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4-Nitro-1-Naphthylamine

    • Product Name 4-Nitro-1-Naphthylamine
    • Alias 4-Nitro-1-naphthalenamine
    • Einecs 202-051-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    324933

    Chemicalname 4-Nitro-1-Naphthylamine
    Casnumber 778-37-2
    Molecularformula C10H8N2O2
    Molarmass 188.18 g/mol
    Appearance Yellow to orange crystalline powder
    Meltingpoint 159-162°C
    Solubilityinwater Slightly soluble
    Density 1.40 g/cm³
    Iupacname 4-nitronaphthalen-1-amine
    Pubchemcid 13332

    As an accredited 4-Nitro-1-Naphthylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle labeled "4-Nitro-1-Naphthylamine, 99%, 25g." Package features hazard symbols, batch number, and safety precautions.
    Shipping **Shipping Description for 4-Nitro-1-Naphthylamine:** 4-Nitro-1-Naphthylamine should be shipped in tightly sealed containers, clearly labeled, and compliant with relevant hazardous materials regulations. Store in cool, dry conditions away from incompatible substances. Ensure appropriate hazard communication, and follow all local, national, and international transport guidelines for chemicals. Handle with suitable protective measures during transit.
    Storage **4-Nitro-1-Naphthylamine** should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and acids. Protect from light, moisture, and sources of ignition. Properly label the container, and store in a designated chemical storage cabinet for hazardous or toxic materials, following relevant safety protocols and regulations.
    Application of 4-Nitro-1-Naphthylamine

    Applications of 4-Nitro-1-Naphthylamine in Industrial Manufacturing

    4-Nitro-1-naphthylamine supports multiple core chemical synthesis processes in modern industry, especially as a key intermediate in sectors demanding strict quality control and proven downstream conversion. As an original manufacturer, we focus on precise formulation requirements and regulatory frameworks throughout the value chain. All application scenarios detailed below derive from actual industry implementation.

    1. Synthesis of Naphthylamine-Based Azo Dyes for Textiles

    Producers of synthetic textile dyes utilize 4-Nitro-1-naphthylamine as a diazo component in formulating specific naphthylamine-based azo dyes, especially for cotton, viscose, and polyamide applications. Typical recipes employ this intermediate for red, orange, or brown dye families, where purity and conversion yield directly affect shade consistency and fastness properties. The compound enters the diazotization process, coupling with aromatic amines under controlled pH and temperature to generate finished dye cakes or solutions, which are subsequently standardized for various textile applications.

    Industry compliance standards

    • OEKO-TEX® STANDARD 100
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals, EU)
    • ISO 105-C06 (tests for colorfastness in textiles)

    Typical usage ratio

    • 5–15% of total active dye mass depending on depth of shade formulation; dosage adjusted to molecular weight and color strength target.

    Downstream process integration

    • Loaded in diazotization reactors, then immediately enters coupling with phenolic or heterocyclic couplers; post-process purification by precipitation or filtration before homogenization and product packaging.

    Final product types

    • Powder and granular textile dyes (direct, acid, disperse types)
    • Liquid dye concentrates for continuous dyeing systems
    • Standardized dye blend formulations for mass textile production
    • Reactive split dyes for fiber-reactive processes

    2. Pharmaceutical Intermediate for Antimicrobial Formulations

    In pharmaceutical manufacturing, 4-Nitro-1-naphthylamine plays a direct role as an intermediate in the synthesis of select antimicrobial agents, including certain sulfonamide derivatives. The material primarily supports facilities employing batch or continuous synthesis, where it undergoes nitro reduction and subsequent sulfonation to assemble core active pharmaceutical ingredients. Stringent API-grade requirements and document control apply throughout, from raw material qualification to isolation and purification of the functional group-bearing derivative.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • U.S. Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.) monographs for relevant APIs
    • FDA 21 CFR Part 211

    Typical usage ratio

    • Initial charge represents 0.08–0.25 molar equivalents per 1 mol product API target; exact ratio designed based on yield projections in hydrogenation and sulfonation.

