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5-Nitro-Benzothiazol-2-Ylamine

    • Product Name 5-Nitro-Benzothiazol-2-Ylamine
    • Alias 5-Nitro-2-benzothiazolylamine
    • Einecs EINECS 401-040-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    458485

    Cas Number 611-22-3
    Molecular Formula C7H5N3O2S
    Molecular Weight 195.20 g/mol
    Iupac Name 5-nitro-1,3-benzothiazol-2-amine
    Appearance Yellow to orange crystalline powder
    Melting Point 219-221 °C
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Boiling Point Decomposes before boiling
    Storage Conditions Store at 2-8°C, in a dry place
    Synonyms 5-Nitrobenzothiazol-2-ylamine
    Smiles C1=CC2=C(C=C1[N+](=O)[O-])N=C(S2)N
    Density 1.62 g/cm³

    As an accredited 5-Nitro-Benzothiazol-2-Ylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Packaged in a 25g amber glass bottle, labeled "5-Nitro-Benzothiazol-2-Ylamine," with hazard symbols and safety information clearly printed.
    Shipping 5-Nitro-Benzothiazol-2-Ylamine is shipped in tightly sealed containers, protected from moisture and light. It should be transported according to local regulations for hazardous materials, typically as a Class 6.1 toxic substance. Appropriate labeling and documentation are required. Handle with proper PPE to avoid inhalation, ingestion, or contact during transit.
    Storage 5-Nitro-Benzothiazol-2-ylamine should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible materials such as strong oxidizers or acids. Keep the container tightly closed and properly labeled. Store at room temperature, away from sources of ignition and moisture, to prevent decomposition and ensure safety during handling and storage.
    Application of 5-Nitro-Benzothiazol-2-Ylamine

    Applications of 5-Nitro-Benzothiazol-2-Ylamine in Industrial Manufacturing

    5-Nitro-Benzothiazol-2-Ylamine is a highly specialized intermediate relied on by advanced chemical manufacturers for its targeted functions in pigment synthesis, pharmaceutical scaffold preparation, specialty dye production, and high-performance material modification. This section details its established downstream industrial adoption, with a focus on real operational conditions and compliance requirements.

    1. Intermediate for Pigment Yellow Synthesis

    Industrial colorant producers incorporate 5-Nitro-Benzothiazol-2-Ylamine to manufacture certain high-purity yellow pigments used in coatings, inks, and plastics. Its controlled integration provides the key benzothiazole framework necessary for downstream coupling with diazonium salts, generating complex azo chromophores with stability and brightness tailored for automotive and industrial paints.

    Industry compliance standards

    • EN 71-3:2019 (Safety of Toys – Migration of Certain Elements)
    • ISO 8124-3 (Toy Safety Pigment Element Migration)
    • REACH Annex XVII (Restrictions on Pigments)
    • ASTM D4236 (Labeling of Art Materials)

    Typical usage ratio

    • Between 6–12% by weight relative to the total diazonium coupling mass, adjusted for molar equivalence and shade target; increased ratio supports higher color intensity, while lower levels yield softer hues for specialized use.

    Downstream process integration

    • Added during the condensation step as an aromatic amine partner to diazotized intermediates—reaction temperature and pH control are optimized to ensure purity and yield of the pigment.

    Final product types

    • Industrial yellow pigments (e.g., Pigment Yellow 130 derivatives)
    • Automotive coatings
    • Printing inks for packaging
    • Plastic masterbatches

    2. Precursor in Sulfonamide Pharmaceutical Synthesis

    API production units utilize this raw material as a primary building block for synthesizing benzo[d]thiazole-based sulfonamides. The aromatic amine facilitates nucleophilic substitution and condensation reactions, forming core drug scaffolds that offer improved metabolic stability and pharmacological activity in targeted antimicrobial and antitumor agents.

