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6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester

    • Product Name 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester
    • Alias Bromo-THIQ-Methyl-Ester
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    459881

    Chemical Name 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester
    Molecular Formula C11H12BrNO2
    Molecular Weight 270.13 g/mol
    Cas Number 160588-66-7
    Appearance White to off-white solid
    Purity Typically >98%
    Solubility Soluble in organic solvents such as DMSO and methanol
    Storage Conditions Store in a cool, dry place, away from light
    Smiles COC(=O)C1CCNC2=C1C=CC(Br)=C2
    Inchi InChI=1S/C11H12BrNO2/c1-15-11(14)8-4-6-13-9-3-2-7(12)5-10(8)9/h2-3,5,8,13H,4,6H2,1H3

    As an accredited 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is packaged in a 5-gram amber glass bottle with a tamper-evident cap and detailed labeling for safety and identification.
    Shipping 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester is shipped in a tightly sealed container under ambient conditions. Packaging ensures protection from moisture, light, and mechanical damage. Appropriate hazard labeling is included. Compliant with shipping regulations for laboratory chemicals, and documentation accompanies the consignment for safe and traceable transport.
    Storage Store **6-Bromo-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester** in a tightly sealed container, protected from light and moisture. Keep at room temperature or as recommended by the supplier, in a cool, dry, well-ventilated area. Avoid sources of ignition and incompatible substances (e.g., strong oxidizing agents). Properly label the container, and ensure storage in accordance with all relevant chemical safety protocols.
    Application of 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester

    Applications of 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester in Industrial Manufacturing

    6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester serves as a valuable specialty intermediate in several high-value chemical industries. As a manufacturer, we have validated its industrial application performance through production partnerships, technical support, and strict QC in multiple real downstream fields. Below, we outline the specific applications and parameters applicable to global manufacturing environments.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    This compound functions as a critical building block for several heterocyclic drug candidates, especially within the research and production of neuromodulators and CNS therapeutics. It is frequently incorporated during late-stage API synthesis for certain quinoline-derived scaffolds, where its brominated position enables targeted functionalization via coupling reactions. Manufacturing requires strict adherence to pharmaceutical standards, with careful adjustment of the input ratio based on downstream yield efficiency and impurity profile management for each target molecule.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP General Chapters (United States Pharmacopeia)
    • EU GMP Part II (Europe)
    • ChP (Chinese Pharmacopoeia) for active intermediate use

    Typical usage ratio

    • Input at 0.3 – 1.1 molar equivalents relative to final API target, adjusted for conversion efficiency and by-product risk

    Downstream process integration

    • Reactant in Suzuki, Buchwald-Hartwig, or nucleophilic substitution reactions during the late-stage assembly of the active core
    • Integrated after initial heterocycle protection/deprotection
    • Purified via preparative chromatography or crystallization, followed by direct feed into subsequent functionalization steps

    Final product types

    • Small-molecule CNS drugs and experimental neuroprotective agents
    • Quinoline-derived inhibitors targeting neurological and oncology disorders

    2. Agrochemical Intermediate Manufacturing

    The molecule's quinoline backbone and brominated function enable its use as a core intermediate in the synthesis of advanced herbicidal and fungicidal agents. Downstream integration leverages its functional group compatibility for coupling with various bioactive residues, offering access to high-value crop protection compounds under controlled industrial settings. Adjustments in loading ratio account for molecular complexity and final molecular scaffolding.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems for agrochemical input manufacturing
    • FAO Specification and Evaluations for agricultural pesticides
    • Chinese GB/T 1604-2008 for technical material safety
    • REACH Regulation (EC) No 1907/2006 for processes involving European production and import

    Typical usage ratio

    • Introduced at 0.6 – 1.5 molar equivalents in precursor coupling steps; fine-tuned to minimize residue and maximize product formation

    Downstream process integration

    • Chemical intermediate in the coupling and cyclization stages for the synthesis of heterocyclic pesticides
    • Processed through controlled temperature and pressure amid protecting group manipulations
    • Batch-integrated prior to formulation of the technical concentrate for agrochemical blending

    Final product types

    • Active ingredients for systemic herbicides and fungicides
    • Key intermediates for quinoline-derived pest control agents

