Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

5-Chloronicotinic Acid

    • Product Name 5-Chloronicotinic Acid
    • Alias 5-Chloro-3-pyridinecarboxylic acid
    • Einecs 214-044-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    122744

    Chemical Name 5-Chloronicotinic Acid
    Cas Number 2942-59-8
    Molecular Formula C6H4ClNO2
    Molecular Weight 157.56 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 225-229 °C
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place, tightly closed
    Pka 2.73 (carboxylic acid)
    Smiles C1=CC(=NC=C1Cl)C(=O)O
    Inchikey XMGLWFWVIZXLKT-UHFFFAOYSA-N
    Synonyms 5-Chloro-2-pyridinecarboxylic acid

    As an accredited 5-Chloronicotinic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g quantity of 5-Chloronicotinic Acid is supplied in a sealed, amber glass bottle with a secure screw cap and labeling.
    Shipping 5-Chloronicotinic Acid is shipped in secure, tightly sealed containers to prevent leaks and contamination, complying with chemical safety regulations. Packaging follows hazardous material guidelines, including protective cushioning. During transit, the chemical is labeled appropriately, and supported by Safety Data Sheet (SDS) documentation to ensure safe handling and delivery integrity.
    Storage 5-Chloronicotinic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. Ensure the storage area is equipped to handle spills and is labeled appropriately. Personal protective equipment should be used when handling to avoid inhalation, ingestion, or contact with skin and eyes.
    Application of 5-Chloronicotinic Acid

    Applications of 5-Chloronicotinic Acid in Industrial Manufacturing

    Our in-house production of 5-Chloronicotinic Acid underpins advanced synthesis in several critical chemical value chains. The material’s functionalized pyridine structure enables precise, stable, and repeatable integration into downstream manufacturing, supporting producers in agrochemicals, pharmaceuticals, and specialty intermediates. Below, we detail major industrial scenarios with process-focused, compliance-driven, and application-specific guidance.

    1. Synthesis of Neonicotinoid Active Ingredients

    Large-scale pesticide manufacturers rely on 5-Chloronicotinic Acid as a pyridine building block during the synthesis of leading neonicotinoid insecticide actives, including imidacloprid and acetamiprid. Its chlorinated ring structure offers controlled reactivity essential for halogen exchange and amination stages. The compound’s purity and traceability are critical in maintaining finished product integrity and regulatory alignment throughout the entire production chain for crop protection agents.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides (including active content and impurity thresholds)
    • EC Regulation No 1107/2009 (EU approval and pesticide registration)
    • ISO 9001:2015 for quality management in agrochemical intermediates
    • Chinese National Standards (GB/T 22153-2008 for imidacloprid APIs)

    Typical usage ratio

    • 5-Chloronicotinic Acid is dosed at 1.05 to 1.15 molar equivalents per target molecule, with slight overage (max. 5%) applied in continuous processes to compensate for yield losses during chlorination or amidation; precise ratio depends on target active and process flow.

    Downstream process integration

    • Employed at the early synthesis stage, entering the reactor for nucleophilic substitution, followed by subsequent cyclization and side-chain functionalization.
    • The acid group activates for amide bond formation with intermediate amines.
    • Strict QA/QC release at the input step to guarantee no batch contamination in multi-ton lines.

    Final product types

    • Imidacloprid (technical and formulated grades)
    • Acetamiprid
    • Thiacloprid
    • Other custom neonicotinoid formulations for seed treatment and foliar spray

    2. Pharmaceutical Pyridine Intermediate Synthesis

    Advanced API and contract manufacturing organizations integrate 5-Chloronicotinic Acid into pyridine modification stages for molecules requiring halogenated heterocyclic scaffolds. It serves as a regulated intermediate in the synthesis of active pharmaceutical ingredients where 5-chloropyridine moieties are crucial for target affinity, especially within anti-infective drug candidates and analgesics. The compound’s traceable supply chain and batch validation support ICH regulatory expectations in finished drug products.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211 (cGMP for finished pharmaceuticals)
    • EU GMP Part II (GMP for API intermediates)
    • Ph. Eur. monograph for relevant finished APIs

    Typical usage ratio

    • 0.9–1.2 molar ratios per API batch, adjusted for process yield and impurity management; optimization based on impurity profile of downstream halogen substitution reactions.

    Downstream process integration

    • Directly charged into condensation or esterification reactors in the presence of activating agents.
    • Functions as a coupling precursor for arylation or amidation steps in multi-step syntheses.
    • Strict in-process checks for chloride content, residual solvents, and by-product control.

