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5-Chloro-2-Nitrobenzamide

    • Product Name 5-Chloro-2-Nitrobenzamide
    • Alias 5-chloro-2-nitrobenzenecarboxamide
    • Einecs 612-407-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    843649

    Name 5-Chloro-2-Nitrobenzamide
    Cas Number 2234-29-1
    Molecular Formula C7H5ClN2O3
    Molecular Weight 200.58
    Appearance Yellow to orange powder
    Melting Point 181-184°C
    Solubility Slightly soluble in water
    Purity Typically ≥98%
    Density 1.61 g/cm³
    Synonyms 5-Chloro-2-nitrobenzamide; 2-Nitro-5-chlorobenzamide
    Smiles C1=CC(=C(C=C1C(=O)N)[N+](=O)[O-])Cl
    Inchi InChI=1S/C7H5ClN2O3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H,(H2,9,11)
    Storage Temperature Store at room temperature
    Application Organic synthesis intermediate

    As an accredited 5-Chloro-2-Nitrobenzamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g package contains 5-Chloro-2-Nitrobenzamide, securely sealed in an amber glass bottle with a printed hazard label.
    Shipping 5-Chloro-2-Nitrobenzamide is shipped in tightly sealed containers, protected from light, moisture, and incompatible materials. Packaging complies with chemical safety regulations. The shipment is labeled as a hazardous substance and handled by certified carriers, ensuring safe transportation. Appropriate documentation, including safety data sheets (SDS), accompanies the shipment for regulatory compliance.
    Storage 5-Chloro-2-nitrobenzamide should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances such as strong oxidizing agents. Avoid moisture exposure. Proper chemical labeling and secondary containment are recommended. Store at room temperature unless otherwise specified by the supplier, and ensure access is restricted to trained personnel.
    Application of 5-Chloro-2-Nitrobenzamide

    Applications of 5-Chloro-2-Nitrobenzamide in Industrial Manufacturing

    5-Chloro-2-Nitrobenzamide serves as a critical intermediate in the synthesis and refinement of specialty chemicals. Our direct manufacturing expertise supports downstream industries with granular quality control and consistent performance in distinct industrial processes. The following application scenarios showcase how this raw material integrates into specialized sectors, focusing on real-world production requirements and regulatory standards.

    1. Pharmaceutical Intermediate for Anti-Infective APIs

    Pharmaceutical manufacturers incorporate this compound as an intermediate during the multi-step synthesis of certain anti-infective active pharmaceutical ingredients, particularly benzamide-based derivatives. Production protocols leverage its reactivity in targeted steps, which enables precise molecule construction within commercial-scale batch reactors. The downstream use requires meticulous documentation and full compliance with GMP for regulated markets.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Annex 1, Annex 8, and Annex 15
    • US FDA 21 CFR Part 211
    • Pharmacopoeial monographs (USP, EP, JP – as applicable to the finished API)

    Typical usage ratio

    • Introduced at equimolar ratios in multi-gram to multi-kilogram step reactions, typically within 0.5–1.2 molar equivalents based on downstream reactant adjustments

    Downstream process integration

    • Loaded in reaction vessels during condensation or amidation stages; monitored under controlled temperature with process analytical technology to verify intermediate conversion

    Final product types

    • Benzamide-structured antibiotics
    • Specialty intermediate APIs for anti-infective tablet or injectable formulations

    2. Agrochemical Synthesis: Fungicide Active Ingredient Manufacture

    Our material is used by agrochemical producers to build advanced aromatic cores for selected fungicide actives. The downstream formulation requires exact impurity control and reproducibility to meet registration and environmental safety requirements in both import and exporting jurisdictions.

    Industry compliance standards

    • FAO and WHO Specifications for Plant Protection Products
    • ISO 16140:2016 for agrochemical analysis
    • REACH Registration (for the EU market)
    • China GB 2763-2021 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • Applied at 0.7–1.1 molar equivalents (relative to other process intermediates), scaled per lot size and seasonal raw material assessments

    Downstream process integration

    • Feeds into the core heterocycle-forming reaction prior to final chlorination or amide coupling, with strict process QC and HPLC impurity fingerprinting

    Final product types

    • Triazole-based and benzamide-based fungicide technical concentrates
    • Wettable granular formulations for crop protection

    3. Colorant Precursor in Dye and Pigment Production

    Specialized colorant manufacturers rely on this intermediate to construct chloro-nitro-substituted aromatic moieties for high-stability dyes and pigments. These colorants are destined for high-end textile and plastics applications, facing stringent migration and light-fastness requirements, as well as compliance testing for traces of residual process intermediates.

