Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

4-Methylsulfonylphenol

    • Product Name 4-Methylsulfonylphenol
    • Alias p-Cresol sulfone
    • Einecs EINECS 240-001-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    936463

    Chemicalname 4-Methylsulfonylphenol
    Casnumber 123-02-4
    Molecularformula C7H8O3S
    Molarmass 172.20 g/mol
    Appearance White to off-white crystalline solid
    Meltingpoint 108-111 °C
    Boilingpoint 316.9 °C
    Solubilityinwater Moderately soluble
    Density 1.36 g/cm³
    Pka 9.4
    Synonyms 4-Hydroxyphenyl methyl sulfone
    Smiles CCS(=O)(=O)C1=CC=C(C=C1)O
    Refractiveindex 1.563

    As an accredited 4-Methylsulfonylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Sealed amber glass bottle containing 250 grams of 4-Methylsulfonylphenol, labeled with chemical name, CAS number, and hazard symbols.
    Shipping 4-Methylsulfonylphenol is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture exposure. During transit, it is kept in a cool, dry, and well-ventilated environment, with appropriate labeling according to relevant regulations. Handling precautions are observed to avoid spills or contact with incompatible substances.
    Storage 4-Methylsulfonylphenol should be stored in a tightly sealed container in a cool, dry, and well-ventilated area. Keep it away from heat, moisture, direct sunlight, and incompatible substances such as strong oxidizing agents. Proper labeling and secure storage are essential to prevent accidental exposure or contamination. Use secondary containment to avoid environmental release in case of spills.
    Application of 4-Methylsulfonylphenol

    Applications of 4-Methylsulfonylphenol in Industrial Manufacturing

    As a manufacturer specializing in high-purity 4-Methylsulfonylphenol, we serve a range of industrial sectors where this intermediate plays a critical functional role in specialty compound synthesis. Below, we detail its most established downstream applications, highlighting regulatory requirements, recommended formula ratios, integration points in customer production lines, and the end-use product categories manufactured with our material.

    1. Pharmaceuticals: Synthesis of Sulfonamide-based APIs

    Pharmaceutical manufacturers incorporate this compound as an intermediate for synthesizing sulfonamide structures in active pharmaceutical ingredients. Its phenolic and sulfonyl groups enable precise substitutions during stepwise organic synthesis for antimicrobial, antidiabetic, and CNS-targeting agents. Usage in this context demands traceability and consistent quality due to regulatory oversight on API precursors.

    Industry compliance standards

    • USP-NF (United States Pharmacopeia–National Formulary) monograph alignment for raw material purity
    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • EMA guideline on starting materials (EMA/CHMP/QWP/545525/2017)
    • FDA 21 CFR Part 211 for pharmaceutical manufacturing controls

    Typical usage ratio

    • Introducing 2-7% by weight of reaction input, depending on desired substitution; adjusted for API molecular target and reaction yield

    Downstream process integration

    • Charged during the early phase of multi-step organic synthesis, before condensation or coupling reactions; requires controlled addition and monitored reaction temperatures to prevent phenolic degradation

    Final product types

    • Antimicrobial sulfonamide APIs (e.g., sulfamethoxazole)
    • Sulfonyl-containing drugs for diabetes management
    • Intermediates for antiepileptic formulations

    2. Agrochemical Intermediates: Herbicide and Fungicide Synthesis

    In the agrochemical sector, processors utilize 4-Methylsulfonylphenol as a building block for synthesizing select phenolic herbicides and fungicides. Its structure facilitates sulfonamide and ether linkages that are essential in modern crop protection chemistry, where both efficacy and environmental persistence are closely regulated.

    Industry compliance standards

    • FAO/WHO JMPR (Joint Meeting on Pesticide Residues) specification alignment
    • OECD Test Guidelines for chemical safety and purity
    • ISO 9001:2015 certified quality management system
    • REACH Annex XVII compliance for restricted substances

    Typical usage ratio

    • Blended at 3-12% of active ingredient synthesis mass; dosage depends on target molecule complexity and agrochemical formulation pathway

    Downstream process integration

    • Added to reaction vessel after catalyst activation during the phenol-sulfonation step; subsequent purification ensures low-impurity grade fit for post-synthesis formulation

    Final product types

    • Selective herbicide actives (e.g., sulfonylurea derivatives)
    • Systemic fungicides based on sulfonamide backbones
    • Pre-formulated wettable powders and suspension concentrates for crop spraying

    3. Polymer Additives: High-Performance Resin Modifiers

    Resin and polymer manufacturers leverage the compound as a specialty modifier to improve chemical resistance and crosslinking density in engineered plastics. By introducing the sulfonylphenolic moiety, downstream processors can achieve enhanced thermal stability and mechanical strength in advanced resin systems for electronics, automotive, and industrial adhesives.

