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5-Fluorotryptamine

    • Product Name 5-Fluorotryptamine
    • Alias 5-FT
    • Einecs 610-012-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    896684

    Iupac Name 2-(5-fluoro-1H-indol-3-yl)ethanamine
    Cas Number 39537-23-0
    Molecular Formula C10H11FN2
    Molar Mass 178.21 g/mol
    Appearance Solid (typically as a crystalline powder)
    Pubchem Cid 83476
    Melting Point Unknown
    Boiling Point Unknown
    Smiles C1=CC2=C(C=C1F)NC=C2CCN
    Inchi InChI=1S/C10H11FN2/c11-7-1-2-9-8(5-7)6-13-10(9)3-4-12/h1-2,5-6,13H,3-4,12H2
    Synonyms 5-Fluoro-tryptamine; 5-F-tryptamine
    Chemical Class Fluorinated tryptamine

    As an accredited 5-Fluorotryptamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A sealed amber glass bottle labeled “5-Fluorotryptamine, 1 gram,” featuring hazard warnings, lot number, and manufacturer’s details.
    Shipping 5-Fluorotryptamine is shipped in tightly sealed containers, protected from light and moisture. Transportation adheres to chemical safety regulations, with clear labeling and documentation. The compound requires handling by trained personnel and is shipped in compliance with local, national, and international hazardous materials guidelines to ensure safe delivery and prevent contamination or degradation.
    Storage 5-Fluorotryptamine should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances. Store in a tightly closed container, protected from light and moisture. Use appropriate safety measures to prevent inhalation, ingestion, or skin contact. Follow all relevant regulatory guidelines for storage of chemicals.
    Application of 5-Fluorotryptamine

    Applications of 5-Fluorotryptamine in Industrial Manufacturing

    5-Fluorotryptamine serves as a specialized intermediate in several high-value industrial sectors, including pharmaceutical synthesis, research-grade reagent production, fine chemical manufacturing, and custom peptide modification. As a direct manufacturer, we support integration into complex workflows where demand for traceability, compliance, and batch-to-batch consistency remains critical.

    1. Pharmaceutical API Intermediate Synthesis

    Leading pharmaceutical manufacturers use 5-Fluorotryptamine to form fluorinated tryptamine segments in various active pharmaceutical ingredients (APIs). The material enters multi-step synthetic routes requiring rigorous GMP control, as well as advanced isolation and purification processes. Its fluorinated indole core supports construction of CNS-active compound libraries. Controlled introduction of the material enables production of investigational and commercial-stage molecules, following strict regulatory submission and validation for every batch.

    Industry compliance standards

    • ICH Q7 Active Pharmaceutical Ingredient GMP
    • US FDA 21 CFR Part 210/211
    • EDQM CEP Certification (if for European markets)
    • Chinese Pharmacopoeia API Intermediate Specification (if for China domestic use)

    Typical usage ratio

    • Applied at 0.8–1.2 molar equivalents relative to downstream indole substitution target; ratio subject to optimization by kinetic and yield data, as well as impurity profile management.

    Downstream process integration

    • Charged into controlled reactor environments after solvent pre-conditioning, subsequent to upstream halogenation or reductive amination steps, then followed by acylation or cyclization as needed in integrated API manufacturing lines.

    Final product types

    • Psychoactive drug intermediates (e.g., serotonin receptor ligands)
    • Fluorinated alkaloids in CNS research programs
    • Rare disease investigational molecules
    • Preclinical batch materials for IND-application

    2. Custom Peptide and Protein Modification

    Biotech laboratories and contract manufacturers employ this compound as a building block in the synthesis of fluorinated tryptophan analogues for site-specific peptide modification. It enables design of labeled, photoactivatable, or stability-enhanced proteins required in drug discovery or structural biology studies. Use remains limited to settings with advanced solid-phase peptide synthesis (SPPS) or solution-phase approaches, employing stringent material certification and full batch documentation.

    Industry compliance standards

    • ISO 13485 for medical device-related peptide APIs
    • Synthetic Peptide cGMP per ICH Q7
    • USP or Ph. Eur. monographs for peptide substances, if the modified peptide is intended as a pharmaceutical ingredient
    • GLP guidelines for raw materials used in non-clinical research material production

    Typical usage ratio

    • Incorporated at a 1:1.05 stoichiometric ratio for target tryptophan analog sites; proportion adjusted according to peptide chain length and sequence complexity.

