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5-Hexenenitrile

    • Product Name 5-Hexenenitrile
    • Alias 5-Cyano-1-pentene
    • Einecs 210-022-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    284461

    Cas Number 109-69-3
    Iupac Name 5-Hexenenitrile
    Molecular Formula C6H9N
    Molecular Weight 95.15 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 151-153 °C
    Melting Point -85 °C
    Density 0.83 g/cm³
    Flash Point 38 °C
    Refractive Index 1.418
    Solubility In Water Insoluble
    Structural Formula CH2=CH-(CH2)3-CN

    As an accredited 5-Hexenenitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 5-Hexenenitrile is packaged in a sealed 500 mL amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 5-Hexenenitrile should be shipped in tightly sealed containers, protected from light, heat, and moisture. It must be handled as a hazardous chemical, following all relevant transport regulations. Ensure labeling complies with UN and DOT guidelines, and use secondary containment to prevent leaks during transit. Suitable for shipment by road, air, or sea.
    Storage 5-Hexenenitrile should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition, strong oxidizing agents, and acids. Protect from direct sunlight and heat. Ensure proper labeling and keep away from incompatible materials. Use secondary containment to prevent leaks or spills and follow all applicable safety and regulatory guidelines.
    Application of 5-Hexenenitrile

    Applications of 5-Hexenenitrile in Industrial Manufacturing

    5-Hexenenitrile serves as a multifunctional intermediate for industrial manufacturing. As a direct manufacturer, we supply this specialty nitrile to customers in high-value downstream markets, where it contributes key nitrile and alkene functionalities to application-specific synthesis and conversion processes. Below, we detail its primary industrial application scenarios, with an emphasis on real-world processing requirements, integration points, and regulatory context.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical producers utilize 5-Hexenenitrile primarily within the synthesis of specialty APIs, including anticonvulsant and cardiovascular agents. It acts as a key building block in multistep synthesis routes that require robust control of impurity profiles and compliance with pharmacopoeial monographs. Custom synthetic process development often employs the nitrile for conversion via catalytic or enzymatic hydrogenation, leading to key amines or acid derivatives before final formulation and QC testing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP, Ph. Eur., JP relevant monographs
    • FDA 21 CFR 210/211 cGMP for finished pharmaceuticals
    • REACH Annex III (intermediate use registration)

    Typical usage ratio

    • Batch synthesis: 1.0–1.5 molar equivalents based on target compound yield
    • Process parameters determined by route optimization to minimize residual nitrile

    Downstream process integration

    • Introduced in the initial alkylation or nitrile functionalization reaction
    • Subjected to hydrogenation, hydrolysis, or reductive amination to construct core drug subunits
    • Isolated intermediates tested under GMP-regulated conditions

    Final product types

    • API precursors for anticonvulsant drugs
    • Active metabolites for cardiovascular pharmaceuticals
    • Specialty amine or acid drug intermediates
    • Key building blocks for research and custom molecule design

    2. Agrochemical Precursor for Selective Herbicide Synthesis

    Agrochemical manufacturers incorporate 5-Hexenenitrile in multi-stage synthesis routes, where it delivers nitrile moieties crucial to the construction of selective post-emergence herbicides. The material's controlled reactivity allows fine-tuning of side chains in new active ingredients. Compliance includes traceability for Restricted-Use Pesticides and adherence to specification limits on residual and by-product impurities.

    Industry compliance standards

    • FAO/WHO Specification and Evaluations for Plant Protection Products
    • ISO 9001:2015 for QC in agrochemical manufacturing
    • EU Regulation (EC) No 1107/2009 for pesticide registration
    • OECD Guidelines for the Testing of Chemicals

    Typical usage ratio

    • Reaction input: 0.9–1.2 molar equivalents as the nitrile source
    • Adjusted per downstream functionalization (e.g., aromatic substitution)

    Downstream process integration

    • Input for active ingredient side chain assembly
    • Utilized during the nitrile-to-amide conversion step
    • Monitored for residuals pre-formulation according to ISO-defined limits

    Final product types

    • Post-emergent selective herbicides
    • Precursor for imidazoline- and triazole-based weed control agents
    • Agrochemical active ingredient intermediates
    • Formulated crop protection products

    3. Monomer Component in Specialty Polymeric Resin Production

    Producers of specialty resins and elastomers employ 5-Hexenenitrile for its pendant alkene and nitrile groups, which offer functional sites for controlled polymerization and crosslinking. The material is dosed based on required molecular architecture in engineering plastics or elastomeric networks subject to stringent quality control, especially for electrical or chemical resistance. End-use compliance with RoHS and EN standards is essential due to the integration into electronics and automotive supply chains.