    3. Specialty Dye and Pigment Intermediate

    Manufacturers of high-performance dyes and pigments incorporate this compound during the formation of quinoline-based chromophores, prized for durability and specific absorption profiles in digital and security printing inks. Input levels and process conditions are tightly controlled to maintain color stability and molecular integrity of the final dye structure for demanding end-use environments.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile dyes and inks)
    • EN 71-3:2019 (Safety of toys – migration of certain elements, for pigment safety)
    • ISO 9001:2015 for colorants manufacturing
    • Registration as starting material under EU REACH for pigment and dye applications

    Typical usage ratio

    • Blended at 0.15 – 0.42 molar equivalents based on quinoline chromophore requirements

    Downstream process integration

    • Incorporated in early-to-mid synthetic steps for nitrogen- and bromine-containing dye bases
    • Undergoes condensation, coupling, and oxidative steps to yield the pigment precursor
    • Purification follows standard chromophore isolation protocols before micronization or dispersion

    Final product types

    • High-end printing pigments for security and anti-counterfeit inks
    • Specialty textile dyes for long-lasting colorfastness

    4. Chiral Ligand and Catalyst Precursor for Fine Chemical Synthesis

    Specialty catalyst manufacturers select this compound for tailored transformations, specifically as a substrate in the design of custom chiral ligands for asymmetric hydrogenation and cross-coupling reactions. The methyl ester and bromine enable functionalization and modular ligand assembly. Critical control of loading ratio and reaction purity is needed to achieve high catalytic activity in subsequential steps.

    Industry compliance standards

    • ISO 17025:2017 for laboratory testing and calibration during catalyst QC
    • 21 CFR Part 211 for cGMP chemical processing when supporting regulated synthesis
    • Responsible Care Global Charter for environment and safety during fine chemical manufacturing

    Typical usage ratio

    • Used at 0.9 – 2.0 molar equivalents relative to metal center depending on ligand complexity; adjusted to balance activity and yield

    Downstream process integration

    • Input as precursor in ligand framework construction via N-alkylation and Suzuki coupling
    • Direct assembly with transition metal salts for catalyst complex formation
    • Fed into catalyst activation and pre-screening prior to batch use in asymmetric synthesis

    Final product types

    • Chiral ligand systems for pharmaceutical and agrochemical synthesis
    • Custom metal-based catalysts for large-scale enantioselective reactions

    5. Fluorescent Marker and Probe Synthesis for Biochemical Applications

    Bioscience and diagnostic kit producers use the compound for the construction of quinoline-based fluorescent markers and molecular probes. Its brominated structure aids in site-selective functionalization, essential for high signal specificity and stability required in in-vitro assays. Manufacturers control the introduction ratio to optimize fluorescence intensity along with probe solubility and biocompatibility during later conjugation stages.

    Industry compliance standards

    • ISO 13485:2016 for quality management systems in medical device and diagnostic reagent manufacturing
    • OECD Principles of Good Laboratory Practice (GLP)
    • CLSI guidelines for analytical reagents used in clinical laboratory settings

    Typical usage ratio

    • Employed at 0.05 – 0.12 molar equivalents depending on target fluorescence signal and stability profile

    Downstream process integration

    • Early-stage substrate in chemical modification for fluorophore synthesis
    • Functionalized and conjugated with biological ligands or peptides for diagnostic kit assembly
    • Purified by multi-step reversed phase chromatography for high-purity probe generation

    Final product types

    • Fluorescent markers for biomedical diagnostics and research
    • Labeled molecular probes for cell imaging and flow cytometry
    Free Quote

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    Certification & Compliance
    More Introduction

    Innovation at the Core: 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester

    Experience and Precision: Building Trust in Every Batch

    Years of hands-on manufacturing flow into each gram of our 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester. From design to purification, we rely on practical methods and tested protocols our chemists have refined on the plant floor, not in theory. Every blend comes from raw materials sourced in direct partnership with reputable producers. We manage each step in-house, taking responsibility from synthesis through quality control. That’s the reason our partners return to us—real results tracked in real world laboratories and factories, supported by transparent communication and dependable products.

    Meeting the Challenge: Chemical Integrity and Consistency

    Our team understands inconsistencies in chemical performance can ruin entire development cycles. We’ve learned this firsthand by collaborating with R&D teams who told us about unexpected anomalies causing setbacks. With our 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester, every batch undergoes a rigorous in-process monitoring routine. Moisture, color, granularity, and purity are measured using modern analytical instruments. We calibrate instruments daily, reference international standards, and store every sample for future verification.

    Chemists rely on reproducibility when they test reactions, so we provide a substance whose specs hold steady across orders. Transparency matters in chemistry. We document retention times, NMR profiles, and test results in a controlled database, available to clients on request, not buried in paperwork or diluted by bureaucracy.

