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5-Chlorovanillic Acid

    • Product Name 5-Chlorovanillic Acid
    • Alias 5-Chloro-4-hydroxy-3-methoxybenzoic acid
    • Einecs 252-047-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    482642

    Product Name 5-Chlorovanillic Acid
    Cas Number 1823-61-2
    Molecular Formula C8H7ClO4
    Molecular Weight 202.59 g/mol
    Appearance White to off-white solid
    Melting Point 205-208°C
    Purity ≥98%
    Solubility Slightly soluble in water, soluble in organic solvents like DMSO and methanol
    Synonyms 4-Hydroxy-3-methoxy-5-chlorobenzoic acid
    Smiles COC1=C(C=C(C=C1Cl)C(=O)O)O
    Storage Temperature 2-8°C (Refrigerated)
    Pka Around 4.4 (carboxylic acid group)
    Ec Number 217-432-3

    As an accredited 5-Chlorovanillic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 5-Chlorovanillic Acid, 25g, is supplied in a sealed amber glass bottle with secure screw cap and detailed safety labeling.
    Shipping 5-Chlorovanillic Acid is shipped in tightly sealed containers, protected from moisture and light. Packaging complies with chemical safety regulations and includes appropriate hazard labeling. During transit, temperature and handling precautions are observed to prevent degradation or contamination, ensuring safe delivery for laboratory or industrial use. Shipping documents include relevant safety data and regulatory compliance.
    Storage 5-Chlorovanillic Acid should be stored in a tightly sealed container, away from direct sunlight and moisture, in a cool, dry, and well-ventilated area. Keep it at room temperature and separate from incompatible materials such as strong oxidizers or acids. Properly label the storage container, and ensure it is stored in accordance with local regulations and chemical safety guidelines.
    Application of 5-Chlorovanillic Acid

    Applications of 5-Chlorovanillic Acid in Industrial Manufacturing

    As a specialized chemical raw material manufacturer, we supply 5-Chlorovanillic Acid to leading industrial sectors where its functional properties directly support controlled synthesis and advanced production efficiency. The following application scenarios reflect its genuine downstream integration, with details on regulatory frameworks, formulation dosages, stage-of-entry, and end-product typologies observed in real-world manufacturing.

    1. Intermediate for Pharmaceutical API Synthesis

    Pharmaceutical manufacturers frequently introduce this material into multi-step syntheses as a key intermediate for developing certain active pharmaceutical ingredients, particularly those incorporating halogenated aromatic scaffolds. Standard use involves strict compliance with traceability and impurity controls, from initial batch weighing to isolation, ensuring consistency in the critical transformation stages within GMP-regulated plants. Analytical and formulation teams adjust inclusion levels to match final API yield goals and maintain stability during subsequent coupling or condensation steps.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF (United States Pharmacopeia – National Formulary)
    • EDQM CEP (European Directorate for the Quality of Medicines - Certificate of Suitability)
    • ISO 9001:2015 Quality Management System

    Typical usage ratio

    • Ranges from 0.5 to 5 molar equivalents relative to the target API precursor, with variations based on stepwise yield optimization and impurity profile requirements.

    Downstream process integration

    • Incorporation during initial condensation or etherification step as a coupling agent; post-reaction purification or extraction followed by crystallization prior to downstream conversion or ring closure processes.

    Final product types

    • Semi-synthetic antibiotics
    • Specific cardiovascular drug actives
    • Anti-inflammatory pharmaceutical intermediates

    2. Advanced Aromatic Compound for Agrochemical Synthesis

    Producers of herbicides and fungicides employ this compound for its role in introducing controlled halogen groups into novel actives. It supports building block chemistry for crop protection agents where selective aromatic substitution is necessary during scale-up. Operators use batch or continuous processes equipped to handle precise dosing, and regular QC validation is required to avoid cross-contamination in multi-product facilities under ISO and REACH guidance.

    Industry compliance standards

    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (EU)
    • OECD Guidelines for the Testing of Chemicals
    • FAO Specifications for Plant Protection Products
    • ISO 17025 for laboratory composition and impurity analysis

    Typical usage ratio

    • Employed at 1.5-3.8% w/w of total reaction mass, adjusted per target molecule and the stoichiometric endpoint of halogen incorporation.

