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6-Bromo-2-Methylquinoline

    • Product Name 6-Bromo-2-Methylquinoline
    • Alias 6-Bromoquinaldine
    • Einecs 621-796-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    257727

    Cas Number 64913-27-3
    Molecular Formula C10H8BrN
    Molecular Weight 222.08
    Iupac Name 6-bromo-2-methylquinoline
    Appearance Light yellow to brown crystalline powder
    Melting Point 74-78°C
    Boiling Point Unknown
    Solubility Slightly soluble in organic solvents
    Purity Typically ≥98%
    Density 1.49 g/cm³
    Smiles CC1=NC2=C(C=CC(=C2)Br)C=C1
    Inchi InChI=1S/C10H8BrN/c1-7-5-6-8-3-2-4-9(11)10(8)12-7/h2-6H,1H3

    As an accredited 6-Bromo-2-Methylquinoline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 6-Bromo-2-Methylquinoline, sealed with a screw cap and labeled with hazard information.
    Shipping 6-Bromo-2-Methylquinoline is shipped in securely sealed containers, clearly labeled according to chemical safety regulations. Packages are cushioned to prevent breakage and protected from moisture and light. Transport complies with local and international hazardous material guidelines, ensuring safe handling and delivery. Appropriate documentation and Material Safety Data Sheets (MSDS) accompany all shipments.
    Storage 6-Bromo-2-Methylquinoline should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from sources of ignition and moisture. Protect it from light and incompatible substances, such as strong oxidizers. Store at room temperature and ensure proper labeling. Use chemical-resistant gloves and eye protection when handling.
    Application of 6-Bromo-2-Methylquinoline

    Applications of 6-Bromo-2-Methylquinoline in Industrial Manufacturing

    As a direct manufacturer with extensive technical experience, we supply 6-Bromo-2-Methylquinoline for recognized downstream industrial operations worldwide. Below, we detail established applications across pharmaceutical intermediate synthesis, agrochemical preparation, dye manufacturing, and specialty chemical production with an explicit focus on industry standards, formulation ratios, process roles, and the resulting end products.

    1. Pharmaceutical Intermediate Synthesis

    6-Bromo-2-Methylquinoline functions as a critical intermediate during multi-step organic synthesis for several quinoline-based active pharmaceutical ingredients. API producers rely on its substitution reactivity and electronic structure within key heterocyclic transformations, especially during bromination and methylation reaction stages. Bulk sourcing adheres to cGMP, strict impurity profiling, and full traceability, supporting custom and generic molecule production where bromoquinoline derivatives comprise an essential pharmacophore.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients)
    • USP & Ph. Eur. monographs for specific APIs (where quinolines are registered)
    • 21 CFR Part 211 (FDA GMP for finished pharmaceuticals, supporting traceability)
    • ISO 9001:2015 (Quality Management System, covering supplier control and batch records)

    Typical usage ratio

    • Standard addition of 0.5–2.0 molar equivalents relative to target coupling agent; adjusted per target molecule’s substitution requirements in final pathway

    Downstream process integration

    • Charged into the reaction vessel post-initial condensation step and prior to ring closure, often under inert atmosphere with controlled temperature ramping to ensure selectivity

    Final product types

    • Antimalarial APIs (e.g., chloroquine derivatives)
    • Cancer research molecules featuring bromoquinoline scaffolds
    • Anti-infectives using functionalized quinoline cores
    • Synthons for targeted small-molecule libraries

    2. Agrochemical Synthesis

    Major crop protection manufacturers utilize 6-Bromo-2-Methylquinoline as a building block within active ingredient pathways for advanced quinoline-based insecticides and fungicides. Its regioselectivity and the presence of a bromo-functional group streamline Halex reactions and heterocycle functionalization during large-scale batch synthesis. Formulators require full raw material specification sheets aligned with international agrochemical regulations to ensure consistent field and regulatory performance.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • REACH (EC 1907/2006) compliance for raw material registration
    • ISO 9001:2015 and ISO 14001:2015 (Environmental Management System)
    • China GB 2763 Maximum Residue Limits (if formulated locally)

    Typical usage ratio

    • Usually 0.3–1.2 molar equivalents relative to other aromatic building blocks per batch, depending on the targeted active load in final EC or SC product forms

    Downstream process integration

    • Introduced at the heterocycle assembly phase, immediately preceding coupling or cyclization with other bromo-, nitro-, or methyl-bearing reagents via high-shear mixing

    Final product types

    • Active ingredient concentrates for foliar spray formulations
    • Technical-grade insecticidal intermediates
    • Precursor compounds for novel fungicide R&D screenings
    • Analytical standards for residue detection programs

