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4-Phenoxybenzaldehyde

    • Product Name 4-Phenoxybenzaldehyde
    • Alias 4-Phenoxybenzenecarbaldehyde
    • Einecs 207-952-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    556307

    Name 4-Phenoxybenzaldehyde
    Cas Number 3481-83-4
    Molecular Formula C13H10O2
    Molecular Weight 198.22 g/mol
    Appearance White to off-white solid
    Melting Point 58-62°C
    Boiling Point 324°C
    Density 1.16 g/cm3
    Solubility In Water Insoluble
    Smiles O=Cc1ccc(Oc2ccccc2)cc1

    As an accredited 4-Phenoxybenzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 250g 4-Phenoxybenzaldehyde is packaged in a sealed amber glass bottle with hazard labeling, batch number, and tamper-evident cap.
    Shipping 4-Phenoxybenzaldehyde is shipped in tightly sealed containers to prevent moisture and air exposure. It is packaged according to standard chemical safety regulations, labeled clearly with hazard and handling information. Transportation follows international guidelines for non-flammable organic chemicals, ensuring safe delivery while minimizing risk of contamination or leakage during transit.
    Storage 4-Phenoxybenzaldehyde should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong acids or oxidizers. Protect from moisture and direct sunlight. Ensure proper labeling and keep away from food and drink. Use secondary containment to prevent accidental spills or leaks.
    Application of 4-Phenoxybenzaldehyde

    Applications of 4-Phenoxybenzaldehyde in Industrial Manufacturing

    As the direct manufacturer of 4-Phenoxybenzaldehyde, we support international industrial partners with consistent, high-purity supply tailored for advanced synthesis needs. Below, we outline key application fields, specific regulatory frameworks, recommended dosing practices, integration into client production regimes, and downstream goods manufactured in each segment.

    1. Pharmaceutical Intermediate Synthesis

    4-Phenoxybenzaldehyde serves as a core building block in developing active pharmaceutical ingredient intermediates, especially for molecules requiring selective aromatic aldehyde introduction. Pharmaceutical manufacturers incorporate it in multi-step synthesis pathways for respiratory, anti-inflammatory, and central nervous system agents. The material must conform to stringent industry QC for traceability and impurity profiles in process validation and registration batches.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211 (cGMP)
    • European Pharmacopoeia (Ph. Eur.) Section 2.2.69 Residual Solvents
    • Chinese Pharmacopoeia ChP 2020 for API intermediates

    Typical usage ratio

    • 5–20 mol% in key condensation or reductive amination steps, adjusted for pathway stoichiometry and targeted API impurity limits

    Downstream process integration

    • Charged into stepwise organic transformations—typically in Grignard, aldol, or Knoevenagel-type condensations—and purified for onward reaction or isolation of pharmaceutical intermediates

    Final product types

    • Respiratory drug intermediates
    • CNS agent precursors
    • Non-steroidal anti-inflammatory drug (NSAID) intermediates
    • Custom pharmaceutical building blocks

    2. Agrochemical Synthesis

    Formulators in the crop protection sector employ 4-Phenoxybenzaldehyde as a customizable aromatic aldehyde for synthesis of selective herbicide, insecticide, and fungicide intermediates. Regulatory agencies require clear contaminant tracking and validated impurity profiles in all upstream ingredients destined for agricultural chemical markets.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EU Regulation (EC) No 1107/2009 on placing plant protection products on the market
    • US EPA 40 CFR Part 158 Data Requirements for Pesticides
    • ISO 9001:2015 certified QC documentation

    Typical usage ratio

    • 10–40% molar input in raw material charge for acylation or cyclization reactions during agrochemical actives synthesis, modulated based on product target yield

    Downstream process integration

    • Incorporated in early- or mid-stage condensation reactions forming backbone structures in herbicide and fungicide actives prior to further derivatization

    Final product types

    • Herbicide actives intermediates
    • Insecticide precursor mixtures
    • Fungicide active ingredient cores
    • Agrochemical formulation building blocks

    3. Liquid Crystal Monomer Synthesis

    Producers in the advanced materials and electronics sectors rely on 4-Phenoxybenzaldehyde as a fine chemical precursor for custom liquid crystal monomer synthesis. It enables introduction of ether-benzaldehyde motifs necessary for high-performance, thermally stable liquid crystalline materials used in display and information technology applications. All manufacturing integrates purity assurance and elimination of ionic contaminants.