    Industry compliance standards

    • ISO 10993-5 (if used in medical device resins)
    • UL 94 (flammability testing for resins)
    • RoHS compliance for electronics applications
    • REACH registration for substances in polyol and epoxy supply chains

    Typical usage ratio

    • Typically incorporated at 0.5-2.5% by weight into resin batches; higher ratios applied for applications where maximum sulfonation is required

    Downstream process integration

    • Integrated during monomer blending or as part of additive package prior to polymerization; performance monitored via QC on finished resin for molecular dispersion

    Final product types

    • High-performance phenolic resins for circuit boards
    • Advanced engineering plastics used in auto components
    • Resin-based adhesives and sealants for industrial assembly

    4. Dye and Pigment Manufacturing: Intermediate for Azo and Sulfonated Colorants

    Dye producers use the compound as a key intermediate in synthesizing sulfonated azo dyes and complex pigments, where its methylsulfonyl group contributes both water solubility and fastness properties. Precision in batch addition is crucial to achieve consistent chromatic performance, particularly in textile and paper applications that demand compliance with environmental and safety protocols.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for restricted aromatic amines in dyes
    • ZDHC (Zero Discharge of Hazardous Chemicals) manufacturing standards
    • EN 71-3 (European standard for migration of certain elements from toys, if relevant)
    • DIN EN ISO 9001 process management for pigment output

    Typical usage ratio

    • Used at 5-15% of total dye intermediate reaction mass; actual ratio determined by color target, batch size, and specific pigment structure

    Downstream process integration

    • Added following diazotization of primary aromatic amines; enters as coupling component during azo bond formation or sulfonation, depending on pigment complexity

    Final product types

    • Water-soluble azodyes for synthetic fiber dyeing
    • Sulfonated pigments for inkjet formulations
    • High-fastness textile dyes for technical fabrics

    5. Specialty Chemical Synthesis: Advanced Electronic Materials

    Producers of electronic chemicals employ 4-Methylsulfonylphenol as an intermediate for fabricating sulfonated aromatic monomers, crucial in the development of ionomers and conductive polymers. This use underpins materials deployed in batteries, capacitors, and microelectronic devices, where each addition step requires strict process validation to conform with advanced materials industry requirements.

    Industry compliance standards

    • IPC-4101 (base materials for printed wiring boards)
    • ISO 14001 environmental management (chemical processing)
    • IEC 61249 for base materials in electronics
    • REACH and RoHS for electrical/electronic materials

    Typical usage ratio

    • Formulators dose at 1-6% of total monomer feed, based on target ionic capacity or conductivity profile required by downstream users

    Downstream process integration

    • Dosed during synthesis of pre-polymer intermediate; precise molar control and reactive environment maintained to achieve substitution at correct aromatic position; monitored via in-line analytics

    Final product types

    • Sulfonated polyarylene polymers for proton exchange membranes
    • Conductive film materials for solid-state batteries
    • Microelectronic substrate coatings
    Free Quote

    Competitive 4-Methylsulfonylphenol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    4-Methylsulfonylphenol: Manufactured with Experience and Care

    Introduction to 4-Methylsulfonylphenol

    Producing specialty chemicals involves more than just following a recipe—it draws on years of hands-on experience with raw material sourcing, batch consistency, and controlling every step of the synthesis. 4-Methylsulfonylphenol stands out as a result of this focus. In practice, our production lines optimize for high-purity output, minimizing unwanted by-products thanks to real-world adjustments made over countless runs. The model number MSP-039 reflects not just a labeling system but the continual refinements behind each lot, tested in our dedicated labs on-site.

    Over decades, our QC teams have aligned techniques for impurity profile monitoring, which plays a major role in differentiating a true manufacturer’s product from off-the-shelf variants. Many producers struggle to maintain purity above 99.5%, but we consistently meet or surpass that mark. We approach every batch with an understanding of downstream impacts, whether it’s for pharmaceutical intermediates, crop-protection actives, or electronics components, where even minor contamination causes problems.

