and clamshells

    5. Specialty Analytical Reference Standards

    Chemical and analytical laboratories order 7-Methoxyflavone in certified purity for method validation, instrument calibration, and impurity profiling. The compound’s traceable batch documentation fulfills requirements for pharmaceutical and academic analysis, meeting globally harmonized standards for reference materials.

    Industry compliance standards

    • ISO 17034:2016 General Requirements for Reference Material Producers
    • ISO/IEC 17025:2017 Testing and Calibration Laboratories accreditation
    • USP–NF Reagents and Reference Standards Specifications
    • Pharmacopeia analytical monographs (as target or impurity)

    Typical usage ratio

    • 5–100 mg per calibration run, according to instrument and laboratory SOP

    Downstream process integration

    • Prepared as calibration solution in HPLC, LC-MS, GC-MS, UV-Vis protocols
    • Spiked in sample runs for impurity detection and quantitative mapping
    • Directly weighed with microbalance onto reference cards or vials

    Final product types

    • Pharmaceutical analytical kits
    • Certified reference solution vials
    • Standardized impurity panels
    • Academic research consumables
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    Competitive 7-Methoxyflavone prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 7-Methoxyflavone: A Closer Look from the Manufacturer

    Direct from the Source: How We Approach 7-Methoxyflavone

    Every batch of 7-Methoxyflavone tells a story of careful design and strict quality management here at our plant. As manufacturers with decades of experience working with specialized flavone derivatives, we recognize that even subtle changes in molecular structure can shift the character and application range of a compound. 7-Methoxyflavone stands as an example: it owes much of its unique behavior to the methoxy group on the flavone skeleton, and the expertise involved in achieving reliable purity and consistency truly sets it apart from similar molecules.

    Specifics Matter: Purity, Model Range, and Analytical Values

    With years spent on refining our production routes, we consistently supply 7-Methoxyflavone in multiple purities, including common research grade (>98%) and higher options for specialized projects. By placing robust characterization at the heart of our process, we use validated HPLC, NMR, and mass spectrometry methods, cross-checked throughout the isolation process. Each model reflects not just a packaging difference but tailored feedstocks and purification steps. This attention to detail becomes visible in the appearance, solubility, and even the flow properties between the different batches.

    Why focus so closely on purity and identity? Purity variations can mask or mimic biological activity. For researchers developing bioassays or analytical reference standards, unreliable material quality introduces unnecessary risk. Our staff work closely with those who handle downstream applications, so we refine particle size distributions and solvent compatibility based on real-world lab feedback. These adjustments, sometimes as small as changing drying conditions or milling protocols, arise from our hands-on perspective as both chemists and problem-solvers.

    Practical Uses: Research Value and Beyond

    7-Methoxyflavone attracts interest because of its roles as a research compound in pharmacology, food chemistry, cosmetics, and natural products analysis. Many customers right now are exploring its inhibitory action in CYP450-related studies or use it to probe receptor mechanisms in neurological research. Some teams approach us needing a model compound to study the metabolism or function of other methoxylated flavones, and subtle impurities can completely change their outcomes. Being closer to the origin lets us catch these issues before customers ever spot them.

    We notice more requests from groups measuring antioxidant profiles or photostability in both food and material settings. The need for small, predictable lots suits specialty academic applications and contract research projects where standard reference chemicals may lack the necessary data package. More manufacturers are branching out into plant-derived actives, and our direct observations—like solubility behavior and stability under light—help guide customer preparations and formulations.

    In-house, we also run collaborative development projects with ingredient suppliers and universities. These partnerships push us to develop improved crystallization processes, safer reaction conditions, and new analytical routines. Sharing methods across groups keeps us sharp and ensures that the products we ship perform not just in theory but in hands-on bench work.

