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5-Methyl-1,3-Benzodioxole

    • Product Name 5-Methyl-1,3-Benzodioxole
    • Alias 3,4-Methylenedioxy-5-methyltoluene
    • Einecs 208-953-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    886212

    Cas Number 2239-26-1
    Molecular Formula C8H8O2
    Molecular Weight 136.15 g/mol
    Iupac Name 5-methyl-1,3-benzodioxole
    Appearance Colorless to pale yellow liquid
    Boiling Point 223°C
    Melting Point -10°C
    Density 1.091 g/cm³
    Solubility In Water Insoluble
    Flash Point 98°C
    Refractive Index 1.546
    Smiles CC1=CC2=C(C=C1)OCO2
    Pubchem Cid 18814

    As an accredited 5-Methyl-1,3-Benzodioxole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 250g 5-Methyl-1,3-Benzodioxole arrives in a sealed amber glass bottle with a tamper-evident cap and safety labeling.
    Shipping **Shipping for 5-Methyl-1,3-Benzodioxole:** This chemical is typically shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It should be transported according to local, national, and international regulations for hazardous materials, often requiring proper labeling, documentation, and temperature or ventilation control during transit to ensure safety and compliance.
    Storage 5-Methyl-1,3-Benzodioxole should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. The storage area should be clearly labeled and equipped to contain potential spills. Use secondary containment if needed and ensure only trained personnel handle the chemical.
    Application of 5-Methyl-1,3-Benzodioxole

    Applications of 5-Methyl-1,3-Benzodioxole in Industrial Manufacturing

    5-Methyl-1,3-Benzodioxole serves as a specialty chemical intermediate in select advanced material and fine chemical production lines. Our manufacturing expertise and process management ensure that our product meets the high regulatory and critical technical requirements demanded by globally recognized downstream industries. Below we specify its established applications, standardized formulation practices, integration into core industrial processes, and the resulting end-use product classes for each application sector.

    1. Fragrance Ingredient Synthesis for Fine Perfumery

    5-Methyl-1,3-Benzodioxole functions as an olfactory building block in the synthesis of complex aroma molecules for premium fragrance compositions. Leading perfumers capitalize on its stable aromatic ring and methyl substitution to introduce sweet, warm, and slightly spicy notes, harmonizing extensively with floral, woody, or gourmand accords. Industrial perfumers require strict compliance with both safety and organoleptic guidelines to achieve market-ready fragrance concentrates.

    Industry compliance standards

    • IFRA Standards for Aroma Chemicals and Fragrance Mixtures (latest amendment as applicable)
    • REACH Regulation (EC) No 1907/2006 (Annexes relevant to fragrance chemicals)
    • European Pharmacopoeia for cosmetic-grade quality
    • ISO 9235: Aromatic Natural Raw Materials—Definition and Nomenclature

    Typical usage ratio

    • 0.01%–1.0% of total fragrance oil formulation, adjusted to concentration protocol and target olfactory profile, with higher ratios in base notes for niche perfumery.

    Downstream process integration

    • Primary introduction at fragrance oil compounding phase within mixing reactors, post-filtration, and pre-fixation prior to bulk filling or encapsulation.

    Final product types

    • Luxury eau de parfum, fine fragrance compounds, home fragrance oils, premium air freshener bases.

    2. Pharmaceutical Intermediate in API Synthesis

    The methyl-benzodioxole scaffold is incorporated as a functionalizable nucleus in the synthesis of select active pharmaceutical ingredients, notably in drugs requiring a stable aromatic ring with electron-donating groups for specific pharmacophores. Process chemists leverage its structure for constructing scaffolds or as a protecting group precursor during multi-step organic synthesis. Careful control of raw material traceability and GMP processing is crucial.

    Industry compliance standards

    • GMP (Good Manufacturing Practice) guidelines per ICH Q7
    • US FDA 21 CFR Part 211 (for pharmaceutical manufacturing)
    • EU EMA quality guidelines for APIs
    • Ph. Eur. and USP monographs relevant to the API route

    Typical usage ratio

    • Stoichiometric ratios based on API synthetic route; typically 0.5–1.5 molar equivalents depending on the reaction step.

    Downstream process integration

    • Entry at intermediate condensation or protection stages during the multi-step batch or flow synthesis of pharmaceutical actives, prior to final purification and crystallization.

    Final product types

    • Intermediate bulk APIs for CNS agents, benzodioxole-based anticancer synthons, research-grade reference substances.