    3. Dye and Pigment Intermediate Manufacturing

    Specialty colorant producers draw on the delocalized electronic structure of 6-Bromo-2-Methylquinoline to generate high-performance heteroaromatic azo and anthraquinone dye intermediates. Its controlled activation enables precision halogen exchange and cross-coupling for fine-tuning chromophore absorption, suitable for demanding textile, inkjet, and industrial coating applications. Downstream process steps and permitted impurity profiles adhere to international dye safety and environmental protection standards.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (human-ecological requirements for dye substances)
    • REACH Annex XVII (restriction of hazardous aromatic amines and byproducts)
    • ZDHC Chemical Gateway conformant requirements
    • ISO 9001:2015 (colorant quality control)

    Typical usage ratio

    • Blend at 0.7–2.5% w/w of the total dye batch weight, with variation based on targeted shade depth and cross-coupling efficiency requirements

    Downstream process integration

    • Added to reaction kettles during early-stage diazotization or coupling steps, occasionally under high-temperature alkaline conditions to maximize chromophore yield

    Final product types

    • Textile dyes (vat, disperse, reactive)
    • Inkjet ink pigment dispersions
    • Industrial coatings (automotive and appliance finishes)
    • Electronic display colorants

    4. Advanced Material Additive Production

    Producers of specialty electronic and photonic materials integrate 6-Bromo-2-Methylquinoline as a precursor for constructing high-purity organic semiconductors, OLED intermediates, and selective light-absorbing complexes. Its brominated structure provides tunable leaving group characteristics that support C–N and C–C bond formations using Pd-catalysis or Suzuki coupling, which is essential for organic electronics and specialty polymer films. The application requires robust process validation and purity confirmation to satisfy downstream material performance specifications.

    Industry compliance standards

    • IEC 61249-2-21:2017 (halogen-free electronic materials)
    • ISO 14644 (cleanroom standards for semiconductor production environments)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances, where applicable)
    • ISO 9001:2015 (process documentation and supplier traceability)

    Typical usage ratio

    • Integrated at concentrations of 0.05–0.8 molar equivalents, adjusted per device architecture and targeted electrical/optical properties in conjugated polymer systems

    Downstream process integration

    • Used in the initial monomer formation or directly involved in palladium-catalyzed cross-coupling steps for advanced organic syntheses ahead of material casting or device assembly

    Final product types

    • OLED intermediate building blocks
    • Organic photovoltaic absorber compounds
    • Semiconducting polymers for flexible electronics
    • Specialty light-absorbing additives for energy devices
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    Certification & Compliance
    More Introduction

    Introducing 6-Bromo-2-Methylquinoline: From Our Facility to Your Laboratory

    In the world of specialty chemicals, the road from synthesis to final product requires judgment, diligence, and a willingness to pursue quality batch after batch. Producing 6-Bromo-2-Methylquinoline reflects that process. This molecule, a brominated quinoline derivative, demands real attention to detail during synthesis and purification steps. It's a core building block for researchers working at the frontiers of pharmaceuticals and advanced material science.

    Reliable Molecular Foundation for Research and Innovation

    6-Bromo-2-Methylquinoline, also known to chemists as 6-Bromoquinoline-2-methyl, has a structure that contains both electron-rich and electron-deficient regions. Our chemists have spent years fine-tuning conditions so its purity consistently exceeds industry standards. Every lot receives HPLC and NMR analysis in-house. We don’t box and ship anything that fails to meet the mark. For labs aiming for repeatable results, stable material ensures their own synthetic pathways start off on the right foot — minimizing headaches caused by trace contaminants often overlooked in bulk commodity grades.

    Applications Shaped by Real Lab Experience

    Among the uses for 6-Bromo-2-Methylquinoline, two major sectors dominate: pharmaceutical intermediates and material science. Medicinal chemists rely on this compound for building more complex molecular scaffolds, particularly where the presence of the bromine atom allows for further cross-coupling reactions using techniques such as Suzuki or Buchwald-Hartwig methodologies. Our team supplies several university and private research units who prefer our material over generic sources. They see fewer batch failures and can trust the reproducibility of their downstream chemistry.

    Beyond drug discovery, this intermediate finds its way into optoelectronic material development. Because the quinoline backbone offers photostability and the bromine group provides a synthetic handle, material scientists develop new ligands and functional frameworks around it. Our commercial partners report improved yields and cleaner reaction profiles with our lots, directly translating into savings on purification and less time troubleshooting.

    Quality Backed by Decades of Experience

    We’ve learned that purity and precise specification matter most in real-world settings, not just on spec sheets. Our batches of 6-Bromo-2-Methylquinoline typically run with a purity not less than 98%, with moisture content below 0.5%. Each run uses starting material from established suppliers, checked on arrival in our own labs. We leverage glass-lined reactors to avoid contamination from corrosion or trace metals—an issue often neglected at smaller production scales. All solvents are distilled on-site before use, further reducing the potential for unexpected side products. End users often share that switching to our material led to higher yields and less “mystery” sludge after workup.

