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6-Chloropicolinic Acid

    • Product Name 6-Chloropicolinic Acid
    • Alias 6-CPA
    • Einecs 215-781-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    155655

    Cas Number 1847-22-1
    Molecular Formula C6H4ClNO2
    Molecular Weight 157.56 g/mol
    Iupac Name 6-chloropyridine-2-carboxylic acid
    Appearance White to off-white crystalline powder
    Melting Point 215-218 °C
    Solubility In Water Slightly soluble
    Density 1.49 g/cm³ (predicted)
    Purity Typically ≥98%
    Pka 2.63 (carboxylic acid hydrogen)
    Synonyms 6-Chloro-2-pyridinecarboxylic acid

    As an accredited 6-Chloropicolinic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 6-Chloropicolinic Acid, 25g: Supplied in a sealed, amber glass bottle with tamper-evident cap and hazard labeling, for laboratory use.
    Shipping 6-Chloropicolinic Acid is shipped in tightly sealed containers to prevent moisture and contamination. It is classified as a hazardous material, requiring labeling according to regulatory guidelines. The chemical is transported in compliance with local and international regulations, ensuring proper documentation, safety precautions, and environmental protection throughout the shipping process.
    Storage 6-Chloropicolinic Acid should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and bases. Protect from moisture and direct sunlight. Use appropriate personal protective equipment when handling. Ensure proper labeling and keep away from sources of ignition and heat to prevent decomposition or hazardous reactions.
    Application of 6-Chloropicolinic Acid

    Applications of 6-Chloropicolinic Acid in Industrial Manufacturing

    As an experienced chemical raw material manufacturer, we deliver 6-Chloropicolinic Acid to a diverse range of industrial clients. The following sections describe real-world downstream applications in agrochemicals, pharmaceuticals, specialty intermediates, materials science, and dye synthesis, with a focus on industry-specific compliance, dosage parameters, integration points, and end products. All scenarios reflect genuine practice trends in global manufacturing.

    1. Herbicide Intermediate for Pyridine-Based Crop Protection

    Agricultural chemical producers frequently incorporate 6-Chloropicolinic Acid in synthetic routes for selective herbicides targeting broadleaf and grass weeds. It serves as a precursor for advanced pyridine carboxylic acid herbicides, participating in condensation and coupling reactions to introduce chlorine substituents required for mode-of-action specificity. Manufacturers must satisfy thorough downstream registration and safety standards in major crop protection markets.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • US EPA 40 CFR Part 180 (Pesticide Tolerances)
    • China NY/T 1972-2010 (Pesticide Common Technical Specifications)
    • European Regulation (EC) No 1107/2009 (Plant Protection Products)

    Typical usage ratio

    • 20–30% of total starting material mass in herbicide precursor synthesis. Adjust blend based on required substitution pattern and process yields.

    Downstream process integration

    • Enters as a chlorinated coupling substrate during Stage 2–3 of multi-step batch synthesis for pyridine ring modification.

    Final product types

    • Select post-emergence herbicides for cereals and oilseed crops
    • Herbicide mixtures for non-crop land management
    • Technical and formulated herbicide concentrates
    • Bulk actives for global pesticide supply chains

    2. Pharmaceutical Intermediate in Antibacterial and Antituberculosis Drug Synthesis

    Several major pharmaceutical manufacturers utilize 6-Chloropicolinic Acid as a key intermediate within their regulated synthesis chains. It provides the chlorine and pyridine moiety required for scaffolds in third-generation antimicrobials, especially those active against Mycobacterium tuberculosis and Gram-negative bacteria. High traceability and GMP-compliant quality control is essential throughout these production lines.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for APIs)
    • US Pharmacopeia (USP) and European Pharmacopoeia (Ph.Eur.) monographs
    • FDA 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)
    • EDQM CEP Certification Protocols

    Typical usage ratio

    • 5–15% relative to other key intermediates in the active pharmaceutical ingredient (API) synthetic step. Ratio determined by scale-up trial, substitution route, API yield, and regulatory control.

    Downstream process integration

    • Introduced at chlorination or ring functionalization stage of API synthesis, often prior to condensation with other drug fragment building blocks.