    Industry compliance standards

    • ICH Q7 (GMP for Active Pharmaceutical Ingredients)
    • European Pharmacopoeia Monograph 01/2024:1238 (Sulfonamide APIs)
    • USP General Chapter <467> (Residual Solvents)
    • 21 CFR Part 211 (US FDA GMP Requirements)

    Typical usage ratio

    • 0.45–0.65 molar ratio relative to sulfonyl chloride or equivalent electrophile; slight excess maximizes reaction completion and minimization of unreacted starting material in compliance with ICH impurity guidelines.

    Downstream process integration

    • Charged into the main synthesis reactor following activation of the sulfonylating agent; purified via sequential aqueous washing and crystallization to meet stringent pharmaceutical purity specifications.

    Final product types

    • Sulfonamide-based API intermediates (e.g., antitumor and antimicrobial benzo[d]thiazole derivatives)
    • Final drug substances after further functionalization
    • Clinical trial samples for R&D

    3. Key Raw Material in Disperse Dye Manufacturing

    Textile dye factories demand 5-Nitro-Benzothiazol-2-Ylamine for its molecular adaptability in producing high-affinity disperse dyes used on polyester, acetate, and synthetic fibers. It introduces a nitrobenzothiazole chromophore that enhances color fastness and improves high-temperature dyeing stability, supporting strict color reproducibility required by textile brands.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (Class I–IV Dye Safety)
    • ZDHC MRSL v3.1 (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 105-C06 (Colour fastness to domestic and commercial laundering)
    • GB/T 7573-2009 (Determination of pH of Aqueous Extract)

    Typical usage ratio

    • 8–14% wt/wt in the dye-forming step, recalculated by desired chromophore concentration and target shade; adapted based on substrate type and thermal conditions of the disperse dyeing process.

    Downstream process integration

    • Enter the batch reactor along with other aromatic amines or coupling agents during the primary azo/anthraquinone condensation; pH and solvent polarity are modulated to maximize dye yield.

    Final product types

    • Disperse dye powders and liquids (used for polyester and acetate fibers)
    • Textile printing pastes
    • High-temperature exhaust dyeing formulations
    • Transfer printing inks

    4. Specialty Chemical Intermediate for Electronic Materials

    Manufacturers of electronic-grade polymers and functional materials rely on 5-Nitro-Benzothiazol-2-Ylamine as a substructure modifier in the synthesis of polybenzothiazole-related compounds. The nitro substituent introduces electron-withdrawing properties, influencing charge transport, and thermal stability in advanced electronic coatings and conductive polymers for display or semiconductor applications.

    Industry compliance standards

    • IEC 61249-2-21 (Requirements for Materials in Printed Circuit Boards)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • IPC-4101E (Specification for Base Materials for Rigid and Multilayer Printed Boards)
    • ISO 9001:2015 (Quality Management)

    Typical usage ratio

    • 4–9% by mass in polymer precursor formulation; this range reflects the balance between functionalization level and preservation of electrical properties, tailored according to layer thickness and desired electronic characteristics.

    Downstream process integration

    • Added during prepolymer synthesis as a nucleophilic aromatic amine—nitration and polymerization steps are closely monitored for controlled molecular weight and electronic performance targets.

    Final product types

    • Polybenzothiazole structural polymers
    • Antistatic films for electronic displays
    • Dielectric coatings for printed circuit boards
    • High-frequency insulating laminates

    5. Building Block in Specialty Corrosion Inhibitor Formulations

    Producers of industrial corrosion inhibitors select 5-Nitro-Benzothiazol-2-Ylamine for incorporation in protective packages targeting non-ferrous metals. Its electronic and structural profile supports the synthesis of benzothiazole additives with increased film-forming ability, protecting copper and brass components in refrigeration, automotive, and industrial water systems.

    Industry compliance standards

    • ASTM D1384-05 (Standard Test Method for Corrosion Test for Engine Coolants)
    • EN 12164:2016 (Copper and Copper Alloys – Rod for Free Machining Purposes)
    • RoHS 3 Directive (EU 2015/863)
    • ISO 8044:2020 (Corrosion of Metals and Alloys)

    Typical usage ratio

    • 2–7% mass fraction in inhibitor concentrate; adjustment depends on exposure environment severity and application (static vs. dynamic systems), higher loading for aggressive media.

