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5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole

    • Product Name 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole
    • Alias TFMPT
    • Einecs 68817-99-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    369904

    Productname 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole
    Casnumber 126328-71-6
    Molecularformula C8H5F3N4
    Molecularweight 214.15
    Appearance White to off-white solid
    Meltingpoint 115-118 °C
    Solubility Slightly soluble in water; soluble in organic solvents like DMSO
    Purity Typically >98%
    Smiles C1=CC(=CC(=C1)C(F)(F)F)N2=NN=NN2
    Inchi InChI=1S/C8H5F3N4/c9-8(10,11)6-2-1-3-7(4-6)15-14-12-13-5-15/h1-4H,5H
    Storage Store at room temperature, protected from moisture and light

    As an accredited 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 25 grams, tightly sealed with a screw cap; white label displaying chemical name, molecular formula, CAS number, and hazard symbols.
    Shipping 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole is shipped in secure, airtight containers compliant with chemical safety regulations. Packaging prevents exposure to moisture or light, and includes proper hazard labeling. Transport follows UN and local legal guidelines for chemicals, typically via ground or air courier with tracking, and requires a signed delivery by authorized personnel.
    Storage Store **5-[3-(Trifluoromethyl)phenyl]-1H-tetrazole** in a tightly sealed container under cool, dry conditions, and protect it from light and moisture. Keep it in a well-ventilated area, away from sources of ignition, strong oxidizing agents, and incompatible substances. Handle under inert atmosphere if sensitive to air. Properly label the container and use appropriate personal protective equipment when handling the chemical.
    Application of 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole

    Applications of 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole in Industrial Manufacturing

    As a direct manufacturer of 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole, we supply this advanced tetrazole derivative to leading industries where high-performance energetic intermediates and specialty synthesis are required. Detailed below are concrete downstream applications, with segment-specific compliance standards, formulation practices, integration stages, and final product types defined for the true scope of this chemical's industrial use.

    1. High-Energy Initiator Compounds for Automotive Airbag Gas Generators

    Automotive safety system manufacturers incorporate this tetrazole as a key energetic intermediate in precise amounts for pyrotechnic initiator charges. The material's exothermic decomposition profile matches key reactivity and gas production parameters required in modern airbag inflator cartridges. Our consistent quality supports both R&D and mass manufacturing, ensuring stable deployment performance in end-user vehicles.

    Industry compliance standards

    • ISO 19014-1:2018 (Safety of pyrotechnic gas generators)
    • UN Recommendations on the Transport of Dangerous Goods
    • Automobile OEM Safety Standards (e.g., FMVSS 208)
    • REACH Annex XVII compliance for restricted substances

    Typical usage ratio

    • 2–6% by weight in multilayer initiator blends; dose adjusted for required gas yield, booster composition, and system volume

    Downstream process integration

    • Directly blended into primary charge formulations during compounding of pyrotechnic mixtures; integrated before pelletizing and casing

    Final product types

    • Automotive airbag inflator charges
    • Seat belt pretensioner initiators
    • Micro gas generators for vehicle safety systems

    2. Synthesis of Specialty Tetrazole Building Blocks for Agrochemical R&D

    Agrochemical formulators use this compound as a tetrazole source to synthesize heterocyclic scaffolds found in next-generation crop protection agents. Its electron-withdrawing trifluoromethyl group enhances the creation of bioactive analogs via downstream cycloaddition and cross-coupling reactions, supporting structure activity relationship (SAR) studies and patentable product development in sustainable agriculture solutions.

    Industry compliance standards

    • OECD Principles of Good Laboratory Practice (GLP)
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • ISO 17025 laboratory accreditation for analytical chemistry
    • EPA 40 CFR Part 169 (Pesticide Registration)

    Typical usage ratio

    • 0.2–1.5 molar equivalents with respect to precursor substrate; exact usage varies by target scaffold synthesis route and screening protocol

    Downstream process integration

    • Introduced at early heterocycle formation step, typically via nucleophilic substitution or click-reaction with nitriles or azides; isolated intermediates further derivatized to final actives

    Final product types

    • Novel herbicide intermediates
    • Seed treatment research actives
    • Analytical reference standards for registration dossiers

