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4-Methylvaleric Acid

    • Product Name 4-Methylvaleric Acid
    • Alias 4-Methylpentanoic acid
    • Einecs 209-780-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    208396

    Name 4-Methylvaleric Acid
    Cas Number 646-07-1
    Molecular Formula C6H12O2
    Molecular Weight 116.16 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 186-188°C
    Melting Point -30°C
    Density 0.922 g/mL at 25°C
    Solubility In Water Slightly soluble
    Refractive Index 1.415
    Flash Point 78°C
    Pubchem Cid 12297

    As an accredited 4-Methylvaleric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 4-Methylvaleric Acid is packaged in a 100g amber glass bottle with a secure screw cap, labeled with safety information.
    Shipping 4-Methylvaleric Acid is typically shipped in tightly sealed containers, such as high-density polyethylene (HDPE) bottles or drums, to prevent leakage and contamination. It should be transported in compliance with local and international regulations, protected from heat, moisture, and incompatible materials. Proper labeling, documentation, and safety data sheets accompany all shipments.
    Storage 4-Methylvaleric acid should be stored in a cool, dry, and well-ventilated area, away from heat sources and direct sunlight. Keep the container tightly closed and store separately from oxidizing agents and strong bases. Use chemical-resistant containers, such as glass or compatible plastics. Ensure proper labeling and restrict storage access to trained personnel. Avoid moisture ingress to prevent degradation.
    Application of 4-Methylvaleric Acid

    Applications of 4-Methylvaleric Acid in Industrial Manufacturing

    4-Methylvaleric Acid plays a critical role as a specialty intermediate in several downstream manufacturing sectors. As a direct producer, we supply this molecule to established global users who demand consistency, precise technical data, and continuous quality assurance. Below, we highlight key application routes and formulations validated through market use and regulatory acceptance.

    1. Synthesis of Flavors and Fragrances Esters

    Leading fragrance houses and flavor manufacturers utilize 4-Methylvaleric Acid in the creation of fruity esters such as 4-methylvaleryl acetate and other branched-chain derivatives, known for their nuanced profiles in both perfumery and food applications. Operators tightly control acid input to optimize esterification yields and comply with additive use thresholds. The raw material feeds directly into batch or continuous catalytic esterification reactors, often under acid catalysis and controlled thermal conditions, resulting in high-purity esters formulated into compounded flavors, fine perfumes, and aromatic bases.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • EU Regulation (EC) No 1334/2008 on flavorings
    • US FDA 21 CFR 172.515 (Synthetic flavoring substances and adjuvants)
    • GMP for Food Contact Materials (Regulation (EC) No 2023/2006)

    Typical usage ratio

    • 0.05%–1% of total ester formulation input mass; adjusted to meet specific aroma intensity and regulatory thresholds

    Downstream process integration

    • Added at the initial acid/alcohol weighing stage before catalytic esterification; monitored by HPLC for reaction endpoint; followed by distillation and refining

    Final product types

    • Flavoring esters for beverage, candy, and dairy sectors
    • Fine fragrance bases and perfume concentrates
    • Scented consumer goods (air care and laundry enhancers)
    • Compounded food flavor drops and syrups

    2. Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis

    API manufacturers source 4-Methylvaleric Acid as a helper acid in the synthesis of pharmaceutical intermediates, especially for compounds where a tertiary branched acid moiety is essential for molecular function. GMP-regulated operators dose the acid at strictly defined stages during multi-step organic syntheses, including amidation and ester formation processes. QC laboratories monitor for residuals under pharmacopoeia limits, ensuring downstream products conform to international drug safety requirements.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Materials
    • USP/NF (United States Pharmacopeia)
    • European Pharmacopoeia (Ph. Eur.)
    • China Pharmacopoeia (ChP)

    Typical usage ratio

    • 0.2–2.5 molar equivalents per primary amine or alcohol function in target intermediate reaction; reactivity and equivalency determined by process validation data

    Downstream process integration

    • Fed through automated microdosing into established reaction vessels during coupling or acylation steps; remaining acid removed by pH adjustment or solvent extraction

    Final product types

    • Anticonvulsant and antihypertensive drug intermediates
    • Ester prodrugs for improved oral bioavailability
    • Chiral building blocks for advanced pharmaceutical syntheses
    • Select veterinary active ingredient APIs

    3. Agrochemical Intermediate Manufacturing

    Producers of agrochemical actives and adjuvants employ 4-Methylvaleric Acid as a precursor for specialty herbicide esters and custom pesticide intermediates where alkyl-branched chain acids influence efficacy and selectivity. Formulators select charge quantity after pilot plant trials to balance reaction speed and desired physicochemical properties. The acid is introduced during chlorination, amidation, or alcoholysis steps under tightly maintained environmental control, protecting process yield and downstream field application characteristics.

