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5-Isopropyl-3-Methylphenol

    • Product Name 5-Isopropyl-3-Methylphenol
    • Alias Thymol
    • Einecs 201-944-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    532778

    Name 5-Isopropyl-3-Methylphenol
    Cas Number 3228-02-2
    Molecular Formula C10H14O
    Molar Mass 150.22 g/mol
    Appearance White to off-white crystalline solid
    Melting Point 61-64°C
    Boiling Point 253-254°C
    Solubility In Water Slightly soluble
    Density 1.01 g/cm³
    Flash Point 110°C
    Refractive Index 1.519
    Synonyms 3-Methyl-5-(1-methylethyl)phenol
    Pubchem Cid 16890
    Smiles CC1=CC(=CC(=C1)O)C(C)C
    Inchi InChI=1S/C10H14O/c1-7-4-5-9(6-8(7)2)10(3)11/h4-6,10-11H,1-3H3

    As an accredited 5-Isopropyl-3-Methylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100g, tightly sealed with screw cap, hazard symbols, labeled "5-Isopropyl-3-Methylphenol," batch number and expiry date.
    Shipping 5-Isopropyl-3-Methylphenol is typically shipped in secure, tightly sealed containers to prevent leakage and contamination. It should be stored and transported in a cool, dry place, away from heat and ignition sources. Proper labeling and documentation are required according to chemical safety regulations, and handling by qualified personnel is recommended.
    Storage 5-Isopropyl-3-Methylphenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. It is important to avoid moisture and ignition sources. Proper labeling and secondary containment are recommended to prevent leaks or spills, ensuring chemical stability and safety during storage.
    Application of 5-Isopropyl-3-Methylphenol

    Applications of 5-Isopropyl-3-Methylphenol in Industrial Manufacturing

    5-Isopropyl-3-Methylphenol (commonly known as IPMP or thymol) serves as a key functional ingredient in several regulated industrial applications. As a direct manufacturer, we focus on reliable, specification-driven supply to downstream processors who value consistent purity and documented compliance for their critical production lines. The following segments highlight specialized usage in selected processing industries, outlining real standards, formulation dosage, stage of integration and end product examples.

    1. Antiseptic Formulations for Oral Care Products

    Oral care product manufacturers incorporate 5-Isopropyl-3-Methylphenol as an approved antimicrobial active in mouthwashes, toothpastes, and denture cleansers for its targeted biocidal effect against oral bacteria. Formulation teams optimize dosage to enhance shelf life and flavor compatibility while maintaining regulatory compliance. This ingredient enters aqueous or gel phases prior to final flavor and humectant additions, ensuring even distribution and effective microbial load reduction in the resulting oral health products.

    Industry compliance standards

    • European Pharmacopeia (Ph. Eur.) standards for antimicrobial actives
    • US FDA OTC Monograph for Oral Healthcare Antiseptics (21 CFR 356)
    • Good Manufacturing Practice (cGMP) for cosmetic and hygiene products
    • ISO 22716 guidelines for production and quality assurance

    Typical usage ratio

    • 0.01% – 0.1% w/w; adjusted depending on formulation pH and co-actives
    • Higher concentrations in mouthwashes formulated for clinical use

    Downstream process integration

    • Dissolved completely in base solution before thickener and surfactant phases
    • Introduced at controlled temperature (typically <50°C) to prevent volatility loss

    Final product types

    • Antiseptic mouth rinses
    • Fluoride toothpastes with antibacterial claims
    • Denture soaking tablets

    2. Preservatives and Sanitizers for Personal Care

    In personal care manufacturing, 5-Isopropyl-3-Methylphenol plays a crucial role as a preservative system for hand sanitizers, deodorant sticks, and liquid soaps, where it targets Gram-positive and Gram-negative bacteria and controls odor-causing microbes. Regulatory documentation is required for every batch, and manufacturers monitor residue profiles in finished formulations through validated testing methods. The raw material is introduced during the preservative blend stage, often post-neutralization to maximize stability and efficacy.