    Industry compliance standards

    • ISO 9001:2015 for QC in polymer manufacturing
    • IEC 61249 (halogen-free polymer use in electronics)
    • RoHS 2011/65/EU for restriction of hazardous substances
    • EN 45545-2 (fire protection in railway applications)

    Typical usage ratio

    • Copolymer blends: 2–15 wt% depending on target properties
    • Adopted at lower ratios for crosslinkable grades or flexibility optimization

    Downstream process integration

    • Introduced in pre-polymer formulation as a functional monomer
    • Reacted via radical, cationic, or anionic mechanisms during bulk or solution polymerization
    • Crosslinking promoted under controlled curing for custom elastomer characteristics

    Final product types

    • Flexible electrical insulation resins
    • Automotive and rail sector elastomers
    • Specialty adhesives for electronics assembly
    • Chemically resistant composite intermediates

    4. Fragrance and Flavor Intermediate in Fine Chemical Synthesis

    Specialty fragrance and flavor chemical manufacturers adopt 5-Hexenenitrile for synthesis of key aldehydes, acids, and alcohols with distinctive green or metallic notes. The raw material is carefully controlled under food-grade and cosmetic GMP rules to avoid unintended odorous by-products. Advanced catalytic hydroformylation, hydrogenation, and controlled oxidation enable downstream conversion to high-value aroma compounds used in food, beverages, and fine perfumery.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Amendments
    • FEMA GRAS certification for flavor ingredients
    • ISO 22716 Cosmetics GMP for fragrance intermediates
    • FDA 21 CFR 172 (food additives permitted for direct addition to food)

    Typical usage ratio

    • Intermediate reactivity: 1.0–1.3 molar equivalents for aroma precursor synthesis
    • Lower application levels in chain extension or controlled functionalization

    Downstream process integration

    • Introduced during synthesis of unsaturated aldehydes (e.g., hexenal derivatives)
    • Processed through hydroformylation, followed by reduction or oxidation
    • Purification stages managed to comply with IFRA and food additive residue limits

    Final product types

    • Green note aldehyde aroma compounds
    • Specialty food and beverage flavor ingredients
    • High-purity fragrance precursors
    • Complex mixtures for perfumery compositions
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    Certification & Compliance
    More Introduction

    5-Hexenenitrile: Practical Handling, Real-World Performance, and Everyday Value

    Direct From Our Plant: A Closer Look at 5-Hexenenitrile

    Manufacturing 5-Hexenenitrile starts with our team bringing together well-established raw materials in a carefully controlled environment. The compound itself, also known by the molecular formula C6H9N, is produced at our facility to rigorous internal standards. Years of hands-on experience tell us that minute deviations in feedstock quality or reaction parameters ripple through the whole batch. This reality keeps us vigilant every day and makes the process design as important as the product itself. The physical form, a clear to pale yellow liquid, defines its practical use in various chemical syntheses—especially in the pharmaceutical and fine chemical sectors.

    We have always found that keeping close tabs on distillation steps and real-time purity checks separates a high-performing intermediate from mediocre output. A consistently high assay, typically above 98%, forms the backbone of what our downstream users count on. Low water content matters not just for storage but for outcomes in Grignard reactions, where moisture readily leads to variable yields. End-users chasing strict process control come to value a guaranteed moisture level under 0.1%, which we verify batch by batch. Controls built into our process—from nitrogen-blanketed storage to glass-lined reactors—keep this figure low and predictable.

    Application Realities: Where 5-Hexenenitrile Makes a Difference

    5-Hexenenitrile’s alkene and nitrile groups open doors in synthesis. We have watched this molecule slide smoothly into use as a building block for making specialty amines, pharmaceuticals, and even agricultural intermediates. Customers with experience in cross-coupling reactions value the molecule’s double bond, which handles functionalization with confidence. The nitrile group stands up to reduction, hydrolysis, and further elaboration.

    One customer, a mid-sized pharma company, shared how their route to an active ingredient worked only when they shifted from a lower-purity competitor’s material to our in-house synthesis. They cited cleaner downstream conversion and fewer byproducts, echoing our own QC logs that showed minimal colored impurities, acid residues, or trace metals. We keep heavy metal analysis a key checkpoint, even though regulations for intermediates don’t always demand it; we have learned over time that the downstream efficiency of hydrogenation and other catalytic steps depends on this vigilance.