    Industry compliance standards

    • OEKO-TEX Standard 100
    • REACH Annex XVII (textile and pigment limits for aromatic amines and chlorinated compounds)
    • EN 71-3:2019 for migration of colorants in toys
    • ISO 105-B02 for color fastness to light

    Typical usage ratio

    • Input at 8–15% w/w in pre-condensation steps, adjusted based on desired pigment load and downstream color strength

    Downstream process integration

    • Introduced during the aromatic core formation or coupling stages, followed by purification columns or crystallization for dye quality upgrades

    Final product types

    • Acid and disperse dyes for polyester and synthetic fibers
    • Organic pigment powders used in plastics and inks

    4. Intermediate for Specialty Chemical Catalysts

    Producers of organometallic catalyst systems leverage this compound in the assembly of advanced ligand architectures. The raw material’s specific substitution pattern supports precise binding site modification, crucial for tuning selectivity and activity in polymerization and fine chemical manufacturing processes.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System
    • Chemical Manufacturer’s Association Responsible Care®
    • Custom customer-driven technical and analytical agreements covering elemental trace metal levels

    Typical usage ratio

    • Formulation input between 2–5% w/w in batch or continuous synthesis steps, variation determined by catalysis performance studies

    Downstream process integration

    • Combined with ligand precursor mixes during homogeneous catalyst assembly; monitored via advanced NMR and GC-MS methods for purity and structure confirmation

    Final product types

    • Immobilized and homogeneous catalyst systems for polyolefin and specialty polymer production
    • Fine chemical manufacturing reagents sold to contract synthesis operations

    5. Precursor in Pharmaceutical Impurity Profiling Standards

    Contract research and analytical labs use this substance to prepare certified reference materials for API impurity profiling. Sourcing directly from the manufacturer ensures full traceability and reproducibility for critical calibrations in regulated LC-MS and GC testing environments.

    Industry compliance standards

    • ISO/IEC 17025:2017 for testing and calibration laboratories
    • USP General Chapters <621> and <1225> for chromatography and validation
    • Ph.Eur. and BP reference material protocols

    Typical usage ratio

    • Used at sub-milligram to low-milligram quantities per analytical reference standard batch, standardized according to chromatographic method validation needs

    Downstream process integration

    • Processed via preparative HPLC and solid-state purification, then formulated into stable reference solutions or neat solid standards for calibration workflows

    Final product types

    • Certified reference materials (CRMs) for pharmaceutical impurity analysis
    • Analytical calibration kits for LC-MS or GC quality control labs
    Free Quote

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    Certification & Compliance
    More Introduction

    5-Chloro-2-Nitrobenzamide: Reliable Chemistry for High-Demand Synthesis

    Experience at the Source: Real Production Talk

    Here we are in the business of making chemicals—hands-on, in-lab, and with genuine accountability for every batch. Day in, day out, precision matters as much as consistency. Our shop’s 5-Chloro-2-Nitrobenzamide reflects that. For buyers and researchers who want more than a datasheet, I’ll lay out what separates our material from the typical stuff you can find in a trader’s warehouse or a random bulk shipment. Years of tweaks, tight process control, and good manufacturing discipline shape each kilogram that leaves our floor.

    What Makes Our 5-Chloro-2-Nitrobenzamide Distinct?

    Walk through our production lines and you’ll see why seasoned formulators come back for our product. The heart of the matter: control at every stage, from sourcing to synthesis to packing. We run closed systems that limit external contamination and use pure precursors, which gives tighter control over purity and trace impurities. Spec for our common model runs at a minimum 99% GC purity (by in-house verification). By pushing that standard, we keep research teams and downstream manufacturers from chasing ghosts in their reactions—real-world productivity rather than troubleshooting bad input.

    There’s nothing generic about the stability profile either. Over countless batches, we’ve chased after photostability, shelflife, and hygroscopicity issues that early formulations exposed. Current bottlings remain free-flowing and unreactive, kept dry with controlled humidity packing. We also choose HDPE-lined drums and sealed polybags for every shipment—no secondhand sacks or risk of seep-through, which means low-volatility off-gassing in hot months, and no “mystery caking” even during transit to humid regions.

