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5-Chloroorthanilic Acid

    • Product Name 5-Chloroorthanilic Acid
    • Alias 5-Chloro-2-aminobenzoic acid
    • Einecs 214-396-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    296071

    Product Name 5-Chloroorthanilic Acid
    Cas Number 94-74-6
    Molecular Formula C6H6ClNO2S
    Molecular Weight 191.64 g/mol
    Appearance Off-white to beige solid
    Melting Point Approx. 160-162°C
    Solubility In Water Slightly soluble
    Boiling Point Decomposes before boiling
    Purity Typically ≥98%
    Pka Approx. 2.6 (carboxylic acid)
    Synonyms 5-Chloro-2-aminobenzenesulfonic acid
    Storage Conditions Store at room temperature, in a tightly closed container
    Iupac Name 5-chloro-2-aminobenzenesulfonic acid
    Ec Number 202-331-1

    As an accredited 5-Chloroorthanilic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical `5-Chloroorthanilic Acid` is packaged in a sealed, amber glass bottle containing 100 grams, labeled with safety and handling instructions.
    Shipping 5-Chloroorthanilic Acid should be shipped in tightly sealed containers, protected from moisture and incompatible substances. It must be labeled as a chemical, handled by trained personnel, and transported according to local, national, and international regulations for hazardous materials. Avoid mechanical shock and ensure temperature stability during transit.
    Storage 5-Chloroorthanilic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and incompatible substances such as strong oxidizers. It should be protected from moisture and direct sunlight. Proper labeling and secure storage minimize risks of accidental exposure or chemical reactions. Follow all relevant safety regulations when handling and storing.
    Application of 5-Chloroorthanilic Acid

    Applications of 5-Chloroorthanilic Acid in Industrial Manufacturing

    5-Chloroorthanilic Acid serves as a critical intermediate in several specialized chemical production chains. Its application is concentrated within sectors demanding precise molecular modifications and high-purity synthesis, supporting the creation of tailored downstream compounds and end products. Below are detailed industrial scenarios where this raw material is integrated according to rigorous standards and process requirements.

    1. Synthesis of Azo and Anthraquinone Dyes for Textiles

    Manufacturers incorporate this compound primarily at the diazotization and coupling stages for precision color matching in high-performance textile dyes. Its consistent reactivity enables the production of stable intermediates, which then proceed to coupling reactions that yield complex dye structures. Quality requirements tighten to prevent variation in chromatic undertones, enabling reliable large-batch dyeing for fabrics used in fashion and industrial textiles.

    Industry compliance standards

    • OEKO-TEX® Standard 100 – Certification for chemical safety in textile applications
    • REACH Regulation (EC 1907/2006) – Registration and restriction of chemical use in EU textile markets
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 9001:2015 – Quality management systems for textile chemical manufacturers

    Typical usage ratio

    • 3–8% by weight relative to primary amine input in diazo dye precursor synthesis; adjust within range based on targeted chroma intensity and dye bath uniformity requirements.

    Downstream process integration

    • Introduced after amination reaction during diazotization step; subjected to controlled pH coupling with aromatic partners to yield azo or anthraquinone intermediate structures.

    Final product types

    • Disperse dyes for polyester
    • Reactive dyes for cotton, viscose, and blended textiles
    • Direct dyes for cellulosic fibers

    2. Pharmaceutical Intermediate for Sulfonamide Drug Synthesis

    This material functions as a structural building block in the synthesis of specific sulfonamide-based antibacterials, addressing demands for high-purity intermediates that minimize impurity carryover into regulated drug substances. The precision of this step affects the pharmacological profile and impurity specification during active pharmaceutical ingredient (API) manufacturing, with direct impact on regulatory approval for end medications.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP) – ICH Q7 for active pharmaceutical ingredients
    • European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) monographs
    • US FDA 21 CFR Part 210/211 – Drug manufacturing standards
    • ICH Q3A/B – Impurities in new drug substances/products

    Typical usage ratio

    • 0.95–1.10 molar equivalents relative to sulfonation chlorides; slightly variable to optimize yield of downstream condensation reactions.

    Downstream process integration

    • Added during amide coupling following acid activation step; controls impurity generation by dictating quality of the intermediate scaffold during multi-step synthetic routes.

    Final product types

    • Sulfonamide antibiotics (e.g., sulfamethoxazole precursor)
    • Other therapeutic sulfa derivatives

    3. Agrochemical Intermediate for Herbicide Formulation

    Downstream agrochemical producers employ this compound during the coupling and cyclization steps of herbicide synthesis, leveraging its substituent pattern to build target-specific actives. Integration at this stage affects bioactivity, selectivity, and environmental degradation profile of resulting products. Process controls ensure traceability and minimize byproducts aligned with environmental and crop safety standards.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 17025:2017 – Laboratory testing and calibration for agrochemical QC
    • European Crop Protection Association (ECPA) stewardship guidelines
    • REACH Regulation (EC 1907/2006) for agrochemical manufacturing

    Typical usage ratio

    • 2.5–6% w/w relative to the total batch for target herbicide actives; actual range determined by structural requirements of the active and targeted formulation strength.