    Specification and Handling: Built from Practical Application

    Within our manufacturing lines, we tailor exact model specifications, matching what research and industry partners actually use. We manufacture 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester with a focus on purity, typically exceeding 98% as validated by HPLC. Chemists who work with our product report smooth solubility in common organic solvents such as dichloromethane, chloroform, and methanol, which makes downstream reactions easier to control.

    Odor, hue, and melting point stay within established ranges; we control humidity throughout storage to reduce degradation or clumping. We store material in air-tight, light-blocking containers, proven over years of internal stress testing and customer feedback. For laboratories with sensitive requirements, we offer batch customization such as micronization or specific particle size selection. We do not deliver broad promises or “one size fits all” approaches; each manufacturing campaign builds from direct consultation with end users.

    Real-World Use Cases: Driving Discovery and Process Efficiency

    Pharmaceutical researchers deploy our 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester as an intermediate in the synthesis of alkaloid derivatives. Several R&D teams inform us of increased yields and reaction clarity compared to using alternative sources, thanks to the purity consistency. Medicinal chemistry programs lean on this quinoline structure when designing antihypertensive and neuroactive agents. We’ve partnered with teams working on structure-activity relationship studies and lead optimization, using this methyl ester as a central build block.

    Chemical process engineers turn to this compound as a reliable scaffold, allowing incremental changes on the parent ring system and halogen substituent. Our product’s methyl ester group remains easily modified for further functionalization, whether used in esterification, hydrolysis, or amidation, which broadens its utility across drug discovery pipelines. Researchers appreciate fewer side-reactions and contaminants, reporting stable chromatograms and cleaner workups.

    Academic labs also benefit, often experimenting under grant budgets and tight timelines. Our product shows up in undergraduate teaching kits and graduate-level synthesis. Professors report dependable results for assigned synthetic transformations, which aids in reproducibility for student experiments.

    Standing Apart: Differences that Matter

    We know most suppliers can synthesize basic bromo-quinolines. We stand apart by eliminating batch-to-batch disparity. Market products often show up with unexplained impurities—residual solvents, unreacted intermediates, or incorrect bromine placement—because too many step away from direct process accountability. Some competitors white-label resold material, lacking traceability. Others supply products that look fine on a single set of specs, but under reaction conditions reveal hidden instability.

    Our hands-on approach from start to finish means details never slip through: our methyl ester functionality stays within specification, titer remains accurate, and proton NMR integration matches theoretical expectation. We offer full traceability—every bottle, drum, or bag leaves our site with a QC-confirmed report and origin tracking.

    Technical support does not come from a call center, but straight from our process chemists and quality crew. We’ve spent years on both the supply and lab usage side, so we answer questions with real solutions. If a development team describes an unexpected issue, we investigate using actual retained samples, not off-the-shelf responses.

    Customers tell us they see the difference in how reactions proceed. When using our 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester, they report fewer screenings of side products on HPLC and less time spent on post-reaction purification. That practical impact influences both research budgets and program timelines.

    Solutions Rooted in Manufacturing Practice

    We keep process improvements ongoing. Our site runs regular Kaizen workshops based on chemist feedback, not managerial guesswork. If a client calls about unexpected discoloration or reactivity, we dive into root cause, study batch histories, and implement fixes. For example, strict adherence to temperature ramp protocols during the bromination step stabilized the ratio of mono- to dibromo substitution this year, reducing rework by nearly 7% site-wide.

    We invest in raw material qualification. Every inbound barrel or drum undergoes a chain of custody check and testing before entering our plant. Forgetting to vet a single batch led to product recall years ago; since then, our materials team built a multi-step gate for both supplier and internal approval. We prefer direct partnership with reliable mines and upstream manufacturers that agree to random spot checks.

    We respond to evolving needs in the chemical industry. The push for greener and safer chemical processes is real, as we have experienced requests for solvent reduction and waste minimization during synthesis. We use sealed reaction vessels and vapor-capture systems, reducing workplace exposure and meeting increasingly strict environmental guidelines. Recently, switching to a solvent recovery system brought waste down by over a third and reduced overall production cost.

    Preparing for Tomorrow: Anticipating Market Needs

    Chemistry never stands still. Demand for specialty quinoline compounds grows with developments in oncology, neurology, and antiviral projects worldwide. We track those trends through customer conversations and regular literature reviews. Our R&D team actively explores route modifications to reduce synthetic steps, lower energy usage, and increase throughput.

