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(4-Methylphenoxy)Acetic Acid

    • Product Name (4-Methylphenoxy)Acetic Acid
    • Alias Methyl p-anisylic acid
    • Einecs 249-591-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    798659

    Chemicalname (4-Methylphenoxy)Acetic Acid
    Casnumber 1878-70-8
    Molecularformula C9H10O3
    Molecularweight 166.17 g/mol
    Appearance White to off-white crystalline powder
    Meltingpoint 102-105°C
    Solubility Slightly soluble in water; soluble in organic solvents such as ethanol, acetone
    Pka 4.18 (carboxylic acid proton)
    Purity Typically ≥98%
    Synonyms p-Tolyloxyacetic acid; 2-(4-Methylphenoxy)acetic acid
    Storageconditions Store in a cool, dry, well-ventilated area away from incompatible substances
    Smiles CC1=CC=C(C=C1)OCC(=O)O
    Inchikey XWGMLFVGJDIALA-UHFFFAOYSA-N

    As an accredited (4-Methylphenoxy)Acetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of (4-Methylphenoxy)Acetic Acid is supplied in a sealed, labeled amber glass bottle with tamper-evident cap for safety.
    Shipping (4-Methylphenoxy)acetic acid should be shipped in tightly sealed containers to prevent leaks and contamination. It must be protected from moisture and stored away from incompatible substances. During transport, follow all relevant regulations for shipping chemicals, including appropriate labeling, documentation, and use of protective packaging to ensure safe handling.
    Storage (4-Methylphenoxy)acetic acid should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight. Always keep the storage area clearly labeled and secure to prevent unauthorized access or accidental exposure. Use appropriate personal protective equipment when handling the chemical.
    Application of (4-Methylphenoxy)Acetic Acid

    Applications of (4-Methylphenoxy)Acetic Acid in Industrial Manufacturing

    As the original manufacturer, we supply (4-Methylphenoxy)acetic acid to a range of advanced industrial sectors. This specialty chemical functions as a key intermediate and functional additive in regulated, high-tech downstream manufacturing environments. Below, we detail principal application tracks, associated compliance requirements, practical formulation guidelines, process entry points, and resulting end-use products.

    1. Synthesis of Selective Herbicide Active Ingredients

    (4-Methylphenoxy)acetic acid serves as a core building block in commercial production of certain phenoxyacetic-based herbicide actives. Agrochemical formulators esterify the acid to generate crop protection products for broadleaf weed control. Due to strict stewardship of agricultural chemical composition, traceability and load rates must align with national pesticide regulations. Product development labs optimize the dosage to balance crop safety and field efficacy according to local registration data. After initial chemical synthesis, manufacturers formulate the resultant esters into emulsifiable concentrates or wettable powders, which undergo QC testing before packaging for farm application.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • European Regulation (EC) No 1107/2009 (Plant Protection Product Authorisation)
    • US EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
    • ISO 9001:2015 for agrochemical manufacturing

    Typical usage ratio

    • 10–35% as acid precursor in synthesis; final herbicide active dose level customized according to weed spectrum and regulatory maximum residue limits (MRLs) per market.

    Downstream process integration

    • Introduced at the esterification stage to generate methyl, ethyl, or butyl esters, followed by downstream formulation, stabilization, and QC prior to final packaging.

    Final product types

    • Emulsifiable concentrate herbicides
    • Wettable powder herbicides
    • Water-dispersible granules
    • Pre-mix formulations for field application

    2. Pharmaceutical Intermediate for Antihypertensive Agents

    This intermediate supports the synthesis of active pharmaceutical ingredients (APIs) in the antihypertensive therapy class, especially as a precursor in the preparation of certain beta-blocker compounds. Its controlled use ensures alignment with current Good Manufacturing Practices (cGMP) for finished pharmaceuticals. Pharma manufacturers integrate this material during stepwise API synthesis, prior to salt formation and purification. Accurate input ratio calculations minimize impurities and maximize API yield, with process monitoring through validated analytical methods. After isolation and crystallization, downstream processing leads to tablet or capsule dosage forms.

