Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

4-Nitro-1-Naphthol

    • Product Name 4-Nitro-1-Naphthol
    • Alias 4-Nitro-1-naphthalenol
    • Einecs 209-987-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    742455

    Name 4-Nitro-1-Naphthol
    Cas Number 2581-87-7
    Molecular Formula C10H7NO3
    Molecular Weight 189.17
    Appearance Yellow crystalline powder
    Melting Point 188-191°C
    Solubility Slightly soluble in water; soluble in ethanol and ether
    Density 1.47 g/cm3
    Pubchem Cid 10235
    Inchi Key MBRUYJDFRGLDNY-UHFFFAOYSA-N
    Smiles C1=CC2=C(C=CC(=C2)O)[N+](=O)[O-]C=C1

    As an accredited 4-Nitro-1-Naphthol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, tightly sealed, labeled with hazard warnings; contains 25 grams of 4-Nitro-1-Naphthol fine yellow powder.
    Shipping 4-Nitro-1-Naphthol should be shipped in tightly sealed containers, protected from light, heat, and moisture. Package in accordance with relevant hazardous materials regulations, as it may be classified as a dangerous good. Ensure proper labeling and provide a safety data sheet. Handle with care to avoid spills or exposure during transport.
    Storage 4-Nitro-1-naphthol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and direct sunlight. Keep separate from incompatible substances such as strong oxidizers and reducing agents. Ensure storage area is clearly labeled, and containers are protected from physical damage to prevent spills and exposure.
    Application of 4-Nitro-1-Naphthol

    Applications of 4-Nitro-1-Naphthol in Industrial Manufacturing

    4-Nitro-1-Naphthol is widely used in specialized sectors of fine chemical manufacturing, supporting key processes in pigments, dyes, pharmaceuticals, and analytical reagents. As a direct producer, we supply to industrial clients requiring consistent purity and compliance across each application scenario.

    1. Pigment Intermediate for Organic Colorants

    This material acts as a core intermediate in the synthesis of naphthol-based pigments, especially azo and lake pigments. In pigment manufacturing, it enters diazotization and coupling steps, delivering stable chromophoric properties required for industrial coatings, plastics, and printing inks. Manufacturers value precise control of intermediate purity to minimize chromatic defects and maximize pigment batch reproducibility. Strictly monitored by established pigment standards, the process calls for efficient handling and detailed formulation adjustment based on end color strength requirements and application medium.

    Industry compliance standards

    • EN 71-3 (Safety of Toys – migration of certain elements, EU)
    • ISO 787/24 (General methods of test for pigments and extenders)
    • ASTM D476 (Standard Classification for Dry Pigmentary Titanium Dioxide Products)
    • REACH Regulation (EU), registration of chemical intermediates

    Typical usage ratio

    • 0.5–2.5 molar equivalents relative to diazo precursor; pigment formulation adjusted per targeted hue and dispersion requirements. Ratios modified as per the coupling efficiency and desired pigment load.

    Downstream process integration

    • Used in the coupling stage following diazotization of aniline derivatives. Incorporated in batch reactors or continuous flow lines, with process QC on intermediate solubility and reaction yield.

    Final product types

    • Azo pigments for printing ink
    • Naphthol Red and Orange lake pigments
    • Pigment dispersions for plastics industry
    • Industrial coatings and masterbatch color concentrates

    2. Dyestuff Synthesis for Textile and Leather Applications

    The compound is a preferred intermediate for synthesizing specialized dyestuffs, especially naphthol-based direct and azo dyes with targeted affinity for cellulose fibers and leather. Industrial dye producers depend on precise purity material for controlled shade reproduction and resistance properties. During dye synthesis, 4-Nitro-1-Naphthol enables coupling reactions to introduce nitro aromatic structures, improving color fastness and pH-resistance. Downstream process conditions require consistent input quality to ensure final dye stability and compliance with textile and environmental standards.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (textile safety)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals, Manufacturing Restricted Substances List)
    • GB/T 7573 (pH value determination in textiles, China)
    • EU REACH Annex XVII (Azo dye restrictions)

    Typical usage ratio

    • 0.8–2.0 molar equivalents per coupling component; optimized per dye chromatic intensity, substrate compatibility, and dye bath formulation.

    Downstream process integration

    • Feeds directly into diazo coupling stage under controlled temperature and pH conditions. Batch or semi-continuous synthesis depending on scale and end-use requirements.