    Downstream process integration

    • Engaged in condensation or cyclization step prior to final formulation, often reacted under inert atmosphere to preserve substituent integrity and bioactivity potential.

    Final product types

    • Pre-emergent and post-emergent herbicide actives (customized for monocot and dicot weed control)
    • Selectivity-adjusted herbicide technical concentrates

    4. Intermediate for Specialty Pigment Synthesis

    Specialty pigment manufacturers apply this chemical during the production of complex organic pigments used in inks, coatings, and plastic coloration. The molecular backbone directly affects pigment stability, brightness, and dispersibility in different media, making control of this intermediate essential for premium pigment grades. Its functional group orientation influences interaction with co-monomers and surface modifiers in pigment post-treatment.

    Industry compliance standards

    • EN 71-3 – Safety of toys: Migration of certain elements (for pigments in children’s products)
    • RoHS Directive 2011/65/EU – Restriction of hazardous substances in electronics and coatings
    • DIN ISO 8780 – Pigment testing procedures
    • ISO 14001:2015 – Environmental management standards in pigment manufacturing

    Typical usage ratio

    • 4–7% of total organic feedstock mass; fine-tuned according to particle size distribution targets and desired chromatic properties.

    Downstream process integration

    • Fed into coupling or polymerization reactor as a core unit; undergoes surface treatment and particle size refinement post-synthesis for achieving dispersion specifications.

    Final product types

    • High-stability organic pigments for solvent-based and aqueous inks
    • Color concentrates for plastics and polymeric masterbatches
    • Specialty colorants for industrial and automotive coatings
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    Certification & Compliance
    More Introduction

    5-Chloroorthanilic Acid: A Reliable Building Block Shaped by Experience

    Understanding 5-Chloroorthanilic Acid at the Manufacturing Source

    In the chemical industry, a product’s reputation gets built on everyday practice, not lofty claims. Our team works with 5-Chloroorthanilic Acid (Model: 98-44-2) at a scale where specifications are more than data points—they become guidelines for safe handling, confident processing, and consistent outcomes. Every batch we ship meets strict quality checks for purity, color, and moisture, because impurity sneaks in easily during sulfonation steps and can ruin downstream reactions. Our technicians, trained over many years, catch any deviations before the product leaves the plant. Here at our facility, we see firsthand how a slight variance in melting point limits affects the final dye or intermediate, so these details stay at the front of our process.

    Model and Specifications: Precision from Practice

    Our 5-Chloroorthanilic Acid comes as a fine powder or crystalline solid, with purity exceeding 99% HPLC by rigorous in-house protocols. Water content stays tightly below 0.2%, because even low moisture can wreak havoc during amide synthesis or sulfonation. Appearance runs from off-white to light beige, reflecting careful filtration and precise temperature control across the reactor trains. Melting range remains steady batch-to-batch, minimizing surprises in continuous automated operations. The close monitoring of inorganic chloride avoids corrosion problems for those in high-purity electronics or pigment synthesis.

    Unlike resellers or importers, we follow production from raw aromatic chlorination to finished acid, sampling at every stage. Chloride sources are always documented, since upstream feedstock quality affects isomer formation and final chemical profile. We train our operators to focus on pH stability and control trace iron, which can poison catalysts downstream. Our process learned from years supplying multinationals and local mills—attention to these details helps customers avoid yield loss, plant downtime, or failed analysis.

    Application Experience: What Sets 5-Chloroorthanilic Acid Apart

    The primary market for 5-Chloroorthanilic Acid lies in azo dye manufacture. We’ve supplied this market through countless dye runs, troubleshooting alongside plant floor operators and R&D colleagues. The amino and sulfonic acid groups anchor chromophores efficiently, producing reds and violets with deeper hues and better washfastness than many substitutes. When pigment plants shift from non-chlorinated anilines to this product, they notice smoother grain growth, higher batch conversion, and fewer filtration cycles—insights we documented side-by-side with their chemists.

    Drug discovery teams knocking out substituted benzoic acids or targeting sulfamoyl intermediates trust our material to behave cleanly in stepwise syntheses. Repetitive use cases in agricultural active ingredient design rely on the integrity of the chloro position and the low ash content we control. Working with 5-Chloroorthanilic Acid in these sectors, we’ve watched how unstable spec or unknown impurities throw off reaction timing or cause expensive column reruns in kilo-labs. Our commitment is to keep these headaches off your desk.

