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4-Pyridazinecarboxylic Acid

    • Product Name 4-Pyridazinecarboxylic Acid
    • Alias 4-Pyridazinecarboxylic acid
    • Einecs 219-210-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    646563

    Product Name 4-Pyridazinecarboxylic Acid
    Cas Number 641-68-9
    Molecular Formula C5H4N2O2
    Molecular Weight 124.10 g/mol
    Appearance White to off-white solid
    Melting Point 267-271°C (decomposition)
    Solubility In Water Slightly soluble
    Smiles C1=CN=NC=C1C(=O)O
    Inchi InChI=1S/C5H4N2O2/c8-5(9)4-1-2-6-7-3-4/h1-3H,(H,8,9)
    Pubchem Cid 123115
    Storage Conditions Store at room temperature, in a tightly closed container

    As an accredited 4-Pyridazinecarboxylic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 4-Pyridazinecarboxylic Acid is packaged in a 25g amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 4-Pyridazinecarboxylic Acid is shipped in tightly sealed containers, protected from moisture and light. It should be packaged according to chemical safety standards, labeled appropriately, and transported under ambient temperatures. Ensure it is handled by authorized personnel, with Material Safety Data Sheet (MSDS) accessible during transit for emergency procedures.
    Storage 4-Pyridazinecarboxylic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing agents. Protect the chemical from moisture, heat, and direct sunlight. Ensure proper labeling and keep it in a designated chemical storage cabinet, preferably in a corrosion-resistant container. Handle with appropriate personal protective equipment.
    Application of 4-Pyridazinecarboxylic Acid

    Applications of 4-Pyridazinecarboxylic Acid in Industrial Manufacturing

    4-Pyridazinecarboxylic acid serves as an essential intermediate across several advanced chemical production sectors, playing a critical role in the synthesis of high-performance ingredients and additives. As an original manufacturer with extensive experience in process chemistry and industrial scale-up, we highlight only established downstream use-cases where our product enters validated manufacturing routes and supports strict regulatory demands.

    1. Agrochemical Active Ingredient Synthesis

    Major agrochemical plants employ 4-Pyridazinecarboxylic acid as a core precursor in manufacturing selective herbicides and pesticide actives. Its pyridazine ring structure is utilized in heterocyclic coupling steps to produce molecules targeting broadleaf and grassy weed species, especially in cereal and orchard crop protection. Process control during amide or esterification reactions ensures formation of intermediates fitting established regulatory dossiers for global crop inputs.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • EU REACH Regulation (EC) No 1907/2006 Registration
    • EPA Pesticide Registration and Tolerance Standards (USA)
    • GB 2763 - China National Food Safety Standard for Maximum Residue Limits

    Typical usage ratio

    • 5–15% w/w in target active ingredient synthesis, adjusted to optimize yield and selectivity depending on downstream functionalization or coupling partners

    Downstream process integration

    • Introduced at the initial condensation or cyclization stage, followed by purification and derivatization for final API formation

    Final product types

    • Pyridazine-class herbicides (e.g., selective cereal herbicides)
    • Synthetic intermediates for fungicide actives
    • Formulated pesticide emulsions and granules
    • Technical-grade agrochemical concentrates

    2. Pharmaceutical Intermediate for Cardiovascular Agents

    Within the pharmaceutical sector, leading API manufacturers utilize this compound during the assembly of pyridazine-bearing drug molecules, notably antihypertensive agents and certain vasodilators. Its functional carboxylic group permits further transformation under controlled conditions during multi-step syntheses according to cGMP protocols, typically feeding into heterocycle coupling or amidation steps that define active molecular frameworks.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • USP/NF Monographs (United States Pharmacopeia)
    • EP (European Pharmacopoeia) Quality Standards
    • Health Canada Drug Establishment Licensing

    Typical usage ratio

    • 1–8% molar equivalents (relative to final API backbone), dependent on molecular target and reaction mechanism

    Downstream process integration

    • Charged during ring-closure or side-chain installation, followed by hydrogenation or halogenation, preceding API crystallization and isolation

    Final product types

    • Antihypertensive bulk APIs (e.g., certain dihydropyridazine drugs)
    • Finished pharmaceutical tablets and capsules
    • Injectable cardiovascular solutions

    3. High-Performance Polymer Modifier

    Advanced polymer manufacturers incorporate 4-Pyridazinecarboxylic acid to introduce pyridazine moieties into aromatic polyamides and specialty resins. Chemical engineers add it as a chain extender or crosslinking modifier in melt-kneading or solution-polymerization steps, imparting improved thermal stability, flame retardancy, and permeability attributes to engineering plastics applied in automotive, electronics, and filtration products. Polymer end properties depend on controlled dosage and functional group reactivity during synthesis.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Polymer Production
    • UL 94 Flammability Testing for Plastics
    • IEC 60216 Thermal Endurance for Electrical Insulating Materials
    • RoHS Directive 2011/65/EU for Electronic Materials