    Final product types

    • Direct dyes for cotton and viscose
    • Azo dyes for leather finishing
    • Reactive dye intermediates
    • Dispersed dyestuff powders and granules

    3. Pharmaceutical Intermediate: Synthesis of Naphthol Derivatives

    This compound serves as a key starting raw material for several pharmacologically active molecules and intermediates. Its nitro and naphthol functionalities allow for selective transformations including reduction and substitution chemistries. Pharmaceutical manufacturers utilize 4-Nitro-1-Naphthol in the production route of various APIs, where it enters tightly controlled synthesis lines under cGMP protocols. Production batches require full traceability and analytical validation to comply with global pharmacopoeias and regulatory filings.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP/NF (United States Pharmacopeia/National Formulary)
    • European Pharmacopoeia (Ph. Eur.)
    • 21 CFR Part 211 (US FDA cGMP for Finished Pharmaceuticals)

    Typical usage ratio

    • 0.1–1.0 mole per API synthetic route step; ratio determined by the target molecule and process scale. Pharmaceutical-grade purity required.

    Downstream process integration

    • Introduced in early or mid-stage synthesis sequences, typically in heterocycle formation, coupling, or nitration/reduction processes. Strict QC and trace metals testing implemented at each stage.

    Final product types

    • Naphthalene-based pharmaceuticals
    • Antimicrobial intermediates
    • API impurity profiling standards
    • Custom synthesis molecules for contract R&D

    4. Analytical Chemistry Reagents

    Research and industrial quality control laboratories use 4-Nitro-1-Naphthol as a specialty reagent for detection, titration, and standardization purposes. Its specific chemical structure supports colorimetric determinations in trace metal analysis and advanced research workflows. High-purity material is required to avoid analytical interference. End-users expect detailed CoA documentation and consistent lot performance to ensure valid results in regulated and unregulated laboratory environments.

    Industry compliance standards

    • ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
    • NIST Standard Reference Materials (SRM, USA)
    • GLP (Good Laboratory Practice, OECD)
    • JIS K 8001 (Japan General Rules for Reagents)

    Typical usage ratio

    • 0.01–0.1% w/v in standard analytical solutions; ratio determined by detection sensitivity required and matrix composition.

    Downstream process integration

    • Added during reagent preparation phase. Used for specific colorimetric or spot test protocols, often as a standardizing component in quantitative analysis kits.

    Final product types

    • Analytical reagent kits
    • Trace metal detection solutions
    • Calibration standards for spectrophotometry
    • Research laboratory test formulations

    5. Agrochemical Research: Synthesis of Bioactive Compounds

    This raw material supports the discovery and scale-up synthesis of certain agrochemical candidates, especially in R&D for herbicides and fungicides that incorporate naphthalene backbones. Agrochemical manufacturers employ it in early to mid-stage structure-activity investigations, taking advantage of substitution reactivity. High batch-to-batch consistency is essential for reliable field-testing of pipeline molecules. Process safety and environmental compliance are closely coordinated with major regulatory agencies during pilot and commercial production.

    Industry compliance standards

    • OECD Principles of GLP (Good Laboratory Practice)
    • FAO/WHO specifications for plant protection products
    • US EPA 40 CFR 158 (Data requirements for pesticides)
    • ISO 9001:2015 (Quality management for production and R&D)

    Typical usage ratio

    • 0.05–0.5 mole per product batch in active ingredient synthesis; scaled based on target compound structure and project phase.

    Downstream process integration

    • Used in custom synthesis steps involving electrophilic aromatic substitution or reduction, prior to formulation development and toxicity screening.

    Final product types

    • R&D agrochemical candidates
    • Herbicide intermediates
    • Fungicide research standards
    • Lead compound analogs

    6. Polymer Additive Precursor

    Selected specialty polymer producers utilize this compound as a precursor for functional additives, primarily to modify polymer matrix color, thermal resistance, or UV stability. Its integration into additive synthesis requires controlled feed rates, and mixing protocols tailored to the base polymer and extrusion equipment. Manufacturing sites monitor the quality and lot uniformity to prevent end-product variability, aligning with polymer and plastics industry chemical safety and migration standards.