    Industry compliance standards

    • Current Good Manufacturing Practices (cGMP, ICH Q7)
    • United States Pharmacopeia (USP) monographs
    • European Pharmacopeia (Ph. Eur.) general and specific monographs
    • International Conference on Harmonisation (ICH) Q3A/B for impurities

    Typical usage ratio

    • 5–18% molar equivalent in stepwise synthesis; adjusted based on route yields and validated by pilot batch data.

    Downstream process integration

    • Charged during intermediate coupling or alkylation steps under inert atmosphere, followed by purification, crystallization, and API salt formation.

    Final product types

    • Antihypertensive active pharmaceutical ingredients (APIs)
    • Finished drug product granules/tablets
    • Bulk intermediates for medicinal chemistry supply chains
    • Regulatory reference standards

    3. Fine Chemical Intermediate for Electronic Chemicals Manufacturing

    Within the electronics sector, (4-Methylphenoxy)acetic acid supports the synthesis of performance additives and specialty intermediates used in advanced photoresists and microelectronic coatings. Wafer fabrication plants require adherence to semiconductor grade QC to control ionic and metal impurities. Material enters amidation, esterification, or cross-coupling reactions, with tight batch control to ensure contamination-free output. Dosage depends on the specific polymer resin structure targeted. Downstream, end products serve as key components in photolithography and display manufacturing, where purity levels impact final device yield and longevity.

    Industry compliance standards

    • SEMI Standards (e.g., SEMI C93 for chemicals)
    • ISO 9001 for electronic chemical production
    • Customer-specific semiconductor grade COA requirements
    • JIS K 0557 for fine chemical analysis

    Typical usage ratio

    • 0.5–6 wt% in resin masterbatch synthesis; precise input rate adjusted per polymer molecular weight target and customer device integration profile.

    Downstream process integration

    • Introduced at initial coupling or condensation reaction step in high-purity synthesis reactors, followed by filtration, blend compounding, and QA/QC prior to cleanroom packaging.

    Final product types

    • Resist polymers for semiconductors
    • Photoactive materials for LCD and OLED fabrication
    • Printed circuit board processing chemicals
    • Dielectric and passivation layer additives

    4. Intermediate for Fragrance and Aroma Chemical Synthesis

    Specialty aroma chemical producers employ (4-Methylphenoxy)acetic acid in the synthesis of certain odorant molecules supplied to the fragrance and flavor industry. Production must follow IFRA and food additive regulations for aroma precursors, especially when destined for food, beverage, or personal care applications. The ingredient is typically involved at the acylation stage, affecting structural notes and volatility characteristics. Input amount depends on the final fragrance molecule and intended sensory profile. Downstream, isolated aroma chemicals are formulated into perfumes, flavors, and consumer goods after purity assessment and regulatory declaration.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards
    • Food Chemicals Codex (FCC) for flavor use
    • EU Regulation (EC) No 1334/2008 (Flavourings and food ingredients)
    • ISO 9235 for aroma definitions and terminology

    Typical usage ratio

    • 1–8 mol% in aroma synthesis pathways; batch ratio depends on target note intensity and allowable trace impurity threshold for finished product labelling.

    Downstream process integration

    • Charged during Friedel–Crafts or acylation step, followed by purification, distillation, and blending for final product standardization.

    Final product types

    • Aroma intermediates for fine fragrance houses
    • Flavour ingredient isolates for food and beverage
    • Personal care fragrance bases
    • Household and functional scent compounds

    5. Monomer Modifier in Polymer and Resin Manufacturing

    Chemical producers include (4-Methylphenoxy)acetic acid as a monomeric modifier to impart hydrophobicity and chemical resistance in engineering plastics and specialty resins. It is commonly used in correlation with acrylic, polyester, or epoxy resin development. Input is closely regulated by ISO polymer safety standards and RoHS appliance requirements. Blending ratios are determined through pilot resin tests for targeted mechanical and physico-chemical performance, with process engineers monitoring conversion rates and dispersion through the polymer matrix. End-use products feature elevated solvent resistance and tailored mechanical properties, serving automotive, electronics, and coatings manufacturers.