    Downstream process integration

    • Introduced in synthesis batch as primary aromatic amine component, subjected to catalytic hydrogenation and sulfonation; intermediate isolation by vacuum filtration, followed by crystallization and drying.

    Final product types

    • Bulk active pharmaceutical ingredient (API) intermediates for sulfonamide antimicrobials
    • Finished antibiotics requiring subsequent tableting or capsule filling
    • Sterile API precursors for parenteral formulations
    • Crystalline reference standards for in-house quality control

    3. Intermediate in Rubber Chemical Accelerators Production

    Chemical plants manufacturing vulcanization accelerators for the rubber industry rely on 4-Nitro-1-naphthylamine as a precursor in specific thiazole-based and sulfenamide accelerator syntheses. Its role is pivotal in controlling the molecular structure and reactivity profile of the final accelerator, which determines processing safety and end-use mechanical properties. The compound is typically transformed via amination and condensation steps with sulfur sources or thiol donors, requiring precise upstream material handling and batch control.

    Industry compliance standards

    • ASTM D4678 (Rubber Compounding Materials—Accelerators—Classification)
    • ISO 9001:2015 Quality Management Systems
    • China GB/T 21841 (Vulcanization Accelerators)
    • REACH (EC 1907/2006) compliance for rubber chemicals

    Typical usage ratio

    • 2.5–8% by weight relative to batch scale of intended accelerator; optimization based on reaction yield and end-use performance requirements.

    Downstream process integration

    • Charged to reaction vessels preceding condensation with sulfur donor under controlled heat and agitation; resulting accelerator crystallized and dried, prior to screening and blend formulation.

    Final product types

    • Semi-finished granules of thiazole or sulfenamide accelerators
    • Fully formulated rubber accelerator masterbatch for tire and automotive rubber
    • High-purity accelerator powders for specialty rubber goods
    • Pelletized accelerator blends for industrial hose, belt, and cable production

    4. Building Block for Organic Pigment Synthesis

    Producers of advanced organic pigments for paints, coatings, and plastics employ 4-Nitro-1-naphthylamine as a synthetic building block in the generation of naphthol pigment structures, essential for high-performance coloration in industrial and automotive applications. The compound enters the pigment synthesis workflow during the initial coupling and cyclization reactions, where its role is to form stable chromophoric systems; precise process control supports particle size uniformity and enhanced lightfastness in the final dispersible pigment products.

    Industry compliance standards

    • ISO 1248 (Pigments—Specifications and methods of test for organic pigments)
    • ASTM D5531 (Organic Pigments for Coatings)
    • EN 71-3 (Safety of Toys—Migration of Certain Elements, for pigments in toys and coatings)
    • RoHS Directive 2011/65/EU (for colorants in electrical/electronic equipment)

    Typical usage ratio

    • 1–6% of dry pigment precursor batch, depending on the required shade depth and target dispersion stability in the finished colorant system.

    Downstream process integration

    • Added during primary coupling under pH and temperature control, then cyclization and filtration; pigment paste or powder isolated via spray drying or vacuum filtration, before performance additives are blended.

    Final product types

    • Naphthol-based pigment powders for industrial paints and high-gloss coatings
    • Dispersible pigment pastes for thermoplastics and masterbatch concentrates
    • Pigment preparations for architectural and decorative paint systems
    • Colorant dispersions for specialty inks

    5. Chemical Reagent for Diagnostic Test Kits

    4-Nitro-1-naphthylamine is integrated as a chromogenic agent or indicator component in certain biochemical diagnostic test kits for laboratory and clinical analysis. Diagnostic manufacturers require high-grade purity to ensure specificity and minimize background interference. The raw material is included in the formulation step associated with colorimetric or enzymatic reactions, contributing to sample detection reliability and reproducibility, such as in enzyme substrate assays and urinary screening kits.