    Understanding the Demand: End-Use Stories and Real Performance

    The folks who buy from us don’t all sit in university labs. We see 5-Chloro-2-Nitrobenzamide ending up in dye intermediates, pharmaceutical step-ups, active agro precursors, and analytical tools. In each pattern, precision matters. A synthetic chemist scaling an API starting block can’t afford phantom side products slipping into his batch. The dye plant technical lead wants color intensity without unpredictable byproduct hues. By sticking with strictly controlled precursors and batch-wise validation—including elemental analysis, water content assessment, and spectrographic scans—we keep that promise.

    Our batches always test for trace metals and halide contamination. This rigor meets the demands of cGMP-adjacent sectors who can’t tolerate variable reactivity. The standard specs are checked against each lot, with full records stretching back years. The feedback loop of repeated use and new customer trials guides our improvement. You won’t be troubleshooting mystery spots or fogged NMRs here.

    Comparing With What’s Out There: Quality Is Not a Marketing Slogan

    Spend enough years in this industry, you can spot the difference between a producer’s lot and a third-party repack. Simple visual checks show less dust, fewer fines, more consistent granular sizing on our product because we never let old, damped-out stock get reblended or “made good” by drying ovens. Production happens batch-to-order, keeping every lot traceable and fresh. The difference shows in less time pre-filtering and no “batch-to-batch jumpiness” in solubility or color gradation.

    Other sources may tout high purity, but runaway thermal color or odor is common in poorly controlled manufacturing. We monitor every batch with in-house HPLC as well as third-party reference labs in the case of international shipments, so what shows up on the manifest matches what actually arrives. Less residue, less persistent yellowing, and no unexplained off-odors—that’s the net result of producing under strict in-house scrutiny, not just pulling from an unlabeled warehouse pile.

    Handling and Formulation Realities

    Technicians using our 5-Chloro-2-Nitrobenzamide never wonder if their powder will clump, track static, or throw off clogs in automated feeders. Granule sizing and flow character were refined after end users in tableting and blend lines reported their pain points. Actual solvents and temperatures used in the field drove our selection of drying curves and handling procedures, not theory from a textbook. That cuts down on formulation surprises and helps scale up from R&D to pilot to full run with confidence.

    Every time we send a batch for pre-shipment check, we confirm moisture content and purity to keep consistency. Shelf stability runs confirm no drop-off in dissolution, so what’s freshly packed in the factory lands with the same qualities at the customer end. That comes from experience facing real-life shipping and storage environments, not just simulated warehouse conditions. Customers appreciate actually being able to use the chemicals as planned, without fussing over last-minute re-drying or re-filtering.

    Working with Our End Users: Responsive Service Rooted in Manufacturing Reality

    Our applications team gets asked every week about compatibility with large-scale pharmaceutical syntheses, custom coloring systems, and even regulatory registration support. Because we maker ourselves, our technical support can actually dig into process specifics: solvent recommendations, impurity control methods, and shelf stability in various packaging. Feedback often arrives in the form of “It arrived in the drum exactly as expected…and made it through our critical step without needing any workarounds.” Not every supplier can follow up with batch-level details from their own logs, but we do—real records from our own hands, not hearsay.

    By tuning our product and workflow for compatibility with popular synthesis routes, we’ve helped both smaller innovation labs and larger manufacturers keep their runs predictable. Supplements such as detailed batch dossiers, impurity scans, and packing configuration options let customers make compliance and qualification routines quicker. Years of dealing with import rules, flags on sodium content, or nitro residue restrictions enable us to answer regulatory and end-user queries based on experience—not generic certificates.

    Practical Uses: Going Beyond Textbook Chemistry

    5-Chloro-2-Nitrobenzamide fills an important spot in the world of downstream synthesis and advanced materials. Its structure lines up nicely for conversion into more complex organics. Real-world examples show this intermediate unlocking new chemical spaces, such as specialty agrochemical precursors where every impurity could trip a patent application. Other clients draw on its stability in color fastness applications, where trace metal or chloride levels change the outcome. By keeping the specs reliable, customers don’t have to recalibrate processes mid-contract.

    Pharmaceutical intermediates often require fine-tuned batch characterization, not just from a cost standpoint but also liabilities around unknowns. By sticking to proven production procedures, we’ve helped developers keep their R&D teams focused on value-added chemistry, not rescue operations for suspect inputs. Even in advanced dye systems, batch consistency means a plant manager doesn’t waste time adjusting downstream filtration or reacting to unexpected by-products.