    Downstream process integration

    • Integrated during amino acid coupling cycles in SPPS synthesizers, entering between deprotection and coupling stages, with subsequent purification by reverse-phase HPLC or FPLC in compliance with validated process standards.

    Final product types

    • Site-specifically fluorinated peptide APIs
    • Functionalized diagnostic peptides
    • Modified protein standards for NMR spectroscopy
    • Synthetic peptide reagents for structural biology screening

    3. Fine Chemical Synthesis of Fluorinated Indole Derivatives

    Advanced chemical manufacturing facilities leverage the material for scalable synthesis of fluorinated indole compounds. End-use sectors include agrochemical R&D, flavor and fragrance intermediates, and specialty chemical supply. Production demands analytical-grade input and continuous process control to restrict by-product formation and ensure specification adherence, applying techniques such as column chromatography and in-process FTIR or HPLC validation.

    Industry compliance standards

    • ISO 9001 certified quality management for fine chemical production
    • REACH Registration (EU) for new chemical entities
    • Chinese Hazardous Chemicals Registration, where applicable
    • Specific analytical purity monographs as required by downstream technical dossier

    Typical usage ratio

    • Loaded at 0.9–1.5 equivalents versus indole precursor depending on desired fluorination level and targeted downstream derivative structure.

    Downstream process integration

    • Introduced following substrate activation in batch or continuous flow reactors, combined with acyl chloride, alkylation reagents, or coupling agents, under solvent and temperature conditions tailored to product purity targets.

    Final product types

    • Fluorinated indole building blocks for further derivatization
    • Agrochemical intermediate compounds (not direct pesticides)
    • Specialty indole derivatives for fragrance and flavor R&D
    • Technical grade fine chemical products

    4. Analytical Research Reagent Manufacture

    Producers of analytical standards incorporate this compound as a reference and calibration reagent for method validation, stability studies, and bioanalytical quantitation. Laboratories require material fully characterized by NMR, HPLC, MS, and impurity profiling, delivered according to research-use-only (RUO) or ISO standard packaging with accompanying batch analytical data. Thorough traceability and documentation ensure compliance for GLP/GCP applications.

    Industry compliance standards

    • ISO/IEC 17025 (laboratory reference standards)
    • GLP—OECD Principles for chemical analysis reagents
    • ISO Guide 34 for reference material producers (now superseded by ISO 17034)
    • RUO labeling compliance for export, per local regulations

    Typical usage ratio

    • Prepared at reference concentrations ranging from 100 µg/mL to 1 g/L depending on instrumentation (LC-MS/GC-MS); weighed-in precisely for standard solution or qualitative spot testing as needed.

    Downstream process integration

    • Packaged into certified vials or ampoules after final purification and QA release; utilized in downstream calibration or recovery validation protocols in analytical or environmental laboratories.

    Final product types

    • Certified chemical reference standards
    • Internal calibration solutions for LC-MS quantification
    • Stability testing controls
    • Research-use-only analytical reagents
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    Certification & Compliance
    More Introduction

    5-Fluorotryptamine: Our Commitment to Reliable Chemical Innovation

    Taking a Closer Look at 5-Fluorotryptamine

    Our years in synthetic chemistry have taught us that every molecule we deliver must stand up to precise demands and ever-higher expectations. 5-Fluorotryptamine exemplifies this approach—not just another building block, but a thoughtfully produced intermediate that reflects years of hands-on research and optimization in our labs. Chemists and developers in pharmaceutical, life science, and diagnostic fields keep coming back to this compound for a reason: it does its job consistently, batch to batch, because we take its development seriously.

    5-Fluorotryptamine: Specifications That Matter to Chemists

    We manufacture 5-Fluorotryptamine as a white to off-white crystalline powder, offering the C10H11FN2 formula with a molecular weight of 178.21 g/mol. In our process control, we emphasize purity—GC and HPLC regularly confirm levels above 98%, because the work downstream depends on this level of cleanliness. The melting range typically falls between 104 and 108°C. In our hands, moisture and trace metal control have been a focus, as organofluorine compounds often exhibit greater sensitivity to environmental exposures. Each kilogram undergoes rigorous scrutiny: we always check for residual solvents, as even parts-per-million contamination can distort sensitive assay results further down the synthesis chain.