    Typical usage ratio

    • 0.2–3% by weight of total monomer load, with adjustment based on target copolymer architecture and end-use technical requirements

    Downstream process integration

    • Added during prepolymer charge or co-monomer blending in condensation or imidization reactors for specialty polymer grade production

    Final product types

    • Aromatic polyamide molding compounds
    • High-temperature engineering resins
    • Flame-retardant plastic parts for electronics and aerospace
    • Membrane filtration substrates

    4. Dye and Pigment Precursor for Specialty Colorants

    Colorant manufacturers use 4-Pyridazinecarboxylic acid as a precursor to synthesize specialty azo and metal-complex dyes with enhanced lightfastness and unique shade stability. The compound’s heterocyclic framework enables selective diazotization and coupling reactions, forming dye intermediates integrated into textile, inkjet, and plastics coloring systems. Purity and quality control during manufacturing are tailored to downstream environmental and performance specifications.

    Industry compliance standards

    • OEKO-TEX® Standard 100 Chemical Restrictions
    • EN 71-3: Migration of Certain Elements (Toy Safety Dye Limits)
    • ISO 105 Series: Color Fastness Testing
    • ECHA REACH Annex XVII (Azo Dyes Restrictions)

    Typical usage ratio

    • 3–10% by weight within dye intermediate synthesis stage, adjusted based on target chromophore and desired metal complexation for final shade

    Downstream process integration

    • Introduced in diazotization or subsequent coupling reactions to build colorant backbone, followed by purification and blending with dispersing agents

    Final product types

    • Specialty azo dye powders for textile printing
    • Metal-complex dyes for synthetic fiber coloration
    • Inkjet pigment concentrates
    • Plastic coloration masterbatches

    5. Catalyst Ligand Synthesis in Industrial Catalysis

    Specialty catalyst producers utilize 4-Pyridazinecarboxylic acid as a building block for custom ligand architectures used in homogeneous and heterogeneous catalytic systems. The carboxylated pyridazine ring coordinates effectively with transition metals, providing binding motifs that improve selectivity and turnover in processes such as olefin polymerization and fine chemical hydrogenation. Ligand production requires precise control of stoichiometry and metal-ligand reaction pathways, satisfying demanding performance validation tests.

    Industry compliance standards

    • ISO 17025 Testing Laboratory Accreditation for Catalytic Materials
    • ASTM D3240 Testing for Polymerization Catalyst Performance
    • EU Regulation No 10/2011 on Food Contact Materials (if used in plastics manufacturing)
    • REACH Registration for Specialty Chemicals

    Typical usage ratio

    • 0.5–2 molar equivalents per catalytic metal center, tuned to optimize ligand field strength and catalytic activity depending on metal and process

    Downstream process integration

    • Reacted in ligand precursor synthesis, followed by complexation with targeted metal salts, forming catalyst precursors or ready-to-use catalyst solutions

    Final product types

    • Transition metal catalytic complexes (e.g., for synthetic polymer production)
    • Specialty ligand additives for fine chemical synthesis
    • Homogeneous hydrogenation and oxidation catalysts
    • Catalyst masterbatches for polymer reactors
    Free Quote

    Competitive 4-Pyridazinecarboxylic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 4-Pyridazinecarboxylic Acid: Versatile Building Block from an Expert Chemical Manufacturer

    What Sets Our 4-Pyridazinecarboxylic Acid Apart

    Working with chemical synthesis for decades, we have learned where careful control and purity make the greatest difference. Our 4-Pyridazinecarboxylic Acid represents this commitment. Every batch is produced right here, managed by our staff from raw material inspection to the finished product in its container. This hands-on approach means we see first-hand how even a minor deviation in synthesis or drying conditions can affect crystal habit, solubility, or downstream reactivity.

    Our customers rely on 4-Pyridazinecarboxylic Acid (Model: YD-PZCA-02) for its precise specification: white to off-white crystalline powder, melting point 222-224°C, and HPLC purity exceeding 99%. These numbers weren’t picked because they look good on paper. They reflect what our research partners and manufacturing clients demanded after extensive trials, and we have responded with each production run. Our chemists monitor trace moisture and related compounds constantly, since excess water or uncontrolled byproducts can complicate custom syntheses. We stick to a moisture content under 0.2% and keep heavy metals well below 10 ppm, not because it’s easy to do every time, but because years of experience confirm this improves yields further downstream.