    Industry compliance standards

    • IFRA guidelines for personal care ingredient usage
    • COSMOS/Ecocert certification in natural formulations
    • EU Cosmetics Regulation (EC) No 1223/2009
    • U.S. FDA 21 CFR 301 for topical drug and cosmetic ingredients

    Typical usage ratio

    • 0.01% – 0.2% w/w, variable depending on matrix, skin contact risk, and storage
    • Higher end of range for antimicrobial deodorants and leave-on sanitizers

    Downstream process integration

    • Added during liquid phase mixing, preceding emulsifiers
    • Filtered to <5 microns before batching into filling lines

    Final product types

    • Alcohol-based hand sanitizing gels
    • Deodorant roll-ons and sticks
    • Liquid antibacterial hand washes
    • Syndet bars for dermatological use

    3. Biocide Formulation for Industrial Cooling Water and HVAC

    Industrial operators use 5-Isopropyl-3-Methylphenol in closed and semi-open recirculating water systems to inhibit biofilm and microbial growth on surfaces and in pipelines. The material’s stable behavior in alkaline and neutral pH conditions supports long operational cycles, reducing unscheduled system downtime. Process engineers dose the material into make-up water or directly at main pump intake with monitoring of active levels through routine on-line or laboratory checks for compliance and effectiveness throughout the cycle.

    Industry compliance standards

    • US EPA registration for industrial biocidal actives (FIFRA)
    • EU Biocidal Products Regulation (BPR, Regulation (EU) 528/2012)
    • ASTM E645 for antimicrobial assessment in water systems
    • ISO 11906 baseline for water treatment agents

    Typical usage ratio

    • 2–10 ppm active ingredient concentration; dosage tailored to system volume, organic load, and biofouling risk

    Downstream process integration

    • Metered dosing into circulation loop reservoir or as shock treatment
    • Compatibility checks with corrosion inhibitors and dispersants prior to blending

    Final product types

    • Ready-to-use cooling tower biocide formulations
    • Pre-mixed HVAC system hygiene treatments
    • Closed-loop water circuit microbial control

    4. Veterinary and Livestock Antimicrobial Additives

    Feed and veterinary product manufacturers add 5-Isopropyl-3-Methylphenol as a non-antibiotic agent for controlling spoilage and disease vectors in animal housing and feed storage. The ingredient’s low volatility and broad-spectrum activity allow its application in powdered feeds and disinfectant wash solutions. Quality control labs test for residuals post-processing to confirm conformance with veterinary health regulations and minimize transfer to food products from treated livestock environments.

    Industry compliance standards

    • Directive 2002/32/EC on undesirable substances in animal feed (EU)
    • US FDA Center for Veterinary Medicine (CVM) ingredient review
    • GMP+ FSA feed safety assurance certification
    • OIE (World Organisation for Animal Health) code compliance

    Typical usage ratio

    • 5–50 mg/kg in feed additives, tailored by animal type and feeding frequency
    • 0.01%–0.05% w/v in facility cleansing solutions

    Downstream process integration

    • Dry blended into mineral or premix bases before granulation
    • Diluted and applied via spraying or washing for environmental control

    Final product types

    • Medicated feed supplements (non-antibiotic)
    • Livestock barn antimicrobial sprays
    • Poultry processing facility cleaning agents
    Free Quote

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    Certification & Compliance
    More Introduction

    5-Isopropyl-3-Methylphenol: From the Manufacturer's Perspective

    Real Hands, Real Chemistry

    On the factory floor, few products demand such careful oversight and fine-tuned process control as 5-Isopropyl-3-Methylphenol. We shape this material every day, beginning with a tight quality input, then monitoring each stage until it leaves our barrels for the next leg of its journey. This chemical attracts attention not only for its demand in pharmaceutical and cosmetic sectors but also because its physical stability and purity make it an essential building block that downstream partners count on.

    Model and Consistent Specifications

    Chemistry rewards repetition and discipline. Our 5-Isopropyl-3-Methylphenol leaves the reactor within a narrow melting point range, with color and odor held to strict parameters. Experience taught us that fluctuations create hassle for formulation teams, so we calibrated and recalibrated our process until labs reported predictable results batch after batch. The model here isn’t just internal codes or regulatory tables—it’s the blueprint we refine through real feedback and after-the-fact testing, ensuring material that flows smoothly into both established and experimental product lines.

    Because we work directly with buyers—from global personal care brands to medicinal product makers—practical insight guides every lot. Moisture level, crystalline form, and specific gravity affect end use. We mark up each shipment’s documentation not to tick a box, but because our partners call our line when a measurement falls short. Fine-tuning shipment specs became second nature; years of listening to customer labs means we recognize subtle indicators of impurity or volatility long before they would ever register as a final-product problem.