    Real Differences: Beyond Commodity Chemistry

    It’s easy to confuse this product with cousins like 4-chloroaniline or isomeric ortho-aminobenzoic acids. Field experience quickly draws the line. Our 5-chloro substitution delivers unique orientation for azo couplings, making color development stronger or shifting lambda max as needed by fiber or paper plants. In sulfa drug frameworks, the ortho relationship of chlorine and amino directs selectivity and enhances final purification. These features aren’t marketing talking points—they come from dozens of plant audits and lab failure investigations.

    Manufacturers without deep process control may see off-target isomer content creeping up, introducing side-reactions or increasing waste. We’ve taken apart competitor samples with irregular crystal morphology or odd melting points, and seen firsthand how they clog reactors, foul separation columns, or require double recrystallization at the user’s expense. Our in-line analytics and closed-loop temperature management keep by-product formation to a minimum, so end-users receive a cleaner, faster-reacting raw material. These incremental wins protect both your margins and your lab team’s time.

    Supporting Progress through Reliable Chemistry

    Many users meet 5-Chloroorthanilic Acid searching for an edge in color strength, process time, or compliance with ever-tightening environmental rules. From wastewater characterization—where off-color ions indicate incomplete uptake—to final end-use toxicity screens, this material can make or break a new formulation qualification. Decades in this business taught us that overlooking trace solvents or poor bulk density means headaches long after the invoice clears.

    Our team invests heavily in pre-shipment QA because surprises discovered downstream rapidly escalate costs for everyone. Regulatory demands on persistent organic pollutants and heavy metal content push us to examine every vessel, pump, and packaging liner for cross-contamination. By working from a full-traceability model, we give downstream processors confidence when submitting dossiers to regulators or pursuing next-generation chemistries. Our product history contains lessons from managing both large-scale faulty deliveries and simple day-to-day troubleshooting. These experiences shape robust supply chains and short learning curves for formulation teams.

    Lessons from the Factory Floor: Why Reliability Matters

    Some partners focus only on paperwork or price per kg, but years in production have shown us it never stops there. We’ve seen what happens when a slightly off-spec shipment stalls entire high-throughput labs. Lab techs spend weekends debugging reversed-phase methods, only to trace it back to an extra percent chloride or elevated color index. In fine chemical manufacture, even a faint yellow tint from unremoved side-products can block progress. These aren’t theoretical risks; as a manufacturer, we’ve stood beside customers while reactors sat waiting for reliable input.

    As batches scale from grams to tons, small inconsistencies balloon into real challenges. Re-scaling a successful pilot batch means taking careful note of reaction kinetics and impurity knock-on effects at every kilogram. Collaborations with formulators showed us that trace metals become critical in automated pigment dispersion stages. It’s one thing to ship tonnage to a dye plant and another to ensure the third production line behaves the same as the first. Feedback from our users prompts regular investment in process analytics and solvent control.

    Working alongside Customers: Solutions Born from Partnership

    We treat production as a two-way street, aiming to match specs with the everyday reality of chemical handling—dust control, venting needs, and reactivity in closed vessels. Often, customers call us after a competitive material fails basic drop tests or leaches unexpected color. Our team hosts them on plant visits to walk through full documentation, batch sampling, and even residual solvent checks. By opening up our QA/QC protocols, we help researchers justify both in-situ trials and long-term registrations. Adjustments in drying methods or packaging weights stem from these shared sessions, not just lab requests.

    One textile customer came struggling with plugging in their dye filtrate. Analysis of their previous bulk chemical pointed straight to inconsistent grain size and leftover oils, which we avoid through controlled crystallization and post-wash sequences. Another case in pharmaceutical development highlighted that barely-there halogen impurities tripped high-sensitivity HPLC detection, delaying their regulatory filing. After switching to our process-controlled material, their stability runs improved, giving them the green light they needed for launch.

    Troubleshooting and Continuous Improvement

    We see the real use-cases: high-shear mixers, long-term storage in damp conditions, or hot benzene coupling reactions. Each context draws out a different “must-have” property. Whether it’s free-flowing powder, batch-to-batch reproducibility, or just knowing the supply won’t flicker, we know why tight specification matters. By visiting customer plants, our chemists get hands-on input from the machinery operators and see how minor tweaks—process temperature, final pH, packaging liner—affect filtration and yield. This approach sharpens our attention to practical detail.

    Our batch records serve more than compliance—they become a living document for process refinement. If downstream users report any deviation in filtration speed or reactivity, we’re equipped to backtrack entire production runs. Operators learn to spot warning signs before they reach scale, sharing insights with our quality leads and process engineers. Customer-facing chemists translate these findings into regular updates to our protocols. Whether it’s a subtle taper in melting curve or a shift in IR spectrum, catching it at the source averts lost days and expensive rework at the user’s end.