    Final product types

    • Active pharmaceutical ingredients for antituberculosis tablets and capsules
    • Bulk pharmaceutical chemicals for contract development and manufacturing organizations (CDMOs)
    • Intermediates for research compound libraries targeting infectious diseases
    • Diagnostic agent standards

    3. Precursor in Agrochemical Fungicide Synthesis

    Downstream fungicide manufacturing routes employ 6-Chloropicolinic Acid as a specialized building block to deliver chlorinated heterocycles with necessary bioactivity against fungal pathogens in cereals and fruits. Its role is critical for preparing intermediates with tailored efficacy profiles and environmental persistence, especially for commercial-scale molecule customization.

    Industry compliance standards

    • OECD Principles of Good Laboratory Practice (GLP) for agrochemical R&D
    • ECHA REACH Regulation (EU) 1907/2006 for chemical registrations
    • Brazil ANVISA Act 10.813 for pesticide manufacturing
    • Japan Agriculture Chemicals Regulation Law

    Typical usage ratio

    • 10–25% of the fungicide intermediate batch feedstock, adjusted for desired molecular substitutions and formulation specifics.

    Downstream process integration

    • Addition at the cyclization and chlorination process step, followed by functional group modification for final fungicidal activity optimization.

    Final product types

    • Pyridine-derived fungicidal actives
    • Liquid and solid fungicide formulations for agricultural spraying
    • Seed treatment concentrates
    • Intermediates for advanced crop health solutions

    4. Intermediate for Lightfast Pigment and Dye Manufacture

    Specialty pigment and dye manufacturers apply 6-Chloropicolinic Acid in their processes to induce specific chromophore patterns in organic colorants. It helps produce highly stable, light-resistant pigments demanded in textiles, plastics, printing inks, and coatings. Selection of this intermediate supports both vivid coloration and tight batch control on fastness properties.

    Industry compliance standards

    • REACH Annex XVII (Restriction of certain dangerous substances in pigments/dyes)
    • EN 71-3:2019 (Migration of certain elements in coloring agents for toys)
    • SATRA TM20: Color Fastness to Light Standard (textiles and leathers)
    • ISO 105-B02 (Color fastness testing)

    Typical usage ratio

    • 3–8% based on organic substrate feed for pigment synthesis. Exact percent tailored to desired color strength, hue, and photostability requirements.

    Downstream process integration

    • Integrated during the nucleophilic substitution or coupling reactions, contributing to the base structure of the pigment chromophore.

    Final product types

    • Lightfast dyes for textile applications
    • Pigmented plastics resins
    • Industrial printing ink concentrates
    • Stable colorants for coatings and paints

    5. Material Science Intermediate for Specialty Polymers

    Manufacturers in the advanced materials sector adopt 6-Chloropicolinic Acid as a reactive intermediate to synthesize high-performance polymers with pyridine core structures. These materials offer increased thermal stability, chemical resistance, and unique electronic properties for use in membranes, engineering plastics, or specialty composites. Precision in processing ensures batch-to-batch consistency for demanding industrial customers.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management Systems for industrial production)
    • ISO 14001:2015 (Environmental Management in material production)
    • RoHS Directive 2011/65/EU (Restriction on hazardous substances in electrical/electronic equipment)
    • ASTM D638 (Tensile testing of plastics and composites)

    Typical usage ratio

    • 5–12% relative to total monomer or oligomer formulation. Adjusted according to the targeted final properties and process conversion efficiency.

    Downstream process integration

    • Incorporated at the condensation or functionalization stage prior to polymerization, influencing molecular backbone structure and performance profile.

    Final product types

    • Pyridine-based engineering plastics
    • Membrane materials for industrial separation
    • Specialty copolymer resins for electronics
    • Composites for high-heat or chemical exposure
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    Certification & Compliance
    More Introduction

    6-Chloropicolinic Acid: Strength in Consistency and Purity

    Our Manufacturing Experience Shapes Every Batch

    Decades of hands-on chemical production have taught us to look for what others might overlook. In this field, every detail counts. At our facility, 6-Chloropicolinic acid stands out as one of those products where process matters as much as the final result. Our teams have spent years perfecting the method to bring out the best from each synthesis. Many of our partners come to us after issues with off-color, unreliable purity, or trace solvent residues from less precise runs. We don't leave room for guesswork. Each campaign follows a sequence honed through pilot-scale optimization and real-world feedback from our own batch reactors.

