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5-Bromo-2-Methoxyphenethylamine Hydrobromide

    • Product Name 5-Bromo-2-Methoxyphenethylamine Hydrobromide
    • Alias 2C-B Methoxy
    • Einecs 634-603-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    222272

    Chemical Name 5-Bromo-2-Methoxyphenethylamine Hydrobromide
    Molecular Formula C9H12BrNO·HBr
    Molecular Weight 316.02 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 210-214°C (decomposes)
    Solubility Soluble in water
    Cas Number 262735-21-1
    Purity Typically >98%
    Storage Conditions Store at room temperature, keep container tightly closed
    Synonyms 2-Methoxy-5-bromophenethylamine hydrobromide
    Stability Stable under recommended storage conditions

    As an accredited 5-Bromo-2-Methoxyphenethylamine Hydrobromide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, opaque screw-cap bottle labeled "5-Bromo-2-Methoxyphenethylamine Hydrobromide, 10 grams," featuring hazard symbols and lot number.
    Shipping 5-Bromo-2-Methoxyphenethylamine Hydrobromide is shipped in tightly sealed, chemical-resistant containers, clearly labeled according to regulatory standards. The packaging ensures protection from moisture and light. It is transported following all applicable hazardous material guidelines to prevent damage, contamination, or leaks during transit. Appropriate documentation accompanies every shipment for regulatory compliance.
    Storage 5-Bromo-2-Methoxyphenethylamine Hydrobromide should be stored in a tightly sealed container, protected from light and moisture, at room temperature (typically 20–25°C). Store in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizing agents. Always follow standard laboratory safety protocols, including proper labeling and restricted access, to prevent accidental exposure or contamination.
    Application of 5-Bromo-2-Methoxyphenethylamine Hydrobromide

    Applications of 5-Bromo-2-Methoxyphenethylamine Hydrobromide in Industrial Manufacturing

    Our 5-Bromo-2-Methoxyphenethylamine Hydrobromide is produced to support advanced chemical synthesis in demanding industrial sectors. The following application scenarios draw on practical experiences from downstream manufacturers who integrate this compound as a core intermediate in regulated, operational environments. Each scenario is built around verified end-uses and precise formulation criteria, addressing the real requirements of advanced material and pharmaceutical markets.

    1. Pharmaceutical Intermediate for CNS Active Molecule Synthesis

    Downstream pharmaceutical producers rely on this compound as a critical building block during multi-step syntheses of central nervous system (CNS) drug candidates, particularly when designing brominated phenethylamine scaffolds used in psychoactive and neurological research APIs. Our product supports robust batch-to-batch reproducibility in controlled environments where purity and traceability are required by regulatory filings.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • FDA 21 CFR Part 210/211 (when used in drug substance manufacturing in the US)
    • EU Regulation (EC) No 1907/2006 (REACH) for chemical substances and mixtures
    • Ph. Eur. 2.2.46 and USP <467> for residual solvent controls

    Typical usage ratio

    • 0.8–1.2 molar equivalents per targeted CNS compound, adjusted for step yield optimization and side-product minimization

    Downstream process integration

    • Introduced as a primary amine coupling partner in condensation, reductive amination, or halogenation steps, typically at stage 2 or 3 in CNS molecule synthesis workflows

    Final product types

    • Psychoactive pharmaceutical intermediates for research
    • Finished CNS active pharmaceutical ingredients (APIs) in pilot scale
    • Reference standards for analytical laboratories
    • Impurity markers for regulatory submissions

    2. Custom Synthesis of Fluorescence Molecular Probes

    Labs specializing in fluorescent labeling agents employ this brominated phenethylamine as a core precursor in the creation of molecular probes. The unique structure lends itself to targeted halogen exchange and further functionalization steps, crucial for generating probes with high specificity in bioimaging and diagnostic device manufacturing. Control over bromine atom placement enables reproducible downstream labeling efficiency and signal response.

    Industry compliance standards

    • ISO 13485:2016 for medical device and diagnostic reagent manufacturing
    • RoHS 2011/65/EU and REACH Annex XIV for restricted substances
    • OECD Test Guidelines (for labeling agent safety evaluation)

    Typical usage ratio

    • 0.9–1.05 molar equivalents per probe precursor, with precise adjustments for fluorophore yield/hazard minimization

    Downstream process integration

    • Engaged at the halogen exchange or O-alkylation stage, preceding fluorophore attachment or linker modification

    Final product types

    • Bioimaging fluorescent dyes
    • Chemiluminescent antibody labeling kits
    • Diagnostic microarray probes
    • In vitro cell marker reagents

    3. Production of Specialty Aromatic Amine Stabilizers

    Chemical formulators in the polymer modification industry use this compound as an intermediate for synthesizing amine-based stabilizers required in high-performance thermoplastics. The distinctive brominated aromatic ring structure boosts thermal resistance and oxidative stability in the final amine stabilizer, which downstream manufacturers blend into engineering resin compositions for demanding technical applications.