    In-House Knowledge Earned Over Years

    Sourcing high-grade starting materials requires solid relationships with upstream partners rather than relying on spot optimization. Our procurement specialists keep tight control over storage, ensuring feeds are fresh and protected from humidity shifts or trace contaminants. This attention filters through every barrel, every day, right down to how technicians monitor reaction times. The fine-tuning of parameters like temperature, solvent ratios, and stirring speeds—details often overlooked or left unmonitored—reflects practical know-how gained on the floor, not just from textbooks.

    We find over and over that our clients come back after trying generic alternatives, especially in applications where consistency and traceability directly affect their yield and final product reliability. Feedback from experienced users in the polymer, agrochemical, and API synthesis fields highlights that 4-Methylsulfonylphenol sourced from a full-scale manufacturer displays more predictable reactivity. This arises from narrower molecular weight distribution and reproducible melting points, which we verify with batch certifications backed by chromatograms, not just theoretical values in literature.

    Meeting Real-World Demands with the Right Specifications

    Understanding specifications is not just about checking off a datasheet. Our product, labeled as MSP-039, achieves key metrics including purity >99.5%, low water content, and visible crystal clarity, measurable by the human eye, not just instruments. Seasoned operators evaluating color and odor know right away when something’s off, even before running tests.

    Weight, melting range, and solubility are all documented and checked with reference standards. Over years of manufacturing this molecule, we have learned that respecting storage needs—cool, dry conditions away from sunlight—matters as much as reaction control. Clients have often reported how small changes in supply handling at other facilities led to reduced shelf life and performance dips. Our team takes responsibility for every delivered drum, following through with after-sales checks if requested.

    Applications Backed by Reliable Production

    4-Methylsulfonylphenol appears in diverse synthesis pathways. Some clients rely on it for constructing advanced resins, others for specialty pharmaceuticals, and some for experimenting with new material coatings. Each use case places slightly different demands on the product, but all share a need for lot-to-lot reproducibility and minimal batch deviation. Tech transfer teams at client sites regularly visit our plant to audit the actual line, not just documents, so they can see first-hand how our control of purity results in lower waste and higher throughput on their end.

    For electronics, where trace impurities interfere with dielectric performance or conductivity, customers stress-test samples under real operational conditions. They come to us reporting that off-brand sources introduced unknowns that blocked downstream processes or caused operational failures. In the pharmaceutical space, molecule carryover or trace organics from reused vessels have ruined entire campaigns in the past. We combat this with documented vessel cleaning and a dedicated team tracking every stage of the process.

    Standing Apart from Traders and Repackagers

    Unlike intermediaries who source and resell product with varying origins, we have full traceability back to each lot’s precursor chemicals, operator logs, and QC records. Direct manufacturing contracts often require disclosure of every process change, so process validation is embedded into our routine. We have seen clients faced with regulatory queries after buying from repackagers unable to show chain-of-custody. With everything made and bottled at one site, documentation stands up to both customer and regulatory scrutiny.

    Whereas traders rely on third-party test reports, our in-house data links directly to batch numbers. This lets downstream partners trace questions about reactivity or anomalous behavior to actual manufacturing dates and conditions. Over time, our team has learned from customer feedback and field failures how to further narrow tolerances, leading to improvements in crystallization protocols, filter choices, and even logistics methods.

    Supporting Sustainability and Safety Concerns

    Chemical manufacturing’s environmental impact has never been more visible. We have proactive programs in place for waste recovery, solvent recycling, and energy management. Our facility uses a closed-loop water system and installs sensors at potential emission points, which exceeds mandated compliance in many jurisdictions. This doesn’t just happen on paper; operators sit in daily planning meetings reviewing how much solvent they've saved compared with historical averages, learning from hands-on incidents to prevent future losses and upsets.

    The safety profile of 4-Methylsulfonylphenol benefits from decades refining hazard control. Our staff manage containment with effective air handling and quick-response spill stations. Regular drills reinforce habits across shifts. The same diligence appears in our logistics documentation, so supply chain partners know storage conditions and handling recommendations have real meaning, not generic copy-paste statements that fit any chemical.

    From Lab Scale to Bulk Production: Lessons Learned

    Years ago, scaling this molecule from bench to plant revealed new insights you just can’t gain in a university setting. Crystal growth rates change with mixing speeds only possible in full-scale reactors. We track these variables using tailored equipment chosen for this compound’s properties. Operators have learned how even audible cues from a running batch can signal a need for intervention, years before such nuances make it into SOPs.