    Industry compliance standards

    • ISO 13485:2016 (Medical devices—Quality management systems)
    • Clinical and Laboratory Standards Institute (CLSI) guidelines
    • FDA 21 CFR 820 (for in vitro diagnostic device manufacturing in the US)
    • IVDR (EU In Vitro Diagnostic Medical Devices Regulation 2017/746)

    Typical usage ratio

    • 0.05–0.2% by mass of test reagent blend; formula tailored to substrate load and detection sensitivity needed per test format.

    Downstream process integration

    • Blended with buffer and enzyme-containing solutions during pre-mix or lyophilization (freeze-drying); final test strips or liquid kits assembled under controlled environmental conditions; QC testing for color intensity and stability.

    Final product types

    • Enzyme-substrate reaction diagnostic strips (e.g., for hydrolytic enzyme detection)
    • Liquid reagent kits for clinical laboratories
    • Pipette-ready colorimetric assay solutions
    • Screening kits for metabolic analyte quantification
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    Certification & Compliance
    More Introduction

    Introducing 4-Nitro-1-Naphthylamine: A View from the Manufacturer’s Floor

    Working in the chemical manufacturing field offers a unique perspective on specialty compounds like 4-Nitro-1-Naphthylamine. We see the journey from raw material to finished product with every batch we run. Our experience producing this fine chemical goes back years, not seasons. It’s an aromatic amine whose importance stretches beyond its chemical structure; each shift, each inspection, and each quality check adds up to something with genuine impact in applied industries.

    Our Familiar Model of 4-Nitro-1-Naphthylamine

    We manufacture 4-Nitro-1-Naphthylamine according to strict standards that define its chemical makeup as C10H8N2O2. Samples from each lot are tested for assay to ensure purity isn’t compromised. Unwanted impurities such as related naphthylamines and other nitro derivatives are kept well below 0.5%—regular analytical checks are the backbone of keeping quality high. Our finished product appears as a yellow-to-orange crystalline powder, reflecting both the integrity of source materials and careful handling throughout our process.

    Different from the Rest: Real-World Production Distinctions

    What separates this compound from others starts at the origins of production. Batch after batch, our team adjusts temperature profiles, solvent ratios, and reaction times to optimize yield without sacrificing consistency. The naphthylamine family contains several closely related compounds—structural isomers like 2-nitro-1-naphthylamine or non-nitro derivatives can sometimes slip into imported or resold goods, especially where tight process control is absent. Our on-site synthesis reduces the risk of cross-contamination, preventing common quality dips that tend to creep in through outsourced blending or third-party toll processes.

    The 4-nitro position on the naphthyl ring does more than just define its name. In our experience, that nitro group dramatically influences downstream applications in chemical synthesis. The positioning of substituents in aromatic amines impacts both reactivity and specificity in custom reactions, so using the right isomer isn’t just academic—customers have called us after finding alternative materials didn’t behave as expected in azo dye coupling, advanced pigment development, or pharmaceutical intermediates.

    Facing Technical Challenges on the Shop Floor

    Not every operation runs perfectly. Our staff watch temperature controls on reactors during nitration, and they know even a few degrees off-target change can trigger the formation of unwanted isomers or reduce yield. These hands-on adjustments shape what 4-Nitro-1-Naphthylamine becomes at the molecular level. Filter cake compaction, drying routines, and crystal sizing all affect the ease with which downstream users can employ this compound in their own labs, so we pay attention to real handling feedback from long-term customers. Powder flow, wettability, and shelf stability—all dictated by process choices we make right here, not by formulation tables in a distributor’s warehouse.

    Practical Applications Driving Production

    4-Nitro-1-Naphthylamine takes on significant roles in applied chemistry, especially among dye and pigment manufacturers. Its unique electron-withdrawing nitro group, paired with a naphthylamine backbone, offers predictable performance as both a coupling component and intermediate for further chemical elaboration. Chemical research teams working on diazotization reactions or custom dye classes rely on predictable purity for reproducible results. Instrumentation signals for this compound remain sharp and clean, minimizing side reactions and wasted effort.

