Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing sales7@sinochem-nanjing.com 3389378665@qq.com
Follow us:

4-Naphthalen-1-Yl-4-Oxo-Butyric Acid

    • Product Name 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid
    • Alias 4-(1-Naphthyl)-4-oxobutyric acid
    • Einecs 259-669-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    817929

    Chemical Name 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid
    Molecular Formula C14H12O3
    Cas Number 38112-38-4
    Appearance White to off-white solid
    Melting Point 93-95°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥98%
    Storage Conditions Store at room temperature, keep container tightly closed
    Iupac Name 4-(Naphthalen-1-yl)-4-oxobutanoic acid
    Smiles C1=CC=C2C(=C1)C=CC=C2C(CCC(=O)O)=O

    As an accredited 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25g amber glass bottle, tightly sealed, labeled "4-Naphthalen-1-Yl-4-Oxo-Butyric Acid," includes hazard symbols and handling instructions.
    Shipping 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. Packaging complies with international regulations for hazardous substances. The product is kept cool and protected from light during transit. Shipping includes safety documentation and labeling, ensuring secure handling and regulatory compliance throughout delivery.
    Storage 4-Naphthalen-1-yl-4-oxo-butyric acid should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from strong oxidizing agents, heat sources, and incompatible materials. Use appropriate personal protective equipment (PPE) when handling. Proper labeling and storage in accordance with chemical safety regulations are essential to ensure safety.
    Application of 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid

    Applications of 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid in Industrial Manufacturing

    As a direct manufacturer of 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid, we supply this specialty intermediate to leading organizations in fine chemicals, pharmaceutical precursors, agrochemical synthesis, organic pigment development, and advanced material research. The following application scenarios detail how downstream industries use this molecule in practical, production-scale environments under real sector regulations and established processing flows.

    1. Pharmaceutical Intermediate for API Synthesis

    Many advanced pharmaceutical manufacturers use this material as a building block in the stepwise construction of certain anti-inflammatory and anticancer active pharmaceutical ingredients, where its naphthoyl and keto-carboxylic functional groups provide key reactivity for selective ring-closure and condensation steps. It typically enters during the early to mid-stage synthesis, where downstream formulators control its input tightly to manage yields, reaction selectivity, and impurity profiles to comply with regulatory filings such as CEPs or DMFs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • USP-NF (United States Pharmacopeia–National Formulary)
    • European Pharmacopoeia (Ph. Eur.) for intermediate qualification controls
    • 21 CFR Part 211 (Finished Pharmaceuticals) for traceability and records

    Typical usage ratio

    • 0.15–0.52 molar equivalents per production batch; the quantity is computed from the desired mass yield of the target advanced intermediate, with adjustment for reaction stoichiometry and expected conversion efficiency (usually 70–90%).

    Downstream process integration

    • Usually introduced during Step 2 or Step 3 after initial ring or chain assembly, in a controlled condensation or alkylation as part of a batch or semi-continuous flow system. Real-time analytical monitoring (HPLC, NMR) is used to track formation of the key pharmaceutical intermediate.

    Final product types

    • Anti-inflammatory API intermediate (e.g. derivatives for kinase inhibitor drugs)
    • Anticancer pharmaceutical grade intermediates used in further multi-step synthesis of registered APIs
    • Complex aromatic frameworks for targeted small-molecule drugs

    2. Precursor for Agrochemical Active Ingredient Synthesis

    Formulators in the agrochemical industry select this specialty compound for constructing certain naphthalenic moieties within advanced herbicide and fungicide structures. Its aromatic-ketone carboxylic backbone offers specific reactivity for C–C and C–N bond formation, serving as a foundation in multi-step production lines for patented crop protection agents. Usage concentration reflects active loading targets and downstream process yield optimization protocols.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 Quality Management for agrochemical synthesis
    • GB/T 15621–WG1 Chinese standard for pesticide production control
    • REACH (EC 1907/2006) safety and hazard management (where applicable)

    Typical usage ratio

    • Used at 0.12–0.35 molar equivalents relative to target active group; final input is scaled by targeted batch output and varies by conversion efficiency requirements in the preparation of intermediate agrochemical actives.

    Downstream process integration

    • Incorporated during the nucleophilic coupling phase, usually after initial backbone structure establishment, where its ketone-carboxy moiety enables further aryl or amide bond formation. It is reacted in solvent media under specific temperature controls to prevent side product formation.