    3. Active Pharmaceutical Ingredient (API) Intermediate for Development Pipelines

    Pharmaceutical developers leverage this tetrazole as a building block in synthesis of advanced intermediates, especially for compounds requiring specific aromatic substitution patterns and nitrogen-rich heterocycles. The robust stability under mild conditions facilitates scalable process routes, supporting projects from early route scouting through GMP pilot production for preclinical and investigational new drug (IND) submissions.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Ph. Eur. Monographs on API intermediates
    • US FDA 21 CFR Part 210/211 (Current GMPs for Finished Pharmaceuticals)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 1.0 molar equivalent per coupling or cyclization stage; adjusted based on synthetic yields and purification strategy during route optimization

    Downstream process integration

    • Charged during the multi-step condensation or cyclization phase to construct tetrazole-containing pharmacophores; utilized before final API deprotection and purification

    Final product types

    • Clinical phase API intermediates
    • Small-molecule reference materials
    • Pharmaceutical research-grade standards

    4. Performance Additive in Explosive Formulations for Mining and Civil Blasting

    Commercial explosives manufacturers add this tetrazole derivative to enhance detonation performance and adjust the sensitivity profile in advanced mining charges. Its clean gas output and controlled energy release characteristics make it suitable for precision blasting where environmental regulations restrict NOx and hazardous byproduct emissions, while maintaining desired blast fragmentation patterns in stone quarrying and tunnel boring operations.

    Industry compliance standards

    • EN 13631-3 (Explosives for civilian use - High explosives)
    • ATEX Directive 2014/34/EU for equipment and protective systems
    • OSHA 1910.109 (Explosives and Blasting Agents)
    • IMDG Code for safe transport of explosives

    Typical usage ratio

    • 0.5–3% by weight depending on the desired brisance and blast pressure; tuning based on ANFO, emulsion, or slurry matrix

    Downstream process integration

    • Metered directly into the charge prep line prior to cartridge molding or bulk emulsion blending; thoroughly mixed to assure uniform energetic properties

    Final product types

    • High-precision mining charges
    • Quarry blasting cartridges
    • Specialized tunnel excavation explosives

    5. Synthesis of Fluorinated Specialty Chemicals for Electronics Applications

    In electronic materials synthesis, this trifluoromethylated tetrazole serves as a precursor in the design of advanced dielectric compounds and surface modifiers required for high-frequency printed circuit boards (PCBs) and semiconductor process chemistry. Its unique combination of thermal stability and fluorine content provides targeted dielectric properties, satisfying next-generation requirements for communication hardware manufacturers.

    Industry compliance standards

    • IPC-4101 (Specifications for base materials for printed boards)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • IEC 61249-2-7 (Laminates and prepregs)
    • ISO 14001 Environmental Management Systems

    Typical usage ratio

    • 0.1–0.8% in resin modifier masterbatch; adjusted according to required dielectric loss and percolation threshold in formulated blends

    Downstream process integration

    • Added during monomer blending or prepolymer modification steps ahead of resin curing or film casting; ensures incorporation at molecular level

    Final product types

    • Low-loss PCB laminates
    • Specialized semiconductor dielectrics
    • Fluorinated surface treatment agents
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole: A Reliable Solution from the Manufacturer’s Floor

    A Closer Look at Our 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole

    Deep in the heart of the chemical industry, reliability starts with careful synthesis and clean work. Our team develops 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole with an eye on every flask, batch, and shipment. Long experience in handling fine organic intermediates has shown us which steps matter for stability and which shortcuts threaten consistency. For the research community and production specialists, seeing genuine commitment on the manufacturing side brings peace of mind, especially when the world demands tighter specs and fewer surprises.

    The Chemical Character: Properties and Potential

    The trifluoromethyl-phenyl tetrazole family owes its popularity to its subtle strength. Our model, identified by the structure C8H5F3N4, strikes the right balance between electron-withdrawing influence and manageable reactivity. Clear crystalline form makes it easy to verify quality by eye, but behind that appearance lies a backbone designed for both rugged performance and professional reliability.

    We focus our batch processes with purity at the core, documented by routine HPLC and NMR analyses. The molecular weight, around 214.15, remains consistent from lab scale to pilot quantities. Our in-house teams monitor melting point without fail, confirming integrity along the path from reactor drum to customer vials. True confidence in a chemical builds from such fundamentals.