    In the field of industrial pigments, requests for our product often come paired with questions on batch consistency. Unlike more forgiving anilines, simple isomeric deviations alter shade, brightness, or fastness of the final pigment. We view ourselves as part of the chain that bridges base chemical synthesis and customer’s nuanced formulation tweaks on the factory floor. Having fielded concerns over unpredictable dye shade from alternative sources, our production team maintains direct tights on reaction byproducts that might otherwise change finished properties in subtle or serious ways.

    Another important use comes in the pharmaceutical sector. Sourcing teams in this area are not only focused on technical purity but also on consistent impurity profiles. Their compliance with regulatory requirements is only as reliable as the consistency of the input chemicals. We’ve seen how trace residuals—benign by many standards—raise red flags in pharma labs, causing project delays or even lost approvals. Having direct control over every variable on the synthesis line lets us address these worries at the source, not through repeated new-lot testing and uncertain waivers.

    Safety, Handling, and Worker Knowledge

    Manufacturing 4-Nitro-1-Naphthylamine isn’t only about the product itself. People working with nitroaromatic substances learn fast that environmental and personal safety comes first. Loading reactors with solid naphthalene and metering in nitric and sulfuric acids forms the heart of our process. At the same time, secondary containment and specialized ventilation setups keep our workers safe from dust and offgas byproducts—including low-level nitrous fumes, even under well-ventilated conditions. Employees know the difference between working with benign raw naphthylamine and handling nitrated intermediates; good habits forged by repetition and ongoing training keep our facility not just compliant but reliably safe.

    Real-world handling uncovers details you won’t find on data sheets. Sometimes color shifts in product relate less to batch-to-batch chemistry than to micro-contamination of packaging or drum lining, so we’ve traced and addressed these headaches down to the point of export. Avoiding clumping, caking, or humidity activation in storage is a lesson learned through long winters and sticky summers in our warehouse, not guessed at from online templates.

    Learning through Customer Experience

    Feedback from longtime buyers influenced how we approach production schedules and internal spec targets. Over years in business, we’ve narrowed our process settings because certain pigment and research houses reported lot-to-lot variability, especially when buying from less established suppliers. Some clients, especially in custom synthesis, specify end-use requirements demanding higher than industry “standard” purity. We target a margin above the expected spec to keep all applications—routine or sensitive—running without disruption.

    After-sale technical service brings issues to light that don’t show up on initial certificates. Users of 4-Nitro-1-Naphthylamine in continuous flow systems told us they struggled with fine dusting from oversize particle fractions, so we adjusted our milling sequence and sieve curve. Small tweaks to moisture controls have reduced the odds of product setting up in hoppers. Our development team spends as much time answering troubleshooting calls as it does planning new runs. We see those conversations not as complaints, but as a direct channel for ongoing quality improvement—real manufacturing reliability flows both directions between our floor and your process line.

    Comparing to Other Commonly Used Aromatic Amines

    After years making and handling naphthylamines, we know firsthand how 4-Nitro-1-Naphthylamine sets itself apart from common alternatives like 1-naphthylamine, 2-naphthylamine, or even simpler nitroanilines. The placement and nature of the nitro group influence both environmental hazard profile and reactivity patterns. Unlike plain aromatic amines, this molecule behaves with sharper selectivity in electrophilic substitution reactions. Chemists working on diazo coupling routes utilize this selectivity for targeted molecule assembly.

    Handling profiles also differ. Naphthylamines generally test less volatile and more stable under standard storage conditions compared with other nitroaromatics, but 4-Nitro-1-Naphthylamine’s specific crystalline layout adds distinct flow and solubility characteristics. In pigment and dye work, switching between positional isomers directly affects the brightness and stability of finished products. We field technical queries weekly on apparent mismatches in product performance traced to incorrect isomer selection—one misplaced nitro group can defeat months of downstream color or property optimization.