    Final product types

    • API intermediates for anti-infectives (e.g., cefdinir, other β-lactams with pyridine rings)
    • Analgesic precursor chemicals
    • Specialty contract-manufactured pharmaceutical blocks

    3. Agrochemical Herbicide Intermediate Production

    Formulators producing phenoxy- and pyridine-based herbicides use 5-Chloronicotinic Acid to introduce a halogenated aromatic signature in precursor molecules. Its stability in multi-step syntheses makes it valuable for configuring selectivity and systemic activity in modern weed management agents. Established analytical protocols and specification compliance address downstream risks in environmental residue and registration testing.

    Industry compliance standards

    • Chemical Inspection and Regulation Service (CIRS) China Pesticide Act
    • OECD Guidelines for the Testing of Chemicals (analytical standards and process validation)
    • REACH Registration (Europe) for environmental and toxicological data submission
    • ISO 17025-accredited QC laboratories for analytical method validation

    Typical usage ratio

    • 0.8–1.0 equivalents, tailored to molecular backbone of the herbicide; slight overage used to push completeness in nucleophilic aromatic substitution without excessive by-product formation in closed-system batch reactors.

    Downstream process integration

    • Added after the initial aromatic ring assembly phase to ensure regioselective chlorination and coupling efficiency.
    • Undergoes thermal or base-catalyzed coupling with alkoxy or amino side chains as part of the final API assembly.
    • Managed via closed-system additions for product containment and operator safety.

    Final product types

    • Phenoxyor pyridine-based herbicide actives (including experimental pipeline molecules)
    • Bulk technical-grade herbicides before formulation
    • Granular and suspension concentrate (SC) herbicide products

    4. Specialty Dye and Pigment Intermediate

    Producers of functional dyes, metal complex pigments, and electronic materials use 5-Chloronicotinic Acid to introduce chloride-activated positions into pyridine-based colorant molecules. Integrating this raw material into colorant synthesis provides distinct hue quality and thermal stability as required in display, plastics, and ink industries. Specific attention is paid to purity and trace metals, as downstream process efficiency and compliance are tightly correlated with raw material integrity for end-use electronics and color products.

    Industry compliance standards

    • EN 71-3 (Safety of toys – migration of certain elements for colorants in plastics)
    • RoHS Directive (2011/65/EU) for electronic device pigment use
    • ISO 18451-1 for pigment and dye classification (industry-recognized terminology and sampling)
    • REACH Annex XVII – Restrictions on heavy metals for pigment applications

    Typical usage ratio

    • 0.5–1.1 molar equivalents based on dye polymer chain length, target fastness, and substituent configuration; formulation optimization for cost-yield and brightness during applied research scale-up.

    Downstream process integration

    • Reacted in condensation or coupling reactions following the formation of the dye base skeleton.
    • Feeds directly into halogenation tanks managed under inert gas atmospheres to prevent oxidation of the intermediate.
    • Purity and by-product screening occur before polymer blend or pigment precipitation stages.

    Final product types

    • Functional dyes for liquid crystal and OLED displays
    • Pigments for engineering plastics, automotive coatings, and high-value printing inks
    • Metal complex dyes for textile and specialty fiber applications
    Free Quote

    Competitive 5-Chloronicotinic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    5-Chloronicotinic Acid: Direct from the Manufacturer’s Perspective

    Our Commitment to Reliable 5-Chloronicotinic Acid

    Making chemicals demands hands-on experience, stubborn quality control, and the willingness to solve problems that other players in the supply chain rarely see. We come at 5-Chloronicotinic Acid not as a trader but as the manufacturing partner who formulates, reacts, dries, and purifies this critical building block ourselves—every finished batch owes its consistency to people who know what happens inside the reactor and how a dusty powder behaves when the air dries it a little too fast.

    Years of daily work taught us what matters most about this product. Consistency keeps production flowing, but purity gives customers the flexibility to use 5-Chloronicotinic Acid in advanced chemical synthesis. We know from experience: chemists rely on every gram performing the same as the last shipment, whether the application involves crop protection, pharmaceuticals, specialty pigments, or electronic chemicals.

    Understanding the Model and Specifications

    5-Chloronicotinic Acid (CAS 4318-56-3) shows up as an off-white to pale yellow crystalline solid. Our offering usually targets a purity of no less than 99% by HPLC—anything less brings downstream headaches for everyone. Through solid-liquid separation, vacuum drying, or chromatographic polishing, our chemists go the extra step only manufacturers can manage. Moisture, ash, and heavy metal residues tell their story on every COA, and we reject batches that fall out of our tight spec.

    We track consistency by more than a tidy number. Density, particle size, and solubility all affect how easy it is for you to handle the material and feed it into the next process. Batch homogeneity means a lot to us, so we carefully monitor every step, from synthesis to drying. Chemists in the lab use TLC, melting point checks, and an eye for color to make fast judgments, flagging anything that doesn’t meet our standard before it leaves the plant. You’ll notice the steadiness in appearance and the way our acid dissolves—no mysterious residue or off-odors.