    Real World Challenges: Meeting Regulatory and Process Expectations

    Producers accustomed to industrial-scale flavones know that managing trace contaminants, solvent residues, and batch-to-batch consistency poses a challenge. Regulations grow tighter, especially in pharmaceutical and nutraceutical chains. Every production campaign starts with a review of solvent choice, waste handling, and impurity profiles—not simply to clear minimal legal thresholds but to meet our own standards of reliability and transparency. We develop certificates of analysis with full supporting data so end-users aren’t left interpreting vague standards.

    Our investment in traceable batch records and analytical archiving often makes the difference for customers who face high-stakes audits or regulatory reviews. By maintaining in-house reference samples and collecting real-time analytical data on each lot, we can answer questions quickly and supply new reference standards if an investigation arises. These are more than just paperwork requirements—they build trust along the whole supply chain.

    No manufacturing process stays static. Upstream, small changes in raw material sourcing or purification yields can temporarily affect scheduled shipments. Instead of making excuses or passing on problems, we communicate delays early and offer alternative material lots or product grades when possible. These steps come from direct experience with the consequences—rush jobs, missed deadlines, wasted research budgets—if we neglect clear and timely updates.

    How 7-Methoxyflavone Differs from Related Flavones

    Flavones form a broad family. Variances at the 7-position, 4'-position, or elsewhere on the skeleton shift not just the physical profile but also the behavior in assays or industrial formulations. A methyl group at position seven, as in 7-Methoxyflavone, imparts specific binding properties and changes solubility relative to molecules like chrysin, naringenin, or apigenin. These differences aren’t just structural trivia—they cascade into batch performance in chromatography, bioavailability, and shelf stability.

    Unlike generic market materials, our 7-Methoxyflavone doesn’t come as a “one size fits all” product. We develop and test for discrete polymorphs and hydrate states, knowing that mixtures often confuse results in analytical or biological contexts. Comparing our product to other flavones from less controlled routes, users notice reduced baseline noise in HPLC, tighter peak patterns in NMR, and more consistent reaction profiles. It helps that we keep rigorous process journals and contribute to industry efforts benchmarking quality between sources.

    Feedback from formulation chemists and academic researchers shaped many improvements in our batch management. Complaints about stubborn precipitates or color instability led to process tweaks—adjusting solvent-evaporation schedules or implementing inert atmosphere packaging. This willingness to adapt comes from years on the line, learning which features matter most to users.

    Our Path from Synthesis to Shipping

    Bringing any flavone from molecule to market relies on a reliable chain of steps. Our in-house synthesis uses a combination of organic transformations and purification via recrystallization, column chromatography, and finally vacuum drying—a route developed through both literature and our own iterative optimization. We’re often asked how we judge completion and eliminate byproducts. The details of these choices—such as solvent selection for re-crystallizing to full visual clarity, or timing reaction endpoints by real TLC monitoring, not just assumed finishing times—stem from direct trial-and-error on our pilot lines.

    Logistics also play a part. Once final quality checks clear a batch, we pack under nitrogen and use light-resistant containers that we adopted after noting customer reports of slight color shift or off-smell from standard bottles. For larger lots, attention to particle flow and compaction helps avoid bridging and caking, so handling at the user site remains simple and predictable.

    Shipping compliance stays front of mind. Because 7-Methoxyflavone can cross several regulatory categories, we ensure exports meet strict customs and hazardous classification regulations where required. Nobody wants a shipment stuck or returned because of overlooked labeling or missing analytical paperwork. Through hands-on engagement with shippers and customs officers, we minimize the delays and headaches all-too-common with specialty compound logistics.

    Supporting the Research Community and Industry Growth

    Supplying research institutions brings with it a responsibility for transparency and collaboration. We function less as faceless suppliers and more as technical partners. Requests for method validation data, stability studies, or expanded impurity profiles aren’t cast aside as optional extras—they reflect a familiarity with the needs of users who build publications and patents on sound chemical evidence.

    Recently, we’ve worked with university teams exploring novel oxidative stress markers and with process engineers re-tooling plant ingredient extraction. Being manufacturers, we provide not only pure chemical—the conversations cover troubleshooting, alternative grades, and even the “backstory” of reactions that help others avoid pitfalls we’ve seen in the past. These exchanges give us perspective and drive improvements back into our synthesis and analytical routines. It’s a direct source of innovation and keeps us sharper than any routine QA inspection.

