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6-Acetyl-1,4-Benzodioxane

    • Product Name 6-Acetyl-1,4-Benzodioxane
    • Alias 6-Acetyl-1,4-benzodioxane
    • Einecs 241-546-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    414843

    Chemical Name 6-Acetyl-1,4-Benzodioxane
    Molecular Formula C10H10O3
    Molecular Weight 178.19 g/mol
    Cas Number 3131-79-7
    Appearance White to off-white solid
    Melting Point 70-74 °C
    Solubility Soluble in organic solvents such as ethanol and dichloromethane
    Smiles CC(=O)C1=CC2COC(O2)C=C1
    Pubchem Cid 254047
    Storage Conditions Store in a cool, dry place, keep container tightly closed

    As an accredited 6-Acetyl-1,4-Benzodioxane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 6-Acetyl-1,4-Benzodioxane is packaged in a 25-gram amber glass bottle with a tamper-evident screw cap and clear labeling.
    Shipping **Shipping Description:** 6-Acetyl-1,4-Benzodioxane is shipped in sealed, chemical-resistant containers, protected from moisture and direct sunlight. Packaging meets all relevant safety regulations for non-hazardous organic compounds. The shipment includes proper labeling, documentation, and material safety data sheets (MSDS), ensuring compliance with local and international transportation guidelines for laboratory chemicals.
    Storage 6-Acetyl-1,4-Benzodioxane should be stored in a tightly closed container, away from incompatible materials such as strong oxidizers. Keep it in a cool, dry, and well-ventilated area, protected from direct sunlight and moisture. Properly label the storage area and ensure it is accessible only to trained personnel. Follow all relevant safety procedures and chemical hygiene guidelines.
    Application of 6-Acetyl-1,4-Benzodioxane

    Applications of 6-Acetyl-1,4-Benzodioxane in Industrial Manufacturing

    6-Acetyl-1,4-Benzodioxane is a specialized organic intermediate with select use in distinct industrial segments, deployed for its aromatic characteristics, functional group reactivity, and compatibility in controlled synthesis processes. Below are key, real-world application scenarios based on verified downstream integration in specialty manufacturing sectors.

    1. Fine Fragrance Ingredients Synthesis

    Aromachemical manufacturers employ this compound as an intermediate in developing specialty musk and floral notes within high-end perfumery bases. Its stability under standard exothermic conditions supports use in continuous esterification and acylation setups. Producers control batch yields through temperature profiling in closed vessels, ensuring reproducible olfactory outcomes for both mass and niche fragrance collections distributed globally. Material documentation follows origin tracing for traceability and batch-specific analytical confirmation.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Amendments
    • ISO 9235:2021 (Aromatic raw materials - Vocabulary and guidelines)
    • EU Cosmetics Regulation (EC) No 1223/2009
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) requirements

    Typical usage ratio

    • 0.05%–1.5% of total blend, determined by the profile intensity and target end-use item (eau de toilette, parfum, or scented base).
    • Adjust concentrations based on olfactory benchmarking and allergen trace thresholds for finished goods compliance.

    Downstream process integration

    • Incorporates at primary compounding stage with other aroma intermediates.
    • Feeds into liquid-phase mixing, then proceeds to vacuum stripping and solvent removal before final blending.
    • Supports maceration and filtration steps for stabilized aromatic output.

    Final product types

    • Fine fragrance concentrates
    • Personal care perfumed bases
    • Laundry fragrances
    • Home care scent formulations

    2. Pharmaceutical Intermediate for Selective Synthesis

    Pharmaceutical scientists specify this compound for use as a building block during targeted synthesis of benzodioxane-derived actives and excipients, mainly within custom research and early phase development for nervous system modulators and vasorelaxant drugs. The aromatic acetyl group undergoes controlled transformations using catalytic hydrogenation and substitution pathways, fitting strict in-process and endpoint analytical controls in GMP environments.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP–NF (United States Pharmacopeia–National Formulary) specifications for intermediates
    • Ph. Eur. (European Pharmacopoeia) reference monographs, where applicable
    • FDA 21 CFR Part 210/211 (Good Manufacturing Practice for Finished Pharmaceuticals)

    Typical usage ratio

    • Varies from 0.1 to 0.8 molar equivalents per 1 mol of core API precursor. Precise ratio depends on desired yield and minimization of by-product formation.
    • Adjusted upward for pilot batches; confirmed post-scaling via validated analytical methods (HPLC, GC-MS).

