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4-Methylthiazole

    • Product Name 4-Methylthiazole
    • Alias 4-Methyl-1,3-thiazole
    • Einecs 211-989-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    709107

    Cas Number 693-95-8
    Molecular Formula C4H5NS
    Molar Mass 99.15 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Musty, roasted, nutty
    Melting Point -25 °C
    Boiling Point 113-115 °C
    Density 1.08 g/cm³ at 20 °C
    Solubility In Water Slightly soluble
    Flash Point 29 °C (closed cup)
    Refractive Index 1.536 at 20 °C
    Pubchem Cid 13720

    As an accredited 4-Methylthiazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 4-Methylthiazole is supplied in a 100 mL amber glass bottle, featuring a screw cap and chemical hazard labeling for safety.
    Shipping 4-Methylthiazole should be shipped in tightly sealed containers, protected from moisture and incompatible substances. It must be clearly labeled and packaged according to local, national, and international regulations for hazardous chemicals. During transport, avoid extreme temperatures, open flames, and sources of ignition due to its flammability and potential health hazards.
    Storage 4-Methylthiazole should be stored in a cool, dry, well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed and protected from direct sunlight. Store at ambient temperature and avoid excessive heat or moisture. Proper labeling and safety precautions should be maintained to prevent accidental exposure or contamination.
    Application of 4-Methylthiazole

    Applications of 4-Methylthiazole in Industrial Manufacturing

    4-Methylthiazole serves critical roles across several key chemical manufacturing sectors. The following sections detail its major downstream application fields, including compliance, usage ratio, integration in production, and end product portfolios for each industry.

    1. Food Flavor Enhancer Production

    4-Methylthiazole features as a flavor precursor and enhancer where manufacturers synthesize savory accords, predominantly within meat, roast, and seasoning profiles. Its fame stems from its essential contribution to Maillard-derived aromas in processed foods such as seasonings, sauces, and instant meal bases. It must pass stringent food safety checks and operates under controlled dosing due to its potent organoleptic profile.

    Industry compliance standards

    • FDA 21 CFR 172.515 (Flavoring substances)
    • EU Regulation No 1334/2008 (Flavourings and certain food ingredients)
    • GB 2760-2014 (China National Food Safety Standard for Use of Food Additives)
    • JECFA food additive approvals and specifications

    Typical usage ratio

    • 0.01–5 ppm in final formulations; actual dosage determined by sensory panel results, type of product matrix, and regional flavor regulations.

    Downstream process integration

    • Dosed into spice blends or flavor bases during blending stages; post-addition preferred to minimize thermal loss; can be dissolved in ethanol or propylene glycol carriers for uniform mixing.

    Final product types

    • Meat and poultry flavoring concentrates
    • Snack seasoning powders
    • Savory instant noodle soup bases
    • Ready-to-eat meal flavorings

    2. Pharmaceutical Intermediate Synthesis

    This compound acts as a heterocyclic building block in the synthesis of various drug candidates, especially in anti-infective and CNS-active agent development pipelines. Its consistent quality attributes and trace impurity profile support direct entry into regulated API manufacturing and pre-clinical research.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP <823> (Radiopharmaceuticals—Production, Compounding, Dispensing, and Repackaging), as applicable to intermediates
    • Ph. Eur. (European Pharmacopoeia) general chapter 5.21, control of impurities
    • SFDA (China) Drug Master File (DMF) registration procedures

    Typical usage ratio

    • Stoichiometric amounts based on specific synthetic pathways; often 0.5–1.2 molar equivalents relative to other coupling agents or reactants, with quantity adjusted to target yield and process efficiency.

    Downstream process integration

    • Enters as a nucleophilic component in heterocycle-forming reactions, commonly under controlled temperature and inert atmosphere; purification steps include distillation or crystallization depending on downstream purity requirements.

    Final product types

    • Pharmaceutical intermediates for anti-infective APIs
    • Pyridine and thiazole-based CNS compound candidates
    • Building blocks for synthesis of regulatory-submitted drug substances
    • Key intermediates for contract research and manufacturing organizations (CRO/CMO)

    3. Agrochemical Active Ingredient Manufacturing

    Agrochemical formulators utilize this thiazole derivative for constructing pesticide scaffolds, especially in fungicide and insecticide molecule assembly. Requirements focus on consistent chemical lot-to-lot reproducibility, minimized by-product formation, and conformity to agrochemical registration dossiers.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals
    • ISO 9001:2015 (Quality Management Systems in Agrochemical Production)
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products approval)
    • China ICAMA registration (Agrochemical registration system)

    Typical usage ratio

    • Varies based on targeted active molecule; 0.3–2.5 equivalents in multi-step pesticide synthesis, modified depending on reaction optimization and impurity control strategy.