    No Substitute in Click Chemistry and Beyond

    Experienced synthetic chemists often reach for tetrazole derivatives when building more complex work. Our 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole delivers high performance in “click” reactions, especially for triazole formation via cycloaddition protocols. We’ve worked alongside university and pharma partners who depend on brief, clean conversions. Fast, reliable bonds at the tetrazole nitrogen improve process yields and save cost with every cycle. There are few ways to get the same results with more basic materials.

    This product tackles peptide bond mimics, energetic material precursors, or sophisticated ligands. The trifluoromethyl group on the aromatic ring enhances stability while preserving processability. Subtle shifts in electron density open new routes for catalysis or functional group conversion.

    Commercial clients tell us that attempts to substitute other aryl tetrazoles often fall short. Minor shifts in position or missing trifluoromethyl substituents change reactivity in unpredictable ways. Our 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole delivers reproducible effects, even in demanding late-stage synthesis.

    Clean Synthesis: From Lab to Industrial Scale

    For a chemical producer, consistency becomes an everyday focus. As we scale up, attention must rest on waste reduction, worker safety, and process predictability. Our facility incorporates closed systems to prevent exposure and minimize contamination. Automated feeding and precision temperature control help us avoid hot spots that risk side products.

    We use locally sourced starting materials when possible, supporting both cost stability and supply chain strength. This commitment, along with our robust purification steps, cuts down on lot-to-lot variations. Every team member, from the analytical chemist to the operator on mixing duty, knows the materials they handle leave our floor with a clear pedigree.

    Larger orders receive the same attention to detail as smaller ones. Each packaging run includes environmental testing, not as an afterthought but embedded in the process. Raw analytical data accompanies every shipment, letting users verify that what arrives is exactly what they expect.

    Sustainability: Built into Every Process

    Sustainability now stands with quality and safety as a standard expectation in chemical manufacturing. As a producer, overlooking environmental impact creates more problems than it solves. We focus effort on high-yield routes and solvent conservation. Cleaner reactions draw from high-purity inputs, but also from smart recovery and recycling practices.

    Our team works to lower process water consumption by investing in repurposed solvents wherever feasible. Excess solvent and process water enter dedicated treatment, rather than being treated as simple waste. This reduces operational costs and lessens our facility’s environmental footprint, which matters both to neighbors and partners across the supply chain.

    For solids like 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole, optimizations such as robust crystallization and dry filtration techniques ensure minimal solvent loss. Our operators test every process adjustment, measuring outcomes on real batches, not just pilot summaries.

    Supporting R&D and Large-Scale Operations

    Researchers in both academic and private labs feel the weight of managing precious budgets. Through years of direct contact, we understand the frustration with variable performance and off-spec batches, often sourced through long chains of distributors. Our customers get full data on product origin, trace elements, and handling history, which builds lasting trust.

    Bulk consumers—CDMOs and pharmaceutical firms—face steeper compliance requirements every year. They want predictable timelines, clean documentation, and clarity from their suppliers. We work with these partners from project planning through every reorder. Even unconventional requests—special sieving, custom batch splitting, hazard labeling—get addressed by team members who know how the product travels.

    Sometimes, clients require modifications, such as higher purity or specialized handling due to downstream regulatory demands. We employ phase-gated process evaluations to make such adjustments, leading to better results with less waste. Teams coordinate site visits and audits freely, understanding that transparency trumps uncertain promises.

    Experience Sets the Gap between Product Lines

    Many synthetic chemistries share names and functional groups, yet the gap between nearly identical molecules often determines project success or delay. We regularly field calls after competitors missed production targets or batches came in with contamination. The details differ—residual palladium, water content, incomplete conversions—yet the lesson stays the same. Building control over reaction exotherms, work-up, and purification starts at the equipment level and grows with team experience.

    Our operators know 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole by smell and behavior, catching early signs of deviation before they register in the analytics lab. Fast intervention means less rework and stronger guarantees for our clients. Feedback loops from customers shape process changes, with documentation handed back to users so adjustments in end-use formulations become possible.

    This direct connection between our facility and your bench means less downtime and fewer unexpected delays. New users benefit from this history, as our field chemists share case stories of solved bottlenecks and protocol tweaks. The learning never stops—if you have unusual application targets, our development chemists want that conversation.

    What Makes Our 5-[3-(Trifluoromethyl)Phenyl]-1H-Tetrazole Different?

    Plenty of producers can claim “high purity” or “fine chemicals.” Not every supplier stands behind their lot numbers with end-to-end data on synthesis, storage, and transport. Years in this trade have taught us which details really matter.