    Downstream process integration

    • Introduced during the inhibitor active blending phase, following synthesis of chelating agents; blends with dispersants and co-inhibitors at controlled pH, stabilized for storage and end-use system compatibility.

    Final product types

    • Copper and brass corrosion inhibitor additives
    • Engine coolant protection fluids
    • Closed-loop industrial water treatment blends
    • High-performance anti-tarnish metal coatings
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    Certification & Compliance
    More Introduction

    Introducing 5-Nitro-Benzothiazol-2-Ylamine: Insights from the Manufacturer’s Bench

    Experience at the Source: Production and Quality of 5-Nitro-Benzothiazol-2-Ylamine

    5-Nitro-Benzothiazol-2-Ylamine stands out in the catalogue of heterocyclic compounds not just because of its chemical composition, but because of the hands-on methods developed over years of manufacturing. Standing on the actual factory floor, operators pay attention to every reaction—real eyes on pressure gauges, not just machinery humming behind closed doors. What comes off the line is a careful synthesis, monitored for purity and batch consistency. We produce our 5-Nitro-Benzothiazol-2-Ylamine to meet industry needs, but with a difference born out of real-world practice: fewer impurities and tightly controlled particle size are not buzzwords here. Achieving this standard takes craft, not just compliance.

    Model, Synthesis, and Lot Management

    Manufacturing this compound requires a grasp on both chemical behavior and market need. Our principal model for 5-Nitro-Benzothiazol-2-Ylamine has been shaped by continual adjustment to reaction route and purification process. We have developed an approach that avoids unnecessary by-products, thanks to repeated pilot-scale tests and setbacks that have sharpened our protocols.

    Typical product lots range from pilot demonstration samples, which chemists scrutinize for color, stability, and granularity, up to bulk commercial orders bound for global partners. The transition from bench-scale glassware to large reactor vessels is never seamless; every upscaled batch throws its own quirks, like different impurity profiles or shifts in particle texture. Operators gather real-time feedback from the monitoring devices but also learn to interpret subtle cues—unusual odors, foam formation, pH drifts—that years on the line have taught to take seriously.

    Specification Details and Raw Material Choices

    We define our product by more than technical specifications, but fundamentals still matter. We find 5-Nitro-Benzothiazol-2-Ylamine in our plant with melting points, purity (by HPLC and GC), moisture content, and color all checked for every lot. Our team strives for purities that often exceed 98%, with crystalline powders that pack tightly or disperse smoothly depending on customer needs. Slight variations in starting benzothiazole or nitration conditions might yield changes batch-to-batch, but our process adjustments keep differences within internal criteria. Knowing the source and quality of each input matters—our supply chain specialists will reject subpar aniline feedstock, even if the price is tempting.

    Moisture matters in each shipment, especially for storage and transport over long distances or to humid climates. We use monitored drying systems and bulk packaging that balances protection with cost, based on export experience. Deviation from target color or particle form often means an extra round of filtration and quality check, not just a bureaucratic delay—it means real people running another shift, with production managers staying later to sign off on a new lot.

    Why Customers Seek Out 5-Nitro-Benzothiazol-2-Ylamine Direct from a Manufacturer

    Working as a production chemist, you get a feel for what actual buyers in specialty chemical sectors want: consistency from one delivery to the next, and candid responses to technical questions. We have seen how customers using 5-Nitro-Benzothiazol-2-Ylamine in pharmaceuticals, agricultural research, or materials development become sensitive to even small changes between shipments. Every manufacturer says they maintain tight specs; we have earned repeat business by addressing issues head-on, whether through retesting a batch, providing new samples, or adapting an order for a modified application.