    Direct Use in Key Industries

    Our teams watched trends evolve over the years. Initially, most of the 5-Isopropyl-3-Methylphenol supply moved into classic antiseptic applications—liquid soaps, topical cream bases, oral hygiene products. This material’s antimicrobial properties earned it standing in the pharmacopoeias of multiple countries. Firms used it in everything from dental rinses to surgical hand scrubs, because it resisted both volatilization during blending and breakdown under typical shelf life conditions. Our plant kept up, scaling lines so we could guarantee volume without sacrificing integrity.

    Lately, demand shifted. R&D groups from top-tier cosmetic companies began calling for higher-purity grades, free from off-odors and coloration that might interfere with clear gel formulations or high-performance emulsions. On the manufacturing side, we adjusted protocols—switching purification routes, investing in more sensitive filtration equipment, and running each batch through additional rounds of inspection. Small changes allow the same compound to fill new purpose, from acne creams to sophisticated anti-aging products claiming broad-spectrum antimicrobial effects. We consult with application scientists, walking through end use and pointing out physical characteristics important for formulation stability—a result that comes only from years of shipping both small and industrial volumes.

    What Makes This Grade Distinct

    Raw chemistry rarely runs smooth; only those who’ve stood alongside the reactor know the fine margin between a passable product and a truly reliable one. What puts our 5-Isopropyl-3-Methylphenol in its own league stems from long-term focus on batch consistency. We pull fresh analytic data every hour of production—GC traces, melt tests, colorimetry, plus rigorous impurity checks. The details matter more than any certificate. Some competitors offer broad material classes under similar naming, but shifting odor or unpredictable solubility reveals much about their production methods. Our direct process control gives exactly the monte of the phenol isomer that end users expect.

    At a practical level, those differences appear in downstream behavior. Manufacturers blending into antiseptic gels or oral products know when a lot veers off target. Sub-scale producers sometimes view trace impurities as minor, but we’ve seen entire batches scrapped because an unnoticed by-product triggered regulatory recall. Over time, our operational discipline built trust with the kind of clients who stake their reputation—and their compliance—on every drum received.

    Resolving Typical Challenges

    Not every batch runs perfectly. A tank that ran slightly hot or a feedstock off by a fraction can spell real-world trouble. Over the years, we faced each potential headache: color shifts that could ruin a clear formulation, residual moisture creeping up enough to encourage caking, and occasionally traces of unwanted isomers appearing in the finished product. Experience, not guesswork, drove us to invest in inline sensors and automate corrective feedback loops. Reviewing logs and listening to process techs allowed us to minimize waste and maintain both economic and technical standards.

    Customers sometimes ask about the persistent phenolic odor—a defining fingerprint of this compound. Some look for almost odorless grades for highly sensitive personal care products. A few years back, we collaborated with buyers to isolate exactly which trace molecules created the most problematic notes, then modified purification. That partnership didn’t show up in paperwork but in steadier sales, fewer returned lots, and a notable boost in product performance as rated by third-party panels.

    Learning the Material's History and Evolution

    Factories don’t operate in a vacuum. Our methods evolved alongside changes in regulatory tolerance, pressure from natural alternatives, and the always-shrinking margins of modern bulk chemistry. Early in the material’s commercial life, few cared about low-level isomer separation, provided antimicrobial performance showed up in a QC lab test. Later, tighter thresholds for cosmetic safety and consumer concern over ingredient sources led our R&D team to scrutinize not just what went in, but what remained at the end. Batch-by-batch adjustment defines how we operate under public scrutiny.

    Some years saw major supply chain headaches, as raw chemical prices swung and transport delays threatened customer timelines. Keeping buffer inventory and forging relationships with secondary suppliers meant we could keep our promises. That experience—lessons learned in lean years—put us on stronger footing when demand spiked and every kilo counted. It’s tempting to view manufacturing as little but repetition. In reality, years spent refining our own route created subtle but critical changes in both process efficiency and product profile.