    Daily Challenges: Handling, Storage, and Safety

    In manufacturing, corner-cutting on safety is never an option. 5-Hexenenitrile comes with real hazards; the acrid odor signals cyanide risks, and safe handling setups are essential. At the plant, all drum filling and reactor transfer operations are carried out in ventilated enclosures. Spill control plans and emergency cyanide antidotes (such as hydroxocobalamin) are standard provisions on our lines. We train our logistics and warehouse teams to understand product-specific risks and ensure clear labeling leaves no room for error.

    We noticed early on storage stability emerged as a core question. The molecule remains stable when shielded from moisture, air, and heat. We recommend—out of years of first-hand trial—that rigid, sealed containers stored in cool, dry rooms deliver the least complaint from our own QA team. There’s no moving around the fact that opening a drum and exposing the liquid to humid air starts the clock on hydrolysis and polymerization, which shows up as off-odors and color drift.

    Comparisons and Distinctions: How 5-Hexenenitrile Stacks Up

    Customers sometimes ask why not use hexanenitrile, acrylonitrile, or other simple nitriles. Our chemists have hands-on experience with these alternatives. Pure hexanenitrile, lacking the unsaturation, limits avenues for further synthetic manipulation. Acrylonitrile, although cheaper, brings its own regulatory headaches and reactivity quirks. 5-Hexenenitrile, on the other hand, hits a real sweet spot in alkene-bearing nitriles: its chain length supports versatile chemistry, while the double bond’s accessibility gives it a unique edge in cycloaddition and cross-metathesis.

    In our pilot plant, multiple trials have proven that hydrogenation yields differ between 5-Hexenenitrile and other nitriles, particularly in catalyst lifetime and product purity. 5-Hexenenitrile’s structure allows for milder reaction conditions and cleaner end-states for amine or acid products. Companies scaling up new routes appreciate avoiding the side-reactions that cloud acrylonitrile-based syntheses.

    Specifications that Influence Workflow

    After years on the job, we see every specification through the lens of repeatable, practical results. 5-Hexenenitrile at our facility meets a consistent purity threshold because batch-to-batch deviations waste time and money. Every customer who scales up from a few liters to drums values knowing that what worked in the lab will work in a 200-L reactor. We keep GC and Karl Fischer results on hand, and we don’t hesitate to troubleshoot carbonyl contamination, water ingress, or packing issues. Our operators have learned from past shipping delays that a brittle drum closure or non-uniform packaging causes more headaches than any modest cost saving.

    Density and boiling point (measured near 148–152 °C) make a direct difference in distillation design and plant throughput. Customers rarely see the storage and shipping decisions that go into maintaining the right pressure and temperature regimes, but keeping the product away from moisture-laden air preserves the clarity and reactivity that users expect.

    Regulatory Perspectives: Real Impacts, Not Red Tape

    Our daily work means staying ahead of the changing regulatory landscape. We watch updates to REACH and TSCA lists. While 5-Hexenenitrile itself may not yet appear on some watchlists, the EU and US are constantly revising import and end-use controls for nitriles. Our exports undergo a compliance review to ensure all documentation and downstream uses match local regulation. Responsibility falls on us as manufacturers—not traders—to track every outgoing kg.

    Our safety data sheets, updated at least quarterly, reflect new toxicology studies and local labeling mandates. Over time, we learned to adopt UN-approved drums, and we do not shy away from investing in additional hazard communication and language-specific labeling. Every carton and barrel that goes out the door links directly to our batch system, making tracking and recall possible for every client consignment.

    Troubleshooting: Common Questions and Practical Answers

    Daily work in the plant brings up practical issues. Occasionally, customers report haze or a faint off-smell—often the result of trace moisture absorbed during transit or brief storage outside rec’d conditions. We recall one batch shipped during the rainy season where a marginally compromised seal let humidity in, showing up as a slight color shift and heavier headspace odor. Post-shipment, we replaced these drums at cost and stepped up internal QC for leak-paths. Such cases drive home the importance of real-world feedback loops.

    Operators in end-user plants may ask why a batch with identical COA values still gives different yields. We have learned that small variances in plant warehousing and local atmospheres play a more significant role than printed specs suggest. In one example, storage in a sunlit warehouse caused premature degradation, which we traced to thermal cycling that encouraged polymerization. We now guide customers to opt for shaded, consistently cooled storage spaces and avoid partial drum exposure.