    Final product types

    • Naphthalenic herbicide intermediates
    • Fungicidal active ingredient precursors (e.g. systemics for rice and wheat diseases)
    • Multi-aromatic agricultural chemical synthons

    3. Intermediate for Organic Pigments and Dyes

    Colorant manufacturers incorporate this acid in the synthesis of high-performance naphthalene-based pigments, where it enables formation of key carbonyl- or carboxyl-functionalized nuclei for azo and anthraquinone chromophores. The molecule enters the process at a stage that allows downstream coupling with diazotized aromatic amines or other reactive co-monomers, forming vivid and stable color compounds as required for demanding coatings and plastics pigments markets.

    Industry compliance standards

    • EN 71-3:2019 (Safety of toys – Migration of certain elements) for pigment safety
    • ISO 18451-1:2015 (Colorants – Terminology)
    • ETAD Code of Ethics for chemical pigments
    • RoHS (Directive 2011/65/EU) for pigment applications in electronics and toys

    Typical usage ratio

    • 0.08–0.27 mole fractions in pigment batch synthesis; formula varies according to pigment shade, targeted covering power, and compatibility with host plastics or coating matrices.

    Downstream process integration

    • Added as the primary naphthalene donor in stepwise coupling, typically entering during the condensation or diazotization stage, followed by purification and salt conversion operations. Continuous-flow and batch pigment synthesis lines both utilize the material for purity and color stability.

    Final product types

    • Naphthalene azo pigments for plastics and printing inks
    • Anthraquinone-based industrial colorants for coatings
    • Engineered dyes for textile pre-treatment and fiber coloration

    4. Chemical Intermediate for Advanced Research and Materials Synthesis

    R&D laboratories and industrial pilot plants use this substrate as a specialized precursor for synthesizing high-value organic structures, including custom ligands, advanced monomers, and framework compounds needed for next-generation materials, optoelectronics, and specialty catalysts. Its combined aromatic and functional group structure makes it suitable for controlled cross-coupling, chelation, or condensation processes in advanced organic synthesis.

    Industry compliance standards

    • ISO/IEC 17025 Testing and calibration laboratories compliance for research-grade compounds
    • OECD GLP (Good Laboratory Practice) for experimental process control
    • Specific internal SOPs for purity, traceability, and analytical documentation
    • Documentation standards for grant-funded or patentable material development

    Typical usage ratio

    • 0.05–0.25 equivalents per reaction; bench and pilot chemists determine input according to molar balancing of targeted molecular architectures, with full experimental trace for reproducibility and scale-up trials.

    Downstream process integration

    • Entering at functionalization or backbone modification stages, material is dissolved or suspended as required for direct reactions with halogenated, amine, or metal-complexed reactants, followed by isolation and post-synthetic purification techniques (recrystallization, chromatography).

    Final product types

    • Novel ligands for homogeneous catalysis
    • Material monomers for specialty polymers with aromatic backbone
    • Functionalized building blocks for optoelectronic and sensor applications
    Free Quote

    Competitive 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: sales7@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    4-Naphthalen-1-Yl-4-Oxo-Butyric Acid: Reliable Quality from Direct Manufacturing

    Clear Choices from Real Production Experience

    Years spent in our own chemical production plant teach us there’s a big difference between selling chemicals and making them. With 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid, the difference shows up in the consistency of every drum. This compound grew out of practical demand in pharmaceutical and advanced organic synthesis projects; we built our process around achieving a stable, high-purity output to keep our partners’ work predictable. Our facility specializes in aromatic ketone acid derivatives, and projects using 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid are a permanent fixture in our production planning, not just an occasional contract.

    Production Matters: What Years at the Reactor Teach

    Every kilogram we put into the world starts with raw materials we vet ourselves, not just by the COA but with hands-on pre-processing to weed out variance. Our trained team monitors the multi-step Friedel-Crafts and subsequent oxidation stages, watching not only for yield percentages but the actual phenolic cleanliness and color. Colleagues in fine chemicals know side reactions can sneak in, especially during catalytic oxidation or work-up; with daily hands-on operation and batch documentation, these surprises get managed before they hit the drums. Our philosophy: nothing leaves the reactor uncharacterized.

    A lot of what shapes our process boils down to feedback from clients in APIs, dyes, and specialty intermediates. They report that traces of halogenated impurities or inconsistent melting ranges complicate scale-up, particularly in synthetically sensitive downstream routes. So, we invest in in-house chromatography and crystallization, along with HPLC-based quality checks, rather than trusting to the bare minimum. This keeps the butyric acid unit robust and ensures that every order matches real-world batch specs, with a reproducible melting point, clear tan color, and minimal post-processing.