    Industry compliance standards

    • RoHS Directive 2011/65/EU (electronics materials safety)
    • ISO 9001:2015 for traceability and batch QC
    • REACH Regulation (EC) No 1907/2006 for SVHC control
    • SEMI C93 standard for electronic chemicals

    Typical usage ratio

    • 15–35% by mol in principal condensation and etherification steps during liquid crystal monomer assembly, based on final phase behavior requirements

    Downstream process integration

    • Introduced as a coupling substrate for etherification and formylation, often in presence of metal catalysts or acidic media, followed by polymerization/initiation to target monomer

    Final product types

    • Liquid crystal single monomers
    • Advanced LCD substrate molecules
    • Thermotropic liquid crystal polymer intermediates
    • Smart display raw materials

    4. Aroma and Fragrance Intermediate

    Within the aroma chemical sector, 4-Phenoxybenzaldehyde supports the synthesis of key aromatic intermediates, serving as a controlled precursor for aldehyde-containing fragrance ingredients. Composers in fine and functional fragrances appreciate its provision of sweet, floral, and mildly balsamic notes following tailored downstream functionalization. Compliance with cosmetic and IFRA regulations is critical.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards Update
    • EU Cosmetic Regulation EC No. 1223/2009
    • US FDA Title 21 CFR Part 701 (Cosmetic Labeling)
    • ISO 9225:2012 for aromatic raw materials testing

    Typical usage ratio

    • 3–12% of total aldehyde component input in blended aroma compound synthesis, rates governed by olfactory intensity target and regulatory threshold per end-product category

    Downstream process integration

    • Reacted via controlled acetalization or oxidation in aroma batch reactors, then fractionated to yield pure or blendable fragrance aldehydes

    Final product types

    • Luxury fine fragrance bases
    • Functional perfumery aldehydes
    • Cosmetic grade scent additives
    • Household aroma concentrates

    5. Polymer Modifier and Plastic Additive Manufacturing

    Manufacturers processing engineering plastics and specialty polymers utilize 4-Phenoxybenzaldehyde as a co-monomer or end-group modifier to impart controlled flexibility and aromatic compatibility. The material’s integration occurs during base polymer or oligomer synthesis, requiring rigorous monitoring of incorporation rates and thermal stability in the additive sector.

    Industry compliance standards

    • FDA 21 CFR 177.1520 (plastics for food contact)
    • REACH SVHC Inventory screening for polymer additives
    • UL 94 for polymer flammability testing
    • ASTM D256 for plastics impact properties

    Typical usage ratio

    • 0.5–5% by weight in copolymer batch formulations, refined per desired impact resistance, flow, or aesthetic requirement in finished plastic

    Downstream process integration

    • Introduced at copolymerization or melt blending stage to modify end-chain functionality or co-monomer ratio, followed by extrusion or injection molding

    Final product types

    • Engineering plastic copolymer blends
    • High-gloss cosmetic packaging components
    • Functional thermoplastic additives
    • Custom specialty polymer formulations
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    Certification & Compliance
    More Introduction

    Introducing 4-Phenoxybenzaldehyde: Chemical Performance Built on Experience

    A Reliable Ingredient in Fine Chemical Synthesis

    Producing 4-Phenoxybenzaldehyde has taught us more about the demands of the chemical industry than nearly any other aromatic aldehyde. Every batch that leaves our facility reflects a hands-on understanding of what downstream users face, from fluctuations in raw material quality to the importance of batch-to-batch reproducibility. Our years spent manufacturing this compound—a clear, crystalline substance with a distinct yet manageable aromatic profile—have shown us just how unforgiving processes can be when specifications drift. The structure itself, with a phenoxy group at the para position, opens up a versatile range of chemical reactivity that proves valuable for those in agrochemical synthesis, flavor and fragrance development, as well as pharmaceutical intermediates.

    Physical Specifications That Matter in the Lab and on the Line

    Typical lots of 4-Phenoxybenzaldehyde coming from our reactors deliver a purity above 99%, and this threshold isn’t just a marketing line. We maintain this by routinely monitoring all feedstock and intermediates for trace contaminants—tracking not just the usual suspects, like heavy metals or moisture, but also unseen minor reactants which complicate downstream transformations. Our chemists have observed how even small deviations in melting point or color can foreshadow performance issues later on, especially for customers planning sulfonation, reductive amination, or Grignard reactions. Our team doesn’t skip steps. We run full GC-MS runs on each lot, using both internal and external reference standards, so customers see consistent analytics from shipment to shipment.