    Real Impact in Application—Not Just High Purity

    5-Chloronicotinic Acid serves as a stepping stone for pyridine derivatives found in everything from crop protection agents to pharmaceutical intermediates. Our experts learned over the years: every downstream application reacts differently to trace contaminants that can sneak in if you cut corners. The small traces of organic or inorganic impurities that trading houses sometimes pass along won’t show up in our material.

    Synthetic chemists tell us how they rely on a pure, reliable source of 5-Chloronicotinic Acid to assemble more complex pyridinic building blocks. In the agrochemical industry, downstream coupling and functionalization stages are only as efficient as the starting acid allows. Unreliable purity leads to side reactions and poor yield—a waste no manufacturer welcomes. Our tight controls over byproduct formation mean the product flows smoothly into your batch reactors, cuts back on unplanned maintenance, and helps avoid costly purifications.

    Fine chemical synthesis involves sensitive steps. Sometimes a stray bit of metal residue or excess moisture can throw off entire campaigns of work or mess up isolation of a targeted intermediate. By controlling the production environment ourselves, all the way down the line, we’re able to deliver acid you can trust for demanding coupling reactions, Suzuki or Buchwald–Hartwig transformations, and other processes that leave little room for error. Many customers apply 5-Chloronicotinic Acid in production-scale systems, not only lab trials, so each kilo must deliver results.

    Differences that Stand Out in the Crowd

    Over our years in this field, we’ve learned: not all 5-Chloronicotinic Acid powders are the same, and subtle differences matter far more than traders realize. Material sourced from an uncertified third party, for example, sometimes shows up with excessive moisture, lumping, or powder that clings to packaging. We focus on stable drying and antistatic handling to ensure the crystalline powder pours freely and won’t attract atmospheric water. Our packing team uses moisture-barrier outer bags and lines every drum themselves, eliminating shortcuts that create quality headaches for end users.

    Competing suppliers often combine several synthetic routes or outsource part of the process, which brings in the risk of batch-to-batch contamination. By managing all steps in-house, our process avoids mixing materials with unknown histories. The result: our 5-Chloronicotinic Acid shows narrow melting point ranges and reproducible color and odor profiles, an important physical check for process chemists. We routinely cross-check batch samples for low-level contaminants, especially those known to interfere in pharmaceutical or crop protection synthesis. In particular, absence of certain halogenated byproducts remains critical for regulatory compliance and safety.

    Differences go beyond the laboratory bench, though. Our QA and production staff keep in close communication with downstream users, so any trend in yield, work-up problems, or product color shift gets our immediate attention. We don’t mind taking urgent calls from experienced process managers who catch something subtle—like a tiny shift in material flowability—because our team understands it might flag a reactor cleaning step or a drying anomaly. This immediate feedback allows us to diagnose, correct, and improve batch quality before problems stack up.

    Real Manufacturing Know-how

    Nothing replaces in-house manufacturing for 5-Chloronicotinic Acid. We maintain synthesis lines that use robust, scale-up-tested chemistries. Our early trials taught us about sodium hypochlorite knock-on effects, so we optimized catalyst use and chose reactor materials that won’t shed ions into the batch. Some competitors use older glass-lined reactors susceptible to microcracking, which can compromise product integrity—our investment in modern steel-vessel technology avoids these pitfalls.

    We understand the quirks and pitfalls that show up in scale-up. Solvent choice, temperature ramping, and agitation speed either produce a clean acid or push up impurity levels. Our production technicians receive ongoing training to spot incomplete chlorination or weird byproduct signals. They know the exact point when a batch finish can move from the reactor to filtration, so we don’t lose out on yield or quality.

    Handling volatile solvents and strong acids takes both vigilance and knowledge. Spill control, ventilation, and effluent containment all flow from a manufacturer’s perspective—no lab coat chemistry or distant supply chain guesswork. We take responsibility for the safety and environmental impact at every step, then track material flow from raw precursor to final kilolab drums. Customers benefit from our deep process control and the lessons we’ve learned scaling 5-Chloronicotinic Acid from the gram scale to multiple tons per month.

    Usage Insights Born from Experience

    Users of 5-Chloronicotinic Acid don’t work in a vacuum. Our interactions with pharmaceutical companies, pesticide formulators, and dye manufacturers taught us that accuracy in dosing, particle size, and impurity control matters just as much as assay spec. Granulation or solution preparation hinges on powder performance, so we ship product in packaging that seals out moisture and minimizes caking. Plant operators keep lines moving by tipping our product directly into hoppers or solubilizing for batch reactions, so flowability isn’t a nice-to-have—it’s crucial.