    Specifications Earned through Use, Not Theory

    We target a purity level above 98% for 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid, which has become a bench-mark thanks to years of customer feedback. The melting point sits comfortably between 137 and 140 degrees Celsius and moisture stays below 0.5%. Experience shows that higher moisture—or a slip on residual solvents—clouds the reactivity, affecting coupling steps in pharmaceutical syntheses. Reproducibility counts, as chemists in the lab need to avoid variability in both solubility and reactivity.

    As a manufacturer, we don’t just take customer requests and pass them up the chain. Chemists in our plant respond to actual synthesis issues. When a client encountered unpredictable yields because of subtle halogen contamination in a different supplier’s batch, we tracked the impurity back to a cheap, unfiltered catalyst. Now, we use a cleaner, more expensive substitute, tested batch-by-batch, because that’s how a direct producer avoids the headaches caused by middlemen who focus only on specs and price.

    We pack this product in tough polyethylene inner liners, inside steel drums, not just for regulatory compliance but because humidity ruins years of work. There’s no substitute for seeing the heartbreak in a warehouse when a whole intermediate batch fails because of careless packaging on a rainy dock. That’s why our product almost always arrives in the same condition that left our plant—free flowing, light tan, and ready for use.

    Real-World Applications: Beyond Brochure Descriptions

    Labs and manufacturers come to 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid for the naphthalene ring fused into a butyric acid backbone. In actual medicinal research, this structure behaves as a valuable synthon for diverse analogs, especially where electron-rich aromaticity and ketone functionality combine in complex formation. Our product often serves as a starting point in anti-inflammatory and anti-cancer research, though the transformation frequently demands clean and predictable reactivity only available from tight process control. Clients developing new pigment intermediates or optoelectronic compounds also report that the naphthalene core delivers unique photophysical properties, especially in blue-light absorbing regions.

    We hear requests for customization because academic groups and industrial process chemists genuinely want the flexibility to push this molecule beyond textbook chemistry. Our team listens: we’ve optimized batches to fit high-throughput screening, which means not just a pure product but ultra-low levels of trace aromatic impurities and fine-tuned crystallinity. Often, researchers mention how the crystal habit affects their column loading, so our drying and sieving methods reflect feedback from years of analytical and preparative work.

    Actual Differences: Why Direct Manufacturing Yields a Better Acid

    Compared with generic or re-packed chemical intermediates, manufacturing at scale and under a traceable, transparent process brings several practical advantages. Years ago, we fielded recurring complaints about color deepening and product heterogeneity from customers who’d sourced intermediary products from resellers. Digging in, we traced the issue back to uncontrolled process variables—chiefly pressure fluctuations during the secondary oxidation and improper temperature ramps during dehydration. Cutting corners, or relying on ambiguous “double certification” never solved anything; only supervising each critical control point with batch logs, redundant sensors, and chemist oversight yielded results the downstream users could trust.

    Our 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid rarely succumbs to the "greying" and soft clumping that some buyers see from unregulated markets. This avoids headaches during solvent transfer, especially in pharmaceutical pilot lines or colorant manufacturing. It’s not just about achieving the right chromatographic profile; process uniformity delivers safer handling, less waste, and greater ease scaling from lab bench to tonnage lots. As a chemical manufacturer, we see the production cycle from raw naphthalene derivatives all the way to the drum. We stand behind every ton, batch number, and certificate.

    Supporting Sustainable and Responsible Chemistry

    Production resources matter. Chemical manufacturing can’t ignore waste, by-products, or sustainability just to meet monthly output. Our plant has built closed-loop solvent recovery into the butyric acid process so as to reclaim and reprocess the bulk of organic solvents. This reduces the use of fresh input and cuts hazardous waste by measurable amounts each year. For some applications, we’ve collaborated with clients to develop “green” solvent variants, using lower-toxicity solvents in the final crystallization. Results sometimes require trade-offs—slower crystallization or larger equipment—but we work with our customers toward their own compliance and sustainability targets, not just ours.

    Our staff regularly audits water and power consumption, using heat exchangers to recover energy from exothermic steps. The direct savings show up on the balance sheet, yes, but more importantly, the process improvements reduce risk of regulatory surprises and help partners navigate complex global supply chain compliance. Having our own analytical lab and production crew on-site allows immediate response to feedback and innovation from users who want to adopt safer or more sustainable versions of 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid in their operations.