    Our synthesis crews have worked with nearly every direct competitor material in this chemical class. We see firsthand the subtle differences that arise from both structure and process—whether from locally prepared materials or imported technical grades. Uncontrolled cross-contamination, solvent residues, and unpredictable process aids show up first to our eyes as subtle visual shifts or textural changes, months before they become customer complaints. Our control over every input and every operator step stands as a direct advantage in both predictability and reliability.

    Meeting Regulatory and Market Pressures Head-On

    Today’s market doesn’t leave room for error. Buyers demand full transparency on impurity profiles, trace metals, and batch history. Requirements coming from downstream users—especially in Europe, the US, and Japan—keep pushing us to invest in tighter analytical controls and documentation routines. It’s not just about passing a certificate of assay. We log every batch, every deviation, and every corrective action through a digitized record-keeping system. Auditors see the same trend lines and root cause analyses our floor managers review. Trust grows one uninterrupted record at a time.

    Unlike chemical traders, we have the real-time knowledge to discuss supply continuity and crisis management without filter. Recent years exposed fragile supply links for many feedstocks, pushing global buyers to seek out genuine manufacturing partners capable of running flexible schedules. We keep raw material sourcing as close to home as possible and hedge against extended shortages by maintaining alternate vendor relationships for key intermediates. That way, our output remains steady through global market lulls or transportation snags.

    Solutions for Consistent, Quality Material Supply

    A manufacturer’s solution to supply chain unpredictability doesn’t end with basic procurement. We see firsthand how demand for high-purity 4-Nitro-1-Naphthylamine fluctuates with the global output of azo pigments, and how upstream disruptions ripple into downstream project delays. Our team addresses these reality checks by doing what many traders skip: monitoring actual consumption at customer sites and adjusting run sizes to ensure consistent supply with minimal dead stock. Stockpiling against historical surges isn’t guesswork; it’s based on conversations with pigment labs and pharmaceutical buyers about upcoming launches or production cycles.

    One major improvement we invested in several years ago involves in-house micronization and crystallization controls. By customizing our own final particle sizing, we can ship batches with target flow and solubility properties. That reduces variability for customers formulating dry blends or working with continuous reactors. By not relying on outside grinding or blending, we control dusting, minimize foreign particle introduction, and cut back on repackaging complaints. Consistency isn’t an afterthought—it’s built into every bag and drum we palletize for shipment.

    Data management supports these efforts on our end. Every transfer, drying batch, and sieve test is logged, traceable, and audited against customer feedback. If a challenge emerges—such as an off-odor or odd color note—we pull actual batch records and address the issue directly with the technical staff, not a call center. Repeated learning from these direct lines shapes future production, all in plain language and proven actions.

    Feedback-Informed Continuous Improvement

    Our work in manufacturing 4-Nitro-1-Naphthylamine has taught us to embrace feedback and remain adaptable to real-world needs. Through hundreds of deliveries and customer formulations, we shape our product not around abstract standards but in response to genuine user experience. As project timelines shorten and regulatory hurdles grow, direct insight into why a product matters and how it performs under stress separates meaningful chemical manufacturers from resellers or copycats.

    From the start of a synthesis run through to loading the last truck, the responsibility to produce high-caliber 4-Nitro-1-Naphthylamine rests entirely within our team’s hands. Every course correction—large or small—grows out of knowing the risks, listening to the concerns, and drawing on years of hands-on chemistry. Our commitment shows not in slogans, but in the detailed stories of customer challenges solved and quality delivered, shipment after shipment.

    In our view, 4-Nitro-1-Naphthylamine isn’t just another PDF on the web or a CAS number in a catalog. It’s the sum of careful process work, ongoing partnership with end-users, and a stubborn focus on practical results. That’s the real perspective of those who spend their days making this material—not speculating about it.