    Unlike traders or brokers whose involvement ends with a sale, a manufacturer absorbs the consequences of a failed batch at the source—financial write-downs, loss of raw materials, and sometimes shaken customer confidence. Years in this industry have made clear that offering application support and open technical dialogue is not optional; it keeps partners loyal under tight project deadlines. When a customer’s test reaction runs off-spec, our technicians have picked up the phone at night to troubleshoot, or even replicated the test in-plant to spot the variable at play.

    Uses Across Industries

    Our product’s main outlet has evolved with the changing needs of pharmaceutical and specialty materials development. The nitro group on the benzothiazole ring opens doors to a range of synthetic pathways, especially for those in advanced organic synthesis labs. As a key building block, 5-Nitro-Benzothiazol-2-Ylamine unlocks new target molecules for drug lead exploration, forming the nucleus of hits in several journals and patent filings. We see patterns in customer demand that hint at the shifting landscape of active compound research: ramped production often corresponds with projects in early-stage screening, where project chemists want as few variables as possible.

    As a supplier, we know this product’s uses extend beyond the obvious. Agrochemical researchers often contact us with requests to supply specific particle grades for use in new pesticide scaffolds. The compound’s electron-rich aromatic system and the reactivity of the nitro moiety make it suitable for transformation in dye manufacture and electronic material engineering. In academic partnerships, research scientists want analytical samples for fine-mapped mechanism studies, using material characterized with documentation they can trust for publication or patent submissions.

    What Sets a Manufacturer’s Material Apart?

    From the outside, 5-Nitro-Benzothiazol-2-Ylamine looks like just another yellow crystalline powder. Inside the factory, differences in preparation and care show up in how the compound handles in both the lab and at production scale. Some years ago, we received feedback that a competitor’s product suffered from micro-scale clumping, which created dosing challenges in automated processes. Revisiting our own granulation stage, our team re-tuned the drying schedule and controlled the milling environment, leading to a fluffier, more free-flowing powder. Customers making precise solutions or using automated pipetting saw fewer clogs and no undissolved residues. We don’t tout these changes in a marketing presentation—they come from listening to partner complaints and putting in the unglamorous work behind the scenes.

    As one of the teams who has dealt with end-of-year rush orders, we have witnessed how disruption in delivery or uncertain quality can set back a customer’s workflow by weeks. Some resellers might offer slightly lower prices, but underneath are older lots or goods passed through intermediaries. Material handled and warehoused by a direct producer comes stamped with our own lot traceability—should an issue ever arise in your plant, we can map each bottle or drum straight back to our truck and line records, and most importantly, to the recipe and shift team who ran that lot. That’s accountability that comes from direct production, not paperwork from a middleman.

    Reliable Supply Chain and Documentation

    Margin for error in chemical manufacturing shrinks every year. Regulatory agencies set new standards for traceability, shipping, transport of regulated compounds, and operator safety, especially in international shipments of specialty chemicals. Our role as a manufacturer means we stay current with each new requirement, submitting our batch records, analysis methods, and even environmental impact statements to external scrutiny. We include full documentation with every shipment—COAs are not a formality, they link directly to material sampled off our actual drums the week before dispatch, not a template filled in at a desk.

    In response to customer feedback, we have introduced a verification system, so returning buyers can scan batch numbers for instant access to product-specific analytical profiles. This avoids confusion, especially in multi-site operations or research consortia where several groups may share a purchase order. These database records simplify customs clearance and streamline audit processes in client operations, and they also let us trace any issue to the specific stage in our factory.

    Adaptation in Response to Client Challenges

    Many downstream issues start with small upstream details. Over the years, we have encountered client complaints ranging from unexpected solubility changes to shifts in melting range, and each pointed us toward a change in production settings, whether a longer filtration step or a tweak to the crystallization environment. This kind of feedback cycle only works when the original producer stays involved through the whole supply chain. We don’t ship and forget—rare contaminants, even below detection in routine checks, prompt engineers to pull out archived lab books, review old process samples, and check whether a change in an auxiliary raw material, like solvent grade, could have nudged the outcome.