    Real-World Applications Meet Manufacturing Know-How

    4-Phenoxybenzaldehyde continues to earn a place in countless syntheses thanks to its robust compatibility with both nucleophilic and electrophilic reagents. Those working on herbicide intermediates often start their research with basic condensation or oxidation reactions—processes where side reactions spell lost time and lost money. Through years of feedback and collaborative trouble-shooting with R&D chemists in these fields, we’ve honed both our production and our technical support. We know small things add up. For instance, even what seems like a routine choice between solvents (toluene, xylene, or DMSO) can influence product yield and purity, so we subject every batch to real-world application testing, benchmarking against typical scale-up conditions our partners describe.

    Standing Apart from Commodity Aromatics

    Looking at the broader market, a lot of “me too” benzaldehyde derivatives appear similar on paper. Spend a day at the bench, though, and their differences become clear. Many competitors deliver 4-Phenoxybenzaldehyde cut from mixed-source raw stock, leading to subtle shifts in molecular weight distributions or troublesome trace impurities. What we produce comes entirely from traceable, single-origin phenol and benzaldehyde streams—removing the headaches associated with batch variability. Having walked many labs through failed scale-ups due to off-brand or blended material, we stay stubborn about using fresh, unblended feedstocks and never changing grade midstream.

    We also keep our analytical protocols transparent. Customers who want to see shift-by-shift chromatograms or spectra from archive files can get them, because we log every production lot back to the shift tech on duty. Accountability and traceability are more than buzzwords here. They’re a way of integrating our expertise directly into each shipment, giving chemists a way to diagnose trouble faster if something unexpected pops up during scale-up or downstream processing.

    Meeting Challenges with Practical Solutions

    Over time, several common pain points have come up among users of 4-Phenoxybenzaldehyde. One involves sensitive catalytic hydrogenations, which can fail if even a few ppm of specific byproducts sneak into the reaction flask. Through regular collaboration with catalytic process engineers, we’ve tuned our process so the final product runs cleaner than regulatory minimums for hydrogenation feed purity. Each production adjustment we make—whether it’s a tweak to reaction temperature, pressure, or purification media—arises directly from a real-world issue observed on-site or with a partner.

    Handling and storage practices also set apart a good chemical from a problematic one. Some users note that poorly stabilized 4-Phenoxybenzaldehyde discolors or forms polymeric residues under ambient air. Our process involves nitrogen blanketing during both synthesis and packaging, minimizing the risk of aldehyde oxidation or unwanted condensation. We use rigid, sealed containers, chosen after stress-testing transport and warehouse conditions typical for bulk and specialty orders. Instead of forgetting about the product once it leaves our gates, we routinely survey clients on performance and shelf life numbers, adjusting protocols in response to what’s happening in practice—not just in theory.

    Firsthand Experience Shapes Usage Advice

    Because we see customer workflows up close, we notice patterns others miss. Intermediates like 4-Phenoxybenzaldehyde often play supporting roles alongside related aromatic aldehydes, such as 4-methoxybenzaldehyde or 4-chlorobenzaldehyde. Switching between them quickly exposes hidden pitfalls. For example, our technical staff has tracked instances when a process set up for our product failed with an imported alternative, due to elevated orthosubstituent levels or different reagent interactions. The lesson here isn’t just about purity—it's about deeply knowing the biochemical reactivity at play, and adjusting both synthesis and support documentation to help customers avoid costly trial and error.

    We’ve also learned that the optimal use case isn’t always obvious. In the world of high-value pharmaceutical development, a seemingly small difference in impurity profile can impact regulatory filings or even affect a drug’s stability. We keep up with evolving pharmacopoeial standards, and share candid advice on suitability for use in new drug applications or food-related processes. Our team regularly contributes feedback to product guides and safety data sheets, shaped by day-to-day monitoring of what actually happens during multi-step transformations, not just what a specification sheet claims should happen.

    Differences That Matter for your Process

    Across the chemical supply chain, users ask us what separates our 4-Phenoxybenzaldehyde from what’s available from traders or resellers. The answer comes down to vigilance in every phase—right from raw material acquisition, through synthesis, to final QC. Our facility sources phenol and benzaldehyde directly from long-term partners, cutting out the risks tied to spot purchases or reprocessed lots. Each step—from monitoring solvent residues to checking for trace isomer content—flows from our own learning curve, shaped by feedback from hundreds of downstream applications.

    We do not blend production from differing batches to meet targets. Instead, each lot traceably matches a strict process window, which simplifies both scale-up and regulatory documentation for our partners. The impact becomes clear when chemists require tight lot-to-lot performance for sensitive applications. Even minor process changes can show up in analytical fingerprints, so we maintain both process stability and full transparency about any deviations, down to the lab notes level. If a customer flags a performance anomaly or a question about trace impurities, our team reviews the original run records rather than guessing or handwaving.