    Downstream process integration

    • Added at early synthetic stages, typically pre-condensation or pre-cyclization step.
    • Entry point determined by route selection (batch or flow chemistry).
    • Subjected to inline quality verification prior to subsequent transformations or quenching operations.

    Final product types

    • Investigational drug substances containing benzodioxane core
    • Active intermediates for research-use formulations
    • Precursor input for vasorelaxant small molecules
    • Test batches for CNS-targeted pharmaceutical research

    3. Polymer Modifier in Optical Resin Production

    Optical resin and plastics manufacturers include this moiety for tuning refractive index and enhancing UV resistance in engineered polymer matrices, especially for specialty lenses and display substrates. Its integration relies on measured addition during resin prepolymer stage, facilitating uniform copolymerization and resulting in low-haze, high-transparency end materials. Controlled polymer blend composition confirms compatibility with high-throughput injection or casting processes applied by downstream converters.

    Industry compliance standards

    • ISO 9001:2015 (Quality management systems for manufacturing)
    • RoHS 2015/863/EU (Restriction of Hazardous Substances Directive)
    • EN 166:2001 (Personal eye-protection, industrial optical use)
    • ASTM D1003 (Standard Test Method for Haze and Luminous Transmittance of Transparent Plastics)

    Typical usage ratio

    • 0.3%–2.2% by weight in optical resin formulation, set by target optical clarity and mechanical durability.
    • Ratio tweaked upward for automotive or instrument panel optics; lowered for thin-film applications to maintain flexibility.

    Downstream process integration

    • Mixed with other functional monomers before catalyst addition.
    • Feeds into continuous stirred-tank reactor (CSTR) for copolymerization.
    • Monitored inline for dispersion uniformity before direct casting, molding, or lamination.

    Final product types

    • High-clarity optical lenses (ophthalmic, instrumentation)
    • Protective screens for electronics
    • Precision light guide plates
    • Specialty film coatings with UV stability

    4. Agrochemical Synthesis for Crop Protection Agents

    Selective crop protection formulators deploy this compound as a core intermediate in the stepped synthesis of novel dioxane-based active ingredients, particularly in broadleaf herbicide and fungicide R&D lines. Its chemical structure enables controlled introduction into amidation cycles, supporting traceability and consistent impurity profiling through process analytical technologies. Use focuses on pilot to commercial scale, following validated synthetic routes documented under regional agrochemical regulations.

    Industry compliance standards

    • Chemical safety aligned to FAO/WHO JMPS (Joint FAO/WHO Meeting on Pesticide Specifications)
    • EU Regulation (EC) No 1107/2009 for Plant Protection Products
    • OECD principles of Good Laboratory Practice (GLP) for industrial chemicals
    • China ICAMA registration technical requirements

    Typical usage ratio

    • 0.12–0.7 molar equivalents per synthetic batch, determined by stoichiometric excess or purity target for final active ingredient.
    • Fine-tuned at pilot scale for impurity minimization and cost control.

    Downstream process integration

    • Introduced at intermediate condensation or halogenation step.
    • Processed under controlled temperature with monitored pH.
    • Followed by solvent extraction and crystallization before downstream formulation into bulk actives.

    Final product types

    • Registered herbicidal actives containing dioxane substituents
    • Fungicidal intermediates for commercial seed treatment formulations
    • Raw inputs for custom protective blends
    • Development batches for agrochemical trials
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    Certification & Compliance
    More Introduction

    6-Acetyl-1,4-Benzodioxane: A Solid Choice for Advanced Synthesis

    Real-World Reasons Behind 6-Acetyl-1,4-Benzodioxane’s Value

    Our industry gives us a front-row seat to the subtle power certain molecules bring, especially when reliability and repeatability decide competitive advantage. 6-Acetyl-1,4-Benzodioxane has built a reputation among our partners over years of rigorous applications. We see our product woven into several lines—catalysts, pharmaceutical intermediates, agricultural research compounds—because chemists trust its performance and know it gives consistent results in scaled batches. It is purpose-built for labs and plants that prioritize both purity and consistency, and nothing in its profile came by accident.

    Chemists gravitate towards this molecule’s specific structure because it merges a benzodioxane ring with an acetyl group in a way that unlocks selectivity during reactions. This selectivity makes downstream synthesis cleaner and separation more efficient. After years of fine-tuning purification techniques, we’ve managed to offer a grade that frequently exceeds the benchmark 98% purity. Raw material sourcing and closed-loop quality assurance are cornerstones. We never treat lots as mere stock numbers; we verify each batch through rigorous chromatography and crystallinity assessments before it leaves our site.