    Industry compliance standards

    • REACH (EC 1907/2006) for agrochemical intermediates within the EU
    • ISO 9001:2015 Quality Systems for chemical synthesis plants
    • National pesticide registration system requirements (USA EPA, China ICAMA)
    • FAO/WHO specification guidance for pesticide technicals

    Typical usage ratio

    • 5–15% of total intermediate synthesis batch input, with pilot trials establishing precise dosage to optimize downstream reactivity and environmental profile

    Downstream process integration

    • Acid introduced to agitated reactor during formation of acid chlorides or direct amidation with heterocyclic amines; monitored by in-process NMR and extracted by phase separation post-reaction

    Final product types

    • Herbicide esters for grain and specialty crops
    • Pesticide intermediates for systemic fungicides
    • Custom adjuvant chains for retention enhancing agents
    • Stabilized technical grade agrochemicals

    4. Plasticizer and Polymer Modifier Additive Manufacturing

    Leading plastic and polymer compounders integrate 4-Methylvaleric Acid when synthesizing plasticizer esters and specialized polymer chain-modifying agents. This ingredient influences flexibility, molecular weight distribution, and cold-temperature impact in target plastic systems. Technical teams establish precise acid ratios to achieve target migration and extraction resistance in end-use formulations. The compound enters production at the initial polymerization or melt blending stage, followed by extrusion or granulation into pelletized masterbatches.

    Industry compliance standards

    • EU Regulation 10/2011/EC on plastic materials in contact with food
    • US FDA 21 CFR 177.1010 (Olefin polymers and modifiers)
    • ISO 9001 and ISO 14001 process and environmental management
    • RoHS Directive (EU) 2015/863 for electronic polymers

    Typical usage ratio

    • 0.2–3 wt% of total dry resin feed, optimized per application for mechanical strength, plasticity, and regulatory extractables

    Downstream process integration

    • Metered into heated compounding extruder or added prior to esterification of raw polymer batch; followed by physical testing for migration and compatibility

    Final product types

    • Flexible PVC and ethylene copolymer films
    • Automotive and appliance wire insulation compounds
    • Plasticized flooring and industrial sheetings
    • Electrical protective tapes and flexible packaging materials

    5. High-Performance Lubricant and Metalworking Fluid Component

    Major formulating plants and specialty blenders use 4-Methylvaleric Acid in the production of synthetic ester-based lubricants and custom additive packages for metalworking fluids. Technical staff adjust input ratios based on viscosity profile targets, oxidative stability, and thermal endurance required in demanding industrial settings. The raw acid undergoes esterification with polyols or fatty alcohols before blending into finished lubricant bases, guided by stringent contamination and stability controls to meet critical downstream performance benchmarks.

    Industry compliance standards

    • ISO 6743 series (Lubricants and lubricating oils)
    • ASTM D445 (Viscosity Determination)
    • DIN 51517 (Lubricants – Lubricating oils and related products)
    • OECD 301B (Ready biodegradability test for eco-lubricants)

    Typical usage ratio

    • 1–8 wt% in synthetic ester blends or as 15–25% of additive concentrate, tuned according to required base oil compatibility, boundary lubrication, and heat stability

    Downstream process integration

    • Acid input at controlled temperature into continuous or batch reactors prior to full blending and vacuum stripping; monitored by GC to ensure complete conversion and eliminate free acid traces

    Final product types

    • Chemically stable synthetic lubricants for automotive and aviation use
    • Metalworking fluid formulations for high-load machining operations
    • Gear and hydraulic oils with enhanced low-temperature performance
    • Biodegradable lubricants for environmental compliance sectors

    6. Specialty Surface Coating and Resin Production

    Advanced coatings and resins producers integrate 4-Methylvaleric Acid for its influence on curing profiles, adhesion properties, and chemical resistance of alkyds, polyesters, and cross-linked polymer finishes. The acid modifies backbone structure during resin polycondensation, affecting viscosity, hardness, and ultimate film performance. Formulators identify dosage through pilot-scale evaluation, balancing reactive functionality against weathering demands and regulatory migration limits.

