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4-Propoxylmandelic Acid

    • Product Name 4-Propoxylmandelic Acid
    • Alias 4-Propoxy-2-hydroxyphenylacetic acid
    • Einecs 212-686-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    571842

    Name 4-Propoxylmandelic Acid
    Cas Number 1674-47-3
    Molecular Formula C10H12O4
    Molecular Weight 196.20
    Appearance White to off-white solid
    Melting Point 109-113°C
    Solubility Soluble in water and organic solvents
    Synonyms 4-(Propoxy)mandelic acid; p-Propoxymandelic acid
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place, tightly closed container
    Smiles CCCOC1=CC=C(C=C1)C(C(=O)O)O
    Inchi InChI=1S/C10H12O4/c1-2-6-14-9-5-3-8(4-7-9)10(12)13/h3-5,7,10,12H,2,6H2,1H3,(H,13,14)

    As an accredited 4-Propoxylmandelic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle with tamper-evident cap, labeled “4-Propoxylmandelic Acid, 100g,” including safety symbols, batch number, and handling instructions.
    Shipping 4-Propoxylmandelic Acid is shipped in tightly sealed containers to prevent contamination and moisture absorption. Packages are clearly labeled according to chemical safety regulations. Standard shipping typically follows local and international guidelines, ensuring appropriate handling and temperature control as required. Hazard documentation and safety data sheets are included with every shipment for compliance.
    Storage 4-Propoxylmandelic acid should be stored in a tightly sealed container, protected from moisture and light, in a cool, dry, and well-ventilated area. Keep it away from incompatible substances such as strong oxidizing agents. Avoid extreme temperatures and sources of ignition. Proper chemical labeling and restricted access are recommended to ensure safe storage and prevent accidental exposure.
    Application of 4-Propoxylmandelic Acid

    Applications of 4-Propoxylmandelic Acid in Industrial Manufacturing

    As a specialized manufacturer of 4-Propoxylmandelic Acid, we deliver consistent, high-purity material to support critical industrial sectors. This compound plays a vital role in several advanced synthesis applications, each with specific compliance, usage, and process integration needs.

    1. Pharmaceutical Intermediate for β-Blocker Synthesis

    Downstream pharmaceutical manufacturers rely on our 4-Propoxylmandelic Acid in the multi-step synthesis of active pharmaceutical ingredients (APIs) for selective β-blockers. In commercial production lines, it enters as a chiral building block, where control of enantiomeric purity is essential for regulatory approval and therapeutic safety, demanding strict process validation and documentation. This application requires careful adjustment of addition rates based on batch scales and yields during amidation and subsequent reduction steps. End products undergo rigorous QC as prescribed by international pharmacopoeias.

    Industry compliance standards

    • U.S. FDA 21 CFR Part 211 (Current Good Manufacturing Practice for Finished Pharmaceuticals)
    • European Pharmacopoeia (EP) monographs for β-blockers
    • ICH Q7A: Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • Chinese Pharmacopoeia (ChP) applicable sections for APIs

    Typical usage ratio

    • 5–12% w/w in chiral intermediate phase; levels set by target molecule yield and conversion rates in reaction sequence

    Downstream process integration

    • Added during chiral precursor coupling and subsequent amination steps for API assembly; managed under controlled temperature and inert atmosphere

    Final product types

    • Metoprolol, Atenolol base and salt APIs
    • Propranolol intermediates
    • Finished β-blocker oral tablets and injectables

    2. Intermediate for Advanced Agrochemical Actives Manufacturing

    In advanced agrochemical synthesis environments, 4-Propoxylmandelic Acid serves as a key intermediate for selective herbicide and fungicide molecular frameworks. Its use maximizes yield and facilitates downstream transformations due to its unique propoxy functionality. Regulatory compliance dictates strict batch recording, trace impurity identification, and adherence to safety data requirements during formulation. Production engineers adjust addition rates in response to target compound complexity and residue profiling as per government-mandated technical dossiers.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • European Union Regulation (EC) No 1107/2009 on plant protection products
    • U.S. EPA guidelines on pesticide chemical manufacturing (40 CFR Part 158)
    • ISO 9001:2015 Quality Management System for chemical intermediates