    Industry compliance standards

    • EU Regulation No 10/2011 (Plastic materials and articles in contact with food)
    • ASTM D2565 (Weathering of plastics and polymeric materials)
    • ISO 11357 (Plastics—Differential scanning calorimetry (DSC) methods)
    • REACH SVHC list (Candidate Substances of Very High Concern)

    Typical usage ratio

    • 0.1–1.0% by weight relative to base polymer; level adjusted based on compatibility, additive loading limits, and end-use specifications.

    Downstream process integration

    • Incorporated into additive synthesis reactor prior to compounding/extrusion. Monitored via inline QC and downstream blending into polymer masterbatches.

    Final product types

    • Polymer additive masterbatches
    • UV-stabilized polymer resins
    • Functional color additive concentrates
    • Specialty plastic packaging compounds
    Free Quote

    Competitive 4-Nitro-1-Naphthol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Understanding 4-Nitro-1-Naphthol From the Manufacturer’s View

    Getting to the Root of 4-Nitro-1-Naphthol Production

    Spending years manufacturing 4-Nitro-1-Naphthol, I’ve learned that the practical side of chemistry rarely shows up in technical brochures. Every chemist reads about aromatic nitro compounds and then hits a winding road of surprises once machinery gets fired up. We make 4-Nitro-1-Naphthol in batches and this isn’t some copy-paste formula; every production run tells its own story. The raw naphthol, the nitro group, and the conditions we use all play their hands in the quality that comes out of the plant. Our experience sits in scaling up from flasks to full reactors, keeping color tight and purity high, pushing impurities down with each tweak. For those interested in why consistency matters, just ask anyone running large-volume dyes or advanced intermediates – even small changes in our product can ripple through entire supply chains.

    A Closer Look at Purity, Color, and Stability

    Years ago our feedstock ran into issues: subtle yellowing that skated right along the edge of acceptable limits. On paper, “specifications met,” but real-world production saw yield drop for one longtime partner. Nobody likes blending away color drift just to pass a spectrometer. So we took a different approach, revisited the purification steps, and pushed the main peak far beyond standard 98%. Not chasing certificates, but actual batch-to-batch stability. Customers noticed the shift immediately: fewer complaints, higher throughput, less time spent troubleshooting downstream.

    Today every drum leaving our facility carries our pride. Product is always dry, dust-free, healthy crystallization—never cakes or clumps, no surprises after transit unless someone forgets to seal the drums. Every shift, we’re not just making specs; we craft material for real-world chemistry work where each little detail on our end might save a half-day’s troubleshooting somewhere else.

    Typical Applications for 4-Nitro-1-Naphthol

    Real feedback comes from the factories that need our product on their lines, not from textbook applications. The dye industry uses 4-Nitro-1-Naphthol as a crucial building block; we’ve received sullen calls whenever the supply is late or unexpected. Color strength and chemical compatibility, especially for azo and anthraquinone derivatives, depend on pure intermediates. Any batch gone wrong means off-shade dye and hours of rework downstream.

    Pharmaceutical and agrochemical synthesis tap into this compound as a coupling agent, or in the case of some medicinal chemists, a bridge to more complex moieties. Reliability and reproducibility form the backbone here: any hiccup from our end delays somebody’s clinical timeline or regulatory approval. The material we ship gets used as the backbone for testing new treatment pathways, often for compounds with commercial value but patient importance as well.

    Laboratory research also dips into our supply. Not every lab can afford to test lots from five suppliers just to reach publishable results. Crystallography experiments, photochemical investigations, mechanistic studies — the crystal form and cleanliness we provide dictates how well scientists can trust their numbers.

    What Differentiates 4-Nitro-1-Naphthol from Other Naphthols?

    Chemists might glance at product names and see small distinctions, but a manufacturer’s lens sees something sharper. The nitro group at the 4-position doesn’t just nudge reactivity; it changes how the compound holds up to processing, reacts in synthesis, even dissolves or stains glassware. 1-Naphthol on its own seems straightforward, more people use it as an antioxidant or precursor, it’s cheap and everywhere.

    Add that nitro at the 4-spot and you get very different behavior. Our customers who tried switching to alternative isomers or low-end blends found compatibility issues, color leaching in dyes, and unpredictable melting points. Even subtle differences — color hue under daylight, reactivity in diazotization — can disrupt a workflow. We hear it most from teams juggling tight specs for specialty pigments or medical intermediates: there’s just no clean substitute once you get to scale.