    Pharma partners have moved toward continuous processing, where lax control triggers cascades of downtime or risk. We prepared by supplying custom packaging and drying protocols. Our ability to adapt particle size distribution and water content for continuous-feed systems gives manufacturers less time spent on system cleaning and troubleshooting.

    We also engage with regulators and independent quality auditors, understanding chemical compliance grows more complex each year. As a producer, we register and update relevant documentation and traceability records. We routinely pilot post-market surveillance programs, so customers hear from us after delivery, not just before the sale.

    Supporting Progress: Open Communication and Real-World Experience

    Over the years, our production crews have seen common mistakes upstream compounders and toll manufacturers make: over-scaling with low-grade materials, under-investing in basic instrument calibration, or neglecting storage environment controls. By taking these lessons to heart, we keep lines of communication open with each partner. Questions are answered by the same chemists who run synthesis or quality assays. We don’t rely on status reports or intermediaries—our product and our word come from direct experience.

    Industry networks and technical conferences play a critical role. Every year, our scientists join collaborative exchanges with academic and private research groups, sharing lessons about synthesis methods, impurity control, and new applications for our compounds. We publish summaries of batch improvements, learning from feedback in journals and direct lab visits.

    Clients rely on us for more than a material—they count on judgment born of time on the bench and production floor. We run root cause analysis when things go wrong and celebrate breakthroughs together when better yields or novel derivatives hit the literature. That partnership, built on persistence and open feedback, has sustained our business and the labs alongside us.

    Pushing Quality Forward: Not Resting on Reputation

    Quality in chemical manufacturing is hard-won. Reputation comes not from marketing, but from batches passing rigorous testing and real projects succeeding in the field. We have invested in GC-MS, HPLC, NMR, and Karl Fischer titrations, running these on both every outgoing batch and routine retained samples. Any deviation means internal rework, not “good enough” handwaving. This means fewer surprises for our downstream partners—managers, process engineers, and bench chemists.

    In the last few years, we expanded technical support, helping customers adapt our 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester into higher-volume pharmaceutical and agrochemical syntheses. Requests for documentation—spectral data, impurity profiling, and reaction optimization—get same-day responses in most cases. If a buyer’s downstream program encounters a challenge, we log it in our internal quality management system and discuss cross-lab solutions.

    We stay focused on authentic improvement, not slick branding. Regular audits and third-party inspections hold us accountable, which strengthens our process and reassures clients from high-compliance sectors like pharmaceuticals and agrochemicals.

    Tackling Industry Challenges: Pollution, Purity, Supply Security

    Manufacturing specialty intermediates can generate hazardous emissions. Our process engineers adapted to local legislation and best practices suggested by industry working groups. Years ago, uncontrolled venting of reaction gases led to local complaints, so we installed scrubbers and closed-loop filtration on our reactor outlets. Routine employee health monitoring and regular site maintenance keep our workplaces safe. Waste products are separated, catalogued, and sent to certified incinerators that track disposal traceability. This keeps our records clean and minimizes impact on the community.

    Global demand causes feedstock shortages and price swings, sometimes tempting producers to cut corners. We resist this by building long-term procurement contracts, holding emergency inventories onsite, and refusing to dilute specifications for short-term profit. Buyers trust us because we notify them of issues proactively, work through delays transparently, and never substitute untested material.

    We also share these experiences by mentoring new chemical engineers and hosting site tours for local students. Investing in the next generation promotes industry resilience—and provides us with a steady stream of critical thinkers to carry our commitment forward.

    Looking Forward: Honoring Craftsmanship and Responsibility

    Manufacturing a reliable 6-Bromo-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Methyl Ester is not just hitting a purity metric. It means building every batch on a platform of learned skill, direct oversight, and openness to feedback. Customers see us as a bridge between lab science and real-world production challenges. We treat each order as a tangible responsibility—packed with care and precision, ready to perform in demanding research or process settings.

    We believe in evolving our methods, but some values remain steady: integrity in sourcing, transparency in documentation, and technical mastery in synthesis. The compound’s role in pharmaceutical pipelines, agrochemical innovation, and academic discovery grows broader each year. With every batch that leaves our plant, we honor the craft and commitment built by the people behind the chemistry.

    Industry does not move forward by cutting corners or hiding behind paperwork. We invite our partners to ask hard questions, tour production, and experience firsthand the difference built by engaged chemists who know their craft. Each bottle reflects not just the standard of this generation, but a promise to keep improving, batch after batch.