    Supporting the Next Stage: Partnerships Rooted in Manufacturing

    Our experience isn’t just about making powder—it’s about taking products from early concept to registered materials operating in complex, regulated supply chains. We listen to those on the line with regulatory questions, documentation requests, or detailed impurity queries. Production records trace every raw material, and each modification in the synthesis protocol gets logged for future runs. We’ve seen how small tweaks upstream help a batch sail through downstream regulatory trials.

    Many times, a researcher on the customer side unlocks a new application or highlights a rare impurity trend. Our production documentation gives us a leg up in reproducing the right batch for follow-on work, because we record everything in exhaustive detail. It builds trust and enables a level of technical collaboration absent in sources that don’t control their own synthesis chain.

    Adaptability in Real Production Environments

    The demands placed on intermediates such as 5-Chloro-2-Nitrobenzamide are always moving. New formulations come up as industry shifts and regulatory pressure increases. In our facility, that means regular assessments—humble trial syntheses, stability checks, side-by-side application runs. We’ve built changes into the routine: if a customer needs a new sodium-free route or wants a different particle size for a new feeding system, the transition just means a few lines of paperwork and a pilot run, not months of contract negotiation.

    Each new tweak in our procedure carries through to repeatable production, not just the test batch. Production logs remain open for customer review, and every large order gets feedback time between initial sample and main shipment. Sometimes it’s as simple as a shift supervisor catching a slight color drift, sometimes it’s catching a spike in byproducts from a precursor—either way, rapid adjustment keeps the customer’s process safe from surprises.

    Accountability Means Full Production History

    With so many actors in the chemical trade, true vertical producers are rare. We track back every drum to the exact synthesis run, and every input shipment—traceability that means you don’t get chemical roulette. In the event of a technical issue, you get our process data, not excuses. Our protocols stretch to repeatable impurity fingerprinting, load-to-load consistency, and the low level of residual solvents buyers look for in regulated work.

    Working through challenges—be it sudden raw material price spikes, logistics fires, or new compliance standards—has honed our scene sense. It’s more than a high purity number on a sheet; it’s about making sure no batch leaves before it meets what’s printed on the spec. This is practice steered by real concerns from the field rather than marketing slogans.

    Safety, Practical Guidelines, and User Feedback

    Manufacturing for research and high-volume industry means learning alongside our users. We bring practical tips direct from our own handling experience. Storage away from sunlight and strong bases prevents unnecessary losses. Field reports from end users guide us to reinforce those instructions—not out of theory, but observation. End users encounter variations depending on climate, so we tune our packaging after seeing how the product comes out after weeks in warehouses half a world away. It’s that ground-level feedback loop shaping each improvement.

    Our attention to quality has real-world safety consequences. We weed out suppliers who send irregular raw lots, monitor for new banned contaminants, and choose process routes that minimize volatile byproduct risk. Customers articulate where packaging, shelf life, or reactivity fall short in other materials; those reports become action items in our own protocols. We keep decision-making technical, transparent, and presentable in the form of batch and safety documentation. For clients needing audits or third-party validation, production floor walkthroughs and process transparency are standard—part of being a manufacturer, not a middleman.

    Continuous Improvement and Future-Ready Processes

    No product stays the same forever—especially in an environment where buyers expect regulatory compliance, evolving technical standards, and real-world problem-solving. We emphasize continuous training for our crew, regular updates to synthetic routes, and digital tracking of every process step. Gaps found during regular customer QA cycles get fed back into future production. As new environmental standards and downstream applications emerge, we shift procedures before issues turn up in the field.

    Some customers request lower halide profiles, others look for more rigorous solvent removal in final drying stages. We have adapted batchwise purification to accommodate increasingly sophisticated R&D requirements. Automated process monitoring, digital logs, and open-door policy for external audits make us nimble without sacrificing quality. Honest working relationships with clients—built over years, not quarters—give us early warning about new trends and shifting regulations.

    The Manufacturing Legacy: Results You Can Trust

    Running a real chemical plant, you learn that every step counts. If our 5-Chloro-2-Nitrobenzamide did not meet expectations, clients would turn elsewhere, and word would travel fast. Real-world reliability makes the difference, not price games or generic paperwork. We keep our materials pure, our production honest, and our documentation open, so downstream processes run smoother and operators keep coming back. Ask around in quality-driven labs and manufacturing circles—trust in a producer’s word travels by reputation as much as anything printed on the label.

    Each drum that leaves our site represents hundreds of small choices in technique, materials, and process control. Our ongoing mission is better product with fewer headaches in the field, tuned to match every batch’s needs and the future challenges of the industries we support. Feedback remains our best teacher, and our customer’s results our biggest reward.