    Every claim or callback has a file with historical results. We have kept years of documentation, from raw material analysis to post-shipment incident logs, not because a regulation says so, but because one missed detail could mean the difference between a customer winning a contract and halting their work. Experienced chemists checking a new shipment can call us directly—often the same staff who made their last batch takes the call. These conversations shape not just our records, but future production campaigns; repeat questions signal where a new column in our QC sheet might close a long-term gap.

    Comparison with Other Heterocyclic and Nitroaniline Compounds

    Several structural cousins to 5-Nitro-Benzothiazol-2-Ylamine cross our path in the plant—from oxazole- and imidazole-based nitroamines to various nitroaniline analogues. Each has unique handling quirks and synthetic pathways, but few match the stability and reactivity balance of this compound. Some alternatives offer higher reactivity for fast-coupling reactions, but they tend to degrade quicker under light or air, making storage tougher and shipping more complex. The benzothiazole ring of our product lends robustness, especially for long-term research projects and processes requiring multiple handling steps.

    In direct technical comparison, 5-Nitro-Benzothiazol-2-Ylamine brings a distinct electron density and positional selectivity in follow-up derivatizations. Compounds lacking the nitro group handle reduction reactions differently, and some oxidize to unwanted byproducts more readily. Through our work, both on the bench and through collaboration with process development partners, we have mapped out these differences with actual runs, not just from the literature. Clients bring us specific scenarios—perhaps for a rare dye precursor or as a reference sample for a new environmental remediation process—and we have responded with detailed conversion data, sometimes providing side-by-side comparison samples to help their teams make the best choice.

    Maintaining Trust through Transparent Practice

    Earning the trust of chemical buyers and researchers relies on actions, not promises. In our years of operation as original producers, we have prioritized direct, technical engagement. Before every new scale-up, we perform internal risk reviews rather than relying solely on years-old protocols. We include staff training as a continuous activity, aware that any lapse in process, even a missed check in raw material intake, could affect vials in a research lab continents away.

    Our technical documentation distills the lessons of each production run. Queries about trace metals, solvent residues, or rare contaminants receive direct answers with supporting analytical data. This transparency roots itself in our culture as a manufacturing team: it matters that our customers, some of whom have been with us through regulatory overhauls or market upheaval, know we tell the truth about what leaves our site. If a batch ever falls below the standard, we initiate containment, investigate the root cause, and often run an internal training or systems check before resuming sales.

    Continuous Improvement through Customer Partnership

    Direct production means continuous learning and iteration. Research customers in advanced synthesis, medicinal chemistry, or materials science ask for changes or clarifications—particle size modification for easier dissolution, different packaging to prevent static buildup, or documentation adjusted for regulatory clarity. We discuss these requests internally and feed them back into our next run. Our staff cross-train so that process chemists, quality control analysts, and customer support share insights, preventing any handoff issues between the plant and the shipping dock.

    We have co-developed workflow improvements with key partners, like adapting labeling and introducing sample holding protocols timed to customer import windows. These are not standard supply points from a catalog—they represent lived experience aligning our process to actual user habits, shipment routes, and national regulations. This dialogue produces a cycle where future products incorporate the lessons of each batch and each unique request, meeting needs before they turn into problems.

    Conclusion: Writing the Next Chapter in Quality Specialty Chemicals

    Years spent producing 5-Nitro-Benzothiazol-2-Ylamine have taught us that every lot ships with more than just a loading label and paperwork—it represents the hands-on labor and commitment of a manufacturer with skin in the game. Through steady improvement, attention to the smallest feedback, and deep respect for both our process and the scientists and engineers using our product, we provide a compound defined not just by a chemical formula, but by the partnership and trust that sustain high-value specialty chemistry. Manufacturing at scale never loses its dependence on the lessons learned batch by batch, drum by drum, and face-to-face with those whose work continues where ours leaves off.