    Industry compliance standards

    • ISO 9001:2015 for quality management systems in chemical manufacturing
    • UL 94 for flame-retardant components (where stabilizers enter final plastics)
    • FDA 21 CFR 177.1520 (for polymer additives in food-contact applications, where applicable)
    • EU REACH SVHC exclusion, for supply into restricted polymer markets

    Typical usage ratio

    • 0.5–1.5% by weight of resin blend in final stabilizer additive concentrate, modified according to performance test data

    Downstream process integration

    • Integrated during the condensation synthesis phase for amine stabilizer preparation, followed by blending in polymer compounding lines

    Final product types

    • Antioxidant amine masterbatches for polyolefins
    • Thermoplastic polyurethane (TPU) stabilizer packages
    • Engineering plastic additive concentrates
    • Polymer modifier additives for specialty films and sheets

    4. Building Block for Advanced Organic Electronics Materials

    Producers of organic electronic components incorporate this phenethylamine derivative within synthesis routes for creating advanced conjugated molecules. The controlled halogen positioning supports downstream modifications such as Suzuki and Buchwald-Hartwig cross-coupling, essential for assembling custom electronic materials with tuned band gaps and enhanced charge-carrier mobility in organic semiconductors.

    Industry compliance standards

    • IEC 62321 for hazardous substance restrictions in electronics
    • ISO 14001:2015 for environmental management in specialty chemicals
    • Customer-specific purity/testing guidelines (e.g., <0.05% halogen impurity tolerance)

    Typical usage ratio

    • 0.7–1.3 molar equivalents per synthetic moiety, tuned by device performance metrics and processing route

    Downstream process integration

    • Employed during precursor synthesis steps prior to cross-coupling, often as the first step in custom organic electronic dye and polymer material workflows

    Final product types

    • Organic light-emitting diode (OLED) emitter precursors
    • Thin-film transistor (TFT) monomer intermediates
    • Photoactive layer materials for organic solar cells
    • Specialty dopant precursors for organic electronics
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    Certification & Compliance
    More Introduction

    5-Bromo-2-Methoxyphenethylamine Hydrobromide: A Closer Look from the Manufacturer’s Floor

    Quality and Precision at the Source

    Every day, our team works with compounds that demand accuracy and care from the ground up, and 5-Bromo-2-Methoxyphenethylamine Hydrobromide stands out on our production line. Years of hands-on experience mixing, reacting, purifying, and analyzing chemicals marked how even small differences in raw material selection and processing conditions show up in the final product. In our facilities, we monitor each stage closely, not just to hit a set of specs, but to make sure each batch shows a steady chemical profile with minimal impurity load. All steps, from bromination to hydrobromide formation, are scaled and controlled with attention to air, temperature, and moisture, as these factors play strong roles in phenethylamine stability.

    Process Insights: More Than a List of Specifications

    We measure this product in both fine and granular forms, always sensitive to dust formation, which impacts both handling and shelf-life. Our regular checks include chromatography and NMR, looking beyond the assay percentage. People often ask why small differences in purity, say a few tenths of a percent, matter. In years of supporting research and development chemists, we noticed analytical results improve and downstream side-reactions fall away when batch consistency remains stable over time. Spectral signatures and impurity profiles build a kind of “fingerprint” for each lot, something we watch as closely as the percent purity or water content.

    Product Realities: Using 5-Bromo-2-Methoxyphenethylamine Hydrobromide

    Practically, research laboratories most often dissolve this compound in aqueous or polar organic solvents as a precursor or intermediate, typically as part of chemical or pharmaceutical discovery. Preparation methods affect coloration, odor, and ease of solubility. Some hydrobromide salts clump or cake in moist conditions; we identified a threshold for storage humidity and use packaging that counters water ingress. We’re transparent with shipping windows and best-use timelines, since these keep stability issues in check, especially for customers that count on analytical consistency in bioactivity or reactivity screens.

    What sets this molecule apart from close chemical relatives traces back to bromine’s position on the ring and the attached methoxy group. These small changes alter reactivity—both on the bench and in a biological assay. We noticed that direct halogenation or dealkylation steps are more selective with this arrangement compared to meta or para derivatives. Our process keeps a close eye on byproduct minimization, sidestepping routes that might sneak in multi-halogenated impurities familiar to anyone who’s tried uncontrolled aromatic bromination.