    Industry compliance standards

    • ISO 14001 for environmental management
    • REACH Regulation (EC) No. 1907/2006 for polymer monomer registration
    • RoHS Directive 2011/65/EU for appliance and electronics
    • UL 94 flammability standards

    Typical usage ratio

    • 2–12% by weight in copolymer batch; higher levels for enhanced hydrophobic effect, adjusted based on testing of physical property shifts.

    Downstream process integration

    • Mixed into resin melt or pre-polymerization feed, with uniform dispersion secured by high-shear mixing prior to catalytic polymerization, then integrated into compounding or extrusion lines.

    Final product types

    • Engineering polymers for automotive interiors
    • Insulation coatings for wire and cable
    • Solvent- and weather-resistant adhesives
    • Advanced functional films and sheets
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    Certification & Compliance
    More Introduction

    (4-Methylphenoxy)Acetic Acid: Experience from the Plant Floor

    Introduction to Our Work with (4-Methylphenoxy)Acetic Acid

    Over the decades in chemical manufacturing, we have shaped our understanding of (4-Methylphenoxy)Acetic Acid through real production schedules, shifts spent monitoring reactors, and constant feedback from customers working in fine chemicals and agro-tech. Our team approaches this compound with an eye on repeatability, purity, and structural integrity. While synthetic chemistry keeps moving forward, practical insight earned at scale on this compound’s unique nature never goes out of date. Consistency—that’s what seasoned hands in our plant value above all.

    Our Typical Model and Specifications

    Day-to-day, (4-Methylphenoxy)Acetic Acid, with the common structural formula C9H10O3, arrives off the drying line as a white crystalline powder. Over years of work, batch after batch lands between 99.0% and 99.5% purity by HPLC, with melting points already set between 102 and 105°C. This stability keeps reprocessing and adjustment at a minimum. Using pressed pellet FTIR, we see clean signals that guarantee quality expected in downstream catalyst and intermediate environments. We carry out moisture testing because the molecule absorbs water during humid months, which can affect reactivity or caking risk. It shows a faint, sweet aromatic note, not overwhelming, but always distinctive and easy to recognize for staff running the packaging section.

    Manufacturing in high volume means keeping particle size distribution predictable. We routinely run sieve analyses, targeting the range between 100 and 250 microns. Screening off over-fines and oversized fractions at the mill means downstream operators don’t complain about inconsistent bulk density, poor flowability, or dissolution speed. We have seen competing products arrive clumpy or variable in hygroscopicity, which always creates inefficiency for the end user.

    Direct Uses in Industry and Our Experiences

    The most direct application we see for (4-Methylphenoxy)Acetic Acid is as an intermediate in herbicide, fungicide, and plant growth regulator synthesis. Sourcing managers have explained that this compound lays the groundwork for some selective broadleaf weed controls and certain specialty organic intermediates. Those who tried switching to substitutes—such as phenoxyacetic acid or methyl-substituted benzoic acid—often report lower conversion rates or more by-products in downstream steps. Feedback from formulation labs indicates that (4-Methylphenoxy)Acetic Acid uniquely balances hydrophobic and hydrophilic character, blending into both esterification and amidation synthesis. This flexibility saves process steps in multi-stage manufacturing.

    Researchers from agricultural firms sometimes request small-lot modifications: slightly different particle size, or optimized purity cuts for pilot campaigns. We know that small impurities—be it methylated or oligomeric side products—lead to higher filtration burdens and downstream discoloration. We troubleshoot at the roots, cleaning up reaction profiles using advanced crystallization or post-reaction washing. In seasonal production runs, agricultural chemical blenders come to us with formulation challenges, especially in sensitive seed coatings or leaf-surface actives. Here, (4-Methylphenoxy)Acetic Acid stands out because of its uniform crystalline structure, which minimizes clumping and allows fast, reproducible dispersion in application tanks.

    Feedback from the Field

    On regular visits to downstream processors, we sit down with shift leaders to learn what happens to our acid once it leaves our loading dock. Over the years, operators using our product for synthesizing methyl-4-phenoxybutyrate note reduced filter plugging and improved crystal structure in their own isolated intermediates. Technical staff at custom manufacturing companies have commented that scaling up their process with our batches always brings less need for downstream purification and less variability in end-product assay. One customer, working in a high-volume agro-surfactant blend, tracked lower unwanted by-products by HPLC over several runs after switching to our material—and fed back how this reduced their final QA rejects.