    We keep our supply chain close. Raw starting materials are vetted by our own analysts, and finished 4-Pyridazinecarboxylic Acid avoids contamination from external storage or repackaging. Many clients have spent time and money fixing mystery problems caused by intermediaries cutting corners or introducing unidentified cross-contamination. Our customers consistently report fewer problems scaling up since they receive material with a single, straightforward history.

    Supporting Innovation across Industries

    Our primary motivation remains enabling our partners to build more complex molecules more reliably. 4-Pyridazinecarboxylic Acid, as a carboxylic acid with a pyridazine backbone, draws particular interest in pharmaceutical, agricultural, and specialty chemical synthesis. Medicinal chemists value the reactivity of the carboxylic group coupled with the distinct electron distribution on the pyridazine ring. Many heterocyclic active ingredients begin with this core as a precursor. We've observed success stories where our product serves as the platform to access anti-inflammatory, antiviral, and antitumor scaffolds.

    On the agrochemical front, our product supports the search for selective and environmentally friendly herbicides and fungicides. Pyridazine derivatives have carved out a niche for their unique bioactivity and resilience; agritech companies working to develop next-generation crop protectants have told us that run-to-run purity and minimal trace contaminants drive lower development costs and quicker regulatory approval.

    For advanced materials projects, clients developing new polymers and coatings come to us because consistent 4-Pyridazinecarboxylic Acid avoids surprises during polymerization or crosslinking. Research teams often cite trace amines or residual solvents from less rigorous manufacturing as culprits behind failed experiments. To address this, our drying and purification steps run longer and are monitored more closely than industry averages, so that customers receive nothing except the compound they requested.

    Practical Insights from Direct Manufacturing

    Manufacturing 4-Pyridazinecarboxylic Acid looks straightforward on a flowchart, but experience teaches that meticulous attention is required throughout. Solubilizing the starting materials requires closely watching pH and temperature. Allow too much variance, and byproducts increase, yield drops, and extra purification becomes necessary. We have built our procedures around minimizing rework, since repeated processing wastes energy and risks introducing impurities.

    Our filtration and drying methods changed over the years to optimize handling, packaging, and application. For example, incorrect crystallization speeds can trap solvent in the product, causing later degradation or lower reactivity. By refining cooling cycles and using multi-stage drying, we provide material with a long shelf life, uniform particle size, and high chemical stability. Any excess dust or fines are removed since customers using automated weighing systems require material that flows easily and dispenses reproducibly.

    Our packaging team inspects each lot visually and chemically before shipment, which helps us spot and resolve problems before our customers ever need to worry. Damaged containers or improper seals get flagged immediately. It hasn’t always been a smooth learning curve — we’ve adapted packaging after feedback from a client who traced a troublesome impurity spike back to a leaching effect from a generic drum liner. We shifted immediately to specialty liners with defined extractables, resulting in improved reproducibility for several bulk pharmaceutical companies relying on us.

    Comparisons and Distinctions

    Discussions about pyridazine derivatives often turn to how 4-Pyridazinecarboxylic Acid compares to related compounds like 3-pyridazinecarboxylic acid or isonicotinic acid. The difference may appear subtle to someone leafing through a catalogue, but our teams have worked through the complications these differences cause in synthesis. The position of the carboxylic group substantially affects both electronic properties and reactivity: in our experience, the 4-position brings better solubility in polar organics and fewer side reactions with electrophiles.

    Many competitors offer generalized fine chemicals with basic characterization and little insight into impurities. From the manufacturing side, those ‘commodity’ products often pull from large, mixed-feed reactors that handle multiple chemistries per shift. We operate smaller, dedicated reactors with cleaning and blanking procedures after every batch, focused solely on heterocyclic carboxylic acids. This limits contamination risks and leads to fewer failed reactions or loss of material during scale-up.

    Our product maintains tight batch-to-batch consistency in melting point and particle size, which allows research and production partners to validate their processes just once rather than with every new drum or shipment. Reproducible performance carries real value in regulated environments, including drug ingredient synthesis or agricultural chemical trials.

    Real-World Applications Drive Our Approach

    From the early days, the most important lessons have come from our customers’ stories about their end products. One pharmaceutical group shared detailed feedback after using our 4-Pyridazinecarboxylic Acid to synthesize a new antiviral candidate. Their synthesis ran cleaner and more predictably than with previous sources, in part due to lower residual solvent and improved control over the acid group. Lower side-product formation meant they could speed up pilot trials and file data with greater confidence.