    Model Consistency: Batch After Batch

    Offering model 1102-CP, we keep a close eye on what goes into and comes out of the process. This means consistent performance, batch after batch—not only through strict raw material screening but also through mid-process sampling and post-synthesis purification. Chlorine level, picolinic backbone integrity, residual acid content: each gets tracked through targeted analytics such as HPLC, GC-MS, and NMR profiling.

    Specifications That Serve the Real World

    We only claim what we can guarantee. Each lot of our 6-Chloropicolinic acid posts an assay of at least 98%, based on dry basis, confirmed by internal and third-party labs when requested by customers. Water content stays under 0.5%. We leave no room for guesswork on melting point—customers routinely see readings between 181°C and 184°C. Particle size sometimes goes overlooked in this sector, but we've found that for downstream transformations or advanced formulations, smooth flow and easy dispersion start with a tightly defined, controlled mesh size. From our line, material comes out within 90% of particles passing 100 mesh without the heavy caking or static build-up that creates bottlenecks in the rest of the supply chain.

    Why Purity and Traceability Drive Our Focus

    Most stories we hear from manufacturing lines using 6-Chloropicolinic acid focus on the headache of unknown impurities. Impurities from incomplete chlorination, leftover starting material, or halogen-substituted byproducts end up not just in byproduct waste but in the final application. In our experience, even minor deviations at this step can throw off downstream performance, slow down reaction times, or introduce unpredictability to agrochemical formulations or specialty synthesis pipelines.

    Many producers push for only a minimum spec, but we have learned from hard-won experience in trouble-shooting customer issues that the real-world impact often hides below the threshold of the usual purity guarantees. We use in-line and batch-end checks to confirm that even low-abundance byproducts are identified and removed, and the data stays archived back to the original run date. In audits or trace-back situations, this transparency reduces confusion and builds confidence across the whole supply chain.

    End Use Cases: Beyond Lab Trivia

    Our main contacts in the market know 6-Chloropicolinic acid as a critical intermediate. Specialty herbicide synthesis takes up much of the tonnage, specifically for advanced pyridine-based molecules where the chloro group directs downstream substitution. Researchers value the defined site on the ring and the electronically tailored halogenation, allowing for precision further down the synthetic chain.

    Other applications involve heterocyclic building blocks for pharmaceuticals—antiviral or antibacterial leads sometimes start with this backbone to build molecular complexity. Years of feedback from medicinal chemistry groups tell us that inconsistent supply or unreliable specs lead to failed screening batches or, worse, trace-level contaminants that skew biological testing. In our process, we stay vigilant so every kilogram offers reproducibility, batch after batch.

    Some customers use our 6-Chloropicolinic acid in advanced material R&D: specially functionalized polymers, new resin systems, or second-generation catalysts where the acid group anchors ligands or tethers. We have learned that in such work, even the smallest surfactant or chloride residual risks giving rise to process variability or equipment issues. We engineer for that level of scrutiny.

    What Sets Our Product Apart

    Not all 6-Chloropicolinic acid on the market comes from direct synthesis. There's a temptation to shortcut production by using recycled or reclaimed feedstock, which in practice may save costs but often leaves a background trace of foreign chemicals. Years of experience show that every step in the manufacturing process, from raw material sourcing through the shutdown and clean-out protocols, shapes the outcome. Our manufacturing team sticks to strict batch sequencing and dedicated line use during runs, which minimizes cross-contamination and supports compliance with both local and export-oriented quality standards.

    We consistently hear customers say that our lots have excellent filtration properties and only minimal dust-off—key differences for users needing low-exposure material handling or trouble-free dispensing in dry rooms and laboratory settings. Packing also matters. We use double-lined, anti-static bags, never plain PE, keeping transit moisture at bay and reducing static that can make weighing and transfer a headache. Such details look minor from the outside, but in use, they shape whether a project stays on schedule or faces downtime.