    Industry compliance standards

    • EN 71-3 (Migration of certain elements – coatings in toys)
    • ISO 12944 (Paints and varnishes – Corrosion protection of steel structures)
    • US FDA 21 CFR 175.300 (Resinous and polymeric coatings for food contact)
    • ASTM D3022 (Crosslinking and chemical resistance testing)

    Typical usage ratio

    • 0.1%–2.5% by resin solids, with process adjustment for film build and surface profiling per site requirements

    Downstream process integration

    • Charged as a comonomer during resin backbone synthesis; influence monitored by real-time viscosity and GPC testing; final dispersions checked for acid value and film integrity

    Final product types

    • Architectural and industrial alkyd coatings
    • Polyester coil coatings for metal finishes
    • High-durability furniture and flooring varnishes
    • Food-contact approved can coatings
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    Certification & Compliance
    More Introduction

    Introducing 4-Methylvaleric Acid: Practical Experience from the Manufacturer’s Floor

    Direct from the Source: Understanding 4-Methylvaleric Acid

    In our line of work, 4-Methylvaleric Acid stands out not only because of its distinct branched structure, but also for the consistency and versatility it brings to industrial chemistry. We have spent years refining its production process, making sure every batch meets the high expectations of both domestic and international partners. The product most commonly goes by its chemical name, though some prefer to use the systematic nomenclature or its CAS number. No matter the name, the real difference shows in performance and reliability during key applications.

    Our Model and Approach to Purity

    We produce 4-Methylvaleric Acid in several consistent grades. One grade, which we call MVA-99, focuses on achieving a purity of 99% minimum. This level has grown popular with long-term clients who require predictability in their syntheses, from small-scale laboratory reactions to full industrial production. In-house gas chromatography and titration methods guarantee this level of purity every shipment. Any batch below specification does not leave our plant. At each stage, our technicians document and respond to every variable — humidity, temperature drift, even subtle shifts in supply chain sourcing of raw materials, because we know that the smallest impurity may affect outcomes downstream. The acid looks colorless to pale yellow and takes the form of a viscous liquid at room temperature. Sharp, penetrating odor marks its carboxylic acid function, which our loading teams know all too well.

    Where 4-Methylvaleric Acid Fits In

    Customers across different industries come to us for 4-Methylvaleric Acid primarily because of its reliability as a building block in synthesis. Agrochemical producers use it for specialty herbicides and intermediates, taking advantage of its methylated side chain for selectivity not available in straight-chain alternatives. Fragrance manufacturers value it for its contribution to fruity and tangy notes, which come straight from the structure of the acid itself. Some resins and plasticizer producers mix it for the same reasons, favoring its properties over other caproic acids in order to fine tune flexibility, solvency, or film-forming characteristics.

    The most notable differences compared to other short-chain fatty acids shine through in reactivity and solubility. The methyl group at the fourth position sets it apart from n-valeric acid, for example, by introducing a steric element that changes how it interacts with reagents during condensation reactions. Physical properties — a slightly higher boiling point, viscosity, and lower volatility compared to unbranched analogs — factor into logistics: Distillation tower runs last a little longer, storage tanks vent less vapor, and downstream processes gain stability. More than one client has told us that after swapping it into their blend, they saw changes in odor profile and reaction times that allowed greater flexibility upstream. None of these insights come from a textbook — we learn them through feedback, troubleshooting, and running parallel batches when something unusual happens on the production line.

    Production Expertise Yields a Safer and More Reliable Acid

    Safety stands front and center throughout production. Carboxylic acids like this one always demand careful respect. Over the years, we have optimized vessel linings and seal materials that hold up to its slight but persistent corrosivity. Operators wear splash goggles, acid-resistant gloves, and respirators when transferring bulk material between reactors. Fume hoods and local exhaust keep workplace concentrations far below occupational exposure limits. We're often asked about hazard controls: the procedures we use didn’t arise from simply following codes — they result from our ongoing risk assessments and regular dialogues with operators and process engineers.

    We also monitor and fine-tune waste treatment. Neutralization and off-gas scrubbing prevent unreacted acid from entering water or air. Partnering with local authorities, we build wastewater handling that meets — and often outperforms — environmental requirements for carboxylic acid disposal. This work has real impact, reducing long-term risks for downstream users and neighbors alike. We see that immediate handling at the factory shapes project outcomes all the way through to shipment and final use.