    Typical usage ratio

    • 3–8% w/w depending on agrochemical backbone structure and conversion protocols in early synthesis stages

    Downstream process integration

    • Fed into coupling or cyclization reactions for triazole or phenoxy derivatives under monitored pH and reflux conditions

    Final product types

    • Selective post-emergence herbicide technicals
    • Azole-based fungicide actives
    • Ready-to-use agrochemical formulation concentrates

    3. Precursor in Specialty Aromatic Resin and Polymer Synthesis

    Manufacturers of aromatic resins and specialty copolymers use 4-Propoxylmandelic Acid for introducing controlled hydrophobic and aromatic characteristics into polymer backbones. It enters batch reactors during polycondensation, influencing key resin features such as molecular rigidity, melting point, and compatibility with organic additives. Industry QA teams often set feed levels to balance process viscosity with end-user specification sheets, ensuring compliance with polymeric additive and crosslinker regulations for industrial coatings and adhesives.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for polymer substances
    • RoHS (Restriction of Hazardous Substances) for polymeric components in electronics and coatings
    • ASTM D256 (Standard Test Methods for Plastics)
    • ISO 14001:2015 for environmental management in resin production

    Typical usage ratio

    • 1.5–6% w/w in pre-polymerization charge, adjusted for target product hardness and glass transition temperature

    Downstream process integration

    • Dosed into polycondensation or copolymerization kettles; process temperature and reactant ratios optimized for desired resin properties

    Final product types

    • UV-curable aromatic resins
    • Functional copolymer additives for electronics encapsulation
    • High-performance adhesive formulations for industrial assembly

    4. Building Block in Advanced Dye and Pigment Production

    Dye and pigment chemists select 4-Propoxylmandelic Acid when synthesizing propoxy-substituted aromatic dye components to achieve high hue intensity and increased lightfastness. This compound is fed into diazotization or condensation steps as a controlled aromatic source to ensure consistent chromophore formation, with dosing determined by the spectral absorption requirements of end-use applications in textile and plastics coloring. Quality inspection teams must verify batch purity to align with international pigment traceability and safety documentation.

    Industry compliance standards

    • ISO 9001 for colorant manufacturing quality systems
    • EN71-3:2019 for toy and textile pigment migration
    • Oeko-Tex Standard 100 dye residue limits
    • ASTM D3964 for colorant compositional analysis

    Typical usage ratio

    • 0.5–2% w/w depending on target dye molecular structure and required shade intensity; validated by spectral QC

    Downstream process integration

    • Fed into aromatic diazotization or condensation synthesis stages, usually before sulfonation or metallation processes

    Final product types

    • Propoxy-substituted azo and anthraquinone dyes
    • Industrial textile and plastic pigments
    • High-purity colorants for printing inks

    5. Precursor in Chiral Catalyst and Ligand Preparation

    In asymmetric synthesis processes, 4-Propoxylmandelic Acid is utilized for constructing chiral catalytic ligands used by fine chemical manufacturers. It is introduced into ligand assembly reactions which demand high levels of stereoselectivity and must eliminate trace metal contaminants to comply with GMPs for fine chemical intermediates destined for pharmaceutical contract synthesis. Usage rates are carefully determined by complexation studies and reaction scale, ensuring high catalytic turnover and batch-to-batch consistency.