    Supply Chain Trust Begins at the Source

    Being the manufacturer gives us the rare chance to address problems at the root. For instance, we've responded in real time to customer feedback about off-odors or color drifts by tracking entire lots back through our batch books. We share transparent data on origins, giving our customers the kind of confidence that allows them to move forward in high-value end uses.

    Forward integration means we also control our logistics—and more importantly, our documentation. Every drum or keg leaves our site with an unbroken data chain, so traceability isn’t just a slogan but a fact investors and laboratory managers can see. Regulatory filings for REACH or other foreign market entry get support at the application level, not just raw data pulled from a template.

    Addressing Customer Challenges Directly

    One recurring issue we meet involves the false equivalence between technical-grade intermediates and high-purity, application-validated material. Low-price offers from non-manufacturing traders often hide unknown blends or non-validated grade changes mid-shipment. Our teams have received emergency requests to replace inconsistent material at short notice, especially when pilot plants and full-scale lines face downtime because of unreliable product.

    The strongest partnerships emerge when we are part of the solution early in the R&D phase—not just a vendor contacted after a problem arises. We regularly support process teams with pre-shipment samples, collaborative test protocols, or even custom impurity profiles to help customers de-risk their new product development work. This boots-on-the-ground support builds relationships deeper than any shelf-labeled offering ever could.

    As regulatory and environmental standards move, we have upgraded our processes to anticipate required data—rather than scrambling to catch up after a non-compliance notification. Year-over-year tracking helps us spot process drift early. We like to say that an ounce of prevention saves a week of trouble-shooting with customers and auditors.

    Supporting Sustainable and Responsible Production

    Manufacturing at scale brings real challenges. Chlorinated intermediates present particular pressure points in effluent treatment, emission control, and waste minimization. Our team faces these head-on with closed-loop recovery for solvents, scrubbing systems for off-gassing, and regular third-party audits on discharge metrics. Sustainability goals begin on the shop floor, not at the marketing desk.

    We’ve invested in in-process analytics to reduce lost yield and minimize side-reactions, which cuts down on unnecessary waste and maximizes reactor throughput for each lot produced. Our staff take pride in their technical know-how—best practices pass down line-by-line in standard operating procedures, but also in the on-site know-how that comes from running these reactions at full scale. It’s how we keep quality up while bringing down net environmental impact.

    No Need for Guesswork in Your Acquisition

    We understand the pressures that formulators and synthetic chemists face. Project delivery depends on secure material, as any delay or spec-drift can balloon costs or ruin a batch. To respond, we keep robust stock in several packaging forms—fiber drums, lined paper bags—shipped with full certificate of analysis and conformance to customer contract specs. Rush orders get expedited, with live tracking offered for high-sensitivity applications.

    Technical support teams from our side do more than just pass along TDS documents. We engage directly, discussing process improvements or flagging any unusual characteristics noted in incoming inspection data. In cases of process upsets or unplanned regulatory audits, our in-house experts work with customer QA teams to navigate requirements for documentation or root cause tracing.

    We Listen, We Build, We Grow With Customers

    Changing end-market requirements keep us humble. Our development chemists review the shifting landscape of chemical regulations, purity expectations, and application guidelines. Over the years, we’ve seen the bar rise: customers once satisfied with technical grade now ask for pharmaceutical or fine chemical-level specs. Regulatory authorities demand data not just on product composition but also on process traceability and supply chain responsibility.

    As upstream providers, we carry the responsibility to adapt, not stay stuck while the world moves forward. Feedback loops matter to us. Our best breakthroughs have always come from a straight conversation with users. What they encounter in scale-up, we work back into our batch records, our process maps, our line upgrades.

    Each order we dispatch reflects this ongoing relationship—the reliability, technical support, and supply confidence that a producer expects from their source material provider. 6-Chloropicolinic acid is more than just a molecule to us; it's a responsibility we take seriously, shaped by years of manufacturing experience, and tested continuously through the real-world challenges our customers share with us daily.