    Learning from Each Customer and Every Run

    Manufacturing specialty chemicals teaches humility. Each client faces unique technical and regulatory environments, and our hands-on production gives us the flexibility to adapt. We’ve seen requirements swing as drug master files change, agricultural laws tighten, or food safety standards shift. Our response is to document and validate every production change in real time and build both automation and human oversight into the QC process.

    Our staff draw on research backgrounds and decades of plant-floor experience. For every improvement implemented—be it a new filtration step or an upgrade to how we dry final product—we test directly against the variables that impact downstream synthesis. The quality you get as a result is built on nearly continuous audit and review, not just occasional inspection. Instead of relying on one finished-goods test, we keep inline analytics that allow active process adjustments to keep every lot inside specification before the final sample leaves the lab.

    Supporting Both Exploratory and Routine Use Cases

    Some of our customers order small volumes for pilot studies or research-scale trials, while others scale up for full plant production. Both groups expect consistency, and our manufacturing protocols reflect that expectation. By maintaining long production campaigns and strict control over batch identity, we give researchers confidence in reproducibility. In larger-scale operations, this stability means fewer headaches during process validation, no unexpected impurity drift, and less rework down the line.

    We do not promise a one-size-fits-all solution. Some applications require tailored support—close consultation on solvent compatibility, or fast feedback when a reaction result deviates from expectations. Our approach blends practical advice drawn from shop floor production and technical troubleshooting, ensuring the compound you receive fits the intent of your synthesis, not just the spec on a label.

    Regulatory and Compliance: Up to Date as Standards Evolve

    Regulations governing aromatic aldehydes have shifted dramatically in recent years, especially in fields such as food flavoring or pharmaceutical synthesis. Because we drive our own compliance process, we routinely refresh our documentation to reflect the latest international standards. Whether you work under REACH, GMP, or US FDA guidelines, our production and testing records remain available for technical audits. If a new contaminant emerges on a regulatory “of interest” list, our analytics team validates our production against those targets, and we update customers proactively.

    Direct production control means we can field customer compliance questions in real-time, from impurity questions to residual solvent data. Our archives date back years, allowing clients to track process evolution and regulatory alignment. This transparency helps those preparing for agency filing or external review, reducing the risk of unforeseen delays or corrective actions during audit.

    Choosing Experience Over Middlemen

    Our background in full-cycle chemical manufacturing sets us apart from market intermediaries. We know where each drum starts, how it moves through synthesis, purification, and final finishing, and exactly how it ends up with the customer. Communication with both experienced process chemists and newcomer R&D teams happens directly—no added steps or confusion. When something needs troubleshooting, our own staff who designed and ran the batch take the call, short-cutting guesswork and speeding up resolution.

    Those who have tried both brokered and direct manufacture supply routes tell us the difference quickly becomes clear. Direct control means rapid response to unusual batch outcomes, and our familiarity with every stage (from bulk reaction to chromatographic cleanup) gives us a leg up in flexibility. Rather than simply distributing, we stand fully behind our product each time a new requirement or process variable arises.

    Responsibility for the Environment, and for People

    Our manufacturing roots drive a commitment to more than just product performance. We have upgraded facilities repeatedly to meet stricter waste treatment and emissions control benchmarks. We track and minimize the use of hazardous auxiliaries, regularly reviewing alternative solvents and greener workup techniques. Every batch of 4-Phenoxybenzaldehyde produced under these constraints now leaves a smaller footprint, both locally and downstream.

    Our teams work with full PPE and continuous exposure monitoring, recognizing that sustainable production protects both people and product. We apply scrap reduction and energy efficiency best practices learned through audits and in-house Kaizen campaigns. Our focus on process safety and operator wellbeing means your product comes from a workspace as rigorously controlled as any research lab.

    Why Our 4-Phenoxybenzaldehyde Means More than a Product

    Having walked every production line from raw material drum to finished flask, we know 4-Phenoxybenzaldehyde doesn’t just fill a line on a chemical inventory. It supports entire synthesis campaigns, acts as a key building block in molecules that define the next generation of powders, flavors, and treatments, and ultimately answers to a chemist’s sense of precision and reliability. Each drum we produce is backed by the experience of a manufacturing crew that takes personal pride in seeing every downstream process run smoothly.

    You can expect consistency in every lot, direct knowledge from those who made it, and openness to feedback on process or purity. Through constant dialogue with our users, transparent documentation, and ongoing investment in cleaner, safer production, our team delivers more than a product—we provide a partnership forged on real-world experience and built for the challenges of tomorrow’s fine chemistry.