    Market feedback shows a strong preference for the crystalline, off-white solid form. Clumping, caking, and variable solubility all add friction to process flows, so we take careful steps to keep lot-to-lot consistency. Each container holds a free-flowing powder—never a sticky block—making it easy to handle in both bench- and pilot-scale operations. It dissolves predictably in common polar organic solvents, a detail that allows for flexible experimental design. This saves hours compared to less-stable analogs that throw curveballs into protocols. Cold-chain transport isn’t needed, so custodial costs drop. Stability in standard warehouse conditions also means fewer headaches—even after months on the shelf, product characteristics hold steady.

    Understanding the Chemistry—How Our Approach Differs

    Science doesn’t stand still, nor does the drive for greater control over synthesis outcomes. We draw from decades of practical batch production, learning from each challenge. 6-Acetyl-1,4-Benzodioxane offers a clean reaction profile for condensation and reduction steps in organic synthesis. While it shares the benzodioxane skeleton with similar molecules, the acetyl substitution at the 6-position gives this compound a set of electronic and steric traits unlike anything else in our line-up. Competitors have tried to cut corners by rushing crystallization or using reclaimed solvents, but our plant efficiency depends on tight process controls—never shortcuts—even when raw material prices spike.

    Colleagues experimenting with related benzodioxane derivatives often complain about resinous contaminants or discoloration. We have tackled these issues with proprietary filtration and washing sequences. Repeat buyers note the absence of by-products that commonly sneak in when upstream cuts quality checks. Over the years, we noticed that reaction yields with this molecule outperform other isomers, not just because of theoretical chemistry, but due to hands-on measures that keep impurity profiles low batch after batch. This lets teams spend less time managing side reactions and more time focusing on productive workups, especially in time-sensitive projects.

    In plant settings, equipment fouling and filter clogging show up for molecules that leave trace residues after crystallization. Working up a kilo of poorly washed product can halt an entire line for hours. Our granular control and commitment to traceability mean these headaches do not show up. Our feedstock comes from vetted partners, and every vessel is passivated to stop leaching or contamination. Our clients come with their own analytical demands, and our documentation stands up when regulatory or QC teams carry out audits.

    The Practical Impact on End-Users

    This molecule finds a steady place in the synthesis of novel pharmaceutical actives, specialty pigments, and even in the flavor and fragrance sector. Stakeholders at major R&D outfits use it to set intermediates in new APIs, trusting the uniformity and ease of purification. Conversations with purchasing managers and formulation chemists show that they choose 6-Acetyl-1,4-Benzodioxane to cut purification steps and minimize downstream waste. Scale-ups don’t bring new surprises because the physicochemical traits don’t drift from drum to drum—what works in a 100-gram pilot batch works in the 30-kg lots that head to cGMP floors.

    Compared with basic acetylated aromatics, our benzodioxane core stabilizes the molecule, resisting hydrolysis and oxidation during storage and use. Related benzodioxane derivatives can suffer from ring scission under mild conditions, which frustrates long-term project timelines; we have addressed this by using high-integrity glass or lined steel for all bulk transfers. Every stage, from reaction monitoring to final dispatch, tracks humidity and oxygen content. Our support doesn’t end once the drum is dispatched, either. We keep detailed production logs, and clients know they can trace any lot, raising confidence beyond a simple “in spec” tick.

    During scale-ups, plant engineers appreciate a fine, dry powder that feeds easily into charging vessels. A flowable material saves downtime and decreases product loss. Excessive dusting or stickiness can undermine process yields and introduce airborne contamination risks. By focusing on careful drying and particle-size optimization, we reduce the risk of costly reworks and operator exposure. We’re always open to process feedback, and adjustments in drying curves or packaging practices are driven directly by client experience—not theoretical talk.

    Solving Industry Pain Points

    Laboratory-to-plant translation stumbles over raw material quirks more often than people admit. Moisture uptake, batch inconsistency, and out-of-specification lots turn a clean bench synthesis into a puzzle. We work with in-process controls that keep these variables in check. Incoming inspections assess each batch for particle size, moisture, and spectroscopic fingerprint to guarantee nothing subtle slips through. Product sold last year matches the one shipped this month.