    Experiences with Product Integration and Technical Support

    Integrating 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid into new polymer synthesis or next-gen dye formulation often starts with bench chemistry, but it quickly expands to process integration. Customers report differences in solubility rates, filterability, and even storage stability compared to other aromatic acids. Our long-run batches help streamline such optimization. Any time we scale up, we supply not just a sample but also share real process logs, impurity profiles, and analytical support. Downstream R&D benefits most when everyone has the data to solve unexpected bottlenecks, and over the years, we’ve helped debug everything from longer reaction times due to trace stabilizers, to color mismatches in pigment production caused by microimpurities.

    We routinely provide guidance—based on our direct hands-on plant experience—about solvent selection, addition rates, and process temperatures. No question about our product goes unanswered by people who haven’t seen or worked with the reactor or the drum. Unlike generic market-facing descriptions, we talk real numbers, practical limits, and the actual realities of scaling up a reaction line from hundreds of grams to hundreds of kilograms.

    Managing Quality: Not Just a Buzzword

    Quality comes down to measurable practices, not just batch release certificates or a regulatory badge. Every week, our QA team pulls random drums, runs full NMR and HPLC analyses, and compares actual product to analytical standards retained from development batches. If any deviation appears, we pause shipping, inform clients proactively, and review process logs to prevent recurrence. There are no shortcuts; experienced staff, onsite calibration, and tight documentation form the core of our operations.

    Several long-standing partners in pharmaceutical development report that switching to our directly manufactured 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid led to fewer purification steps downstream, higher yields, and more reliable timeline projections. They cite lower impurity thresholds as a key factor. That comes from our practice of not just monitoring reaction endpoints but also characterizing each isolation step—whether or not a customer requests the data.

    Compliance—Driven by Real Practice, Not Paperwork

    For every metric ton that leaves our plant, an environmental and safety audit backs up our processes and containment. Our on-site team tracks full batch genealogy; every container of 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid can be traced to its production line, with details on starting material, process conditions, and staff involved across each shift. This helps not only with audits or client visits but builds genuine trust in an industry where traceability protects everyone’s bottom line and reputation.

    The stakes get higher in sensitive end-use markets. We pay attention to REACH registration, transportation hazard documentation, and detailed impurity breakdowns, because smooth customs clearance depends on having that chain of information ready to share. Rather than treating regulatory burden as a box-ticking chore, our operators work as partners with logistics teams and customers to prevent snags that stall production lines or clearances.

    Adaptation—Learning from Users and Plant Experience

    The real world keeps teaching better ways to produce, store, and distribute 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid. As a chemical manufacturer, we find that every batch teaches new lessons. When we began offering larger drum sizes to a customer in advanced material science, staff discovered alterations were needed in anti-caking agent procedures to keep the product free-flowing. On another project, a client scaling up from kilograms to metric tons needed small changes to filtration timing, which led us to tweak our in-line filters for better throughput and lower particulate count.

    We adjust—not by theory, but by putting new SOPs in place after careful trial, logging, and client communication. This flexibility comes not from abstract process charts but from walking the production floor, speaking with plant and R&D staff, and troubleshooting together. Inevitably, it means chasing down quirks in each product run, whether it’s a tiny change in raw material source or shifting ambient humidity. Our focus remains fixed on supporting new applications, whether it’s a custom particulate size for a new dye platform, or tailored impurity profiles for clinical trials.

    Long-Term Partnerships: Why Customers Stay

    Long-term relationships in the chemical manufacturing business grow out of trust earned through reliable delivery, troubleshooting support, and constant product quality. We know that customers sourcing 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid want a supplier who understands not just the molecule, but the complex requirements involved in formulation, reaction development, and even packaging. Chemical buyers stay because they experience fewer surprises and get honest answers—whether it's about new batch timelines or technical support. We involve customers early in process changes and are transparent about lead times, inventory, and even the learning curve when working on tweaks for novel applications.

    We don't cut corners on documentation or technical backup; technical data is always supported by actual plant results, never just marketing copy. For every challenge, whether it’s a request for novel salt forms, microbatch samples, or support in a high-stakes regulatory audit, our operations team uses real case knowledge and test data. The result: customers experience fewer scaling hurdles, more predictable downstream chemistry, and greater safety than with lower-tier or brokered materials.

    The Road Ahead: Standing by Every Drum

    Investment in new synthesis routes, analytics, and process optimization pushes the product and company forward. As applications of 4-Naphthalen-1-Yl-4-Oxo-Butyric Acid continue to expand in next-gen pharmaceuticals, advanced colorants, and performance materials, manufacturing experience keeps us ahead of pure trading approaches. The lessons we learn from each batch, each client, and each round of troubleshooting help us scale and innovate responsibly and reliably. By staying focused on chemical competence, honest feedback, and real process transparency—not just theoretical capability—we support the scientists and engineers who build tomorrow’s applications.