    3. Fine Chemical Synthesis for Agrochemical Intermediates

    The compound is selectively introduced as a precursor during the synthesis of heterocyclic agrochemicals, due to its stable methylated dioxole ring enhancing molecular rigidity and environmental stability of certain active compounds. Its use focuses on targeted molecules where aromatic substitution is essential, delivered under controlled environmental criteria for downstream processing to comply with agricultural safety requirements.

    Industry compliance standards

    • FAO agricultural chemical specification guidelines
    • OECD Environmental, Health and Safety Publications (Testing and Assessment)
    • Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
    • ISO 9001:2015 Quality Management for chemical manufacture

    Typical usage ratio

    • 3–12% w/w as a key intermediate inclusion in advanced synthetic routes, variable by crop protection molecule and target field stability.

    Downstream process integration

    • Charge to main reactor during coupling or cyclization stages, typically under inert atmosphere, prior to isolation and downstream formulation.

    Final product types

    • Precursor intermediates for herbicides, insecticides, and plant growth regulators with aromatic functionality.

    4. Industrial Flavor Compound Synthesis

    Owing to its stable vanilla-like aroma with a mild spicy undertone, 5-Methyl-1,3-Benzodioxole is used to construct synthetic flavoring agents that serve food and beverage manufacturers. Food chemists select it to impart depth and complexity in confectionery flavors, and its controlled addition is regulated under national and international food safety frameworks. Its purity and trace contaminant levels are stringently monitored for food-grade status.

    Industry compliance standards

    • FEMA GRAS status (Flavor and Extract Manufacturers Association, Generally Recognized As Safe)
    • US FDA Code of Federal Regulations Title 21, Part 172 (Food Additives Permitted for Direct Addition to Food)
    • EU Regulation No 1334/2008 on Flavorings and Certain Food Ingredients
    • GB 2760-2014: Chinese National Food Safety Standard for Food Additives

    Typical usage ratio

    • 0.001%–0.1% in finished flavor preparation, calculated based on sensory threshold, matrix compatibility, and compliance with legal maximum residue levels.

    Downstream process integration

    • Metered dosing into liquid or emulsion phase during compounding of food flavor bases, followed by homogenization and QC release testing before spray drying or encapsulation.

    Final product types

    • Food flavor concentrate, beverage flavor bases, confectionery aromatization compounds, bakery flavor emulsions.

    5. Specialty Chemical Intermediate for Dye and Pigment Manufacturing

    The methylated benzodioxole core enables synthesis of stable colorants and fine pigments featuring enhanced solubility and lightfastness. Dye manufacturers employ it in the production of select performance dyes under high-purity standards, especially for high-value textile, plastic, and specialty coating markets that require precise chromophore modification and minimized toxic byproducts.

    Industry compliance standards

    • EN 71-3: Safety of Toys—Migration of certain elements (for pigment applications)
    • REACH Regulation (Annex XVII: Restricted Substances in Dyes)
    • OEKO-TEX® Standard 100: Textile and Leather Regulations (for dyestuff contaminants)
    • ISO 105 series: Textiles—Tests for Colour Fastness

    Typical usage ratio

    • 5–20% by weight of chromogenic intermediate mass in pigment or dye manufacturing; ratio determined by desired hue, stability, and downstream purification efficiency.

    Downstream process integration

    • Initial charging into diazotization or coupling reactors prior to chromophore finalization, followed by precipitation and milling prior to product stabilization.

    Final product types

    • Specialty textile dyes, industrial pigment dispersions, high-stability inkjet inks, UV-resistant masterbatch colorants.
    Free Quote

    Competitive 5-Methyl-1,3-Benzodioxole prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Meet 5-Methyl-1,3-Benzodioxole: A Reliable Building Block for Industry

    Success in chemical manufacturing comes down to consistency, traceability, and the real-world benefits raw materials bring to a process. As a seasoned producer, we've worked alongside customers who face steady, persistent pressure to reduce impurities and find compounds that support ambitious targets for both cost and quality. We know well that every ingredient decision shapes outcomes on the line, for technicians, formulators, and the teams who ultimately drive innovation in flavors, pharmaceuticals, and specialty materials. Among the dozens of fine chemicals we produce, 5-Methyl-1,3-Benzodioxole stands out as a unique and versatile compound that earns its place in demanding synthesis routes day after day.