    Why Chemists Prefer Our 5-Fluorotryptamine Over Other Sources

    The discussion in the lab quickly shifts from price or delivery schedules to consistency and reliability. Some commercial lots we’ve evaluated in the past arrive with inconsistent particle size or exhibit background impurities that lurk below the threshold of casual inspection but slow research or manufacturing. We recognize the frustration this causes—your team shouldn’t need to repeat purifications on a supposedly high-grade reagent, wasting valuable time and materials.

    We responded by overhauling our recrystallization steps, implementing finer staged controls within our nitration and reduction process. This means the freebase flows easily, dissolves without residue in standard solvents, and never throws surprises in spectral analysis. By keeping our process vertically integrated—from fluorination through to the final amination—no corners are cut.

    Where 5-Fluorotryptamine Sees Real Value

    We have customers who need 5-Fluorotryptamine to prepare serotonin analogs, probe substrates, or unique indole derivatives for CNS-targeted research. The indole core bridges classic biochemistry with the front edge of medicinal chemistry. Researchers continually explore substitutions at the 5-position for unique receptor binding profiles or improved pharmacokinetics; the fluorine atom’s electron-withdrawing impact and subtle steric tweak can alter in vivo properties enough to enable new drug leads or radiotracers.

    Beyond pharma, demand has come from peptide science and custom dye synthesis, where indole-based scaffolds form the base for labeling, connectivity, and signal generation work. The tunable reactivity of the molecule—especially the dual nucleophilicity and electrophilicity around the indole—means aggressive chemoselectivity, minimal side-product formation, and lower post-reaction cleanup. Over the years, these features win praise from scale-up scientists and process engineers who prize streamlining and predictability.

    Our Approach: Real-World Practicality Over Glitzy Promises

    Many producers focus on price by shortcutting process validation. We’ve seen how this plays out: higher rates of batch failures, delayed product launches, and recalls. Rather than racing others to the bottom, we stuck to robust standard operating procedures, using real-time monitoring and gravimetric checks at each stage—steps many competitors rush through or ignore. Our staff conducts hands-on inspections, not just instrument readouts.

    Each production cycle generates a full analytical docket, including NMR, IR, GC-MS, and Karl Fischer titration, so every client receives meaningful batch data—without needing to ask. We keep open dialogue with end-users, listening closely when a synthetic pathway throws up a surprise or a routine assay starts showing drift—this feedback loops directly into process review, informing material handling and purification investments.

    Specifications and Batch Handling in Day-to-Day Practice

    On batch receipt, clients often want a product that pours without caking and stays non-hygroscopic over weeks at ambient conditions. Because 5-Fluorotryptamine can degrade under aggressive humidity or light, we switched to opaque, nitrogen-flushed containers, then monitored stability in a range of real laboratory environments. Fungibility—easy weighing, clean transfer, no static build-up—comes from packaging details many overlook.

    We went through several packaging iterations, talking to researchers who work in small vials or kilo bioreactors. Each time we redesigned, we sent lots to third-party labs for abuse testing—temperature cycling, shaking, and simulated international shipping—then waited for feedback. Every improvement, from inner liners to newly sourced desiccants, addresses a pain point one of our actual users has faced. Our QC team regularly checks warehoused material for shelf-life integrity, not trusting retention samples to tell the whole story.

    Real-World Use Cases: Learning from Our Customers

    A pharmaceutical group in Germany needed 5-Fluorotryptamine for rapid analog synthesis. They initially reported chromatographic tailing when switching suppliers. After detailed chromatogram analysis and mass spectrometry comparison, micro-impurities—undetectable by TLC, but present in commercial samples—were inhibiting catalyst turnover in downstream steps.

    After providing our tighter-cut material, the same group improved their yield by thirteen percent and saw elimination of baseline drift, reducing their overall synthesis time by more than a day per analog. Examples like these keep driving us: knowing our compound fits the needs of medicinal chemists and does not compromise the pace of drug discovery.

    Another customer in diagnostics needed ultra-clean 5-Fluorotryptamine for coupling reactions with minimal metal and halide contamination. Their old approach involved double-purifying each received batch before sensor fabrication. Once our routinely tested specifications matched their requirements, unnecessary extra purification was eliminated, and waste disposal costs dropped.

    Distinguishing Ourselves: Not All 5-Fluorotryptamine Is Created Equal

    Many resellers source from inconsistent overseas producers without fully vetting process controls, relying on a single COA. Our chemical plant keeps all records and batch histories accessible and traceable. We produce all material at our own facility, not by contracting synthesis to third parties or brokers—allowing us to control the smallest details, from reagent sourcing (pharma-grade only) to operator training. Our wet chemists perform process validation every quarter, updating and refining synthetic protocols as tools and monitoring capabilities improve.