    Meeting Research Demands Head-On

    Whether for pharmacological investigations or synthetic method development, getting this compound right means eliminating batch drift. From our work with academic and industrial groups, we learned that handoffs between suppliers lead to headaches: inconsistent melting points, shifts in analytical HPLC baselines, or unexplained spot colors on TLC plates. Our reaction protocols favor reproducibility, not just yield, since customers notice even subtle changes in product behavior—sometimes years apart. We keep reference samples of every lot dating back quite a while, and run parallel assays on new lots before releasing them, so returning customers know exactly what they’ll get.

    Rigorous Controls—Why We Insist on Them

    In our industry, the difference between a usable batch and one that gets returned often ties to things like residual solvents, contaminant ions, or micro-trace impurities that escape notice at first glance. Regulatory bodies and institutional buyers increasingly inspect supply chains for such issues. For every batch of 5-Bromo-2-Methoxyphenethylamine Hydrobromide, we keep a meticulous log of raw material sources, batch timings, reaction temperatures, and the analytical pathway from crude product to final packaged form. Our reputation with buyers depends on these details, particularly during audits or repeat orders. Often, what separates a smooth project from a set-back is our willingness to invest time and people in pre-shipment checks and real-time communication with customers regarding any unscheduled changes.

    Understanding the End Use—Practical Impact

    We recognize that our customers might be running batch scale-ups, animal studies, or preparing new reference standards. Their work is sensitive to the tiniest differences in product profile, much as ours is. In the early days, we made the mistake of assuming “on-spec” meant “interchangeable.” Direct feedback showed us otherwise. Researchers told us about failed reactions, shifts in yields, or new spots on their chromatograms following supplier switches or even new runs from the same source. Today, that insight shapes our approach: we keep open lines with customers, encourage method-sharing, and troubleshoot in plain language.

    Our product’s unique performance shows most clearly in chemical stability and manageable storage. End users report fewer color shifts or clumping issues, especially compared to similar phenethylamines supplied as hydrochlorides or free bases. We selected the hydrobromide form specifically due to its shelf-stability and solubility profile under typical laboratory conditions. Unlike some alternatives that demand inert-atmosphere storage or freezing, our process yields a bench-stable solid—though we still encourage sensible storage in a cool, dry place.

    Differences that Matter—Hydrobromide vs. Other Forms

    Customers sometimes compare our hydrobromide salt to available free bases or alternative salts. We see real functional differences. Hydrobromides resist atmospheric moisture better than free amines, cutting down on sticky masses or unwanted caking. Over years of storage studies and returned product investigations, we found that hydrobromide batches ship better and reformulate more predictably into working solutions. Some applications require hydrochloride salts, which dissolve rapidly but show variable thermal stability or sometimes increased sensitivity to light. Our hydrobromide stands up to extended light exposure and regular shipping stress, something we tested by simulating logistics scenarios.

    The salt form also impacts safety and handling. Free amines in this family sometimes release vapors or corrode container closures; hydrobromide’s crystalline structure traps the amine efficiently, minimizing potential workplace exposure. From a manufacturer’s view, these differences translate directly to lower risk and fewer maintenance headaches.

    Solid-phase chemistry, especially for peptide conjugates or immobilization steps, benefits from hydrobromide stability. We adjust drying conditions and particle sizing to align with these uses, having seen that fine powders create more reliable dispersions, while larger granules reduce dust hazard. Over years of reviewing feedback from chemical process engineers, we refined our process to deliver both powder and granule grades, with clear labeling so users pick the right lot for the job at hand.

    Focus on Purity—A Relentless Pursuit

    Each run through our reactors ends with a detailed account of impurities, crystal size, batch color, and spectroscopic signature. Only material meeting our established profile moves onward to packaging. In our environment, where trace contamination can derail entire projects, we clean vessels and transfer lines with validated procedures, reviewing logs before green-lighting the next synthesis. When tighter impurity control is requested, we allocate smaller batches to custom purification, often consulting directly with user labs to pinpoint exact analytical needs. Several large-scale programs have relied on these tailored approaches, particularly where phenethylamine derivatives require compliance with strict regulatory or pharmaceutical testing.

    Often, researchers underestimate the effect of tiny byproducts unless they see them under an electron microscope or encounter unexplained signals in their data. From our side, monitoring these signatures offers one of the best views into process stability and long-term product consistency. Batch after batch, we see patterns in retention times and minor impurity peaks, which enables us to intervene early and avoid off-spec production. This means less waste, fewer costly reworks, and far fewer product returns for our clients.