    Downstream process integration

    • Dosing into low-temperature aromatic substitution or oxidative coupling reactors, followed by wet milling and intermediate stabilization prior to downstream formulation or microencapsulation.

    Final product types

    • Triazole fungicides (precursor synthesis)
    • Halogenated phenoxy herbicides for cereal protection
    • Agrochemical intermediate concentrates

    3. Building Block for Fragrance Ingredient Manufacturing

    Industrial fragrance and aroma chemical producers depend on this material as a precursor for synthesizing specialty vanillin derivatives and complex ester-based notes. The aromatic backbone enables unique olfactory properties essential for differentiating fine fragrance bases and compounded flavoring substances. Manufacturing requires strict adherence to IFRA guidance and Hazard Analysis and Critical Control Point (HACCP)-validated production controls, with intensive in-process checks for purity and residual solvent content.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • EU Flavouring Regulation (EC) No 1334/2008
    • Food Chemicals Codex
    • ISO 22000 Food Safety Management System (if used in food flavoring production)

    Typical usage ratio

    • Used at 0.2–1.0% by mass within synthetic aroma libraries, scaled by final blending intensity and targeted sensory attributes of finished mixtures.

    Downstream process integration

    • Integration during batch-esterification or aldehyde formation, followed by solvent distillation and purification, and subsequent blending with other aromatic ingredients according to proprietary formula protocols.

    Final product types

    • Vanillin derivative aroma chemicals
    • Flavor and fragrance compound stock
    • Olfactory modifiers and high-purity perfumery ingredients

    4. Reference Material for Analytical and Research Laboratories

    Analytical standards and fine chemical departments use this compound as a controlled reference in method validation, impurity fingerprinting, and calibration for quantitative assays. It plays a crucial role in pharmaceutical R&D and quality control labs, where traceability and purity certification are verified per regulatory testing frameworks. User protocols specify exact concentrations for stock solutions, with full documentation for batch origin, intended research purpose, and LIMS compatibility.

    Industry compliance standards

    • ISO 17034 General Requirements for Reference Material Producers
    • USP Analytical Reference Standards Program
    • GLP (Good Laboratory Practice) Guidelines
    • FDA 21 CFR Part 211 Subpart I – Laboratory Controls

    Typical usage ratio

    • Typically 10–100 mg/L in calibration or spike solutions; actual concentration depends on the detection method (e.g., HPLC, GC-MS) and analytical range required per validated SOP.

    Downstream process integration

    • Weighing and dissolution as primary or secondary standard in volumetric flasks; direct integration into analytical runs for calibration, recovery studies, and validation of semi-quantitative methods.

    Final product types

    • Pharmacopoeial reference substances
    • Certified analytical standards
    • QC assay controls
    • Calibration kits for instrument manufacturers
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    Competitive 5-Chlorovanillic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introduction to 5-Chlorovanillic Acid: A Closer Look from the Manufacturer’s Bench

    Every batch of 5-Chlorovanillic Acid we produce begins its journey in our reaction vessels, under well-tested conditions refined over dozens of production cycles. Years of hands-on experience have taught us that product performance starts long before it reaches the customer—it starts with raw material sourcing, careful process controls, and honest communication about what sets our compound apart in the lab and downstream applications.

    Choosing Raw Materials for Reliable Output

    We pay close attention to the purity and traceability of starting materials for 5-Chlorovanillic Acid. Impurities in the chloro group or the vanillic acid backbone can impact not just finished purity, but reactivity and shelf stability. Sourcing from long-term, vetted suppliers allows us to minimize batch-to-batch variation and meet the demands of customers in research and specialty synthesis. Our production line relies on direct feedback from personnel who have worked their way up from operators to chemists. They’ve experienced the problems that arise from shortcuts and understand why every kilogram must meet uncompromised standards.

    What Sets Our 5-Chlorovanillic Acid Apart

    As a manufacturer who takes ownership of each product, we stand by the physical and chemical consistency of every lot. Our 5-Chlorovanillic Acid comes in crystalline powder form, white to off-white after drying, with typical purity above 99% by HPLC. Melting point, water content, and residue on ignition are not just numbers in a data sheet—they are actual control points measured by our staff, using calibration practices honed by years of troubleshooting and process improvement. Unusual odors, off-colors, or handling surprises don’t leave our facility. We won’t ship a product that doesn’t pass our internal benchmarks.