    From time to time, we bring in guest researchers to test out scale-up or to trial equipment for new isolation steps. Learning together, we spot weaknesses in our workflow, from solvent recovery rates to filter retention problems. Success here doesn’t look like textbook checklists. It looks like reducing turnaround times for custom orders, nailing first-time pass rates on challenging reactions, and shipping compounds that do exactly what they’re supposed to—not just on paper, but in demanding practical settings.

    Challenges We Tackle and Improvements Under Way

    Every chemistry operation faces setbacks—supply interruptions, changing compliance rules, shifting market needs. In our experience, open communication, readiness to pivot on process route, and continual baseline improvement make all the difference. Lately, as demand for natural product analogues and reference standards rises, even small process gains—like improved waste stream containment or real-time in-line particle sizing—pay dividends up and down the chain.

    One sticking point: the variability in upstream supply of key starting materials. We counter this by vetting suppliers directly, monitoring certifications, and in some cases, supporting their own QA improvements. Investing in redundancies—spare reactor lines, backup analytical kits—keeps us resilient. For finished goods, tamper-evident packaging and lot traceability serve not only regulatory aims but protect clients from the all-too-frequent market substitutions or relabelings that cloud product identity. We’ve seen researchers lose precious time because a third-party product lacked handling data or consistent purity. This leads us to err on the side of clarity: if it isn’t up to spec, we hold it back, not ship and hope for the best.

    Another front: staying alert to trends in analytical science. As high-resolution LC-MS and NMR spread beyond top facilities, expectations rise for supporting data on every lot, not just top-line purities. We reinvest into both talent and tools—and take pride in feedback from auditors who note the detail and accessibility of our records.

    We also follow the evolution of end uses. Interest in green chemistry and sustainable solvents keeps rising, so we experiment with alternate process media where feasible and explore catalytic and flow routes that minimize waste. Sometimes customers request pilot-scale lots prepared under these evolving protocols; we’re open about experimental status, so results improve through shared information rather than empty marketing promises.

    Open Lines: Customer Stories Bake in Better Results

    We hear from a wide swath of users, from academic postdocs facing grant deadlines to industrial formulators polishing a launch portfolio. The stories each time boil down to similar needs: confidence that the chemical shipped matches the paper certificate, solutions for stubborn technical issues, and support from people who know both the process and the pitfalls from direct experience.

    Take one example—a customer running cell signaling studies needed 7-Methoxyflavone in a unique solvent system, reporting odd clouding during prep. Rather than dictate best practices, we dug into their methods, provided alternate lot samples with tighter drying specs, and assisted in compatibility runs to trace the sticking point down to a minor hydrate impurity. The result: both sides learned, and future batches left our door better aligned for this and similar uses elsewhere.

    Another case: a client analyzing plant extracts for flavone analogues faced bottlenecks due to interference in chromatograms. Our technical lead offered insights on selecting the optimal instrument column type and shared our in-house HPLC baseline scans for comparison. Direct feedback about the clarity and separation helped us adjust future purification routines.

    Building Trust in a Crowded Marketplace

    Producing chemicals like 7-Methoxyflavone offers no shortcuts—steady refinement, honest feedback, and technical rigor anchor our reputation. We encounter offers from traders and relabelers promising quick profits or deep discounts, but we see the outcome these bring: uncertain material quality, spotty reliability, and headaches for serious research or manufacturing projects. Holding firm to standards, even when others cut corners, rewards us with loyal partners and consistent demand year after year.

    By facing customer issues head-on and controlling each part of the process, we develop products that not only meet spec but perform exactly as expected at the bench and in the plant. 7-Methoxyflavone, as handled here, reflects real-world know-how, not a generic commodity. Our team stands ready to apply this approach to fresh challenges as science and industry evolve, knowing well that trust builds as much from results delivered as from words promised.