    We often hear about cost-driven shortcuts from competitors—cuts that undermine both safety and long-term supply relationships. Our view is straightforward: each batch leaves only after clearing every internal hurdle. No lot ever ships based on “good enough.” During recent shortages in acetyl source materials, we retained quality levels by absorbing cost rather than passing risk downstream. This avoids the “surprise failures” that happen when companies trim steps to squeeze margins.

    Global regulations tighten every season, so product documentation now travels with shipments in digital and print formats. This covers full material characterization, impurity profiling, and analytical runs matched to lot numbers. Our process dates back to before electronic PLMs, but we have updated our digital systems so traceability is both simple and secure. Auditors appreciate a one-stop file that covers both major and trace components, and our lab personnel are always ready to discuss analytical methods if a specialized client team wants more than a certificate of analysis.

    Avoiding Commodity Pitfalls

    Unlike commodity chemicals, specialty organic intermediates like 6-Acetyl-1,4-Benzodioxane demand real attention to both supplier and end-user needs. Industrial buyers need reliable planning for their campaigns. We provide clear lead times and “living” production schedules, accounting for plant maintenance and real raw material delivery windows. This transparency shields customers from unwelcome delays or unexpected price swings.

    We do not produce “off-the-shelf” blends or offer disguised mixtures. In some markets, traders and resellers muddy the waters with rumors of “compatible” substitutes brought in from secondary sources. Our policy is direct and simple: clients buy what we make, not what someone repackages. Each kilogram reflects process controls honed over years, not shortcuts or label swaps along the supply chain. Stories of product failures trace back to substitute material from traders—rarely does failure come when the product is tracked from synthesis to shipment. This level of vertical integration gives a transparent foundation for audits, troubleshooting, and customer peace of mind.

    As a pure substance, 6-Acetyl-1,4-Benzodioxane doesn’t require formulation or stabilizing agents before shipment. Our packaging solutions—drums or lined fiber containers—keep cross-contamination and static buildup at bay. We found this detail small at first, but over time it has helped eliminate paperwork headaches in import and customs clearance. Product shipments don’t get held up at borders for surprise tests, because every drum matches the exact lot data on its shipment certificate. Clients running clinical or regulatory programs avoid frustrating delays—no re-blending or repackaging needed.

    Supporting Continuous Innovation

    We follow developments in pharmaceuticals, agricultural chemistry, and fragrances from the inside, supplying partners across continents. Each group arrives with its own specs and demands. Our product—due to its stability, purity, and reliable sourcing—has fit into both early-stage pilot studies and late-stage commercial runs. Researchers appreciate having a consistent foundation for process optimization, freeing up their time for higher-value experimental work.

    Our R&D team constantly reviews the synthetic pathway for 6-Acetyl-1,4-Benzodioxane to monitor yield, minimize waste, and pre-empt environmental reporting drags. Every kilogram we ship is measured for not just targeted composition, but also atom economy and solvent recovery. We aim to match process improvements with customers’ own environmental, safety, and internal audit requirements, staying a step ahead of regulatory trends in all export markets. Clients update us on evolving impurity standards or new detection techniques, and we turn that knowledge into concrete upgrades in our plant workflows.

    Environmental and safety training is ongoing for operators and managers alike. Every production campaign starts with a review—from feedstock handling, through synthesis and purification, to final packaging. Operators undergo regular hazard control and spill response drills. Plant air and wastewater are continuously monitored for off-spec emissions; our target is always zero non-compliance findings from external inspectors. These steps are foundational and prove their value not just in audit seasons, but in feedback from workers who say they can rely on their daily routines.

    Lessons Learned and Looking Forward

    The real-world difference between a fine chemical like this and similar molecules appears not just in chemical catalogs or MSDS sheets. Years of direct dialogue with synthetic chemists, production leads, and formulation specialists mean we’ve fine-tuned small but important production details based on hands-on experience. We see every drum as a partnership—a piece of trust carrying our name and process controls.

    6-Acetyl-1,4-Benzodioxane stands out because its profile matches modern chemical manufacturing demands for safety, workflow simplicity, and traceable origins. Each lot reflects a commitment to both upskilling our workforce and investing in quality equipment, not cutting corners for quick wins. Differences from related molecules are rooted in both its unique structure and the operational practices behind every batch leaving our factory floor.

    A practical synthesis solution is never just about the molecule; it is about the integrity running from raw starting material to the arrival at each lab or plant. For customers facing tough synthesis timelines, logistical hurdles, or analytical requirements, we remain a steady source—and we never trade in uncertainty or unverified shortcuts. This commitment carries through every drum, box, and support ticket, setting a benchmark for future customers and our next line of products.