    Not every process works flawlessly, and sometimes customers identify air or trace solvent sensitivity in specialty applications. With feedback in hand, our plant chemists revise drying and packaging procedures to minimize these effects. R&D batches produced with customer-specific requirements sometimes lead to changes in our own process controls, spurring process improvement across the line.

    Why Quality and Origin Matter in This Compound

    Sourcing (4-Methylphenoxy)Acetic Acid from actual manufacturers, as opposed to traders, brings tangible benefits to those at the end of the supply chain. We have seen traders push material that fails key purity or moisture specs, or that arrives with ambiguous origin, which creates headaches downstream and breaks confidence in the final application. Original manufacturers offer process history and transparent batch records, alongside technical support from lab and production veterans who understand why certain batch anomalies occur. For us, selling direct means we control not just assay and traceability, but also how quickly problems are identified and resolved. Customers who have bought from third parties eventually return looking for consistency and technical support unavailable from brokers.

    Real Differences: (4-Methylphenoxy)Acetic Acid Versus Closely Related Compounds

    Chemists sometimes ask us to compare our (4-Methylphenoxy)Acetic Acid with plain phenoxyacetic acid, or with cholorinated and methyl-substituted derivatives. While closely related structurally, each brings distinct reactivity and blending behavior. (4-Methylphenoxy)Acetic Acid’s extra methyl group changes solubility in nonpolar solvents and tweaking of hydrogen-bond acceptor/donor capability. In practice, this can tilt the scales in reaction yield and selectivity—particularly in reactions forming ethers or ester linkages, or when achieving phase transfer is critical. Unsubstituted phenoxyacetic acid doesn’t always deliver needed performance in applications that require fine-tuning of polarity.

    Producers working in crop protection development have shown, both in our plant and in their own labs, that switching between methyl and chloro substitutions affects both reactivity and toxicological profile. Chlorine-substituted counterparts sometimes raise environmental compliance concerns. Our own experience, supported by open technical literature, indicates that the 4-methyl group has a favorable toxicological and environmental record—making our product easier to register and introduce in certain regulatory environments. Customers who need robust chemical performance without facing additional labeling, hazard symbol, or reporting requirements trust (4-Methylphenoxy)Acetic Acid as a workhorse intermediate.

    Process Knowledge and Continuous Improvement

    Delivering (4-Methylphenoxy)Acetic Acid in large-scale lots draws on more than lab know-how: years of process improvement, equipment upgrades, and learning by doing shape our finished product. At scale, temperature gradients or trace impurities can sneak in, which less experienced manufacturers miss. Our technical staff run root cause analysis on off-spec batches, looking at everything from reactor feed rates to solvent swap sequences. We keep deep process control logs and in-house analytical capacity—not just for QA checks, but for troubleshooting when a customer’s own process stumbles. Input from those who blend, filter, or react this compound fuels ongoing optimization.

    Employees on the packaging line recognize the importance of packing density, bulk flow properties, and atmospheric exposure. Each step, from reaction through drying and milling down to bagging, shapes customer experience weeks or months down the supply chain. A single error—missed drying endpoint or poor sealing—costs real money in lost utility or scrap at the end user. Plant operators know this from long experience, tightening their routines as feedback from customers and our own QA cycles highlight improvement opportunities.

    Ensuring Regulatory and Supply Chain Reliability

    Regulatory demands on specialty acids like (4-Methylphenoxy)Acetic Acid have grown over the years, requiring greater transparency in manufacturing origin, trace elements, and side product profiles. Our operations track compliance with REACH and relevant national chemical codes, making annual submissions for technical dossiers, and updating safety assessments in response to evolving standards. Technical buyers appreciate transparency about raw material origin and batch-specific spectra. Companies developing new herbicide or intermediate platforms rely on clarity around impurities and process controls, since hidden contaminants or trace byproducts can skew toxicological profile or application safety. Our in-house regulatory staff support downstream documentation needs, with access to archive spectra, MSDS updates, and process change rationales.