    Upstream Sourcing and Supply Chain Transparency

    Producing 4-Methylvaleric Acid starts from sourcing isovaleraldehyde, a raw material sensitive to oxidation and trace impurities. To get better quality, we work closely with primary aldehyde producers, running regular joint audits and expecting full traceability for every lot. Testing for inhibitors, color, and oxidic byproducts helps us prevent contamination right at the beginning. Since logistics can introduce risks at every point, our procurement team tracks shipment conditions, arrival times, and even drum integrity. If any container shows signs of leakage or deviation, that batch gets flagged for internal reprocessing or, in some cases, immediate destruction.

    No amount of automation at the raw material stage eliminates the value of experienced hands. Skilled contributors in our warehouse watch for subtle color shifts and odors that signal something off — much more than any instrument can detect. We stay in touch with chemical logistics partners to make sure everyone is on the same page about the handling required for short-chain acids and aldehydes, which react quickly to heat and sunlight.

    Storage and Shipping: Maintaining Consistency from Plant to End User

    The stability limits of 4-Methylvaleric Acid require cool, ventilated, and UV-protected storage. We pack it in tight-sealed drums built to resist acid attack. Shipping by land, water, or air all bring their own challenges. On warm days, temperature-monitoring stickers and data loggers ride along with the freight so our logistics team catches anything out of specification before it’s too late. Each outgoing lot comes with a certificate of analysis reflecting the actual batch, not a generic document. We send out only what passes our own tests.

    Why 4-Methylvaleric Acid Succeeds Where Others Stumble

    Years of feedback have shown us that not every carboxylic acid works the same way. Straight-chain examples like n-valeric acid and n-caproic acid lack the unique performance that a single methyl branch brings. Some customers running esterification processes for perfumery get better yields and cleaner product using our 4-Methylvaleric Acid, largely thanks to the branched structure resisting overreaction and byproduct formation. This also means fewer problems cleaning reactors between batches, less total acid loss, and lower maintenance requirements.

    Other clients fine-tune performance for custom polymer production. The methyl branch improves plasticizer flexibility and solvency, supporting applications that depend on specific glass transition temperatures, solubility, and stability profiles. Over time, we have mapped out how, sometimes, using the straight-chain version means higher volatility and fugitive emissions, increasing cost, and non-compliance with local regulations. The branched acid remains in the matrix longer, releasing more predictably. This insight owes a lot to hands-on work with both forms during R&D runs.

    The People and Processes Behind Quality

    No automated system replaces a skilled process technician’s eye for detail. Our senior technicians and engineers keep a close watch on every reactor during acidification and distillation, adjusting parameters to match actual conditions instead of relying on theoretical ideals. They train junior team members to listen for bubbling patterns, check for local vapor leaks, and judge color and clarity as the acid comes off the column. Judgment and training matter more for these acids, especially since branched-chain compounds show subtle quirks.

    Raw material inspectors pull samples from every batch and pull aliquots at multiple stages. They compare each sample’s odor and color to our reference standards, logging simple notes that help us solve problems in real-time. For customers needing extra purity, technical staff double-check for the tiniest impurities or side products from incomplete reactions. Only product that passes their inspection makes it into final inventory.

    Customer Collaboration: Sharing Data and Process Improvements

    Many customers involve us early in their application planning, asking for advice on reactivity, supply, and purity. Our technical team often visits client production sites, advising on best dosing, handling, and reaction conditions to minimize waste. These visits often reveal tweaks we can make upstream, ranging from changes in crystallizer cooling rate to adjusted solvent ratios in esterification processes. We see the strongest customer relationships built not from volume discounts, but from the shared process knowledge cultivated over years and hundreds of successful batches.

    Customers in fragrance and flavoring have especially tight purity requirements. They bring up challenges like residual odor, trace acidity, and interaction with delicate plant extracts. Our team takes these issues back to the plant—sometimes leading to major overhauls in purification or storage routines. Such direct feedback loops improve the product for everyone, closing the gap between expectations and real-world results.