    Specifications that Matter in Day-to-Day Use

    Chemists and process engineers require specs that allow for easy weighing, dissolution, and reaction predictability. Our 5-Chlorovanillic Acid model offers a standard particle size—neither too fine for dusting nor too coarse for slow dispersion in solution. We often receive feedback from customers who appreciate the flow properties, as clumping or moisture pickup can slow down formulation or lead to uneven reactivity. We test granule flow and check for static, because we’ve faced those frustrations in our own formulation bays. No need to hammer at lumps or sieve out networks. Each batch will blend and dissolve as expected, without surprises.

    Applications: Built with the End-User in Mind

    From the factory seat, we see the diverse uses of 5-Chlorovanillic Acid. It serves as an intermediate in high-end pharmaceutical syntheses, dyes, and fragrance applications—a chemistry bridge between simple building blocks and complex molecules. In pharmaceuticals, researchers value the well-defined p-chloro and vanillic acid motifs because they allow creation of more targeted derivatives during drug discovery. Years of conversations with chemists have taught us what problems surface during upscaling from milligrams to kilograms: impurity carryover, color development, filter clogging. We address these by testing not just on the bench but scaling up pilot runs so surprises stay on our side of the wall, not the customer’s.

    Differences that Make an Impact

    Direct competitors offer vanillic acid derivatives, sometimes at lower prices, but not all chlorinated variants perform the same in downstream synthesis. Trace contaminants, excessive moisture, or unpredictable crystal habits can alter the course of a multi-step reaction. Our 5-Chlorovanillic Acid has proven, through decades of real-world use, that the small investment in top-tier process control pays off in fewer failed reactions and more reproducible results. We don’t just quote premiums based on purity—we provide insight into the routes and real challenges of scale. Whether the user is modifying enzyme recognition sites or synthesizing a new pigment, our product supports efficient pathway completion.

    Model and Packaging Informed by Practical Experience

    We have experimented with many granulation, drying, and milling techniques. Our current model balances easy rehydration and safe handling. It packs tightly but pours cleanly, reducing product loss from dusting—something often overlooked by suppliers who only repackage bulk goods. We offer standard packaging that guards against moisture, but we also react quickly to customer feedback by customizing liners or jar sizes for special environments. Decades of working with contract manufacturers and academic labs have forged this adaptive approach. The right packaging means less stress in the storeroom and more reliability at the bench or assembly line.

    Quality Control: Beyond the Certificate of Analysis

    A certificate of analysis supports confidence, but it never tells the full story. Our in-house analytics check not only for purity but for batch homogeneity and lot memory. Operators know the subtle differences between healthy and stressed lots—steric hindrance in secondary reactions can become apparent only through side-by-side testing, not spreadsheet numbers. This is why every outgoing batch is cross-compared with historical controls and stress-tested for real-life scenarios like high-humidity storage or high-dilution reactions. Documentation travels with every shipment, but customers also gain access to our technical teams—people who have managed the same challenges in process development and troubleshooting.

    Responsiveness in Manufacturing: Customer Input Shapes Improvement

    Face-to-face meetings with process chemists, formulation teams, and R&D partners have shaped our priorities as a manufacturer. Production tweaks always start with customer-reported feedback. Problems experienced at the application level—such as challenging dissolution profiles in high-shear mixers or slow reactivity with coupling reagents—drive ongoing laboratory studies. Trouble tickets aren’t just notes in a CRM system; they trigger plant discussions, line trials, and, when necessary, process modifications. Our reputation has been built through decades of learning from mistakes, improving batch protocols, and communicating frankly about what works and what doesn’t for specific industries or reaction platforms.

    Traceability and Sustainability Built into the Process

    Many customers ask about traceability back to raw materials, solvent sourcing, and our approach to green chemistry. We designed our 5-Chlorovanillic Acid production with these considerations in mind. We maintain transparent logs of supplier batches, waste treatment, and solvent recovery. Over the years, we switched to safer oxidants, modified extraction techniques to reduce harmful byproducts, and invested in closed-loop filtration. We publish decarboxylation data, water usage, and energy consumption figures tied to each production campaign for customers who need regulatory documentation or proof of responsible manufacturing. These changes were the result of targeted investment, guided by the real impact each tweak made on both efficiency and environmental performance.