    Key Differences in Manufacturing and Handling

    Most differences stem from process control. Nitro compounds demand careful conditions: too much heat, unmonitored reaction time, or bad raw material, and you’re left with over-nitrated side products or dark-colored offcuts. Our team keeps a constant eye on temperature gradients and agitation during nitration. Years of adjusting filtration and washing steps mean we now dial in on “white” and “off-white” instead of just chasing a melting point.

    Our product features tightly managed particle size, which dissolves evenly in most solvents used in downstream syntheses. Some end users needed even finer fractions for certain high-end dyes, so we adopted dedicated grinding and sieving steps—no generic blending, just straight effort shaped by repeated customer feedback.

    Safety gets special treatment. Unlike 1-naphthol, the nitro group brings potential for sensitivity to static and hazards during transfer. Any operator with experience in exothermic organic nitration knows a sloppy spill or loose spark can wreck a week’s line output. We aim for safe, straightforward packaging and shipping, so our partners never face surprises opening our drums or bags.

    Quality Control: Moving Past the COA

    A COA will never show late-night phone calls between plant operators and QC analysts double-checking a questionable spot on the TLC. That’s the world we live in as manufacturers. 4-Nitro-1-Naphthol doesn’t just walk from test tube to customer hands: it’s managed at every station. Our process begins at inbound inspection. Raw materials get checked not just for identity but for trace moisture or suspicious scents that might signal degradation.

    Each batch crosses multiple purity thresholds. HPLC, melting range, residue on ignition, and appearance—all get checked, logged, and, if needed, reviewed as full batch investigations. During a few runs, rejecting half the container filled with “acceptable” product taught us what costs money in the short term saves reputation and keeps customers.

    Only routine repetition teaches the value of these tight controls. Every new hire learns not just textbook methods but actual results from our own lines: how particle size shifts between different grades of antisolvent, or how faint impurities can poison an entire color run two steps down the chain. It isn’t just about the numbers, but the production discipline running behind them.

    Product Specifications and Why They Matter to the End User

    Chemistry in the real world never sits inside certificates and perfect graphs. The actual melting point, moisture content, and solubility we guarantee end up written into someone else’s manual or SOP. One of our key customers ran into crystal habit changes from a competitor’s batch and had to pull an entire week’s output from final QA. They came back to our drums after learning the hard way: small differences in particle handling translate to hours saved or lost in large reactors.

    Our most common models stick to a minimum purity of 98%, most testing above 99%. Users requiring more stringent controls for pharma or electronics work routinely request tailored packages, fresher runs, and certification on extraneous metals. We keep these requests logged and hold sample retention for critical supply chains—because in our world, recall isn’t a word for “what if,” but “let’s check just in case.”

    Moisture is another hidden enemy. Our team integrates vacuum packing and desiccant checks. Any increase in residual water in a drum means trouble for those handling moisture-sensitive coupling or oxidation reactions. Customers have called after receiving shipment from others, bags clumped, unusable for high-precision work. We keep extra eyes on drying, storage, and even suggest shipping method based on season and destination climate.

    Packaging and Supply: Past Experience Shapes Our Practice

    Handling specialty chemicals means every mistake echoes through the supply chain. We learned early that poor packaging turns good product into expensive waste. Our journey with 4-Nitro-1-Naphthol saw switchovers from paper sacks to moisture-proof fiber drums and finally to lining all large-batch drums with foil and vacuum seals. Partners in tropical and coastal regions appreciate this attention when they open a package months after shipping and find the material unchanged.

    Freight mishaps became learning experiences too—strong container seals prevent contamination or spillage, and clear labeling eased customs procedures for export shipments. Direct lines to warehouse teams and carriers helped us track temperature fluctuations, and more than a few batches stopped at holding points for re-testing after transit readings. The result: reputations are made by catching potential trouble before it reaches the end user.

    Cost, Sourcing, and Upstream Realities

    Not every challenge in 4-Nitro-1-Naphthol manufacturing comes from inside the plant. Supply-chain bottlenecks, raw material purity swings, and changes in environmental regulations affect our ability to keep product quality up and prices steady. We have faced spikes when key precursors tightened globally, which led to discussions with both long-term suppliers for improved contracts and with our R&D staff for waste reduction and recovery of by-products.

    We manage costs not by cutting corners but by optimizing batch runs, turning waste minimization into higher effective yields. Wastewater treatments and energy-recycling initiatives entered practice not because we’re forced by regulation, but because every molecule recovered means a little more price stability in the final product. By investing in backup sources and building close working relationships with key suppliers, we reduce risk of downtime or last-minute price jumps.