    We refrain from over-blowing scale: there’s little satisfaction in touting metric tons if purity and traceability falter. Instead, making thousands of multi-kilo lots, shipping to clients in Europe, North America, and East Asia—each conforming to the same strict spec—forms the everyday backbone of our commitment. Repeat customers always see identical results, regardless of location or order size.

    How Documentation, Transparency, and Analytical Depth Build Trust

    While most suppliers supply basic analytics, we document trace-level impurities over time, building a picture for long-term material consistency. Internal audits go beyond ISO requirements because regulatory demands for traceability and batch homogeneity have only grown stricter. Our online batch histories let clients track every lot, from raw material input to packaging, so if questions arise, there’s no need to guess where potential issues began.

    Clients value analytical depth. We include NMR spectra (1H, 13C, and 19F), IR and mass spec traces, showing every peak and integration. For those setting up GLP or GMP-compliant flows, these day-to-day practices remove uncertainty, enable more reliable validation, and avoid time-consuming requalification. Throughout years of feedback, this approach has saved clients costly project delays and regulatory complications.

    The Difference in Customer Support: Chemists Helping Chemists

    Our support team consists of trained chemists with years of bench experience. Troubleshooting isn’t a form-letter reply; it’s a real conversation about reaction conditions, parameters, cleanup, and scale. We care about how 5-Fluorotryptamine interacts with unique solvents or catalysts—because we’ve run those reactions ourselves, not just read about them in literature. If a user’s protocol hits a snag, we walk through likely sources—batch to batch variability, process impurity traces, or equipment calibration—sharing hands-on knowledge where possible.

    It’s easy to forget the value of deep familiarity with process chemistry until an unexpected variable halts a project. Our willingness to guide customers through unfamiliar coupling conditions or purification tweaks saves both sides time, prevents costly failures, and keeps workflows predictable.

    Current Manufacturing Challenges and Our Path Forward

    Maintaining strict environmental and occupational safety is an ongoing commitment with halogenated indoles. We regularly invest in exhaust management, PPE upgrades, and safe handling workshops to protect our employees and the environment. This isn’t a regulatory formality—it’s practical, everyday reality in the plant. Waste streams undergo neutralization and capture, limiting both emissions and material loss.

    Supply chain volatility for specialty reagents, particularly rare fluorinating agents, has posed hurdles over recent years. Our procurement team cultivates direct relationships with top-tier suppliers, leveraging shared forecasts and pooled logistics to buffer against sudden shortages. Safety stocks and parallel sourcing supplement just-in-time inventory, insulating both our operations and customers from disruptive spikes in lead time.

    Process improvements never stop. We continually refine steps for better selectivity, increased atom economy, and reduced by-product loads. Feedback from customers drives plenty of these upgrades: requests for lower residual metals or fewer halogenated solvent traces fuel pilot plant trials and larger process changes.

    Adapting to digital monitoring, we’ve recently deployed custom sensors throughout our reactors, providing real-time analytics and improving reaction reproducibility. These investments shrink the margin for error and allow for quick remote troubleshooting, further speeding up cycle times.

    Safety, Handling, and Responsible Stewardship

    We supply comprehensive material safety data and storage recommendations, based on our own field testing and process experience. Personnel always handle 5-Fluorotryptamine in well-ventilated environments, minimizing exposure risk and ensuring long-term product stability. Our years of handling and transport data show which conditions best protect the product—and employees.

    We stay vigilant for regulatory changes or shifts in best practices. Coordination with environmental and labor authorities keeps all measures current. Even as the volume of 5-Fluorotryptamine shipped grows each year, our top priorities remain safety, integrity, and the responsible stewardship of chemical resources.

    Supporting the Scientific Community with Reliable Materials

    Every lot of 5-Fluorotryptamine sent from our facility represents years of refinement, user feedback, and a direct investment in scientific progress. Confidence is earned, not assumed. We engage with clients large and small—startups, universities, big pharma—because every application deserves the same level of attention and material fidelity.

    By doing more than the minimum—by sharing not just product, but process insight and practical know-how—we see our mission as directly supporting the ambitions of research leaders and innovators worldwide. 5-Fluorotryptamine isn’t a commodity here. It’s a partnership, forged molecule by molecule, with the chemists and engineers pushing boundaries every day.