    Our quality checks go beyond basic specs. We run Karl Fischer titrations, expanded chromatographic analyses, and in-depth impurity profiling. Any red flag, even in parts-per-million, triggers batch reviews. The rare recall comes from our own QA initiative, not from a regulatory shock or upset customer.

    Our warehouse design avoids cross-contamination risk, with materials segregated by hazard class and end-use stability. Unopened inventory gets periodic re-tests. If a batch sits on the shelf longer than six months, it faces renewed scrutiny, and only clean certs allow it to ship. This approach builds trust, but it also avoids headaches for repeat buyers tracking inventory over fiscal quarters.

    We carry this attention through the supply chain. Shipments transit with stability data, and we flag any risks posed by transit temperature or humidity. Our packaging lines use inert, moisture-barrier materials. Outgassing studies and post-arrival checks confirm shipments reach their new homes in perfect condition.

    Supporting Progress Through Process Adaptation

    The march of chemical science never stops. Downstream users constantly explore new ligands, drug scaffolds, or specialty polymers. These shifting needs mean that as the original manufacturer, our agility makes the difference. For 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole, we have retooled reactor lines, adjusted solvent selections for greener operation, and even designed bespoke packaging for controlled-environment delivery.

    We’ve worked hand-in-hand with customers developing novel catalysts, running initial samples on gram scale, then transitioning to multi-kilo campaigns as optimism builds. Consistency across these phases builds confidence in process transfer, especially when registration deadlines loom. From custom particle size to residual solvent specs, we adapt because we know real customers need those answers—not next week, but on project timelines that drive their business.

    Direct access to our production engineers and QA staff closes communication loops. If end-users find unexpected interaction during formulation, our own chemists return to the bench to run parallel tests. This cycle of feedback and refinement is how we catch stubborn issues before they cascade to the customer’s project.

    Transparency, Traceability, and Partnership above All

    Supplying 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole means more than delivering high purity. It requires clarity in communication and full traceability. Our logs run end-to-end, tracking batches from raw incoming lots through to finished product shipping. We retain batch samples for comparison—even years after delivery—so if users need retrospective checks or face new regulatory requests, those materials are available.

    We invite audits and site visits as part of our normal engagement. Customers can view batch records, analytical data, storage conditions, and even speak with the chemists who created their orders. This level of visibility assures partners making critical molecules on strict timelines—especially when downstream products face agency review and registration.

    Our philosophy boils down to mutual respect. If a shipment delay occurs, we communicate the same day. If requests come for lower impurity, faster shipment, or new documentation, we tackle those head-on, engaging our technical and regulatory staff as needed. Being the original manufacturer, we can adapt, troubleshoot, and improve with every order cycle rather than pushing accountability elsewhere.

    This approach has led us to long-standing relationships with R&D groups, process scale-up teams, and procurement managers alike. Across these decades, the formula stays constant: tight process, strong documentation, and open dialogue.

    Future Directions: On the Road to Better Chemistry

    Chemical manufacturing never sits still, especially with products like 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole demanded in evolving fields. We see partners in materials science using it as building blocks for advanced energetic compounds, while pharma developers explore new uses in bioisosteric design. Every new application brings questions: Can we achieve better selectivity in catalysis? Do new purification steps yield drug-grade material? Each challenge becomes a puzzle for our technical teams, tackled with both established know-how and new technology.

    Our teams monitor developments in green chemistry, always seeking less hazardous reagents and improved atom economy. Investments in process automation pay off in better control while reducing worker exposure. Every step—modeling reaction kinetics, designing new purification—strives to lower energy and solvent input.

    We share what we learn with the wider user community, reporting process updates and safety findings. By informing clients, we keep the feedback loop live, turning emerging issues into shared progress.

    Summary: Trust Born from Direct Manufacturing

    Delivering 5-[3-(Trifluoromethyl)Phenyl]-1H-tetrazole at scale takes daily discipline, born from a direct connection to the product and those who use it. On this floor, every order reflects lessons learned through years producing sensitive organic compounds. Customers return not just for molecules, but for the partnership that comes from direct, open, and accountable service.

    We understand real-world research and process demands, navigating the challenges that pop up batch to batch. Each gram or kilo we ship tells a story—of traceable lots, careful synthesis, and ongoing problem-solving. By standing as the manufacturer, we bridge the gap between chemistry’s potential and its results, project after project, delivery after delivery.