    We don’t ship powder that hasn’t passed our own rigorous in-house controls. Routine spot-checks go alongside full-lot validation. Small amounts reserved from each batch give us a running archive for customer support and root-cause analysis in case of unexpected downstream issues. Years of practice taught us that most problems show up not in headline numbers, but in a slow drift away from procedures, so ongoing training and retraining of staff remains a priority.

    Specification and Physical Handling

    6-Bromo-2-Methylquinoline at our facility usually presents as an off-white to light tan crystalline powder. Its melting point has been measured batch after batch to lie consistently within industry benchmarks. Typical solubility values remain in line with published data, making it manageable for both research-scale and pilot-plant applications. We’ve found that stable packaging—using double-sealed containers—maintains product integrity during storage and shipment, whether it’s traveling across a humid coast or arid interior region.

    One lesson learned over years of international freight: temperature swings and rough handling wreak havoc on sensitive organics. We migrated early to tamper-proof, light-blocking drums and observe strict storage guidelines. In our own facilities, we store product within a climate-controlled environment to avoid caking or darkening, both signs of trace decomposition. This extra care pays off when customers find their lot identical in color and texture no matter if the shipment comes in January or July.

    Value Beyond the Certificate of Analysis

    We don’t see 6-Bromo-2-Methylquinoline as just a catalogue listing. Our technical team routinely addresses requests for custom synthesis or modification tied to specific research programs. Sometimes the need is a tighter control on an impurity profile for a regulatory filing. Other times, feedback from the bench leads to minor adjustments in particle size or blending. Back-and-forth communication, grounded in real chemical production and processing, lets us improve with every order rather than treating product delivery as a one-way function.

    We also supply technical notes and best practice tips drawn from our work on this compound. For example, we’ve found certain organic solvents—ethyl acetate, dichloromethane—offer superior results for dissolution and crystallization, compared to older literature recommendations. Sharing these details reduces the trial-and-error time for researchers scaling up new methods. We don’t keep these lessons proprietary; many end users run small research teams lacking time or budget for exhaustive method development, so guidance from our production chemists fills that gap.

    Comparing to Other Quinoline Derivatives

    While several quinoline derivatives serve as building blocks throughout the industry, 6-Bromo-2-Methylquinoline distinguishes itself by balancing reactivity against stability. Unsubstituted quinoline or simple methylquinoline compounds often lack the reactivity needed for palladium catalysis, which limits downstream modification. On the opposite end, some multi-halogenated analogs, though highly reactive, can generate problematic side products. The mono-bromo-methyl combination in our product produces ideal selectivity without the volatility complications seen with di- or tri-halogenated variants.

    We have synthesized and tested several related molecules, including 6-chloro-2-methylquinoline and 8-bromoquinoline, and found the 6-bromo positioning offers the best engagement in C–C and C–N coupling reactions. Affiliate labs corroborated our results—reaction times shorten, catalyst loading drops, and recrystallization runs cleaner with our standard grade.

    Even for customers who initially trial lower-priced alternatives, switching to our material often brings visible improvement in their workups and end-product clarity. Trace levels of metal residues or halide cross-contamination, common to less careful suppliers, do not survive our purification regime.

    Commitment to End-User Success

    Producing 6-Bromo-2-Methylquinoline at the kind of quality demanded by cutting-edge research isn’t about ticking boxes on a checklist. The feedback loop between our chemists and customers keeps every batch attuned to actual laboratory and pilot plant realities. Mistakes during early runs—such as underestimating a trace impurity or shortcutting drying—only reinforced our belief that experience, not paperwork, guides progress. Our process analytical technologies aren’t just buzzwords; these systems allow us to monitor key parameters in real time, minimizing the risk of off-spec production.

    Custom packaging, detailed supply chain tracking, and logistical support aren’t afterthoughts. We’ve invested in supply chain audits, multiple redundant transport partners, and frequent follow-ups with customers to catch or prevent shipping shocks that could affect sensitive organics like this compound.

    As regulatory frameworks tighten, research partners want more than a price quote. They want certainty about batch reproducibility, supply continuity, and a supplier who stands behind every drum. We document each step and store records for quick retrieval. This attention to traceability lets end users meet external audits and regulatory requirements with confidence.

    Supporting Sustainable and Responsible Production

    Modern chemistry carries environmental obligations. Our 6-Bromo-2-Methylquinoline production line integrates waste minimization steps at every phase. Our solvent recovery equipment recycles more than 85% of organic solvents used on-site—reducing hazardous waste volumes—and batch records track every kilo of input and output. This not only lowers our footprint, it also trims cost for customers thanks to more efficient resource use.