    Industry compliance standards

    • ICH Q11 (Development and Manufacture of Drug Substances)
    • ISO 17025 chemical laboratory accreditation
    • USP General Chapter <823> for radiopharmaceutical production (applicable for chiral ligand applications)
    • OECD Good Laboratory Practice (GLP) for intermediate chemicals

    Typical usage ratio

    • 1–3% w/w in catalytic ligand precursor mix, set by stoichiometric balance for target chirality outcome

    Downstream process integration

    • Added to chiral ligand synthesis stage under controlled atmosphere; typically before metal complexation and purification by chromatography

    Final product types

    • Chiral phosphine and amide ligands for asymmetric catalysis
    • Customized enantioselective catalysts for pharmaceutical and agrochemical synthesis
    • Specialty process intermediates for fine chemical output

    6. Intermediate for Custom Fragrance Compound Synthesis

    Fragrance compound developers employ 4-Propoxylmandelic Acid to synthesize propoxy-functionalized aromatic aldehydes and alcohols with distinctive olfactory profiles. The compound is introduced in controlled aldehydation or reduction steps, where feeding regimen is determined by desired note intensity and product volatility. Compliance checks include batch traceability and limits on residual solvents and impurities, following international standards for fragrance safety assessment in consumer products.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • EU Cosmetics Regulation (EC) No 1223/2009 for fragrance raw materials
    • ISO 22716:2007 Good Manufacturing Practices (GMP) for cosmetic products
    • RIFM (Research Institute for Fragrance Materials) toxicological guidelines

    Typical usage ratio

    • 0.2–1% w/w during key aromatic transformation stages, optimized for olfactory strength and blend compatibility

    Downstream process integration

    • Input into aroma compound synthesis after purification and characterization; applied before formulation of final fragrance blends

    Final product types

    • Synthetic aromatic aldehydes with propoxy groups
    • Fine fragrance compound bases for perfumes and personal care
    • Flavor and fragrance ingredients for home care formulations
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    Certification & Compliance
    More Introduction

    Introducing Our 4-Propoxymandelic Acid: A Reliable Choice Backed by Manufacturing Know-How

    Proven Chemistry in Practice

    We’ve spent years refining the art and science of producing 4-Propoxymandelic Acid. In the specialty chemicals industry, small changes in process control or raw material quality can ripple across a customer’s entire product line. Over the past decade, our chemists and operators have worked side-by-side to ensure that every batch of 4-Propoxymandelic Acid achieves clarity, consistency, and high purity — these aren’t just words to us. They mark the difference between smooth, reproducible results and wasted material in the downstream uses that depend on this intermediate.

    You might see 4-Propoxymandelic Acid referred to by its chemical formula or as an intermediate for more complex pharmaceutical and agrochemical compounds. The critical factor lies in its purity profile and the ability to deliver the correct isomer without unwanted by-products. We’ve experimented with various synthetic routes and always come back to a process that supports clean conversion, easy filtration, and reliable crystallization. Yields matter, but the focus remains on building a reputation batch after batch. Our technical teams keep the process under tight temperature and pressure regimes using automated controls, so once the product rolls off the line, it consistently matches analytical targets.

    Quality That Withstands Real-World Demands

    In practical work, 4-Propoxymandelic Acid shows up as a fine crystalline powder with a well-defined melting range. We analyze each lot using HPLC and NMR. Experience tells that small shifts in moisture or by-product content eventually show up as troubleshooting headaches for clients scaling up synthesis. That’s why our teams scrutinize each batch report instead of simply sending standard paperwork through the pipeline. We rely on modern analytical tools, but old-fashioned diligence holds equal value. Crews in our packing department wear gloves out of habit, not policy, because they take pride in the product’s condition all the way to the drum or bag.

    While competitors often ship to specification, we listen to feedback from chemists running glassware or plants where a single percent deviation in a side impurity throws hours or days off production blocks. We run multiple small-scale tests after each production campaign, blending deep knowledge of the chemistry with an awareness of how the compound actually performs across reactions such as etherification or hydrolysis. It’s this hands-on experience — not just a certificate — that shapes our decisions.

    A Core Building Block for Multiple Industries

    Demand for 4-Propoxymandelic Acid has grown as pharmaceutical syntheses trend toward greater selectivity and fewer steps. Companies look for ways to build complex molecules with fewer purification cycles. Our 4-Propoxymandelic Acid supports these goals because chemists can rely on its structural consistency. Clients using it as a starting point for beta-blocker intermediates, antibacterial compounds, or niche agrochemical actives come back to us for more because product uniformity translates directly into better project timelines and less project risk.