    Adaptation and Problem Solving: Learning from Routine and Unusual Troubles

    Shifts in raw material availability, plant utility disruptions, or an unexpected regulatory change can hit production at any stage. We have faced every kind of disruption, from supplier shutdowns during global emergencies to sudden spikes in shipping costs as international routes changed. We respond by stockpiling certain critical intermediates, running conservation processes that stretch inventory, and qualifying backup sources years in advance. This effort pays off every time a crisis hits, letting us fill orders while others in the industry scramble to recover.

    Technical support does not end at the plant gate. Some partners have experienced fouling in their reactors from off-spec acid, often traced back to micro-level contaminants. By sharing our own testing SOPs and cleaning schedules, and sometimes sending samples for direct comparison, we help find the root cause. Rather than pushing stock for quick wins, our sales and technical teams work hand-in-hand so clients get reliable results and full transparency on every delivery.

    Regulatory Respect: Meeting Expectations, Exceeding Standards

    We take regulations seriously, following not only national laws but also the specific requirements of every region we ship to. Documentation for each batch reflects full traceability, composition, and relevant certifications. Some regions demand proof of impurity profiles, allergen absence, or compliance with REACH or similar programs. We maintain up-to-date files for every regulatory inquiry, speeding the customs process and earning trust from multinational partners. Our compliance team works proactively with industry groups, keeping ahead of any framework changes or new restrictions on carboxylic acids, so our clients avoid project delays or disruptions.

    Sustainability and Environmental Responsibility

    Producing 4-Methylvaleric Acid in large volumes can create a notable environmental footprint if not managed properly. We invested early in solvent recovery and catalytic purification stages to minimize waste. Liquid effluents are treated onsite through a multi-stage process: acid neutralization, carbon filtration, and biological oxidation that reduces chemical oxygen demand below even the most demanding regional guidelines. Where possible, mother liquors and distillation residues get recovered into side product streams, serving other clients in different industries. We watch these operations, because in our experience, even small slips can turn into community complaints or lost permits.

    We also review carbon emissions, tracking energy use for every metric ton produced. By switching to higher-efficiency heat exchangers and better thermal insulation, we cut fuel consumption and lower downstream greenhouse gas output. For several years, we have reported these numbers to stakeholders, welcoming both criticism and engagement. As pressure grows from regulators and customers alike, the future will keep rewarding those who control both purity and environmental risk together, not as isolated goals.

    Continuous Improvement Drives Performance

    At every review, quality or otherwise, our process improvement teams look at the full upstream and downstream cycle for 4-Methylvaleric Acid. Engineers, operators, and application specialists sit together to debate tweaks that could boost yield, purity, or ease of handling. Sometimes, small investments — like a new distillation tray design or added online purity detection — make the difference that customers notice. Internally, the feedback loop is tight. Teams log what works, what fails, and bring tough questions from the field right back to R&D.

    Switching even a single component from one grade of carboxylic acid to another comes with unexpected consequences. We track those changes closely, working with clients from bench to production scale, sharing data on performance, byproducts, odor change, and reaction speed. These collaborations often turn up new uses and help clients test their own boundaries without risking yield or traceability.

    Key Takeaways for Buyers Seeking Long-Term Partnerships

    Trust in 4-Methylvaleric Acid starts with knowledge of where it comes from, how it’s handled, and why certain methods outperform others. Over the years, clients who stick with us value the combination of traceable production, technical support, and predictable supply. They know that beneath every shipment lies a story of input sourcing, hands-on quality review, honest troubleshooting, and a real commitment to both performance and safety. As end-use applications evolve, we’ll keep sharing what we learn so everyone gets results that pay off in real terms.

    Looking Ahead: Innovation and Industry Trends

    Industry focus shifts as customers look for greener synthesis methods, safer handling, and consistent supply chain practices. New applications for 4-Methylvaleric Acid continue to surface, especially in advanced materials, green solvents, and the search for non-petrochemical feedstocks. As regulations tighten, companies looking to maintain continuity will need partners who cover the full journey — from basic chemistry knowledge to operational grit.

    As a manufacturer, our aim goes well beyond selling a chemical. We drive innovation by listening, responding to feedback, and anticipating market needs before they hit the mainstream. Every drum, every kilogram of 4-Methylvaleric Acid reflects years of collective experience, shared learning with clients, and an ongoing push for cleaner, higher performing chemistry. For any buyer investing in new formulations or scale-up, the difference between one acid and another comes down to more than just a specification sheet — it comes down to people on both sides of the transaction who understand and respect the details of their craft.