    Any customer paying attention to market trends recognizes when cheap options appear—usually made with little attention to color or impurities and with almost no technical support. Our base of loyal clients keeps coming back not for the cheapest lot, but for peace of mind and reliable application.

    Sustainable Manufacturing and Regulatory Practice

    Years in chemical production taught me that sustainable manufacturing rarely wins headlines, yet matters to every stakeholder. 4-Nitro-1-Naphthol comes with a unique set of environmental challenges—effluent treatment, nitrous gases from nitration, and solvent recovery. We put money and time into modern scrubbers and capture systems, not only to comply but to keep our neighbors and team safe.

    We’re no strangers to regulatory audits: inspectors ask about material flow, energy usage, and even noise from our reactors. Instead of just throwing paperwork at the problem, real-world improvements are built in over time—efficiency upgrades on cooling, switching older reactors for closed-loop systems, and tracking every input into our batches.

    Transparency isn’t an afterthought. Certifications—from ISO standards to regional permits—get renewed through demonstrated performance, not just application fees. Every process improvement we implement gets logged and reviewed, both for compliance and for ongoing efficiency.

    End-User Collaboration and Technical Support

    Stories from the field build our product knowledge as much as in-house tests. Several partners involved in scale-up shared feedback on solvent compatibility and filtration efficiency. We sent technical specialists to customer plants to check how our product handled in real lines, whether being added to spinning dye baths or running in kilo-scale reactors for new actives.

    When labs hit trouble—slow dissolving, test results not matching literature—we provide retained samples and answer calls late at night. The reason is simple: every batch with our name on it carries our reputation, so we treat complaints and troubleshooting as chances to analyze and improve.

    Being open to feedback also helps us customize production. We have shifted drying cycles, packaging methods, and even production scheduling to answer time-critical supply requests. Our flexibility lets downstream users move faster; they know our schedule reflects not some abstract production standard, but an urgent real-world need.

    Why 4-Nitro-1-Naphthol Remains Essential for Innovation

    As much as chemistry moves toward blockbuster materials and cutting-edge molecules, foundational intermediates like 4-Nitro-1-Naphthol do not slip from view. The backbone of dyes, research tools, and valuable intermediates, this compound has given rise to improvements not just in performance but in collaborative chemistry.

    Innovative users keep us on our toes—new pigment classes, pharmaceuticals that need ever-tighter impurity control, and processes that reduce waste or energy usage all build on the stable backbone that our product offers. The world seldom sees this mid-tier intermediate, but entire industries depend on knowing the characteristics will not shift from one lot to another.

    Colleagues at research centers occasionally request small, specialty lots or supply for new compound development. Direct manufacturer support makes those projects feasible: having clear records for every batch, analytical data, and actual samples in hand. From years working directly with researchers, we know small efficiencies often mean the difference between success and delays in product launches.

    Challenges and Opportunities on the Horizon

    A manufacturer’s life means facing new hurdles. Regulations change, environmental standards rise, and global demand shifts year-on-year. We keep ahead by updating both technology and staff training. Automation helps minimize batch error, while lab automation speeds up response time for technical support.

    There’s also a strong trend toward green chemistry, which influences both our production routes and how customers view material streams and waste. R&D for alternative solvents and post-reaction purification allows us to claim genuine progress on sustainability, not just promises.

    Small disruptions—raw material purity, a blocked shipping lane, sudden market swings—test every part of the supply chain. As a manufacturer, we build resilience by keeping regular communication with clients and responding rapidly to feedback, never as an afterthought but as daily practice.

    Lessons Learned as a Long-Term Producer

    Looking across the years, a few things remain true in our journey with 4-Nitro-1-Naphthol. Relationships built through open discussion and reliability—sometimes under pressure—last longer than market-driven transactions. Real-world application never follows a standard script, so our willingness to adapt, listen, and finetune the process matters more than any data sheet ever will.

    By working directly with end-users, from coloring textile fibers to helping scale up new molecules, we see everything that can go right or wrong between the lab and production line. Chemistry is not just science but craft, shaped by a loop of continuous improvement, feedback, and constant attention to detail.

    4-Nitro-1-Naphthol may seem a niche product, but its value is built every day in the work we do—not just to ship molecules, but to provide real support and reliable results where they’re most needed.