    Consistency from early production lines identified batch deviations that might not matter at kilo scale but become major issues in multi-ton orders. We still recall troubleshooting a string of batches where minor shifts in pH led to a by-product forming above specification. Our technical team dissected each run—down to instrument calibration and vessel washout records—until source causes were clear and stable. The improvements made remain part of our daily workflow.

    Partnerships Built on Accountability

    Customers in small labs and large plants regularly ask for full visibility into our processes and results. We view this not as a burden but as a feature of genuine partnership. Teams on both sides are stronger when data reflects true conditions, rather than a sanitized ideal. Open communication extends beyond initial sales to real-time notifications about upcoming maintenance windows, unexpected shipping delays, or any change that could impact order timelines or product quality.

    Ongoing learning from feedback loops with pharmaceutical, agrochemical, and high-performance materials industries means specification sheets update based on practical needs, not dictated by distant offices. Real end-users often spot trends missed by automatic analysis—color drift signaling an uptick in an impurity, or viscosity shifts under storage that hint at a moisture ingress incident. We keep internal records of these reports, refining operation accordingly and letting customers know what drove each change.

    Troubleshooting and Continuous Improvement

    Successful chemical manufacturing involves knowing how to solve the unexpected. Occasional process upsets have at times caused temporary off-grade product. Our team doesn’t hide these incidents—instead, we trace root causes and notify affected partners. Technical support stays available for anyone facing problems in downstream reactions. After action reviews drive future process control—updating work instructions, training operators, and logging technical fixes—so improvements carry forward, not just on paper, but in the next batch run.

    Over the years, technical clients have described spectral traces, impurities, or flow behavior that didn’t match expectation. These real-world signals push our chemists to re-examine not just their own data but how raw input material shifts could cause variable performance. We adjust procurement sources only after pilot testing, to make sure any lot used for future batches delivers the same downstream compatibility. This approach reduces risk for our partners by sharing responsibility in maintaining line stability and application reliability.

    Addressing Market Confusion and Quality Myths

    Some buyers believe all 4-Methylsulfonylphenol on the market meets the same standards because packaging appears identical and global trade makes sourcing seem interchangeable. In real operation, repeated challenges emerge from subtle differences in impurity profiles or batch consistency. Data from user audits shows that production location, control regime, and operator experience have more impact on cGMP compliance or specialty formulation quality than external certifications alone can capture.

    Years of fielding questions about specification mismatches or unexplained failures show the value of knowing your source. Screenshots of dubious COAs or third-party documentation don’t mean much unless data comes straight from the producing reactor. We have seen high-value applications derailed by invisible changes—unlabeled stabilizers on repackaged goods, or traces of by-products from aged inventory. Our commitment to transparency shields partners from these risks.

    Shared Expertise, Lasting Reliability

    The technology behind MSP-039 rewards longstanding experience. From adjusting filtration regimes to specifying pumps and transfer lines that don’t leach contaminants, every operational lesson gets applied to daily running. Batch records reflect not just binary pass/fail but commentary from operators, chemists, and QC techs who have long practical history—and know how to notice what others might miss. Discussion among teams is routine at shift change, with every parameter explained, not just checked.

    Over time, these methods pay dividends for users demanding high standards—those seeking consistent melting points, freedom from metal residues, and full regulatory traceability. Where others rely on broad certificate statements, our partners can check data firsthand, visit the production floor, and verify hands-on controls for themselves. We think this trust, built across years and shipments, forms the real backbone of any successful specialty chemical program.

    Every Batch, Every Barrel: The Manufacturer’s Promise

    Producing 4-Methylsulfonylphenol at the manufacturing level means more than meeting a generic specification. It involves growing institutional memory, learning from each challenge, and investing in skilled staff and plant capability. Every hand that stirs a vessel or checks a chromatogram adds to a history of improvement that isn’t visible on a simple datasheet. In practice, reliable chemical manufacture rewards that cumulative knowledge—translating to fewer problems at our customers’ sites, more successful scale-ups, and smoother audits by regulators and stakeholders alike.

    As a direct producer, sharing what we’ve learned and staying open to customer input drives everything from product upgrades to subtle refinement in handling advice. The story of 4-Methylsulfonylphenol MSP-039 isn’t static; it continues to evolve as people—on both sides of the partnership—contribute experience, insight, and attention to detail. This genuine commitment to hands-on expertise, process control, and open partnership is what sets direct manufacturers apart in a crowded chemical marketplace.