    Downstream process integration

    • Used as a heterocyclic core-introducing reagent early in synthesis; incorporated during main condensation or cyclization reactions, followed by purification for active ingredient isolation.

    Final product types

    • Systemic fungicide actives (thiazole-based)
    • Novel insecticide scaffolds
    • Seed treatment chemical precursors
    • Herbicide intermediates for selective weed control

    4. Fragrance Chemical Manufacturing

    The compound finds frequent use in fine fragrance and aroma ingredient production, adding distinctive roasted, nutty, or meaty nuances to formulated perfumes and food-safe fragrances. Manufacturers must monitor trace-level composition and comply with global aroma chemical safety and labelling regulations during scale-up and formulation.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • REACH Regulation (EC) No 1907/2006 for chemical safety in EU
    • IFRA/IOFI Labelling Manual
    • Cosmetics Regulation (EC) No 1223/2009 (for personal care scents)

    Typical usage ratio

    • Typically applied at 0.1–10 ppm in consumer fragrance compounds; final use level depends on olfactory intensity in the matrix and safety assessment outcome.

    Downstream process integration

    • Added to base aroma compositions either as direct input or post-dilution blend; integrated during compounding of perfume oils or incorporated in encapsulated aroma carriers for controlled-release products.

    Final product types

    • Fine fragrance concentrates
    • Beverage and food-safe aromas
    • Scent blends for baked good applications
    • Fragrance microcapsules for home care and air-freshener products

    5. Specialty Chemical Synthesis for Electronics

    Thiazole derivatives such as this serve as advanced intermediates for high-purity specialty materials required within electronic chemical manufacturing, where strict control over trace metal content and organic impurities ensures semiconductor performance. Batch segregation, traceability, and high-purity handling dominate processing requirements.

    Industry compliance standards

    • SEMI C1-0709 (Specification for Electronic Grade Chemicals)
    • RoHS Directive 2011/65/EU (limit hazardous substances in electronics)
    • ISO 9001:2015 (Quality assurance in high-purity chemical production)
    • Restriction on use of certain hazardous substances in electronic chemicals per international client specifications

    Typical usage ratio

    • Integrates at 0.05–1 molar ratio depending on exact process design for downstream semiconductor or photoresist materials, as dictated by customer technical data sheets.

    Downstream process integration

    • Charged during synthesis of functionalized ligands or complexing agents for electronic substrate coatings, or used as intermediate for custom photoresist monomer formulations.

    Final product types

    • Photoresists for microelectronics manufacture
    • Electronic-grade ligand precursors
    • High-purity coating materials for semiconductors
    • Specialty chemicals for printed circuit board (PCB) fabrication
    Free Quote

    Competitive 4-Methylthiazole prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Understanding 4-Methylthiazole: A Manufacturer’s Perspective

    Introducing Our Workhorse: 4-Methylthiazole

    Making chemicals from scratch is never routine. Every day, in the reactors and labs, we experience just how nuanced chemical synthesis can be. Among the molecules that keep demand steady and expectations high, 4-Methylthiazole stands out. Its molecular formula, C4H5NS, might look simple on paper. But ask a chemist driven by consistency and traceability, and they’ll tell you the story of how even a small change in process parameters affects purity, odor profile, or downstream compatibility.

    From Lab Recipe to Industrial Batch

    We never view 4-methylthiazole as a mere chemical for trade. Its precise synthesis relies on controlled temperatures, raw material integrity, and process patience. It arrives as a clear to pale yellow liquid. You might get a whiff of its distinctive nutty, roasted aroma; believe it, that sharp, toasted note is no accident. Our reactors are set to deliver the optimal characteristics, governed by years of trial, error, and adjustment. We don’t cut corners because a single out-of-spec drum causes headaches across food, fragrance, and pharma customers.

    Specifications That Define Us

    We produce 4-methylthiazole with a minimum purity of 99%, monitored by gas chromatography, so you aren’t left handling unexpected side compounds that complicate your formulations. Our standard packaging—say, 25 kg drums or bulk containers—meets the needs of global processors as well as smaller specialty blenders. Our batches are free from excessive thiazole, moisture remains tightly controlled below 0.1%. We track every shipment by lot for traceability, because internal audits and customer recalls are not hypothetical risks but lived realities.