    Putting Reputation on the Line with Every Batch

    Years ago, suppliers in this chemical specialty space operated behind layers of distributors. End users were left questioning both source and purity. When we decided to produce 5-Methyl-1,3-Benzodioxole in-house, our goal was simple: give researchers, process managers, and purchasing teams full certainty about what they're getting, and how it's made. Every container that leaves our facility carries a story of genuine accountability—raw material controls, qualified operators, and direct support from people who care about your outcomes as much as you do. We know that in this business, a reputation for trust earns more contracts than any marketing claim.

    Manufacturing with Precision: What Defines Our 5-Methyl-1,3-Benzodioxole

    This compound, with a molecular formula C8H8O2, forms a methylated variant of the classic benzodioxole ring. It's not a showcase molecule you'll find in glossy brochures; its value emerges when clean, predictable structure feeds directly into specific chemical transformations. Over the years, we've refined our process to minimize residual solvents, tighten specification windows, and monitor each batch for contaminants that have tripped up projects in years past. Our in-process checks catch off-target reactions early, and our team doesn't ship any material until we're confident it supports everything users expect in research and manufacturing.

    Key Characteristics

    No one benefits from uncontrolled variability. Our technical team invests in constant process improvements, learning from feedback and integrating small changes that keep us at the front of the field for reproducibility and cleanliness. We never take shortcuts on purification: chromatography, distillation, and careful solvent treatment deliver a material that performs reliably in the settings it was designed for.

    The Value in Application: What Customers Achieve with True 5-Methyl-1,3-Benzodioxole

    We’ve seen first-hand how talented chemists and engineers press fine chemicals into service for new syntheses, upgrades in fragrance manufacturing, or complex API intermediates. 5-Methyl-1,3-Benzodioxole brings a unique combination of reactivity and selectivity. In aromatic substitution reactions, it holds its integrity, and in multi-step pathways, its methyl group acts as either a steric director or a precursor to downstream modifications. Over time, specialized teams have used it to build up libraries of derivatives, test new molecular scaffolds, and bridge to more advanced materials. Because they know where it was made and how, our customers work with confidence—tracing their performance back to choices made at our reactors, not guesswork by some anonymous broker.

    Safety, Handling, and Compliance: Built for Professional Settings

    People working in regulated sectors—whether pharmaceuticals, flavors, or advanced coatings—require a clear understanding of raw material safety and logistics. Our 5-Methyl-1,3-Benzodioxole comes with full documentation: we've performed comprehensive analysis on both acute and chronic hazards, and ship only under appropriate containment protocols. Teams can expect genuine partnership when integrating it into new facilities, right down to advice on storage, compatibility, and required PPE. Having handled thousands of kilograms in our own plants, we speak from real experience, not just from what a certificate says. Our warehouse and shipping staff treat each unit with the respect it deserves; that's how we minimize incident rates, protect team health, and keep audit trails simple and honest.

    Choosing 5-Methyl-1,3-Benzodioxole Over Similar Candidates

    To a new user, the differences between methylated benzodioxoles, unsubstituted benzenes, or other ring systems might appear subtle. Over years, customers who started with generic "benzodioxole" blends soon learned the value in a properly methylated product, handled and verified at scale. The methyl group at the 5-position controls the outcome of downstream transformations, influencing regioselectivity, solubility, and volatility. Competitors may offer generic mixtures, but our experience proves purity, isomeric integrity, and controlled distribution of by-products make the crucial difference for separations, chiral chemistry, or final performance in functional materials.

    Our process ensures complete characterization every step of the way, detecting positional isomers that often creep in from uncontrolled syntheses. We've invested in proprietary analytical methods—NMR, Mass Spectrometry, HPLC—to monitor this, and train operators directly on spotting anomalies in real time. Honest feedback from long-term partners taught us which inconsistencies actually disrupt scale-up. One pharmaceutical formulator described an assay that consistently failed to react as expected with off-the-shelf substitutes purchased overseas; one look at our spectral data gave them immediate confidence to restart their development, and not waste another month troubleshooting impurities.

    Integrating Sustainability and Traceability

    Manufacturing any fine chemical means wrestling with demands around waste, emissions, and lifecycle impacts. Years ago, no one asked about origin. Now, traceability and chemistry with minimal by-product burdens are part of every client’s audit. We source key inputs from audited partners and track their journey at each step in our workflow. Our internal tracking system goes beyond compliance checklists; it builds a story we’re proud to share with any compliance officer or sustainability leader. Waste minimization isn’t just policy rhetoric—our team tunes reaction parameters each quarter, aiming for less solvent usage, smarter waste segregation, and simple, recyclable packaging for outgoing shipments.