    Environmental Footprint and Lean Manufacturing

    Modern chemical manufacturing doesn’t escape scrutiny. Regulators and customers both watch hydrocarbon residuals, energy consumption, and waste output. The path to greener chemistry starts at feedstock choice and ends in smart water management. For our 5-Chloroorthanilic Acid, we push waste minimization by in-line recovery of chlorinated mother liquors and acid scavenging. Our analytical team checks for residual aromatic amines and persistent organic pollutants before a drum ships. Reducing the salt load in aqueous effluent lowers downstream costs and shrinks the facility’s impact—feedback our customers care about.

    We develop new catalyst systems and tweak reactor internals to cut gas emissions and energy usage per kilogram. LEAN principles drive our routine: less waiting, less scrap, more efficient drying. These moves trim both cost and carbon footprint, driving value back to bulk customers, R&D teams, and ultimately, the broader supply chain. When regulatory bans prompt a surge in demand for certain isomers, our plant’s flexibility handles volume swings without reaching for quick fixes that compromise output quality.

    Safety in Practice: Protecting People and Product

    Years inside a reactor hall develop a respect for safety beyond compliance paperwork. Handling aromatic amines and sulfonic acids means more than just posting precautionary labels. Dust control, splash-resistant gear, and dedicated handling lines cut real-world risk. Our crew maintains closed transfer systems to protect both worker health and product from environmental exposure. Routine audits, near-miss drills, and regular PPE updates keep vigilance high.

    We provide downstream users with detailed safety profiles—not as a sales pitch, but drawn directly from actual incident logs and best practices. These records span processes ranging from glass-lined reactors to automated blenders. Whether prepping a new batch or loading a truck, our loading crew follows procedures honed over many shipping seasons. Continual training updates guard against procedural drift and complacency. By embedding safety knowledge into every shift, we keep not only our operation but our customers’ plants running securely.

    Supporting Research, Development, and Global Markets

    Our experience extends from native markets to global partners seeking reliability in supply. We’ve supported everything from multinational dye conglomerates scaling up to local textile houses exploring export compliance. In laboratories, we’ve watched how clean 5-Chloroorthanilic Acid speeds up analytical validation, reducing the need for repeated purification or complex derivatization. In pigments, it cuts down dispersant usage, allowing more straightforward matching of color standards demanded in automotive and industrial paints.

    Export regulations and nation-specific purity codes raise unique hurdles. Our QA staff work alongside logistic partners to ensure each shipment matches both local and international benchmarks. We pay special attention to packaging and documentation, tracing every lot from the plant floor to final delivery. Our direct control over raw inputs and flexible packaging formats accommodates both bulk buyers and research-scale users. This flexibility, born of continuous dialogue with customers across regions, minimizes costly customs delays and protects intellectual property.

    Stable Supply, Trusted Outcomes

    Factories run on trust. From small R&D groups launching a new molecule to large dye manufacturers scaling up textiles, end-users want zero surprises from their chemical inputs. Our hands-on experience with 5-Chloroorthanilic Acid—through times of both commodity oversupply and short, tight markets—proves that process discipline makes all the difference. We keep stability front and center, tracking everything from weather-related logistics to changing upstream tariffs, so end-users don’t face last-minute supply gaps.

    Feedback from every sector shapes our work. When resin polymerization users highlighted subtle gel point drifts tied to residual metallic ions, we implemented a new chelation check at the blending stage. When direct textile printers reported foaming issues from indirect suppliers’ product, we re-examined our washing and drying protocols, sharing samples and analytic results in real-time. These ongoing conversations close the loop between plant, lab, and customer, keeping operations moving steadily even in turbulent conditions.

    A Commitment Rooted in Experience

    In our business, trust and respect grow from results—fewer failed batches, faster pigment formation, less troubleshooting in the lab, steadier runs in the plant. 5-Chloroorthanilic Acid, in our hands, isn’t just a line-item on a purchase order. It represents a core ingredient made with years of accumulated knowledge and honest dialogue between those who make it and those who depend on it.

    From small specialty labs tailoring research molecules to full-scale manufacturers delivering at global volumes, our own experience tells us detail matters. We welcome customer collaboration, transparency in process, and open channels for continuous improvement. With regulatory standards rising and market demands shifting rapidly, we back every lot with a real commitment to practical, measurable results.

    Whether overcoming a stubborn color variation, chasing new pigment technology, or gearing up for strict drug registration, teams find in our 5-Chloroorthanilic Acid a proven building block. As we see the future unfold—greener chemistry, tighter specs, tougher regulations—we bring the full weight of our experience and manufacturing skill to the table. With trust earned from real-world performance, this is a product built by people who understand both the science and the stakes.