    What Sets Us Apart: Not All Molecules Are Equal

    You get plenty of choices for sourcing basic thiazoles. Yet, as direct manufacturers, we know the actual pain points users face: batch-to-batch variations, unstable odor, color impurities, or the silent trouble of trace contaminants. Not all suppliers can spot-check and resolve these micro-problems before drums leave the warehouse. Our lab maintains a constant watch for both expected and rare off-spec signatures, with the kind of diligence that’s hard to find in speculative trading houses. We own the chemistry and stand by it at every step.

    How Industry Relies on 4-Methylthiazole

    Most people don’t realize that the nutty, roasted, or cooked flavors and aromas in familiar foods owe a debt to thiazoles. We ship consistent 4-methylthiazole to food ingredient formulators pursuing authentic, pleasant notes in roasted meats, coffee, popcorn, and savory sauces. Our molecule helps flavor houses engineer complexity and depth without raw or burnt aftertastes—every sensory evaluation in our lab confirms the profile before scaling up production. There’s no magic, only method and meticulous attention.

    Perfumers recognize the powerful, persistent top notes that methylthiazoles lend to both fine fragrance and industrial deodorants. Reliability carries even more weight here: a subtle off-odor spikes rejection rates and reruns. We design our process to safeguard olfactory clarity and performance—not just meeting existing IFRA recommendations, but always keeping an eye on emerging regional regulations and evolving customer preference trends.

    Pharma and specialty chemical sectors often ask us about the amine reactivity, solubility, or specific impurity profiles that affect downstream synthesis. Accurate, up-to-date specification sheets and collaborative technical support matter here because missed impurities can derail months of R&D. Our chemical engineers work directly with partners to tune product parameters if their process gets bottlenecked by an unseen contaminant or unexpected physical property.

    The Subtle Differences from Other Thiazoles and Synthetics

    It’s easy to assume all thiazole derivatives perform similarly. We see where that logic fails every week. For example, 2-methylthiazole, while structurally close, delivers a sharper, sulfur-heavy aroma and lacks the softer, rounder roasted nuance of the 4-methyl isomer. Trade professionals sometimes try to interchange the two, only to learn that their finished products fail consumer sensory tests or require much higher dosages—creating both cost and performance headaches.

    Synthetic flavorists sometimes reach for 2-acetylthiazole, prized for popcorn and nut flavors. But its dosage range behaves less predictably, with a more pronounced "brown" note that can overpower delicate profiles. Where a subtle, roasted accent is needed, our well-characterized 4-methylthiazole steps in. No matter the batch size, our process holds impurity levels low, ensuring less batch-to-batch adjustment downstream.

    Quality Without Mystique—Just Discipline

    There’s a misconception that chemical purity beyond a certain threshold becomes a luxury. We know from experience that even minor contaminants, like precursors or over-reaction byproducts, cause flavor drift, discoloration, or instability in finished products. That’s not theoretical. We keep every reactor, storage vessel, and packing line clean, because off-odors and color changes start before shipping, not in the customer’s tank.

    Our quality team runs GC-MS validation on each batch, confirming identity and ruling out critical contaminants before approval. Regular auditing and process review help to keep us ready for stricter requirements tomorrow. We pay attention to the details many overlook, like trace storage life, copper trace levels, or even handling-induced polymerization. These efforts shield you from supply chain downside and regulatory surprises.

    Meeting Customer Problems Head-On

    A distributor handles goods. We solve problems. Sometimes a customer’s process calls for a lower or higher moisture grade, which can make or break their formulation’s stability. Our flexibility allows us to adjust drying and handling accordingly. If a region enacts a new safety assessment or labeling change, we’re ready to update MSDS documents, supply chain information, and physically adjust packaging. These aren’t hypothetical scenarios; they reflect a daily reality of working directly with end users, food scientists, R&D teams, and procurement officers. With each feedback session, we learn and tweak, embedding that knowledge into every production run.

    Product recalls never originate from a decision to follow best practices—they always stem from shortcuts. We see too many in the marketplace. That’s why our internal philosophy is simple: trace everything, never skip QA, and always involve chemists in shipping signoff. This avoids unnecessary drama for everyone down the line.