    Customers working toward environmental benchmarks often approach us for supporting documentation or advice on down-stream solvent treatment. We provide honest assessments of what’s possible. Our team never disguises a limitation with marketing spin, but instead collaborates on batch-specific data, emissions estimates, and pragmatic guidance. This candor wins us repeat business and helps chemists focus their energy on creative solutions rather than regulatory headaches.

    Building Partnerships, Not Just Fulfilling Orders

    We live in a world of growing competition, more acute pricing pressure, and shifting expectations. Many in the industry still chase short-term wins through bulk imports of generic materials. Over time, though, end-users share their frustration with batch failures, slow troubleshooting, and radio silence from vendors. We take a different approach—our chemists are accessible, our technical team answers nuanced questions, and we invite partners to audit our workflow. Buying from us gives you a direct, personal relationship with the factory floor. A decade ago we fought hard to win those first partnerships. Those clients—still with us now—testify to the peace-of-mind that comes with real transparency, and not just a stamp on a label.

    Our expertise doesn’t end at dispatch; we often help troubleshoot odd behaviors when 5-Methyl-1,3-Benzodioxole meets new or legacy systems. Whether it’s refining protocols for automated dosing or debottlenecking after an upstream reformulation, our team works alongside yours. Our best innovations have come from these collaborations. We've integrated adjustments based on our customers’ field data, and they, in turn, benefit from a more predictable, robust product lineup.

    Standing Apart from the Crowd

    Markets have become flooded with low-cost imitation products, many sourced from brokers without transparency about synthesis routes, labor standards, or quality controls. We see the fallout directly: customers coming to us after failed pilot batches and expensive delays, seeking higher reliability and measurable differences in end-use results. Our product earns its price by preventing those headaches. Cost comparisons often fail to take into account the millions lost from downtime, rework, or unstable material. Our clients find that investing in proven raw materials from a dedicated manufacturer pays back in project stability and ease of documentation.

    Our technical literature reflects real production experience, not just abstract properties. Teams rely on our honest assessment of pumpability at various temperatures, compatibility with common solvent systems, and how trace levels of residual byproducts affect their specific protocols. Over time, these insights become the backbone of collaborative, low-risk development. Whether you’re scaling a batch reactor to commercial volumes or running bench-scale optimization, our production and shipping practices ensure confidence at every stage—a promise backed up by a record of on-time delivery and year-on-year customer retention.

    The Importance of Experience in Complex Processes

    We've seen that the real test of a chemical like 5-Methyl-1,3-Benzodioxole comes not from bench-top theory, but from repeated, full-scale application in production facilities. Issues around temperature stability, container compatibility, or process residue don't show up in standard reference sheets. We developed our quality and packaging protocols to keep storage and dispensing trouble-free—even in humid or temperature-cycled environments. If a client has trouble getting material to dissolve or preserve reactivity, we take that information to our R&D team to make improvements. This feedback loop, built on open communication, elevates product performance far above what generic suppliers predict or guarantee.

    Problems encountered during transfer, variable yield in target syntheses, or unexpected color changes can all stem from real-world impurities or uncontrolled process histories. Because we handle full-scale operations ourselves, we recognize the stakes involved. Our dedication is not theoretical—it’s grounded in practical, hard-won solutions to on-the-ground challenges. This combination of production expertise and customer-centric follow-through means that when a project depends on 5-Methyl-1,3-Benzodioxole, you won’t have to cross your fingers, or chase a faceless vendor for answers. You’ll know exactly what to expect—and that’s the standard we live by every day.

    Summary of What Sets Us Apart

    Our commitment goes well beyond formulas and datasheets. We believe in building partnerships based on technical rigor and long-term trust. 5-Methyl-1,3-Benzodioxole, in our hands, serves as both a sophisticated synthetic tool and a marker for what honest manufacturing accomplishes. From R&D managers scaling new routes, to commercial producers aiming for robust yields and smooth audits, our customers come back for transparency, predictability, and real, grounded expertise.

    No batch leaves our facility unless we would trust it in our own processes. That’s a promise built from experience, and it’s why the people who drive industrial progress choose to work with us—and keep us accountable to standards that really matter, project after project, year after year.