    Instead of disposing of byproducts as general waste, we route them through separate processing channels, working with third-party waste handlers who comply with both local and international environmental standards. Government inspections confirm compliance with current EHS (environmental, health, and safety) practices.

    Safety matters in both our facility and at customer workplaces. We host frequent review sessions on handling and storage of halogenated aromatics. Our materials ship with up-to-date SDS and explicit instructions for containment and spill control based on scenarios encountered in real laboratory environments — not just theoretical models. Feedback reports from customers follow a formal process, allowing us to update safety protocols for future shipments when issues arise outside our original documentation. We use these events as learning opportunities.

    Lessons Learned Through Direct Experience

    Since the early days of our production runs, unexpected process deviations have shaped our manufacturing philosophy. In one case, a single blocked filter led to an entire lot showing higher than normal water content. Another time, solvent grade drift from an outside supplier made us overhaul our incoming raw material testing procedures. Every error forced a change in how we review and prequalify materials. Our internal team sees the value of “trust, but verify” at every stage—from raw materials testing down to the final drum sealing.

    We maintain an open-door policy for clients and technical contacts. Several times a year we host on-site workshops for visiting research chemists, sharing both what works in practice and the lessons from batches that did not meet expectations. This exchange means customers can peek at our real-world challenges and spot issues before they reach critical stages in their own labs.

    Building Long-Term Relationships Through Integrity

    Making 6-Bromo-2-Methylquinoline for small orders or ton-scale shipments requires exactly the same care. We refuse to cut corners or deliver material simply to meet a shipping deadline if product integrity would suffer. Nearly all our business comes from repeat customers — research operations, pilot plants, and pharmaceutical firms who expect more than a one-off sale. They remain with us because we listen, adapt, and never shy from explaining how and why a run may require more time or a modification in sourcing.

    Our relationships extend beyond transactions. Several R&D partners now involve us early in project planning, understanding that early communication about reagent sourcing, expected timelines, and potential hazards leads to fewer missteps downstream.

    Success in specialty chemical manufacturing doesn’t stem from possessing top-end reactors or the latest analytical gadgets. It comes from a team’s ability to blend experience with ongoing learning, recognizing mistakes, and setting higher bars for quality. We consider 6-Bromo-2-Methylquinoline more than a line item — it represents a shared journey between manufacturer and user, with full transparency all along the supply chain.

    Real Advantages for the End User

    Whether research chemists synthesize novel heterocycles, develop new ligand scaffolds, or screen for biologically active compounds, starting from a reliable 6-Bromo-2-Methylquinoline batch saves time and delivers better outcomes. Downstream efficiency isn’t just a side benefit — it’s the result of a deliberate, continuous effort. Our facility carries out ongoing investment in both equipment and personnel training based on the challenges faced in real-world chemistry ventures, not just theoretical projections. These investments make our product stand out compared to alternatives.

    We’ve heard from repeat clients in medicinal chemistry that switching from lower-purity material led to sharp improvements in yield, eliminated “ghost peaks” in analytical methods, and reduced the number of purification cycles needed for key intermediates. Material science departments developed devices with enhanced performance and repeatable quality when they sourced from our lots.

    Lab managers often note our willingness to provide both technical backing and logistical flexibility makes their operations smoother. It’s not uncommon for our team to field special requests for custom packaging, emergency air freight, or tricky documentation — and our production and logistics teams coordinate to deliver.

    Continued Improvement Through Transparent Collaboration

    Changing research demands require flexibility. We embrace a feedback-driven approach with every shipment of 6-Bromo-2-Methylquinoline. If an issue arises, we do not hide behind generic responses. Our technical team works directly with customers to investigate, resolve, and—where possible—update production methods. These open conversations help us spot weaknesses and transform them into future strengths.

    Our operation has gradually evolved on the back of lessons learned both in the lab and the field. Not a year passes without a checkpoint review—asking what went right, what failed, and how future batches can improve. As demand for specialized quinoline derivatives grows, our experience places us in a strong position to reliably support both high-volume and cutting-edge applications.

    We view every canister shipped as a testament to a factory’s culture of quality, precision, and genuine care for the end user. Our facility’s track record reflects not just a commitment to chemistry, but a commitment to those who depend on it for real-world breakthroughs.

    A Partner for Progress in Modern Chemistry

    Bringing 6-Bromo-2-Methylquinoline to market requires more than synthetic know-how. It calls for trust built batch by batch, transparency in both success and error, and the ability to anticipate needs before they become urgent. For researchers and material scientists aiming to push innovation forward, our hands-on manufacturing experience and readiness to learn from each challenge provide an assurance unavailable from trading houses or resellers. We stand behind what we produce — not out of obligation, but out of dedication to the shared progress that links manufacturer and innovator.