    Beyond pharmaceuticals, research labs order our 4-Propoxymandelic Acid for its sharp analytical purity—ensuring that reaction screens deliver clean, interpretable outcomes. Material scientists turn to our production lots when prototyping surfactant variants or designing monomers where any trace impurity complicates polymerization. We’ve seen our products travel from kilo-labs all the way up to full-scale plants, so the bridges we build with partners aren’t just transactional—we troubleshoot, refine, and optimize together.

    Model, Packing, and Real-World Application

    We offer our 4-Propoxymandelic Acid most frequently in bulk powder form, packaged to keep easy access while protecting against moisture and cross-contamination. Feedback from regular users steered us away from ornate packaging toward simple, safe, and resealable containers. Our drums and bags offer stability during long transit and storage periods, and every pack receives a documented batch number for traceability. Back at the factory, we maintain a sample retention program, so any claims or concerns receive a rapid response backed by records and actual retained material.

    Sourcing departments ask about solubility, bulk density, and reactivity under typical lab or plant conditions. Standard lots of our 4-Propoxymandelic Acid dissolve easily in ether alcohols, ethyl acetate, or aqueous bases for clean downstream reactions. We’ve run stress tests across ambient, refrigerated, and slightly elevated storage to confirm stable handling properties over reasonable supply chain durations. Customers working at kilo scale or larger appreciate that our product crystals flow and scoop without dust issues, a result of both grinding methodology and dehumidified production spaces.

    Key Differences: What Sets Our Product Apart

    Many chemical suppliers focus on minimum purity claims and short lead times. We recognize those features count for procurement teams, but real value surfaces during scale-up or in regulatory filings. Competing products often vary lot-to-lot, even with a similar chemical name on the invoice. Over the years, we’ve had customers send competitor samples for analysis following unexplained side reactions at their labs. Nine times out of ten, differences show up in minor organic by-products or batch-to-batch color and solubility shifts. Our technicians run head-to-head tests, then adjust our recrystallization or extraction step to suppress the troublesome impurity — not everyone acts on that feedback so directly.

    In some markets, “off-brand” 4-Propoxymandelic Acid fluctuates in grain size and shelf-life, sometimes leading to clumping, caking, or rapid discoloration during humid transport. Engineers here took these reports seriously and invested in improved drying ovens and in-line moisture sensors, so our product stays true from our facility to your stockroom. Warehousing feedback looped back into quality assurance: the result is a physical product that stays free-flowing for repeated sampling and weighs out accurately every time. Whether a customer is blending by hand in a research facility or automating charging in a pilot plant, consistency builds trust.

    Supporting Reliable Synthesis—Not Just on Paper

    We keep logs on every parameter from pressure and solvent quality to drying time. Our records go back several years and drill down to the technician involved—there’s no mystery about procedural changes. This not only helps us with traceability for regulatory teams but supports collaborations with professional chemists facing unique synthesis challenges. Every so often a customer develops a completely novel application and shares a perplexing test result; by referencing detailed historical production data, we work side-by-side to pinpoint or rule out raw material impact.

    From our experience, 4-Propoxymandelic Acid isn’t just a molecule to check off on a list. Its real-world performance shapes how well our own name holds up with repeat clients. A batch with even a slight impurity spike could contaminate thousands of dollars in downstream actives, and any discoloration or moisture pickup creates needless investigation on the customer side. Our metric for “good product” comes from repeat orders with no troubleshooting calls, not just from a generic certificate.

    Meeting Changing Industry Trends with Reliable Expertise

    Recent technological advances mean that more users look at 4-Propoxymandelic Acid as a practical alternative to other mandelic acid derivatives, especially where propoxy groups influence solubility or ease downstream reactions. Industrial users have asked for variants with lower residual solvents, tighter particle size distribution, or specialized documentation to support environmental, health, and safety audits. We’ve responded by upgrading both plant equipment and documentation, streamlining our QC lab workflows to cover extended test parameters on every lot where needed.