    Academic institutes choose our material for advanced ligand synthesis, writing to us about the clear NMR spectra and reliable melting point range. Even small inconsistencies prompt a phone call, and our team digs into each reported lot, frequently inviting the partner to observe analytical runs or suggest alternative characterization methods. We believe that continuous learning from clients drives our quality forward.

    Formulation chemists in the crop-protection industry regularly report how reduced metal content and stable physical form translate into lower batch failures and less troubleshooting during scale-up. For polymer research, the difference between a well-controlled and a marginal quality raw material often appears in reproducibility of mechanical properties in final products. Our support doesn’t stop at shipping, either — we follow up on performance and actively collect long-term stability results from partners to validate our production protocols.

    Solving Industry Problems through Know-How

    The path to producing high-purity 4-Pyridazinecarboxylic Acid hasn’t been simple. Many years ago, our team identified unexpected color shifts in late-stage product stored under certain warehouse conditions. Because even faint discoloration can signal oxidation or microcontamination, we traced the cause to minor, but solvable, changes in warehouse airflow and light exposure. Once the root causes became clear, we resealed work-in-progress material, adjusted storage conditions, and added real-time colorimetry monitoring that catches shifts early.

    As a manufacturer, we’ve also grappled with filamentous byproducts that develop if the cooling profile isn’t strictly controlled after crystallization. Leaving this unchecked led to painful purification losses and inconsistent batch yields. Now, our process relies on staggered cooling and controlled stirring, ensuring uniform morphology in every lot. Chemists who use our acid for scale-up appreciate these small but critical differences, often noting reduced filtration time and greater yield in subsequent steps.

    We regularly engage with regulatory authorities, especially REACH and FDA process auditors, who conduct deep dives into our records and sampling. Our documentation stretches back multiple years to ensure every drum carries full traceability. If an auditor requests five-year stability data or impurity profiles from three years ago, we bring out verified archives. This direct accountability separates a dedicated manufacturer from the noise of downstream resellers.

    We understand that supply interruptions or unexpected variances slow innovation. To avoid these pitfalls, we keep extra capacity and safety stocks of validated 4-Pyridazinecarboxylic Acid, protected in isolated, climate-controlled facilities. Our logistics partners receive detailed instructions, and our crews are trained to inspect packaging and labeling for accuracy — all born from hard-learned lessons battling lost shipments years ago.

    Quality by Experience, Not Marketing

    Producing a benchmark-quality 4-Pyridazinecarboxylic Acid requires more than following a flowchart. We’ve tracked product journey from synthesis, to purification, through drying, and onward to packaging, each step gained through years of attention to detail. Our chemists stay vigilant about process changes, running pilot batches under new parameters before considering even minor adjustments.

    We avoid adopting the latest trends blindly. While digital batch tracking and automated analysis tools help, nothing substitutes for periodic hands-on review by seasoned chemists. We empower our staff to call production halts at the first sign of deviation. Chemistry rewards those who foster a culture of responsibility; we foster that every day.

    Feedback from returning customers tells us we are making a difference. They trust the reliability of our 4-Pyridazinecarboxylic Acid over cheaper knock-offs or generic catalog lots. Consistency and quality don’t arise by chance; they come from a sustained effort, deliberate checks, and willingness to invest in improved controls.

    Stacking up against other pyridazinecarboxylic acids on the market, we focus on purity, accurate assay, and minimizing contaminants. We don’t compromise on drying steps, nor do we push product out the door to fill quotas. Each kilogram reflects a chain of careful decisions made by people who care as much about your outcomes as you do.

    Continuous Improvement: Our Commitment

    We continually invest in improved analytical instrumentation and process refinement based on real-world usage data. Engaging directly with our customers — whether pharmaceutical, agricultural, or academic — means we collect direct feedback about issues and opportunities to drive better outcomes.

    Any incident, however rare, triggers a team review followed by targeted upgrades to procedures and equipment. We believe transparency builds trust, and our doors remain open to questions or site visits. You can expect practical, honest answers from those who make the product, not a remote sales desk.

    From developing new drying protocols to reduce particle caking, to replacing or upgrading reactor linings after wear, every step comes from scrutiny of data, frontline staff input, and ongoing dialogue with the people who rely on our 4-Pyridazinecarboxylic Acid. We see ourselves as your partners in discovery, process improvement, and ongoing production.

    If your business or research needs a stable, high-purity supply of 4-Pyridazinecarboxylic Acid, consider a manufacturer who views quality as the outcome of shared responsibility and continuous learning. We stand ready to supply what you need, answer your technical questions, and support your goals — drawing on generations of practical knowledge in chemical production. Everything we have learned and continue to learn goes into every drum and every handshake.