    Safety and Environmental Stewardship from Sourcing to Delivery

    Each kilo that leaves our facility does so with a traceable history. We maintain a careful approach to chemical waste and solvent recovery, reusing or neutralizing byproducts wherever feasible. By operating under a continuous improvement model, our team identifies ways to recover solvent and energy inputs, reducing both cost and environmental footprint. Waste streams move through active monitoring and treatment, and internal audits examine daily logs for deviations. We see this direct connection between plant floor discipline and product performance, especially since environmental care often dovetails with cleaner batches.

    Packing and shipping practices matter too. Early in our production experience, water vapor found its way into paperboard drums and polyethylene bags when ambient humidity spiked. This resulted in sticky, discolored product that lost value before it even reached a customer. After trial and error, we upgraded our packaging protocols with barrier layers and humidity indicator cards, coupled with rapid sealing on our main conveyor. Consistency in these steps keeps the active product dry, free-flowing, and inside its specification window even after weeks in transit.

    Practical Advice from a Manufacturer’s Bench

    From years spent making and shipping 5-Bromo-2-Methoxyphenethylamine Hydrobromide, we share practical points that go beyond the textbook. Storage in low-humidity environments prevents product from clumping or losing its free-flowing nature. Decanting minimal amounts at a time—using clean, dry scoops—cuts cross-contamination and exposure to the air. Lab staff report the material keeps its off-white profile and solubility when stored in sealed containers out of direct sunlight. In multi-step syntheses, attention to residual traces in glassware and pipette tips carries real value, since even minuscule cross-contamination can impact downstream results.

    For new users, start with small-scale trial runs to check compatibility with solvents and reaction conditions. Our technical team offers real-world experience—discussing solvent selection, temperature settings, or cleanup procedures—since those details often save time and avoid common pitfalls. Direct communication between manufacturers and research teams closes gaps and supports result reproducibility, an aspect we've seen become crucial to repeat project success.

    Responding to Supply Chain Pressures and Evolving Needs

    Over the years, we have seen market pressures fluctuate. Demand swings, regulatory shifts, and global logistics strains often affect availability and pricing. Our response: maintain backed-up supplies of both raw materials and finished product whenever possible. Inventory planning and real-time response play bigger roles than ever—no substitute exists for direct manufacturer engagement. We continue building close ties not only with upstream suppliers but with buyers, since clear communication prevents project derailment. Quick lead times and clear, truthful updates become more than a selling point—they turn into relationships built on trust.

    In cases where demand spikes or new regulatory guidelines appear, we shift production schedules and document every post-synthesis adjustment. We find value in tracing those changes with clarity, which helps buyers address compliance, filings, or approvals. For larger scale requests, we discuss modification options, such as adjusted particle sizing, alternate packaging, or matched sampling to reference materials.

    Supporting Transparency and Reliability—Core to Our Identity

    Many buyers arrive skeptical after inconsistent experiences with resellers or traders. Manufacturing chemicals is not just a supply business—it’s about responsibility to customers that need their research to flow smoothly. Our team builds in redundancy at every process step and records every decision point along the way, so quality remains traceable and reproducible. Whether for medicinal chemistry, scale-up synthesis, or new materials research, those practices drive confidence and long-term partnerships.

    Feedback cycles matter. We look for not just compliments, but complaints, since difficult or time-consuming situations often shine a light on improvement opportunities. Whether packaging problems, small order logistics, or subtle analytical drifts, we treat every feedback point as a cue to refine our craft. Facing those challenges head-on has improved more than our product—it’s changed our attitudes and our connection to the science practiced downstream.

    In Summary—What Sets Our 5-Bromo-2-Methoxyphenethylamine Hydrobromide Apart?

    The core difference starts with deep production experience: we built our controls, purification protocols, and supply chain partnerships from the ground up. We view our compound as more than a commodity—it’s a tool in the hands of researchers working at the edge of discovery. Batch consistency and open communication are the foundation for reliability. Our process starts long before synthesis and ends long after shipment, with ongoing support and a willingness to address challenges as they arise.

    Choosing our 5-Bromo-2-Methoxyphenethylamine Hydrobromide means investing in a relationship rooted in experience, transparency, and hands-on technical support. This approach delivers a product that stands up to scrutiny and supports the end goals of our partners—delivering measurable advantages in every reaction, every analysis, and every discovery journey. Our hands-on experience over years led us to these insights, and we remain committed to making this compound the reliable choice for those who need both quality and the support only a true manufacturer offers.