    In recent years, supply chain disruption has highlighted the value of working direct with a core manufacturer, versus intermediaries. Shortening the supply chain limits risk and guarantees both availability and traceability. Having staff on hand who know reaction timelines, local raw material sourcing, and shipping requirements helps avoid bottlenecks during plant shutdowns or transport delays. We keep backup stock, and plan maintenance windows during low demand—practical measures that keep customer production lines humming, regardless of world events.

    Addressing Real World Issues and Solutions

    Shipping and storage present challenges for all crystalline acids. Heat and humidity in transit threaten caking, decreased shelf life, or slow dissolution. Our packing team selects pharma-grade, double-lined bags, places material on heat-treated pallets, and keeps containers moisture-tight. Storage trials in our own warehouse guide shelf-life recommendations, and create the basis for customer handling guidance. Customers storing material across seasonal temperature swings increasingly ask for batch records demonstrating stability under both cold and humid conditions. Early batch failures instilled habits of rapid corrective action, and ongoing investments in pallet sealing and environmental monitoring. These are not paper solutions, but lessons from cases where a small lapse in diligence led to bigger headaches for both producer and user.

    Waste and environmental responsibility have emerged as areas where (4-Methylphenoxy)Acetic Acid production places constraints on solvent selection, waste water treatment, and energy use. Decades ago, many in the industry brushed off these issues, but regulatory pressure and customer expectation push us to adopt greener solvents and introduce solvent-recovery systems wherever possible. Acidic and organic residues receive onsite neutralization, and our lab tracks byproduct generation, aiming for incremental improvement in both yield and waste reduction. Customers seek transparency on these steps, since increasing regulatory scrutiny and end-user sustainability criteria affect both procurement and market access. While big leaps take time and capital, every short-term improvement—whether upgrading a scrubber, or recycling a solvent batch—has direct impact on the bottom line and reputation.

    Our Commitment to Quality, Safety, and Reliable Supply

    Quality management plays out at every level, from plant floor to finished goods. Staff walk production lines daily, and our QA chemists work closely with operators, not just as auditors but as problem solvers embedded in the operation. Every transport container receives both visual and QC testing to catch physical or analytical inconsistencies before product goes outbound. Years of incident reporting and near-miss tracking have embedded a safety-first mindset, with every team member trained in both process risk and emergency response. This personal investment in quality and safety remains visible through every package sent to a customer—whether a half-ton lot or a custom research-sized batch.

    In tight supply conditions, competing products sometimes fall short on either purity or analytical traceability. Our sustained in-house program, from raw material auditing through post-shipment follow-up, creates the confidence customers cite as an advantage over generic or grey-market lots. The direct line from production to end user—without brokerage—means responsibility stays within our team, and we respond quickly if feedback points to a needed process tweak. This level of accountability keeps customers returning, time and again, building technical relationship on a foundation of trust, knowledge, and shared problem-solving.

    Continuous Dialogue—Built on Trust and History

    Open lines of communication with those using (4-Methylphenoxy)Acetic Acid drive much of what we do. Milestone meetings, customer audits, and joint troubleshooting sessions become part of business rhythm. When formulations shift, or new process requirements develop, a frank exchange between chemists, production supervisors, and technical sales delivers not only solutions but mutual confidence. All of our adjustments—from slight changes in crystal size to tighter impurity ranges—reflect direct conversations with end users who trust the expertise of those working hands-on with the product every day. Over the years, this two-way dialogue has shaped our process, forming an implicit contract with our customers: we solve challenges together.

    Looking back, it’s clear that success with (4-Methylphenoxy)Acetic Acid rests on a combination of technical rigor, practical production wisdom, and open feedback from our customers. What separates this product from generic or repacked competitors isn’t just a number on a spec sheet—it’s the results from the first shipment to the last kilo in a campaign. Every lesson learned in the plant, every hiccup handled with transparency, and every improvement discussed with our customers, leads to a product that delivers on both performance and reliability. For those who demand more than commodity chemicals, and value a supply partner with deep expertise and daily accountability, we remain committed to leading the way—on the ground, at the reactor, and at the customer’s site.