    Thinking Beyond the Lab—Sustainability and Safety

    We know sustainable chemistry is no longer optional. Our investment in closed-loop solvent recovery speaks directly to the need for waste reduction and cleaner effluent. Over the past three years, we’ve reduced waste discharge associated with 4-methylthiazole production by more than twenty percent. Not because it’s a marketing point, but because we see the regulatory trajectory tightening and believe responsible stewardship should lead, not react.

    Like many chemical manufacturers, we constantly update equipment and training to exceed not only legal standards but the occupational expectations we set for ourselves. Our team wears proper protection and practices containment at each production phase. The chemical’s strong odor and low flavor threshold mean any leakage, even at trace levels, is noticed and corrected quickly. Our people know anticipating hazards beats responding after the fact.

    Bridging Experience and Innovation

    We don’t believe in resting on legacy formulations or process parameters. Our R&D group maintains an open dialogue with food engineers, perfumers, and tech scouts who push us to refine our syntheses, improve energy efficiency, and hunt down any minor byproduct that could ignite compliance concerns. Recent process changes have lowered emissions and slashed off-grade material, reducing our raw material input per kilo of finished product. Each process tweak brings us closer to leaner, cleaner, more predictable production.

    Innovation doesn’t stop with chemistry. Our logistics partners undergo regular review. We build resilient supply chains with regionally distributed inventory to buffer against international shipping uncertainty, from port congestion to sudden trade regulation. We’ve seen firsthand how a single disrupted shipment creates headaches for production lines thousands of kilometers away. No customer should have to resort to unreliable parallel imports or risky substitutes when quality and documentation are available from the source.

    Guarding Against Adulteration: A Real Market Threat

    As direct producers, we’re painfully aware of the market’s exposure to substitutions or watered-down product. Some non-manufacturers will cut 4-methylthiazole with less expensive analogues or leave reaction byproducts unfiltered, passing along hidden costs to the customer. Independent lab testing sometimes reveals hefty mismatches between label claim and actual content. Our commitment remains consistent: the only thing you get in our package is real, documented 4-methylthiazole, delivered fresh and with every critical metric traceable back to the reactor.

    Listening to Real Feedback, Not Just Metrics

    End users—especially food technologists and fragrance developers—report that subtle changes in raw material batches have outsized impact on final product flavor, shelf life, or regulatory compliance. Our technical support teams collect these stories and feed insights back into process control software. If a customer notes an unexplained variance in finished product, we review sample retention, re-run analytical screens, and often run parallel pilot batches for diagnosis. This feedback loop removes ambiguity and keeps our production on track with real-world use, not just theoretical specifications.

    Reducing Downtime and Surprises for Partners

    We know downstream manufacturers face enough uncertainty. Ingredient shortages, missed specifications, and shipment delays all add up to production downtime and stressed schedules. That’s why our approach focuses on stability—building some headroom into lead times, offering technical pre-shipment review, and proactively communicating during global logistics interruptions. Our priority remains getting the product delivered to the right dock, with predictable composition and full support for customs and safety documentation.

    Some buyers try to hedge risk with multisource procurement. We respect that. It means our consistency must speak for itself across seasons, regulatory regimes, and market disruptions. Maintaining predictable processes lets partners focus on innovation without worrying about their input materials.

    Looking Forward: Quality and Transparency

    Modern ingredient producers and manufacturers expect not just a product, but a partnership. Regulations governing food, fragrance, and pharma tighten each year; end consumers scrutinize sourcing and transparency. We embrace these changes not as obstacles, but as drivers for a stronger operation. Our transparency—batch-level documentation, specification sheets, regulatory statements, and prompt updates—keeps customers compliant and confident.

    We invest in regular training for our operators and technical teams. Every new analytical instrument, every updated standard operating procedure, translates into fewer mistakes and quicker turnaround. The result impacts your business: better yields, fewer formulation mysteries, and greater certainty with every production run.

    Conclusion: The Difference Direct Manufacturing Makes

    4-Methylthiazole might sound like one chemical among many. Yet, in practice, the difference between a generic, lightly monitored batch and a carefully manufactured, high-purity product amounts to months of shelf life, dozens of flavor or aroma projects saved, and ongoing peace of mind for regulatory and formulation teams. Our hands-on experience, our willingness to integrate feedback, and our insistence on traceability make the difference. We don’t just make molecules; we ensure they keep your products advancing, batch after batch.