    For contract development and manufacturing organizations (CDMOs), agility and reliability count for a lot. We ship product with full analytical support and routinely provide secondary verification from independent labs when customers need data for regulatory bodies in the US, Europe, or Asia. Our existing partnerships with logistics firms mean fast lead times, but we won’t short-circuit QC for short-term gain. Repeat customers benefit from scheduled production runs guaranteeing them both supply security and the analytics they need for internal demands.

    Continuous Improvement Built on Experience

    Our best ideas often come from customer questions or challenges. A request for a lower trace metal content in 4-Propoxymandelic Acid once led us to redesign part of our process piping; another client’s analysis showing early discoloration during long-distance freight inspired us to trial alternate drum liners and anti-caking agents. This iterative approach has helped us cut down rework rates and hold to tighter specification limits each year.

    Technical staff learn production hands-on before moving to quality assurance, so they know what “normal” looks like and can spot subtle inconsistencies long before a problem sneaks through to fill and pack. New analysts calibrate instruments using both commercial standards and our internal reference material. That institutional memory gives us an edge—no one on our team relies solely on a textbook or spec sheet. We value formal training, but cross-team shadowing, mentoring, and incident reviews keep sharp eyes on every job.

    Collaborating With Like-Minded Professionals

    Chemists, engineers, and production managers on both sides of the supply chain respect transparent communication. Each year, we arrange technical visits and audits for key users, opening our process to scrutiny and fresh ideas. That dialogue often sparks improvements—a customer identifies a bottleneck in their synthesis and our technical manager can suggest procedural tweaks upstream. Years of open collaboration build trust and push us to drive every risk lower.

    We actively monitor regulatory shifts and participate in professional networks to keep current on best practices. Our documentation and technical files trace raw material origin, equipment, and process adjustments to cover compliance and liability needs. Production lines adapt for green chemistry targets when clients request fewer hazardous reagents or reduced solvent use. Beyond formal requests, our teams keep their ears open for informal feedback on reaction outcomes, impurity profiles, or even user safety observations; the direct conversation is worth more than polished reports.

    Handling Challenges With Direct Problem Solving

    Supply interruptions, unexpected demand spikes, or raw material issues do enter the picture. Years of honest troubleshooting with partners means we rarely end up in crisis mode, but if a setback arises, our staff work overtime to maintain transparency. Backup inventory, local warehousing, and agreements with trusted freight teams cushion against typical industry shocks. In critical situations—like unexpected port closures or customs delays—we ship partial orders by alternate routes to keep projects on track.

    Sometimes, clients report an unplanned spike in impurity or abnormal reaction behavior. We don’t put the onus back on the client. Instead, teams double-check production records, re-analyze retains, and often run reaction simulations internally to narrow down root causes. Long before any replacement ships or credit is issued, causes and preventive actions receive documentation and review. While the industry moves quickly, word-of-mouth carries immense weight; cutting corners for a quick fix isn’t part of our approach.

    The Long View: Building on Trust and Experience

    Over hundreds of batches and dozens of client applications, 4-Propoxymandelic Acid has taken on a special role for our team. Each lot links back through a chain of material selection, process improvements, customer feedback, and team pride. The final result matters—structural chemistry, analytical report, and how it performs where it counts, in other people’s hands. What makes our product stand apart isn’t just any one feature; it’s the way a community of industry professionals, from production line to laboratory and procurement office, rely on details honed by years of focused effort.

    We see every drum or bag as not just another shipment off the line but as the outcome of daily conversations, years of note-taking, repeated trials, and the kind of know-how that only builds with time. Our investment in 4-Propoxymandelic Acid is more than capital—it reflects respect for those who count on our results. Success earns trust, and that trust sustains the cycle of innovation and integrity, year after year.