    Some users demand customized cuts—say, a certain particle size to improve compounding or a specific moisture threshold for automated dosing. We don’t just label a bag and ship. Instead, we talk through the needs, run pilot batches if required, then lock down process controls to repeat those parameters on every future order. This sort of iteration and adjustment doesn’t always come easy, but it reflects our belief that manufacturing happens in partnership with the people who use what we make.

    When it comes to scale-up, laboratory chemists often lack the vantage point a manufacturer has. Our own technical staff held hands with project managers chasing regulatory filings or FDA submissions, where every trace-level impurity faces scrutiny. We work alongside their teams to confirm that our product supports their validation batches, offering analytical documentation and batch samples early in the project lifecycle. Our track record with regulated industries means process documentation, traceability, and supply chain risk reduction all happen by design, not as afterthought.

    Addressing the Market—Not Just Selling a SKU

    As the global market for pyridine derivatives grows, more players attempt to source and distribute 5-Chloronicotinic Acid. The difference between a manufacturer and a market aggregator lies beneath the surface. Each drum we ship stands on top of decades in the production trenches. Every unusual impurity profile, shift in physical form, or break in the supply chain brings out our team’s experience. We don’t accept price-driven shortcuts. Instead, we prioritize supply reliability, regulatory compliance, and product safety.

    Many customers come to us after poor experiences with resellers who didn’t know about batch instability, off-odors, or polymorphic form changes under long sea transit. As direct manufacturers, our site QA monitors shipping conditions, tracks data on temperature and humidity, and supports customers with storage tips and inventory management advice tailored to the acid itself—not generic commodity stock.

    We understand that, in chemical manufacturing, trust keeps projects alive. One failed batch or missed impurity can derail months of lab work or cost far more than the savings a middleman offers. This is why we invest in people, equipment, and testing capabilities to make sure that our shipment arrives in the same form as when it left our site. It’s not all about selling. It’s about making sure every partnership grows on the foundation of real manufacturing know-how.

    Challenges Only Manufacturers Face—and Solutions We Deliver

    Manufacturing 5-Chloronicotinic Acid brings up challenges that trading houses rarely consider. Scaling from a kilo to several tons creates batch reproducibility headaches—minor changes in temperature profiles or feed rates can skew yields and impurity levels. We tackle these issues through continuous process improvement. We log every run, analyze real-time data, and reward operators who flag tiny variations on the plant floor.

    Metal contamination, a silent risk in large-scale chemical plants, comes from corroded reactor walls or pumps. Our site switched to specialty linings and scheduled maintenance long before most competitors, stopping metal leaching before it can ever touch an outgoing batch. Our staff run weekly ICP-OES checks and compare these trends monthly to catch long-term shifts—by staying observant, we avoid problems before they hit your scale.

    Shipping across borders or over long distances brings another kind of problem: powder compaction, loss of free-flow, or moisture uptake impacts the usability of each drum. As manufacturers, we redesigned our packaging lines for just these issues—using foil-seal drum liners, desiccant pouches, and real-time monitoring of storage conditions. What lands at your dock should look, feel, and perform the same as the day it was produced.

    Regulatory and Environmental Responsibility

    Many forget that 5-Chloronicotinic Acid, while not the most hazardous of chemicals, still presents environmental and safety risks. We don’t pass off these responsibilities to brokers. Waste management, solvent recycling, and air emissions control all fall under our compliance plan. By prioritizing clean chemistry and pursuing energy recovery at our plant, we sleep easier knowing our impact stays as low as achievable.

    Each region’s regulatory climate changes, but we keep ahead by tracking relevant updates and feeding this knowledge back into our documentation and product stewardship. We support users pursuing green chemistry or safer work environments with detailed regulatory disclosures, impurity profiles, and storage guidance. It’s not a burden—it’s an extension of our role as genuine industry participants rather than commodity sellers.

    Summary: Why Source Direct from the Manufacturer?

    Experience with 5-Chloronicotinic Acid reminds us every day: real quality starts at the manufacturing site, not at the warehouse. Raw materials, process control, and hands-on QA shape the product that arrives at your plant. Real-world results—yield, purity, process speed, and safety—all flow from deep expertise cultivated in the factory, not the boardroom.

    If you need 5-Chloronicotinic Acid that delivers results batch after batch, with honest communication and persistence in problem-solving, look to people who have their hands in every stage of the process. We value the trust and collaboration of our clients and stand ready to support long-term projects, challenging custom requests, or just maintaining a steady, reliable supply. It’s not the simplest way to do business, but it’s the way we believe chemicals should be made.