    Stewardship, Responsibility, and Sustainable Operations

    Chemical manufacturing today faces legitimate questions—where raw inputs originate, how waste streams are managed, and whether processes align with both safety and sustainability targets. We took steps to align operational routines with this reality. Even small changes, like reclaiming solvents or switching to alternative energy for heating and distillation, accumulated real benefits. Our factory’s environmental profile now survives not only regulatory audits but also independent reviews by our largest customers.

    Long-term partnerships shape everything from drum labeling to how we pack and palletize finished product. We respond fast to traceability demands, providing origin details, lot-level tracking, and full documentation when needed—not to create barriers, but because questions will only increase as scrutiny grows. Few downstream partners see the hours put toward safe effluent treatment, but these remain part of what keeps our supply position strong. Real-world consequences attach to every tank we deliver, and we don’t take shortcuts to save pennies if it risks later recalls or loss of trust.

    Comparing to Other Phenol Derivatives

    Years of direct production highlighted crucial differences between 5-Isopropyl-3-Methylphenol and other substituted phenols on the market. Subtle positional changes on the aromatic ring shift both effectiveness and blending behavior. Unlike phenol itself or variants with less hindrance, our material brings low volatility and higher thermal stability, reducing risk during high-temperature processing. Other isomers or closely related chemicals fail to provide the same odor characteristics, resistance to breakdown, or regulatory acceptance for pharmaceutical and personal care applications. End users often test a handful of candidates before settling on this one for shelf-life and performance reasons, usually confirmed through real-world product runs.

    In contrast, some buyers once tried bulkier or less pure grades, often sourced from outside the main global supply chain. Issues cropped up—unpredictable solubility, poor color, or difficulty solubilizing alongside commonly used co-actives. Our direct process eliminates these headaches, because of both validated routes and hands-on QC oversight. Both knowledge and accountability set us apart; those without direct experience blending or packaging for sector-specific standards usually miss what long-term partners value most.

    Regulatory and Market Expectations

    With rising safety awareness, regulatory benchmarks for trace contaminants and direct human contact call for more from each lot. Our material aligns with tough pharmaceutical and cosmetic standards, so we constantly review external audits and update internal documentation. Maintaining this level of compliance takes habit, not empty claims. This oversight ensures the finished products—whether as a key stabilizer in hand washes or as an active in oral care—meet relevant pharmacopoeial expectations and satisfy both auditors and end users. Small details, particularly around purity and residual solvents, can mean all the difference for brands seeking export approval or pursuing top grades in their segment. Direct engagement with regulators improves both speed of answer and flexibility for emerging requirements.

    Serving Evolving Customer Needs

    Our approach relies on dialogue. Cosmetic chemists and pharmaceutical formulation leads bring up new questions every production cycle—whether about better dissolution properties, cleaner odor for mass market launches, or improved compatibility with novel surfactants. We answer quickly, sometimes with new production runs or pilot lots adjusted to real-world formulations. If a partner requests finer particle size for faster dispersion or lower water content for longer shelf life, that input feeds straight back to production protocols. Over time, these adjustments sharpen both output and day-to-day reliability.

    We host plant tours for partner engineers and conduct post-shipment checks with customer labs; if there’s a problem detected at their facility, our team pulls archived samples to investigate root causes. There’s no substitute for that kind of transparency—it creates feedback loops that improve not only compliance odds but also customer satisfaction. Experience convinced us that no off-the-shelf spec sheet can account for the minor, cumulative shifts that happen as production scales or customer applications evolve.

    Future-Proofing Supply and Innovation

    Standing still leads to stagnation. We set aside resources for continuous modernization—fresh analytics instrumentation, small-batch reactors for trial runs, and additive purification steps that reduce future compliance trouble. This investment pays back by readying us for rapid response to emerging market or regulatory pressures. As long as end-use industries keep evolving, so must our process. Matching changing expectations with robust, adaptive production means we hold our reputation as both a reliable supplier and a trusted partner.

    Direct Knowledge, Better Supply

    We leave jargon to the marketing crowd. For us, the work comes down to observable results: a shipment that meets lab scrutiny, a process tweak that saves an entire downstream batch, a quiet call late at night from a partner wrestling with an unexpected property shift. Real answers, not canned responses. That’s the standard we set for 5-Isopropyl-3-Methylphenol production, batch after batch, year after year. Every drum that leaves our site carries that experience, and we remain ready to back every order with not just a certificate, but with the knowledge gained from making it ourselves, for the people who depend on real material, not promises.