    Handling and Storage Insights for Downstream Users

    Many users come to us after experiencing setbacks caused by poor handling practices further down the chain. Standard warehouse routines aren’t always enough for moisture-sensitive products like 5-Chlorovanillic Acid. Partially opened containers, exposure to humid air, or mixing with incompatible agents can change both reactivity and appearance, leading to inconsistent outcomes in research or production. We offer detailed, experience-based guidance on handling—suggesting dehumidified storage, rapid resealing, and even material transfer under inert gas in high-value settings. These are not theoretical recommendations, but solutions born of field visits and plant partnerships where real losses were traced back to simple oversights.

    Safe Use and Worker Health: Lessons from Experience

    Operator safety becomes part of the product story in every manufacturing decision. Fine powders like 5-Chlorovanillic Acid can present inhalation risks without effective local exhaust and dust management. Our plant layout integrates engineering controls, staff training, and real-time monitoring—measures put in place after direct feedback and incident reviews. We share practical advice with customers, drawn from our own protocols, so labs and plants can avoid reclaim or exposure incidents. If a process shift creates unexpected risks, we communicate this quickly and offer alternate containment or PPE solutions. We see safety as a shared responsibility, not a regulatory checkbox.

    Supporting Innovation in End-Use Research

    Our technical support team includes practitioners who have worked with 5-Chlorovanillic Acid outside the context of bulk manufacturing—synthesizing dyes, modifying small molecules, and testing new antioxidant systems. They know synthesis doesn’t always follow the textbook. If a customer’s new catalyst system leads to unusual byproducts, we go back to our labs and work through the problem together. Over the years, customers have shared countless project stories: some developing enzyme inhibitors, others engineering flavor substances, still others moving towards sustainable colorants. This close contact with real-world research lets us anticipate needs and respond quickly, not just for troubleshooting, but for new product development and customization requests.

    Comparing Chlorinated Aromatics: What Experience Teaches

    Chlorinated aromatic acids share core similarities, but subtle differences in substituent type, position, and purity level drive big changes in chemical behavior. In side-by-side studies, we’ve found that trace impurities in related compounds can cause color formation, reactive fouling, or failed crystallizations. Some suppliers blend residues from unrelated batches—a quick fix that can sabotage repeat experiments. Years of process control in our facility allow us to minimize cross-contamination and maintain clear identity for each chlorinated aromatic product. Our data show tighter reaction windows and less purification waste for 5-Chlorovanillic Acid built to these standards, saving time and reducing risk of project setbacks at the customer’s site.

    Future-Proofing Through Investment and Learning

    Manufacturing experience has taught us that demand for 5-Chlorovanillic Acid will keep evolving. Today’s pharmaceutical intermediate might become tomorrow’s pigment precursor or specialized antioxidant. We maintain a flexible batching system and open lines of communication with customers to support both legacy processes and new development projects. Our R&D investments target not just process yield, but real-world usability and customer safety. Training and skill upgrades for our staff translate into better consistency, tighter analytics, and lower emissions per ton produced. We adapt based on both market trends and lessons learned through direct involvement in hundreds of customer projects, always striving to solve problems before they reach the production floor.

    Feedback Fuels Product Evolution

    The strongest lessons in manufacturing come not from the easy runs, but from overcoming real process obstacles. Every product improvement we’ve made began with hands-on frustration—a plugged filter, an unpredictable assay, or customer feedback from a failed reaction sequence. We encourage open dialogue, hosting workshops, plant tours, and technical roundtables with experienced users. Suggestions from these sessions drive both small and large changes to how we produce, pack, and deliver 5-Chlorovanillic Acid. Our approach values honest reporting of what doesn’t work, as much as celebrating what does, so future orders continue to improve batch performance and reliability for all users.

    Conclusion: More Than a Product Line

    Producing 5-Chlorovanillic Acid taught us that chemical manufacturing is less about formulas and more about relationships—inside the plant, with suppliers, and especially with end-users. Years of managing batch processes, troubleshooting unique issues, and responding to customer innovations have shaped every gram we send to market. Whether used as a reference standard, a building block in a multi-stage synthesis, or a specialty additive, our experience as direct manufacturers informs every step. We share this experience freely, acknowledging our customers’ challenges and working together toward solutions. Every improvement starts with real feedback and a clear focus—reliable chemistry, safer working practices, and products built to move science forward.