    Sustainability: Addressing Environmental Concerns from the Source

    Running a chemical plant today brings a new set of concerns. Calls for greener processes and tighter waste management keep us evaluating our practices. 5-Hexenenitrile synthesis produces process wastewater and some volatile emissions. Over the years, we invested in closed-loop cooling systems, vapor recovery, and selective scrubbing. We run regular emissions monitoring and post updated data online after every regulatory inspection. These controls mean higher operating costs, but they build a relationship of trust with surrounding communities and industrial partners.

    Solvent recycling sits central to our operation. The same solvents used in extraction and purification are recovered in-house using fractional distillation. This reduces the ceremonial flare-offs seen in older plants and cuts both carbon emissions and solvent purchase budgets. These steps take effort and capital, but after a few years, it became clear that reducing raw material loss more than pays out in bottom-line savings.

    The Value Chain: Direct from Our Production to Industry Use

    Dealing directly with manufacturing gives downstream partners visibility. Our QA teams coordinate with end-users to ensure each batch meets the right reactivity profiles for their processes. We track and analyze returns and feedback. One specialty pharma buyer flagged an unexpected reactivity issue, which turned out to be from an unusual stabilizer impurity we identified and eliminated. That experience brought more than compliance—it deepened our technical exchange and cemented a partnership rooted in practical, plant-floor reality.

    The decision to invest in our own analysis lab and full-time technical staff changed the landscape for us. Years ago, repeated troubleshooting with remote labs chewed up weeks and frayed customer relationships. Having in-house capacity means troubleshooting gets handled in hours, not days, reducing delays for our clients’ batch releases. We pushed for full transparency: GC-FID, moisture content, even odor evaluations performed routinely and shared directly with buyers rather than hidden in broad statistical reporting.

    Industry Feedback: How Process Insights Shape Our Product

    Weekly communications with customers in pharmaceuticals, agrochemicals, and specialty materials help us adjust course quickly. Users scaling up catalytic processes—hydroaminations, cycloadditions, hydrogenations—often report ways our specifications perform under real pressure. Rapid feedback means we fine-tune every process variable, from keeping iron and copper counts low for catalytic stability to monitoring endpoint residuals for sensitive applications. Shared learning from pilot to commercial scale shortens the iteration cycle and lowers costs on both sides.

    Examples abound: A pharmaceutical R&D team refining a new amine synthesis flagged alkene migration as a yield bottleneck. After analysis, we raised packing and transport standards to limit incidental heat exposure and supported them with adjusted shipping schedules. The positive results reflected in repeat orders and new referrals from within their industry network.

    Looking Beyond the Batch: What’s Next for 5-Hexenenitrile Users?

    We regularly assess new synthesis routes that match evolving regulatory and market trends. Ongoing R&D focuses on catalyst screens for more efficient and selective downstream reactions; teams trial emerging methods for greener, non-chlorinated purification. Corporate buyers and formulation chemists appreciate the visibility into how our batches perform in iterative R&D and at full scale.

    End-users working to shrink environmental footprints find that batch traceability, robust documentation, and real-life process advice are just as vital as the purity numbers themselves. We make sure that our product leaves the gate not just compliant with specs, but with direct access for troubleshooting, support, and deeper process optimization.

    Why Work Directly with Real Chemical Manufacturers?

    Buying straight from us, the producer, means no uncertainty about source, storage, or past handling. Where traders and third-party brokers lose the thread, direct conversation with the plant fills in the practical gaps. We stand by every shipment and open our QA and technical support to every customer who wants reliable, traceable supply and honest, experience-driven answers.

    Experience teaches lessons documentation alone cannot. Rooted in daily plant operations, tested by hands-on process control, and strengthened by long-term partnerships, our approach to 5-Hexenenitrile delivers results that go beyond the drum. We keep our eyes on both incremental improvements in quality and transformational process upgrades. Our relationships with users, built on trust and regular feedback, help us refine the product, bolster safety, and open up new application possibilities season after season.

    Author’s Note: Every Batch Carries Our Commitment

    From the reactors that start the synthesis to the day a filled drum leaves our plant, each step reflects both discipline and practical know-how. Hands-on management, honest communication, and investment in both people and technology form the backbone of our operation. Guided by lived experience and real industry feedback, we aim to deliver 5-Hexenenitrile with a standard of care, reliability, and usefulness that downstream partners count on year after year.